Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2NO2 | 2.8 | Crystal structure of the DLLRKN-containing coiled-coil domain of Huntingtin-interacting protein 1 |
| 2QA7 | 2.8 | Crystal structure of Huntingtin-interacting protein 1 (HIP1) coiled-coil domain with a basic surface suitable for HIP-protein interactor (HIPPI) |
| 3I00 | 2.3 | Crystal Structure of the huntingtin interacting protein 1 coiled coil domain |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0097190 | apoptotic signaling pathway |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0048268 | clathrin coat assembly |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0099637 | neurotransmitter receptor transport |
| Biological Process | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway |
| Biological Process | GO:2000588 | positive regulation of platelet-derived growth factor receptor-beta signaling pathway |
| Biological Process | GO:0051897 | positive regulation of protein kinase B signaling |
| Biological Process | GO:0048260 | positive regulation of receptor-mediated endocytosis |
| Biological Process | GO:0099171 | presynaptic modulation of chemical synaptic transmission |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0030100 | regulation of endocytosis |
| Biological Process | GO:0099149 | regulation of postsynaptic neurotransmitter receptor internalization |
| Molecular Function | GO:0035612 | AP-2 adaptor complex binding |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0035615 | clathrin adaptor activity |
| Molecular Function | GO:0030276 | clathrin binding |
| Molecular Function | GO:0032051 | clathrin light chain binding |
| Molecular Function | GO:0005154 | epidermal growth factor receptor binding |
| Molecular Function | GO:0035254 | glutamate receptor binding |
| Molecular Function | GO:0035091 | phosphatidylinositol binding |
| Molecular Function | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding |
| Molecular Function | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding |
| Molecular Function | GO:0032266 | phosphatidylinositol-3-phosphate binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0030136 | clathrin-coated vesicle |
| Cellular Component | GO:0030665 | clathrin-coated vesicle membrane |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098890 | extrinsic component of postsynaptic membrane |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| InterPro
|
InterPro name |
|---|---|
| IPR002558 | I/LWEQ domain |
| IPR008942 | ENTH/VHS |
| IPR011417 | AP180 N-terminal homology (ANTH) domain |
| IPR013809 | ENTH domain |
| IPR030224 | Sla2 family |
| IPR032422 | Huntingtin-interacting protein 1, clathrin-binding domain |
| IPR035964 | I/LWEQ domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF01608 | I/LWEQ domain |
| PF07651 | ANTH domain |
| PF16515 | Clathrin-binding domain of Huntingtin-interacting protein 1 |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-8856828 | Clathrin-mediated endocytosis | Internal node | R-HSA-5653656 | Vesicle-mediated transport |
| R-HSA-9700645 | ALK mutants bind TKIs | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | Internal node | R-HSA-1643685 | Disease |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Enhanced |
| adrenal gland | glandular cells | Medium | Enhanced |
| appendix | glandular cells | Medium | Enhanced |
| appendix | lymphoid tissue | Low | Enhanced |
| bone marrow | hematopoietic cells | Medium | Enhanced |
| breast | adipocytes | Medium | Enhanced |
| breast | glandular cells | Medium | Enhanced |
| breast | myoepithelial cells | Medium | Enhanced |
| bronchus | respiratory epithelial cells | Medium | Enhanced |
| caudate | glial cells | High | Enhanced |
| caudate | neuronal cells | Low | Enhanced |
| cerebellum | Purkinje cells | Medium | Enhanced |
| cerebellum | cells in granular layer | Medium | Enhanced |
| cerebellum | cells in molecular layer | Low | Enhanced |
| cerebral cortex | endothelial cells | High | Enhanced |
| cerebral cortex | glial cells | High | Enhanced |
| cerebral cortex | neuronal cells | Low | Enhanced |
| cerebral cortex | neuropil | High | Enhanced |
| cervix | glandular cells | Medium | Enhanced |
| cervix | squamous epithelial cells | Low | Enhanced |
| colon | endothelial cells | High | Enhanced |
| colon | glandular cells | Medium | Enhanced |
| colon | peripheral nerve/ganglion | High | Enhanced |
| duodenum | glandular cells | Medium | Enhanced |
| endometrium 1 | cells in endometrial stroma | Medium | Enhanced |
| endometrium 1 | glandular cells | High | Enhanced |
| endometrium 2 | cells in endometrial stroma | Medium | Enhanced |
| endometrium 2 | glandular cells | High | Enhanced |
| epididymis | glandular cells | High | Enhanced |
| esophagus | squamous epithelial cells | Low | Enhanced |
| fallopian tube | glandular cells | High | Enhanced |
| gallbladder | glandular cells | Medium | Enhanced |
| heart muscle | cardiomyocytes | Low | Enhanced |
| hippocampus | glial cells | Medium | Enhanced |
| hippocampus | neuronal cells | Low | Enhanced |
| kidney | cells in glomeruli | High | Enhanced |
| kidney | cells in tubules | High | Enhanced |
| liver | cholangiocytes | Medium | Enhanced |
| lung | alveolar cells type I | Medium | Enhanced |
| lung | alveolar cells type II | Medium | Enhanced |
| lung | endothelial cells | Medium | Enhanced |
| lung | macrophages | High | Enhanced |
| lymph node | germinal center cells | Low | Enhanced |
| lymph node | non-germinal center cells | Medium | Enhanced |
| nasopharynx | respiratory epithelial cells | Medium | Enhanced |
| oral mucosa | squamous epithelial cells | Low | Enhanced |
| ovary | follicle cells | Medium | Enhanced |
| ovary | ovarian stroma cells | Medium | Enhanced |
| pancreas | exocrine glandular cells | Medium | Enhanced |
| pancreas | pancreatic endocrine cells | Low | Enhanced |
| parathyroid gland | glandular cells | Low | Enhanced |
| placenta | decidual cells | Medium | Enhanced |
| placenta | trophoblastic cells | Medium | Enhanced |
| prostate | glandular cells | Medium | Enhanced |
| rectum | glandular cells | Medium | Enhanced |
| seminal vesicle | glandular cells | Medium | Enhanced |
| skeletal muscle | myocytes | Low | Enhanced |
| skin 1 | Langerhans | Medium | Enhanced |
| skin 1 | fibroblasts | Medium | Enhanced |
| skin 1 | keratinocytes | Medium | Enhanced |
| skin 1 | melanocytes | Medium | Enhanced |
| skin 2 | epidermal cells | Low | Enhanced |
| small intestine | glandular cells | Medium | Enhanced |
| smooth muscle | smooth muscle cells | Low | Enhanced |
| soft tissue 1 | fibroblasts | Medium | Enhanced |
| soft tissue 1 | peripheral nerve | Medium | Enhanced |
| soft tissue 2 | fibroblasts | Low | Enhanced |
| soft tissue 2 | peripheral nerve | Low | Enhanced |
| spleen | cells in red pulp | Medium | Enhanced |
| stomach 1 | glandular cells | Medium | Enhanced |
| stomach 2 | glandular cells | Medium | Enhanced |
| testis | Leydig cells | Medium | Enhanced |
| testis | elongated or late spermatids | Medium | Enhanced |
| testis | pachytene spermatocytes | Medium | Enhanced |
| testis | preleptotene spermatocytes | High | Enhanced |
| testis | round or early spermatids | Medium | Enhanced |
| testis | sertoli cells | Low | Enhanced |
| testis | spermatogonia cells | High | Enhanced |
| thyroid gland | glandular cells | Medium | Enhanced |
| tonsil | germinal center cells | Medium | Enhanced |
| tonsil | non-germinal center cells | Medium | Enhanced |
| tonsil | squamous epithelial cells | Medium | Enhanced |
| urinary bladder | urothelial cells | Medium | Enhanced |
| vagina | squamous epithelial cells | Low | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|