MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.7.1.137	Transferases; Transferring phosphorus-containing groups; Phosphotransferases with an alcohol group as acceptor; phosphatidylinositol 3-kinase
2.7.1.153	Transferases; Transferring phosphorus-containing groups; Phosphotransferases with an alcohol group as acceptor; phosphatidylinositol-4,5-bisphosphate 3-kinase
2.7.1.154	Transferases; Transferring phosphorus-containing groups; Phosphotransferases with an alcohol group as acceptor; phosphatidylinositol-4-phosphate 3-kinase

Structure

PDB	Resolution (Å)	PDB name
2AR5	1.8	Crystal structure of the mammalian C2alpha-PI3 Kinase PX-domain
2IWL	2.6	Structure of the PX Domain of Phosphoinositide 3-Kinase-C2alpha
2REA	2.5	Crystal structures of C2ALPHA-PI3 kinase PX-domain domain indicate conformational change associated with ligand binding.
2RED	2.1	Crystal structures of C2ALPHA-PI3 kinase PX-domain domain indicate conformational change associated with ligand binding.
6BTY	1.678	Crystal structure of the PI3KC2alpha C2 domain in space group P41212
6BTZ	1.85	Crystal structure of the PI3KC2alpha C2 domain in space group C121
6BU0	2.427	Crystal structure of the PI3KC2alpha C2 domain in complex with IP6
6BUB	2.604	Crystal structure of the PI3KC2alpha PX domain in space group P432

GO term

GO ontology	GO term	GO description
Biological Process	GO:0016477	cell migration
Biological Process	GO:0048268	clathrin coat assembly
Biological Process	GO:0006897	endocytosis
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway
Biological Process	GO:0006887	exocytosis
Biological Process	GO:0008286	insulin receptor signaling pathway
Biological Process	GO:0061024	membrane organization
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling
Biological Process	GO:0006661	phosphatidylinositol biosynthetic process
Biological Process	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway
Biological Process	GO:0010508	positive regulation of autophagy
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis
Biological Process	GO:0014829	vascular associated smooth muscle contraction
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity
Molecular Function	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0030276	clathrin binding
Molecular Function	GO:0035004	phosphatidylinositol 3-kinase activity
Molecular Function	GO:0035091	phosphatidylinositol binding
Molecular Function	GO:0052812	phosphatidylinositol-3,4-bisphosphate 5-kinase activity
Molecular Function	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Cellular Component	GO:0030136	clathrin-coated vesicle
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0043231	intracellular membrane-bounded organelle
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0005802	trans-Golgi network
Cellular Component	GO:0031982	vesicle

InterPro / Pfam

InterPro	InterPro name
IPR000008	C2 domain
IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain
IPR001683	Phox homology
IPR002420	C2 phosphatidylinositol 3-kinase-type domain
IPR011009	Protein kinase-like domain superfamily
IPR015433	Phosphatidylinositol kinase
IPR016024	Armadillo-type fold
IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
IPR029071	Ubiquitin-like domain superfamily
IPR035892	C2 domain superfamily
IPR036871	PX domain superfamily
IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
IPR037705	PI3K-C2-alpha, catalytic domain
IPR042133	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain
IPR042236	Phosphoinositide 3-kinase, accessory (PIK) domain superfamily

Pfam	Pfam name
PF00168	C2 domain
PF00454	Phosphatidylinositol 3- and 4-kinase
PF00613	Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PF00787	PX domain
PF00792	Phosphoinositide 3-kinase C2
PF00794	PI3-kinase family, ras-binding domain

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	Leaf	R-HSA-1430728	Metabolism
R-HSA-1660514	Synthesis of PIPs at the Golgi membrane	Leaf	R-HSA-1430728	Metabolism
R-HSA-1660516	Synthesis of PIPs at the early endosome membrane	Leaf	R-HSA-1430728	Metabolism
R-HSA-1660517	Synthesis of PIPs at the late endosome membrane	Leaf	R-HSA-1430728	Metabolism
R-HSA-432722	Golgi Associated Vesicle Biogenesis	Leaf	R-HSA-5653656	Vesicle-mediated transport
R-HSA-8856828	Clathrin-mediated endocytosis	Internal node	R-HSA-5653656	Vesicle-mediated transport

Location	ECO term	Pubmed
Cell membrane	ECO:0000269	PubMed:10766823
Cell membrane	ECO:0000269	PubMed:11239472
Cell membrane	ECO:0000269	PubMed:17038310
Cytoplasm	ECO:0000269	PubMed:11606566
Cytoplasm	ECO:0000269	PubMed:14563213
Cytoplasmic vesicle, clathrin-coated vesicle	ECO:0000269	PubMed:10766823
Cytoplasmic vesicle, clathrin-coated vesicle	ECO:0000269	PubMed:11239472
Golgi apparatus, trans-Golgi network	ECO:0000269	PubMed:10766823
Golgi apparatus, trans-Golgi network	ECO:0000269	PubMed:11239472
Nucleus	ECO:0000269	PubMed:11606566

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000028	Cryptorchidism
HP:0000104	Renal agenesis
HP:0000121	Nephrocalcinosis
HP:0000158	Macroglossia
HP:0000164	Abnormality of the dentition
HP:0000278	Retrognathia
HP:0000280	Coarse facial features
HP:0000286	Epicanthus
HP:0000294	Low anterior hairline
HP:0000365	Hearing impairment
HP:0000405	Conductive hearing impairment
HP:0000407	Sensorineural hearing impairment
HP:0000431	Wide nasal bridge
HP:0000501	Glaucoma
HP:0000519	Developmental cataract
HP:0000599	Abnormality of the frontal hairline
HP:0000677	Oligodontia
HP:0000691	Microdontia
HP:0000766	Abnormal sternum morphology
HP:0000821	Hypothyroidism
HP:0001263	Global developmental delay
HP:0001297	Stroke
HP:0001328	Specific learning disability
HP:0001518	Small for gestational age
HP:0001744	Splenomegaly
HP:0001999	Abnormal facial shape
HP:0002150	Hypercalciuria
HP:0002162	Low posterior hairline
HP:0002240	Hepatomegaly
HP:0002243	Protein-losing enteropathy
HP:0002300	Mutism
HP:0002650	Scoliosis
HP:0002750	Delayed skeletal maturation
HP:0002901	Hypocalcemia
HP:0002942	Thoracic kyphosis
HP:0002987	Elbow flexion contracture
HP:0003072	Hypercalcemia
HP:0003090	Hypoplasia of the capital femoral epiphysis
HP:0003307	Hyperlordosis
HP:0004322	Short stature
HP:0005257	Thoracic hypoplasia
HP:0005280	Depressed nasal bridge
HP:0006297	Enamel hypoplasia
HP:0006989	Dysplastic corpus callosum
HP:0007042	Focal white matter lesions
HP:0008155	Mucopolysacchariduria
HP:0009237	Short 5th finger
HP:0009928	Thick nasal alae
HP:0010663	Abnormality of thalamus morphology
HP:0010761	Broad columella
HP:0011020	Abnormality of mucopolysaccharide metabolism
HP:0012758	Neurodevelopmental delay
HP:0030084	Clinodactyly
HP:0032325	Lacunar stroke
HP:0100255	Metaphyseal dysplasia
HP:0100864	Short femoral neck

Summary of O00443

Gene: PIK3C2A
Protein: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of O00443

Gene: PIK3C2A Protein: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: PIK3C2A
Protein: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha