Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.1.1.-
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
3.5.1.99
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides;
fatty acid amide hydrolase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0019369 | arachidonic acid metabolic process |
| Biological Process | GO:0009062 | fatty acid catabolic process |
| Biological Process | GO:0052651 | monoacylglycerol catabolic process |
| Biological Process | GO:0045907 | positive regulation of vasoconstriction |
| Molecular Function | GO:0047372 | acylglycerol lipase activity |
| Molecular Function | GO:0004040 | amidase activity |
| Molecular Function | GO:0017064 | fatty acid amide hydrolase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0031090 | organelle membrane |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-2142753 | Arachidonic acid metabolism | Internal node | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm, cytoskeleton | ECO:0000269 | PubMed:17015445 |
| Endomembrane system | ECO:0000269 | PubMed:17015445 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | High | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Medium | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | glandular cells | High | Approved |
| breast | myoepithelial cells | Low | Approved |
| bronchus | respiratory epithelial cells | Medium | Approved |
| caudate | glial cells | Low | Approved |
| caudate | neuronal cells | High | Approved |
| cerebellum | Purkinje cells | High | Approved |
| cerebellum | cells in granular layer | Medium | Approved |
| cerebellum | cells in molecular layer | Medium | Approved |
| cerebral cortex | glial cells | Medium | Approved |
| cerebral cortex | neuronal cells | High | Approved |
| cervix | glandular cells | High | Approved |
| cervix | squamous epithelial cells | Medium | Approved |
| colon | endothelial cells | Low | Approved |
| colon | glandular cells | High | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | cells in endometrial stroma | Low | Approved |
| endometrium 1 | glandular cells | High | Approved |
| endometrium 2 | cells in endometrial stroma | Low | Approved |
| endometrium 2 | glandular cells | High | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | High | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | Medium | Approved |
| hippocampus | glial cells | High | Approved |
| hippocampus | neuronal cells | High | Approved |
| kidney | cells in glomeruli | Low | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | cholangiocytes | Medium | Approved |
| liver | hepatocytes | Medium | Approved |
| lung | alveolar cells | Low | Approved |
| lung | macrophages | High | Approved |
| lymph node | germinal center cells | Medium | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | High | Approved |
| oral mucosa | squamous epithelial cells | High | Approved |
| pancreas | exocrine glandular cells | High | Approved |
| pancreas | pancreatic endocrine cells | Medium | Approved |
| parathyroid gland | glandular cells | Medium | Approved |
| placenta | trophoblastic cells | High | Approved |
| prostate | glandular cells | High | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | High | Approved |
| seminal vesicle | glandular cells | High | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | High | Approved |
| skin 1 | fibroblasts | Low | Approved |
| skin 1 | keratinocytes | High | Approved |
| skin 1 | melanocytes | Medium | Approved |
| skin 2 | epidermal cells | Low | Approved |
| small intestine | glandular cells | High | Approved |
| smooth muscle | smooth muscle cells | Low | Approved |
| soft tissue 1 | chondrocytes | Medium | Approved |
| soft tissue 2 | fibroblasts | Low | Approved |
| spleen | cells in red pulp | Low | Approved |
| spleen | cells in white pulp | Low | Approved |
| stomach 1 | glandular cells | High | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | Leydig cells | Low | Approved |
| testis | elongated or late spermatids | High | Approved |
| testis | pachytene spermatocytes | High | Approved |
| testis | round or early spermatids | High | Approved |
| thyroid gland | glandular cells | High | Approved |
| tonsil | germinal center cells | Medium | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | High | Approved |
| urinary bladder | urothelial cells | High | Approved |
| vagina | squamous epithelial cells | High | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|