MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
4.6.1.19	Lyases; Phosphorus-oxygen lyases; Phosphorus-oxygen lyases (only sub-subclass identified to date); ribonuclease T2

Structure

PDB	Resolution (Å)	PDB name
3T0O	1.59	Crystal Structure Analysis of Human RNase T2

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006401	RNA catabolic process
Biological Process	GO:0045087	innate immune response
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0004521	RNA endonuclease activity
Molecular Function	GO:0004540	RNA nuclease activity
Molecular Function	GO:0033897	ribonuclease T2 activity
Cellular Component	GO:0035578	azurophil granule lumen
Cellular Component	GO:0005788	endoplasmic reticulum lumen
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0043202	lysosomal lumen
Cellular Component	GO:0005764	lysosome
Cellular Component	GO:0005758	mitochondrial intermembrane space

InterPro	InterPro name
IPR001568	Ribonuclease T2-like
IPR018188	Ribonuclease T2, His active site 1
IPR033130	Ribonuclease T2, His active site 2
IPR033697	Ribonuclease T2, eukaryotic
IPR036430	Ribonuclease T2-like superfamily

Pfam	Pfam name
PF00445	Ribonuclease T2 family

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-6798695	Neutrophil degranulation	Leaf	R-HSA-168256	Immune System

Location	ECO term	Pubmed
Endoplasmic reticulum lumen	ECO:0000269	PubMed:16620762
Lysosome lumen	ECO:0000269	PubMed:16620762
Mitochondrion intermembrane space	ECO:0000269	PubMed:28730546
Mitochondrion intermembrane space	ECO:0000269	PubMed:30184494
Mitochondrion intermembrane space	ECO:0000269	PubMed:30385512
Secreted	ECO:0000269	PubMed:15809705
Secreted	ECO:0000269	PubMed:16620762

Phenotype

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0000295	Doll-like facies
HP:0000407	Sensorineural hearing impairment
HP:0000639	Nystagmus
HP:0000750	Delayed speech and language development
HP:0001250	Seizure
HP:0001251	Ataxia
HP:0001257	Spasticity
HP:0001263	Global developmental delay
HP:0001332	Dystonia
HP:0002119	Ventriculomegaly
HP:0002305	Athetosis
HP:0002352	Leukoencephalopathy
HP:0002465	Poor speech
HP:0002514	Cerebral calcification
HP:0003593	Infantile onset
HP:0003677	Slowly progressive
HP:0007042	Focal white matter lesions
HP:0011344	Severe global developmental delay
HP:0011400	Abnormal CNS myelination

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Low	Approved
adrenal gland	glandular cells	High	Approved
appendix	glandular cells	High	Approved
appendix	lymphoid tissue	High	Approved
bone marrow	hematopoietic cells	Medium	Approved
breast	adipocytes	Low	Approved
breast	myoepithelial cells	Medium	Approved
bronchus	respiratory epithelial cells	Medium	Approved
caudate	neuronal cells	Low	Approved
cerebellum	Purkinje cells	Medium	Approved
cerebral cortex	endothelial cells	Medium	Approved
cerebral cortex	glial cells	Low	Approved
cerebral cortex	neuronal cells	Medium	Approved
cerebral cortex	neuropil	Medium	Approved
cervix	glandular cells	High	Approved
cervix	squamous epithelial cells	Medium	Approved
colon	endothelial cells	High	Approved
colon	glandular cells	Low	Approved
colon	peripheral nerve/ganglion	Low	Approved
duodenum	glandular cells	High	Approved
endometrium 1	cells in endometrial stroma	Medium	Approved
endometrium 1	glandular cells	High	Approved
endometrium 2	cells in endometrial stroma	Medium	Approved
endometrium 2	glandular cells	High	Approved
epididymis	glandular cells	Medium	Approved
esophagus	squamous epithelial cells	Medium	Approved
fallopian tube	glandular cells	Medium	Approved
gallbladder	glandular cells	Medium	Approved
heart muscle	cardiomyocytes	High	Approved
kidney	cells in glomeruli	High	Approved
kidney	cells in tubules	High	Approved
liver	hepatocytes	Low	Approved
lung	alveolar cells	High	Approved
lung	macrophages	High	Approved
lymph node	germinal center cells	High	Approved
lymph node	non-germinal center cells	High	Approved
nasopharynx	respiratory epithelial cells	Medium	Approved
oral mucosa	squamous epithelial cells	Medium	Approved
ovary	follicle cells	Medium	Approved
pancreas	exocrine glandular cells	Low	Approved
pancreas	pancreatic endocrine cells	High	Approved
parathyroid gland	glandular cells	Low	Approved
prostate	glandular cells	Low	Approved
rectum	glandular cells	Medium	Approved
salivary gland	glandular cells	Medium	Approved
seminal vesicle	glandular cells	Medium	Approved
skeletal muscle	myocytes	Medium	Approved
skin 1	Langerhans	High	Approved
skin 1	fibroblasts	High	Approved
skin 1	keratinocytes	Low	Approved
skin 1	melanocytes	Medium	Approved
skin 2	epidermal cells	Medium	Approved
small intestine	glandular cells	High	Approved
smooth muscle	smooth muscle cells	High	Approved
soft tissue 1	fibroblasts	High	Approved
soft tissue 2	fibroblasts	High	Approved
soft tissue 2	peripheral nerve	Medium	Approved
spleen	cells in red pulp	High	Approved
spleen	cells in white pulp	High	Approved
stomach 1	glandular cells	Medium	Approved
stomach 2	glandular cells	Medium	Approved
testis	Leydig cells	Low	Approved
testis	cells in seminiferous ducts	Low	Approved
thyroid gland	glandular cells	Medium	Approved
tonsil	germinal center cells	High	Approved
tonsil	non-germinal center cells	High	Approved
tonsil	squamous epithelial cells	Low	Approved
urinary bladder	urothelial cells	Medium	Approved
vagina	squamous epithelial cells	Medium	Approved

Summary of O00584

Gene: RNASET2, RNASE6PL
Protein: Ribonuclease T2

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of O00584

Gene: RNASET2, RNASE6PL Protein: Ribonuclease T2

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: RNASET2, RNASE6PL
Protein: Ribonuclease T2