MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.3.2.23	Transferases; Acyltransferases; Aminoacyltransferases; E2 ubiquitin-conjugating enzyme
2.3.2.24	Transferases; Acyltransferases; Aminoacyltransferases; (E3-independent) E2 ubiquitin-conjugating enzyme

Structure

PDB	Resolution (Å)	PDB name
1I7K	1.95	CRYSTAL STRUCTURE OF HUMAN MITOTIC-SPECIFIC UBIQUITIN-CONJUGATING ENZYME, UBCH10
4YII	1.804	Structure of an APC2-UBCH10 complex reveals distinctive cullin-RING ligase mechanism for Anaphase-promoting complex/Cyclosome
5A31	4.3	Structure of the human APC-Cdh1-Hsl1-UbcH10 complex.
5KHR	6.1	Model of human Anaphase-promoting complex/Cyclosome complex (APC15 deletion mutant) in complex with the E2 UBE2C/UBCH10 poised for ubiquitin ligation to substrate (APC/C-CDC20-substrate-UBE2C)
5L9U	6.4	Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination

GO term

GO ontology	GO term	GO description
Biological Process	GO:0031145	anaphase-promoting complex-dependent catabolic process
Biological Process	GO:0051301	cell division
Biological Process	GO:0010458	exit from mitosis
Biological Process	GO:0010994	free ubiquitin chain polymerization
Biological Process	GO:0031536	positive regulation of exit from mitosis
Biological Process	GO:0045842	positive regulation of mitotic metaphase/anaphase transition
Biological Process	GO:1904668	positive regulation of ubiquitin protein ligase activity
Biological Process	GO:0070979	protein K11-linked ubiquitination
Biological Process	GO:0070936	protein K48-linked ubiquitination
Biological Process	GO:0000209	protein polyubiquitination
Biological Process	GO:0016567	protein ubiquitination
Biological Process	GO:0030071	regulation of mitotic metaphase/anaphase transition
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0061631	ubiquitin conjugating enzyme activity
Molecular Function	GO:0061630	ubiquitin protein ligase activity
Molecular Function	GO:0044389	ubiquitin-like protein ligase binding
Molecular Function	GO:0004842	ubiquitin-protein transferase activity
Cellular Component	GO:0005680	anaphase-promoting complex
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0000151	ubiquitin ligase complex

InterPro / Pfam

InterPro	InterPro name
IPR000608	Ubiquitin-conjugating enzyme E2
IPR016135	Ubiquitin-conjugating enzyme/RWD-like
IPR023313	Ubiquitin-conjugating enzyme, active site

Pfam	Pfam name
PF00179	Ubiquitin-conjugating enzyme

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-141430	Inactivation of APC/C via direct inhibition of the APC/C complex	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-174048	APC/C:Cdc20 mediated degradation of Cyclin B	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-176407	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	Internal node	R-HSA-1640170	Cell Cycle
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	Internal node	R-HSA-1640170	Cell Cycle
R-HSA-176412	Phosphorylation of the APC/C	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-2467813	Separation of Sister Chromatids	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-68867	Assembly of the pre-replicative complex	Internal node	R-HSA-69306	DNA Replication
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	Leaf	R-HSA-69306	DNA Replication
R-HSA-8853884	Transcriptional Regulation by VENTX	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8866652	Synthesis of active ubiquitin: roles of E1 and E2 enzymes	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-9687136	Aberrant regulation of mitotic exit in cancer due to RB1 defects	Leaf	R-HSA-1643685	Disease
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	Leaf	R-HSA-168256	Immune System

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Low	Approved
appendix	glandular cells	Medium	Approved
appendix	lymphoid tissue	Medium	Approved
bone marrow	hematopoietic cells	Medium	Approved
breast	adipocytes	Low	Approved
breast	glandular cells	Medium	Approved
breast	myoepithelial cells	Medium	Approved
bronchus	respiratory epithelial cells	Medium	Approved
caudate	glial cells	Low	Approved
caudate	neuronal cells	Low	Approved
cerebellum	Purkinje cells	Medium	Approved
cerebellum	cells in granular layer	Medium	Approved
cerebellum	cells in molecular layer	Low	Approved
cerebral cortex	endothelial cells	Low	Approved
cerebral cortex	glial cells	Low	Approved
cerebral cortex	neuronal cells	Low	Approved
cerebral cortex	neuropil	Medium	Approved
cervix	glandular cells	Medium	Approved
colon	endothelial cells	Medium	Approved
colon	glandular cells	Medium	Approved
colon	peripheral nerve/ganglion	Medium	Approved
duodenum	glandular cells	Medium	Approved
endometrium 1	cells in endometrial stroma	Medium	Approved
endometrium 1	glandular cells	Medium	Approved
endometrium 2	cells in endometrial stroma	Medium	Approved
endometrium 2	glandular cells	Medium	Approved
epididymis	glandular cells	Medium	Approved
esophagus	squamous epithelial cells	Medium	Approved
fallopian tube	glandular cells	Medium	Approved
gallbladder	glandular cells	Medium	Approved
heart muscle	cardiomyocytes	Low	Approved
hippocampus	glial cells	Low	Approved
hippocampus	neuronal cells	Low	Approved
liver	cholangiocytes	Medium	Approved
liver	hepatocytes	Medium	Approved
lung	alveolar cells	Low	Approved
lung	macrophages	Medium	Approved
lymph node	germinal center cells	Medium	Approved
lymph node	non-germinal center cells	Medium	Approved
nasopharynx	respiratory epithelial cells	Medium	Approved
parathyroid gland	glandular cells	Low	Approved
placenta	decidual cells	Medium	Approved
placenta	trophoblastic cells	Medium	Approved
prostate	glandular cells	Medium	Approved
rectum	glandular cells	Medium	Approved
salivary gland	glandular cells	Low	Approved
seminal vesicle	glandular cells	Medium	Approved
skin 1	fibroblasts	Low	Approved
skin 1	keratinocytes	Low	Approved
skin 1	melanocytes	Low	Approved
skin 2	epidermal cells	Medium	Approved
small intestine	glandular cells	Medium	Approved
smooth muscle	smooth muscle cells	Medium	Approved
soft tissue 1	fibroblasts	Low	Approved
soft tissue 1	peripheral nerve	Low	Approved
soft tissue 2	chondrocytes	Low	Approved
soft tissue 2	fibroblasts	Low	Approved
spleen	cells in red pulp	Medium	Approved
spleen	cells in white pulp	Low	Approved
stomach 1	glandular cells	Medium	Approved
stomach 2	glandular cells	Medium	Approved
testis	Leydig cells	Medium	Approved
testis	cells in seminiferous ducts	Medium	Approved
thyroid gland	glandular cells	Low	Approved
tonsil	germinal center cells	Medium	Approved
tonsil	non-germinal center cells	Medium	Approved
tonsil	squamous epithelial cells	Medium	Approved
urinary bladder	urothelial cells	Medium	Approved
vagina	squamous epithelial cells	Medium	Approved

Summary of O00762

Gene: UBE2C, UBCH10
Protein: Ubiquitin-conjugating enzyme E2 C

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of O00762

Gene: UBE2C, UBCH10 Protein: Ubiquitin-conjugating enzyme E2 C

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: UBE2C, UBCH10
Protein: Ubiquitin-conjugating enzyme E2 C