Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.1.3.-
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases;
3.1.3.4
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases;
phosphatidate phosphatase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0060020 | Bergmann glial cell differentiation |
| Biological Process | GO:0001568 | blood vessel development |
| Biological Process | GO:0033631 | cell-cell adhesion mediated by integrin |
| Biological Process | GO:0006672 | ceramide metabolic process |
| Biological Process | GO:0001702 | gastrulation with mouth forming second |
| Biological Process | GO:0034109 | homotypic cell-cell adhesion |
| Biological Process | GO:0007229 | integrin-mediated signaling pathway |
| Biological Process | GO:0001933 | negative regulation of protein phosphorylation |
| Biological Process | GO:0046839 | phospholipid dephosphorylation |
| Biological Process | GO:0006644 | phospholipid metabolic process |
| Biological Process | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| Biological Process | GO:0022409 | positive regulation of cell-cell adhesion |
| Biological Process | GO:0010595 | positive regulation of endothelial cell migration |
| Biological Process | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0030111 | regulation of Wnt signaling pathway |
| Biological Process | GO:1902068 | regulation of sphingolipid mediated signaling pathway |
| Biological Process | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0030148 | sphingolipid biosynthetic process |
| Biological Process | GO:0006670 | sphingosine metabolic process |
| Biological Process | GO:0042060 | wound healing |
| Molecular Function | GO:0106235 | ceramide-1-phosphate phosphatase activity |
| Molecular Function | GO:0005178 | integrin binding |
| Molecular Function | GO:0008195 | phosphatidate phosphatase activity |
| Molecular Function | GO:0042392 | sphingosine-1-phosphate phosphatase activity |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0070971 | endoplasmic reticulum exit site |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Basolateral cell membrane | ECO:0000269 | PubMed:14527693 |
| Cell membrane | ECO:0000269 | PubMed:12660161 |
| Cell membrane | ECO:0000269 | PubMed:20123964 |
| Cell membrane | ECO:0000269 | PubMed:9705349 |
| Endoplasmic reticulum membrane | ECO:0000269 | PubMed:23591818 |
| Endoplasmic reticulum-Golgi intermediate compartment membrane | ECO:0000269 | PubMed:23591818 |
| Golgi apparatus membrane | ECO:0000269 | PubMed:23591818 |
| Golgi apparatus, trans-Golgi network membrane | ECO:0000269 | PubMed:23591818 |
| Membrane raft | ECO:0000269 | PubMed:17005594 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | High | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Medium | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | glandular cells | High | Approved |
| breast | myoepithelial cells | High | Approved |
| bronchus | respiratory epithelial cells | Medium | Approved |
| cerebellum | Purkinje cells | High | Approved |
| cerebral cortex | endothelial cells | Medium | Approved |
| cerebral cortex | glial cells | Low | Approved |
| cerebral cortex | neuropil | High | Approved |
| colon | endothelial cells | High | Approved |
| colon | glandular cells | Medium | Approved |
| colon | peripheral nerve/ganglion | Low | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | cells in endometrial stroma | Medium | Approved |
| endometrium 1 | glandular cells | High | Approved |
| endometrium 2 | glandular cells | High | Approved |
| epididymis | glandular cells | High | Approved |
| fallopian tube | glandular cells | High | Approved |
| gallbladder | glandular cells | High | Approved |
| kidney | cells in glomeruli | High | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | hepatocytes | Medium | Approved |
| lung | alveolar cells | Medium | Approved |
| lung | macrophages | High | Approved |
| lymph node | germinal center cells | Medium | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | Low | Approved |
| ovary | follicle cells | High | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| pancreas | pancreatic endocrine cells | Medium | Approved |
| parathyroid gland | glandular cells | High | Approved |
| placenta | decidual cells | High | Approved |
| placenta | trophoblastic cells | High | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | High | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skin 1 | Langerhans | High | Approved |
| skin 1 | fibroblasts | High | Approved |
| skin 1 | keratinocytes | Low | Approved |
| skin 1 | melanocytes | Medium | Approved |
| small intestine | glandular cells | Medium | Approved |
| smooth muscle | smooth muscle cells | Medium | Approved |
| soft tissue 2 | fibroblasts | Medium | Approved |
| soft tissue 2 | peripheral nerve | Low | Approved |
| spleen | cells in white pulp | Medium | Approved |
| stomach 1 | glandular cells | High | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | High | Approved |
| thyroid gland | glandular cells | High | Approved |
| tonsil | germinal center cells | Medium | Approved |
| tonsil | non-germinal center cells | High | Approved |
| tonsil | squamous epithelial cells | Low | Approved |
| urinary bladder | urothelial cells | Low | Approved |
| vagina | squamous epithelial cells | Low | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|