Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.1.2.1
Hydrolases;
Acting on ester bonds;
Thioester hydrolases;
acetyl-CoA hydrolase
3.1.2.11
Hydrolases;
Acting on ester bonds;
Thioester hydrolases;
acetoacetyl-CoA hydrolase
3.1.2.2
Hydrolases;
Acting on ester bonds;
Thioester hydrolases;
palmitoyl-CoA hydrolase
3.1.2.27
Hydrolases;
Acting on ester bonds;
Thioester hydrolases;
choloyl-CoA hydrolase
3.1.2.3
Hydrolases;
Acting on ester bonds;
Thioester hydrolases;
succinyl-CoA hydrolase
3.1.2.5
Hydrolases;
Acting on ester bonds;
Thioester hydrolases;
hydroxymethylglutaryl-CoA hydrolase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006637 | acyl-CoA metabolic process |
| Biological Process | GO:0036109 | alpha-linolenic acid metabolic process |
| Biological Process | GO:0006699 | bile acid biosynthetic process |
| Biological Process | GO:0043649 | dicarboxylic acid catabolic process |
| Biological Process | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase |
| Biological Process | GO:0009062 | fatty acid catabolic process |
| Biological Process | GO:0045225 | negative regulation of CD4 production |
| Biological Process | GO:0016559 | peroxisome fission |
| Molecular Function | GO:0016289 | CoA hydrolase activity |
| Molecular Function | GO:0047603 | acetoacetyl-CoA hydrolase activity |
| Molecular Function | GO:0003986 | acetyl-CoA hydrolase activity |
| Molecular Function | GO:0047617 | acyl-CoA hydrolase activity |
| Molecular Function | GO:0052689 | carboxylic ester hydrolase activity |
| Molecular Function | GO:0033882 | choloyl-CoA hydrolase activity |
| Molecular Function | GO:0044466 | glutaryl-CoA hydrolase activity |
| Molecular Function | GO:0047994 | hydroxymethylglutaryl-CoA hydrolase activity |
| Molecular Function | GO:0052815 | medium-chain acyl-CoA hydrolase activity |
| Molecular Function | GO:0102991 | myristoyl-CoA hydrolase activity |
| Molecular Function | GO:0016290 | palmitoyl-CoA hydrolase activity |
| Molecular Function | GO:0004778 | succinyl-CoA hydrolase activity |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005782 | peroxisomal matrix |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-389887 | Beta-oxidation of pristanoyl-CoA | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-390247 | Beta-oxidation of very long chain fatty acids | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-9033241 | Peroxisomal protein import | Internal node | R-HSA-9609507 | Protein localization |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Peroxisome matrix | ECO:0000269 | PubMed:10092594 |
| Peroxisome matrix | ECO:0000269 | PubMed:15194431 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Approved |
| adrenal gland | glandular cells | High | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Medium | Approved |
| bone marrow | hematopoietic cells | Low | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Medium | Approved |
| caudate | glial cells | Medium | Approved |
| caudate | neuronal cells | Low | Approved |
| cerebellum | Purkinje cells | High | Approved |
| cerebellum | cells in granular layer | Medium | Approved |
| cerebral cortex | endothelial cells | Medium | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cerebral cortex | neuropil | Medium | Approved |
| cervix | glandular cells | Medium | Approved |
| cervix | squamous epithelial cells | Medium | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | High | Approved |
| colon | peripheral nerve/ganglion | Medium | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | cells in endometrial stroma | Medium | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | cells in endometrial stroma | Medium | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| epididymis | glandular cells | High | Approved |
| esophagus | squamous epithelial cells | Medium | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | High | Approved |
| heart muscle | cardiomyocytes | Medium | Approved |
| hippocampus | neuronal cells | Medium | Approved |
| kidney | cells in glomeruli | Low | Approved |
| kidney | cells in tubules | High | Approved |
| liver | cholangiocytes | Low | Approved |
| liver | hepatocytes | High | Approved |
| lung | alveolar cells | Low | Approved |
| lung | macrophages | High | Approved |
| lymph node | germinal center cells | High | Approved |
| lymph node | non-germinal center cells | Low | Approved |
| nasopharynx | respiratory epithelial cells | High | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| ovary | follicle cells | High | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| pancreas | pancreatic endocrine cells | Medium | Approved |
| parathyroid gland | glandular cells | High | Approved |
| placenta | decidual cells | Medium | Approved |
| placenta | trophoblastic cells | High | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | Low | Approved |
| skin 1 | fibroblasts | Medium | Approved |
| skin 1 | keratinocytes | Low | Approved |
| skin 1 | melanocytes | Medium | Approved |
| skin 2 | epidermal cells | Low | Approved |
| small intestine | glandular cells | High | Approved |
| smooth muscle | smooth muscle cells | Low | Approved |
| soft tissue 1 | fibroblasts | Medium | Approved |
| soft tissue 1 | peripheral nerve | Medium | Approved |
| soft tissue 2 | fibroblasts | Medium | Approved |
| soft tissue 2 | peripheral nerve | Medium | Approved |
| spleen | cells in red pulp | Medium | Approved |
| spleen | cells in white pulp | Medium | Approved |
| stomach 1 | glandular cells | High | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | High | Approved |
| testis | cells in seminiferous ducts | High | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | germinal center cells | High | Approved |
| tonsil | non-germinal center cells | High | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Low | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|