Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.7.11.1
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
non-specific serine/threonine protein kinase
2.7.11.10
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
IκB kinase
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0038095 | Fc-epsilon receptor signaling pathway |
| Biological Process | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| Biological Process | GO:0050852 | T cell receptor signaling pathway |
| Biological Process | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| Biological Process | GO:0071356 | cellular response to tumor necrosis factor |
| Biological Process | GO:0030866 | cortical actin cytoskeleton organization |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0070498 | interleukin-1-mediated signaling pathway |
| Biological Process | GO:1903347 | negative regulation of bicellular tight junction assembly |
| Biological Process | GO:0035509 | negative regulation of myosin-light-chain-phosphatase activity |
| Biological Process | GO:0018105 | peptidyl-serine phosphorylation |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| Biological Process | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:1903140 | regulation of establishment of endothelial barrier |
| Biological Process | GO:0042325 | regulation of phosphorylation |
| Biological Process | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway |
| Biological Process | GO:0009615 | response to virus |
| Biological Process | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
| Biological Process | GO:0051403 | stress-activated MAPK cascade |
| Biological Process | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0008384 | IkappaB kinase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0004672 | protein kinase activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Molecular Function | GO:1990459 | transferrin receptor binding |
| Cellular Component | GO:0035631 | CD40 receptor complex |
| Cellular Component | GO:0008385 | IkappaB kinase complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0005634 | nucleus |
| InterPro
|
InterPro name |
|---|---|
| IPR000626 | Ubiquitin-like domain |
| IPR000719 | Protein kinase domain |
| IPR008271 | Serine/threonine-protein kinase, active site |
| IPR011009 | Protein kinase-like domain superfamily |
| IPR022007 | I-kappa-kinase-beta NEMO binding domain |
| IPR029071 | Ubiquitin-like domain superfamily |
| IPR041185 | IKBKB, scaffold dimerization domain |
| IPR046375 | IKBKB, scaffold dimerization domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00069 | Protein kinase domain |
| PF12179 | I-kappa-kinase-beta NEMO binding domain |
| PF18397 | IQBAL scaffold dimerization domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1169091 | Activation of NF-kappaB in B cells | Leaf | R-HSA-168256 | Immune System |
| R-HSA-1236974 | ER-Phagosome pathway | Leaf | R-HSA-168256 | Immune System |
| R-HSA-168638 | NOD1/2 Signaling Pathway | Leaf | R-HSA-168256 | Immune System |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | Leaf | R-HSA-168256 | Immune System |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | Leaf | R-HSA-168256 | Immune System |
| R-HSA-202424 | Downstream TCR signaling | Leaf | R-HSA-168256 | Immune System |
| R-HSA-209543 | p75NTR recruits signalling complexes | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-209560 | NF-kB is activated and signals survival | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-2871837 | FCERI mediated NF-kB activation | Leaf | R-HSA-168256 | Immune System |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | Internal node | R-HSA-168256 | Immune System |
| R-HSA-5357905 | Regulation of TNFR1 signaling | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-5357956 | TNFR1-induced NFkappaB signaling pathway | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-5602636 | IKBKB deficiency causes SCID | Leaf | R-HSA-1643685 | Disease |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) | Leaf | R-HSA-1643685 | Disease |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | Leaf | R-HSA-1643685 | Disease |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | Internal node | R-HSA-168256 | Immune System |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | Leaf | R-HSA-168256 | Immune System |
| R-HSA-9020702 | Interleukin-1 signaling | Internal node | R-HSA-168256 | Immune System |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | Leaf | R-HSA-168256 | Immune System |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | Leaf | R-HSA-168256 | Immune System |
| R-HSA-937039 | IRAK1 recruits IKK complex | Leaf | R-HSA-168256 | Immune System |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | Leaf | R-HSA-168256 | Immune System |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | Leaf | R-HSA-1643685 | Disease |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | Leaf | R-HSA-168256 | Immune System |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | Leaf | R-HSA-168256 | Immune System |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:20797629 |
| Membrane raft | ECO:0000269 | PubMed:17287217 |
| Nucleus | ECO:0000269 | PubMed:20797629 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000403 | Recurrent otitis media |
| HP:0001508 | Failure to thrive |
| HP:0001522 | Death in infancy |
| HP:0002028 | Chronic diarrhea |
| HP:0002205 | Recurrent respiratory infections |
| HP:0002719 | Recurrent infections |
| HP:0002721 | Immunodeficiency |
| HP:0002728 | Chronic mucocutaneous candidiasis |
| HP:0003593 | Infantile onset |
| HP:0004313 | Decreased circulating antibody level |
| HP:0004432 | Agammaglobulinemia |
| HP:0005407 | Decreased proportion of CD4-positive helper T cells |
| HP:0005415 | Decreased proportion of CD8-positive T cells |
| HP:0009098 | Chronic oral candidiasis |
| HP:0011108 | Recurrent sinusitis |
| HP:0011463 | Childhood onset |
| HP:0012311 | Monocytosis |
| HP:0030374 | Decreased proportion of memory B cells |
| HP:0031292 | Cutaneous abscess |
| HP:0031381 | Decreased lymphocyte proliferation in response to mitogen |
| HP:0040154 | Acne inversa |
| HP:0040218 | Reduced natural killer cell count |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Enhanced |
| adrenal gland | glandular cells | Low | Enhanced |
| appendix | glandular cells | Low | Enhanced |
| appendix | lymphoid tissue | Medium | Enhanced |
| bone marrow | hematopoietic cells | Medium | Enhanced |
| breast | adipocytes | Low | Enhanced |
| breast | glandular cells | Medium | Enhanced |
| breast | myoepithelial cells | Low | Enhanced |
| bronchus | respiratory epithelial cells | Low | Enhanced |
| caudate | neuronal cells | Low | Enhanced |
| cerebellum | Purkinje cells | Low | Enhanced |
| cerebral cortex | endothelial cells | Low | Enhanced |
| cerebral cortex | neuronal cells | Medium | Enhanced |
| cervix | glandular cells | Medium | Enhanced |
| cervix | squamous epithelial cells | Medium | Enhanced |
| colon | endothelial cells | Low | Enhanced |
| colon | glandular cells | Medium | Enhanced |
| duodenum | glandular cells | Low | Enhanced |
| endometrium 1 | cells in endometrial stroma | Medium | Enhanced |
| endometrium 1 | glandular cells | Medium | Enhanced |
| endometrium 2 | cells in endometrial stroma | Medium | Enhanced |
| endometrium 2 | glandular cells | Medium | Enhanced |
| epididymis | glandular cells | Medium | Enhanced |
| esophagus | squamous epithelial cells | Low | Enhanced |
| fallopian tube | glandular cells | Medium | Enhanced |
| gallbladder | glandular cells | Medium | Enhanced |
| heart muscle | cardiomyocytes | Low | Enhanced |
| hippocampus | neuronal cells | Low | Enhanced |
| kidney | cells in glomeruli | Low | Enhanced |
| kidney | cells in tubules | Low | Enhanced |
| lung | alveolar cells | Medium | Enhanced |
| lung | macrophages | Medium | Enhanced |
| lymph node | germinal center cells | Medium | Enhanced |
| lymph node | non-germinal center cells | Medium | Enhanced |
| nasopharynx | respiratory epithelial cells | Medium | Enhanced |
| oral mucosa | squamous epithelial cells | Medium | Enhanced |
| ovary | follicle cells | Low | Enhanced |
| ovary | ovarian stroma cells | Low | Enhanced |
| pancreas | exocrine glandular cells | Low | Enhanced |
| pancreas | pancreatic endocrine cells | Low | Enhanced |
| parathyroid gland | glandular cells | Medium | Enhanced |
| placenta | decidual cells | Medium | Enhanced |
| placenta | trophoblastic cells | Low | Enhanced |
| prostate | glandular cells | Low | Enhanced |
| rectum | glandular cells | Medium | Enhanced |
| salivary gland | glandular cells | Low | Enhanced |
| seminal vesicle | glandular cells | Low | Enhanced |
| skeletal muscle | myocytes | Low | Enhanced |
| skin 1 | Langerhans | Low | Enhanced |
| skin 1 | fibroblasts | Medium | Enhanced |
| skin 1 | keratinocytes | Low | Enhanced |
| skin 1 | melanocytes | Low | Enhanced |
| skin 2 | epidermal cells | Medium | Enhanced |
| small intestine | glandular cells | Low | Enhanced |
| smooth muscle | smooth muscle cells | Low | Enhanced |
| soft tissue 1 | fibroblasts | Low | Enhanced |
| soft tissue 2 | peripheral nerve | Low | Enhanced |
| spleen | cells in red pulp | Medium | Enhanced |
| spleen | cells in white pulp | Medium | Enhanced |
| stomach 1 | glandular cells | Low | Enhanced |
| stomach 2 | glandular cells | Medium | Enhanced |
| testis | Leydig cells | Low | Enhanced |
| testis | cells in seminiferous ducts | Medium | Enhanced |
| thyroid gland | glandular cells | Low | Enhanced |
| tonsil | germinal center cells | Medium | Enhanced |
| tonsil | non-germinal center cells | Medium | Enhanced |
| tonsil | squamous epithelial cells | Medium | Enhanced |
| urinary bladder | urothelial cells | Medium | Enhanced |
| vagina | squamous epithelial cells | Medium | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| severe combined immunodeficiency due to ikk2 deficiency | MONDO:0014267 | D81 | chapter3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | OMIM:615592 | Orphanet:397787 |
| immunodeficiency 15a | MONDO:0032599 | D81 | chapter3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | OMIM:618204 |