Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.7.11.1
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
non-specific serine/threonine protein kinase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 4C57 | 2.55 | Structure of GAK kinase in complex with a nanobody |
| 4C58 | 2.16 | Structure of GAK kinase in complex with nanobody (NbGAK_4) |
| 4C59 | 2.8 | Structure of GAK kinase in complex with nanobody (NbGAK_4) |
| 4O38 | 2.097 | Crystal structure of the human cyclin G associated kinase (GAK) |
| 4Y8D | 2.1 | Crystal structure of Cyclin-G associated kinase (GAK) complexed with selective 12i inhibitor |
| 5Y7Z | 2.804 | Complex structure of cyclin G-associated kinase with gefitinib |
| 5Y80 | 2.5 | Complex structure of cyclin G-associated kinase with gefitinib |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0007030 | Golgi organization |
| Biological Process | GO:0090160 | Golgi to lysosome transport |
| Biological Process | GO:0007049 | cell cycle |
| Biological Process | GO:0051085 | chaperone cofactor-dependent protein refolding |
| Biological Process | GO:0048268 | clathrin coat assembly |
| Biological Process | GO:0072318 | clathrin coat disassembly |
| Biological Process | GO:0072583 | clathrin-dependent endocytosis |
| Biological Process | GO:0007029 | endoplasmic reticulum organization |
| Biological Process | GO:0010977 | negative regulation of neuron projection development |
| Biological Process | GO:0034067 | protein localization to Golgi apparatus |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:0006898 | receptor-mediated endocytosis |
| Biological Process | GO:0016191 | synaptic vesicle uncoating |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0030276 | clathrin binding |
| Molecular Function | GO:0030332 | cyclin binding |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0031982 | vesicle |
| InterPro
|
InterPro name |
|---|---|
| IPR000719 | Protein kinase domain |
| IPR001623 | DnaJ domain |
| IPR008271 | Serine/threonine-protein kinase, active site |
| IPR011009 | Protein kinase-like domain superfamily |
| IPR014020 | Tensin phosphatase, C2 domain |
| IPR029021 | Protein-tyrosine phosphatase-like |
| IPR029023 | Tensin-type phosphatase domain |
| IPR035892 | C2 domain superfamily |
| IPR036869 | Chaperone J-domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00069 | Protein kinase domain |
| PF10409 | C2 domain of PTEN tumour-suppressor protein |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | Leaf | R-HSA-5653656 | Vesicle-mediated transport |
| R-HSA-8856828 | Clathrin-mediated endocytosis | Internal node | R-HSA-5653656 | Vesicle-mediated transport |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell junction, focal adhesion | ECO:0000305 | PubMed:10625686 |
| Cytoplasm, perinuclear region | ECO:0000269 | PubMed:10625686 |
| Golgi apparatus, trans-Golgi network | ECO:0000269 | PubMed:10625686 |