Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.7.11.1
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
non-specific serine/threonine protein kinase
PDB | Resolution (Å) | PDB name |
---|---|---|
4C57 | 2.55 | Structure of GAK kinase in complex with a nanobody |
4C58 | 2.16 | Structure of GAK kinase in complex with nanobody (NbGAK_4) |
4C59 | 2.8 | Structure of GAK kinase in complex with nanobody (NbGAK_4) |
4O38 | 2.097 | Crystal structure of the human cyclin G associated kinase (GAK) |
4Y8D | 2.1 | Crystal structure of Cyclin-G associated kinase (GAK) complexed with selective 12i inhibitor |
5Y7Z | 2.804 | Complex structure of cyclin G-associated kinase with gefitinib |
5Y80 | 2.5 | Complex structure of cyclin G-associated kinase with gefitinib |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0007030 | Golgi organization |
Biological Process | GO:0090160 | Golgi to lysosome transport |
Biological Process | GO:0007049 | cell cycle |
Biological Process | GO:0051085 | chaperone cofactor-dependent protein refolding |
Biological Process | GO:0048268 | clathrin coat assembly |
Biological Process | GO:0072318 | clathrin coat disassembly |
Biological Process | GO:0072583 | clathrin-dependent endocytosis |
Biological Process | GO:0007029 | endoplasmic reticulum organization |
Biological Process | GO:0010977 | negative regulation of neuron projection development |
Biological Process | GO:0034067 | protein localization to Golgi apparatus |
Biological Process | GO:0072659 | protein localization to plasma membrane |
Biological Process | GO:0006468 | protein phosphorylation |
Biological Process | GO:0006898 | receptor-mediated endocytosis |
Biological Process | GO:0016191 | synaptic vesicle uncoating |
Molecular Function | GO:0005524 | ATP binding |
Molecular Function | GO:0030276 | clathrin binding |
Molecular Function | GO:0030332 | cyclin binding |
Molecular Function | GO:0106310 | protein serine kinase activity |
Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
Molecular Function | GO:0051087 | protein-folding chaperone binding |
Cellular Component | GO:0005794 | Golgi apparatus |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0005925 | focal adhesion |
Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
Cellular Component | GO:0098793 | presynapse |
Cellular Component | GO:0031982 | vesicle |
InterPro | InterPro name |
---|---|
IPR000719 | Protein kinase domain |
IPR001623 | DnaJ domain |
IPR008271 | Serine/threonine-protein kinase, active site |
IPR011009 | Protein kinase-like domain superfamily |
IPR014020 | Tensin phosphatase, C2 domain |
IPR029021 | Protein-tyrosine phosphatase-like |
IPR029023 | Tensin-type phosphatase domain |
IPR035892 | C2 domain superfamily |
IPR036869 | Chaperone J-domain superfamily |
Pfam | Pfam name |
---|---|
PF00069 | Protein kinase domain |
PF10409 | C2 domain of PTEN tumour-suppressor protein |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | Leaf | R-HSA-5653656 | Vesicle-mediated transport |
R-HSA-8856828 | Clathrin-mediated endocytosis | Internal node | R-HSA-5653656 | Vesicle-mediated transport |
Location | ECO term | Pubmed |
---|---|---|
Cell junction, focal adhesion | ECO:0000305 | PubMed:10625686 |
Cytoplasm, perinuclear region | ECO:0000269 | PubMed:10625686 |
Golgi apparatus, trans-Golgi network | ECO:0000269 | PubMed:10625686 |