Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2DJY | Solution structure of Smurf2 WW3 domain-Smad7 PY peptide complex | |
| 2KXQ | Solution Structure of Smurf2 WW2 and WW3 bound to Smad7 PY motif containing peptide | |
| 2LTV | YAP WW2 in complex with a Smad7 derived peptide | |
| 2LTW | YAP WW1 in complex with a Smad7 derived peptide | |
| 2LTX | Smurf1 WW2 domain in complex with a Smad7 derived peptide | |
| 2LTY | NEDD4L WW2 domain in complex with a Smad7 derived peptide | |
| 2LTZ | Smurf2 WW3 domain in complex with a Smad7 derived peptide |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0060395 | SMAD protein signal transduction |
| Biological Process | GO:0034333 | adherens junction assembly |
| Biological Process | GO:0009653 | anatomical structure morphogenesis |
| Biological Process | GO:0048844 | artery morphogenesis |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:1990830 | cellular response to leukemia inhibitory factor |
| Biological Process | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| Biological Process | GO:0030514 | negative regulation of BMP signaling pathway |
| Biological Process | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| Biological Process | GO:0002725 | negative regulation of T cell cytokine production |
| Biological Process | GO:2000320 | negative regulation of T-helper 17 cell differentiation |
| Biological Process | GO:2000317 | negative regulation of T-helper 17 type immune response |
| Biological Process | GO:0030336 | negative regulation of cell migration |
| Biological Process | GO:1902731 | negative regulation of chondrocyte proliferation |
| Biological Process | GO:0010719 | negative regulation of epithelial to mesenchymal transition |
| Biological Process | GO:0030279 | negative regulation of ossification |
| Biological Process | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation |
| Biological Process | GO:0033137 | negative regulation of peptidyl-serine phosphorylation |
| Biological Process | GO:0010801 | negative regulation of peptidyl-threonine phosphorylation |
| Biological Process | GO:0031397 | negative regulation of protein ubiquitination |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0010944 | negative regulation of transcription by competitive promoter binding |
| Biological Process | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:0051444 | negative regulation of ubiquitin-protein transferase activity |
| Biological Process | GO:0060389 | pathway-restricted SMAD protein phosphorylation |
| Biological Process | GO:0022409 | positive regulation of cell-cell adhesion |
| Biological Process | GO:1903043 | positive regulation of chondrocyte hypertrophy |
| Biological Process | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0031398 | positive regulation of protein ubiquitination |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0031503 | protein-containing complex localization |
| Biological Process | GO:0032925 | regulation of activin receptor signaling pathway |
| Biological Process | GO:0055117 | regulation of cardiac muscle contraction |
| Biological Process | GO:0010717 | regulation of epithelial to mesenchymal transition |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:0060373 | regulation of ventricular cardiac muscle cell membrane depolarization |
| Biological Process | GO:0034616 | response to laminar fluid shear stress |
| Biological Process | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:0001657 | ureteric bud development |
| Biological Process | GO:0055010 | ventricular cardiac muscle tissue morphogenesis |
| Biological Process | GO:0060412 | ventricular septum morphogenesis |
| Molecular Function | GO:0070411 | I-SMAD binding |
| Molecular Function | GO:0048185 | activin binding |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0005518 | collagen binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0140416 | transcription regulator inhibitor activity |
| Molecular Function | GO:0034713 | type I transforming growth factor beta receptor binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0001650 | fibrillar center |
| Cellular Component | GO:0071144 | heteromeric SMAD protein complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| InterPro
|
InterPro name |
|---|---|
| IPR001132 | SMAD domain, Dwarfin-type |
| IPR003619 | MAD homology 1, Dwarfin-type |
| IPR008984 | SMAD/FHA domain superfamily |
| IPR013019 | MAD homology, MH1 |
| IPR013790 | Dwarfin |
| IPR017855 | SMAD-like domain superfamily |
| IPR036578 | SMAD MH1 domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF03165 | MH1 domain |
| PF03166 | MH2 domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-201451 | Signaling by BMP | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-5689603 | UCH proteinases | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-5689880 | Ub-specific processing proteases | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-877300 | Interferon gamma signaling | Internal node | R-HSA-168256 | Immune System |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:14657019 |
| Cytoplasm | ECO:0000269 | PubMed:16601693 |
| Cytoplasm | ECO:0000269 | PubMed:17327236 |
| Nucleus | ECO:0000269 | PubMed:14657019 |
| Nucleus | ECO:0000269 | PubMed:16601693 |
| Nucleus | ECO:0000269 | PubMed:17327236 |
| HPO ID
|
HPO name |
|---|---|
| HP:0003003 | Colon cancer |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Approved |
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Low | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | glandular cells | Low | Approved |
| breast | myoepithelial cells | Low | Approved |
| bronchus | respiratory epithelial cells | Low | Approved |
| caudate | glial cells | Medium | Approved |
| caudate | neuronal cells | Medium | Approved |
| cerebellum | Purkinje cells | Low | Approved |
| cerebellum | cells in granular layer | Medium | Approved |
| cerebellum | cells in molecular layer | Medium | Approved |
| cerebral cortex | endothelial cells | Medium | Approved |
| cerebral cortex | glial cells | Medium | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cervix | glandular cells | Medium | Approved |
| cervix | squamous epithelial cells | Medium | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | Medium | Approved |
| colon | peripheral nerve/ganglion | Medium | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | cells in endometrial stroma | Low | Approved |
| endometrium 1 | glandular cells | Low | Approved |
| endometrium 2 | cells in endometrial stroma | Low | Approved |
| endometrium 2 | glandular cells | Low | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | Medium | Approved |
| fallopian tube | glandular cells | Low | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | Medium | Approved |
| hippocampus | glial cells | Medium | Approved |
| hippocampus | neuronal cells | Medium | Approved |
| kidney | cells in glomeruli | Medium | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | cholangiocytes | Low | Approved |
| liver | hepatocytes | Low | Approved |
| lung | alveolar cells | Medium | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | germinal center cells | Low | Approved |
| lymph node | non-germinal center cells | Low | Approved |
| nasopharynx | respiratory epithelial cells | Medium | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| ovary | follicle cells | Low | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | Low | Approved |
| pancreas | pancreatic endocrine cells | Low | Approved |
| placenta | decidual cells | Medium | Approved |
| placenta | trophoblastic cells | Medium | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Low | Approved |
| seminal vesicle | glandular cells | Low | Approved |
| skeletal muscle | myocytes | Low | Approved |
| skin 1 | Langerhans | Low | Approved |
| skin 1 | fibroblasts | Low | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 1 | melanocytes | Low | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | Medium | Approved |
| smooth muscle | smooth muscle cells | Low | Approved |
| soft tissue 1 | chondrocytes | Medium | Approved |
| soft tissue 1 | fibroblasts | Medium | Approved |
| soft tissue 1 | peripheral nerve | Medium | Approved |
| soft tissue 2 | fibroblasts | Medium | Approved |
| spleen | cells in red pulp | Low | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | Low | Approved |
| testis | cells in seminiferous ducts | Medium | Approved |
| thyroid gland | glandular cells | Low | Approved |
| tonsil | germinal center cells | Low | Approved |
| tonsil | non-germinal center cells | Low | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Low | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| colorectal cancer- susceptibility to- 3 | MONDO:0012820 | C19 | chapter2, Neoplasms | OMIM:612229 |