Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.5.1.-
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides;
3.5.1.98
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides;
histone deacetylase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 4A69 | 2.06 | Structure of HDAC3 bound to corepressor and inositol tetraphosphate |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0071498 | cellular response to fluid shear stress |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0032922 | circadian regulation of gene expression |
| Biological Process | GO:1903575 | cornified envelope assembly |
| Biological Process | GO:0000132 | establishment of mitotic spindle orientation |
| Biological Process | GO:0061436 | establishment of skin barrier |
| Biological Process | GO:0016575 | histone deacetylation |
| Biological Process | GO:0001701 | in utero embryonic development |
| Biological Process | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0046329 | negative regulation of JNK cascade |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:2000726 | negative regulation of cardiac muscle cell differentiation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032008 | positive regulation of TOR signaling |
| Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
| Biological Process | GO:0042307 | positive regulation of protein import into nucleus |
| Biological Process | GO:0001934 | positive regulation of protein phosphorylation |
| Biological Process | GO:0031398 | positive regulation of protein ubiquitination |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006476 | protein deacetylation |
| Biological Process | GO:0042752 | regulation of circadian rhythm |
| Biological Process | GO:0007346 | regulation of mitotic cell cycle |
| Biological Process | GO:0040014 | regulation of multicellular organism growth |
| Biological Process | GO:0031647 | regulation of protein stability |
| Biological Process | GO:0051225 | spindle assembly |
| Biological Process | GO:0006366 | transcription by RNA polymerase II |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0051059 | NF-kappaB binding |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0030332 | cyclin binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0004857 | enzyme inhibitor activity |
| Molecular Function | GO:0004407 | histone deacetylase activity |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0160009 | histone decrotonylase activity |
| Molecular Function | GO:0140678 | molecular function inhibitor activity |
| Molecular Function | GO:0160010 | protein de-2-hydroxyisobutyrylase activity |
| Molecular Function | GO:0160008 | protein decrotonylase activity |
| Molecular Function | GO:0033558 | protein lysine deacetylase activity |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Molecular Function | GO:0001222 | transcription corepressor binding |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000118 | histone deacetylase complex |
| Cellular Component | GO:0072686 | mitotic spindle |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0017053 | transcription repressor complex |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1368071 | NR1D1 (REV-ERBA) represses gene expression | Leaf | R-HSA-400253 | Circadian Clock |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-1989781 | PPARA activates gene expression | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | Leaf | R-HSA-1852241 | Organelle biogenesis and maintenance |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | Leaf | R-HSA-1643685 | Disease |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | Leaf | R-HSA-1643685 | Disease |
| R-HSA-3214815 | HDACs deacetylate histones | Leaf | R-HSA-4839726 | Chromatin organization |
| R-HSA-350054 | Notch-HLH transcription pathway | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | Leaf | R-HSA-1266738 | Developmental Biology |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | Internal node | R-HSA-1430728 | Metabolism |
| R-HSA-400253 | Circadian Clock | Root | R-HSA-400253 | Circadian Clock |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | Leaf | R-HSA-1266738 | Developmental Biology |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-8943724 | Regulation of PTEN gene transcription | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-9609690 | HCMV Early Events | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-9707564 | Cytoprotection by HMOX1 | Internal node | R-HSA-8953897 | Cellular responses to stimuli |
| R-HSA-9707616 | Heme signaling | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:25190803 |
| Cytoplasm, cytosol | ECO:0000269 | PubMed:21030595 |
| Nucleus | ECO:0000269 | PubMed:21030595 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Supported |
| adrenal gland | glandular cells | Medium | Supported |
| appendix | glandular cells | Medium | Supported |
| appendix | lymphoid tissue | Medium | Supported |
| bone marrow | hematopoietic cells | Low | Supported |
| breast | glandular cells | Low | Supported |
| breast | myoepithelial cells | Medium | Supported |
| bronchus | respiratory epithelial cells | Low | Supported |
| caudate | glial cells | Medium | Supported |
| caudate | neuronal cells | Medium | Supported |
| cerebellum | Purkinje cells | High | Supported |
| cerebellum | cells in granular layer | High | Supported |
| cerebellum | cells in molecular layer | High | Supported |
| cerebral cortex | endothelial cells | Medium | Supported |
| cerebral cortex | glial cells | Medium | Supported |
| cerebral cortex | neuronal cells | High | Supported |
| cervix | glandular cells | Medium | Supported |
| cervix | squamous epithelial cells | Medium | Supported |
| colon | endothelial cells | Low | Supported |
| colon | glandular cells | Medium | Supported |
| duodenum | glandular cells | Medium | Supported |
| endometrium 1 | cells in endometrial stroma | Medium | Supported |
| endometrium 1 | glandular cells | Medium | Supported |
| endometrium 2 | cells in endometrial stroma | Medium | Supported |
| endometrium 2 | glandular cells | Medium | Supported |
| epididymis | glandular cells | High | Supported |
| esophagus | squamous epithelial cells | Low | Supported |
| fallopian tube | glandular cells | Medium | Supported |
| gallbladder | glandular cells | Medium | Supported |
| heart muscle | cardiomyocytes | Medium | Supported |
| hippocampus | glial cells | Medium | Supported |
| hippocampus | neuronal cells | Medium | Supported |
| kidney | cells in glomeruli | Medium | Supported |
| kidney | cells in tubules | Medium | Supported |
| liver | hepatocytes | Low | Supported |
| lung | alveolar cells | Low | Supported |
| lung | macrophages | Low | Supported |
| lymph node | germinal center cells | Medium | Supported |
| lymph node | non-germinal center cells | Medium | Supported |
| nasopharynx | respiratory epithelial cells | Low | Supported |
| oral mucosa | squamous epithelial cells | Medium | Supported |
| ovary | follicle cells | Low | Supported |
| ovary | ovarian stroma cells | Low | Supported |
| pancreas | exocrine glandular cells | Low | Supported |
| pancreas | pancreatic endocrine cells | Medium | Supported |
| parathyroid gland | glandular cells | Low | Supported |
| placenta | decidual cells | Medium | Supported |
| placenta | trophoblastic cells | Medium | Supported |
| prostate | glandular cells | Medium | Supported |
| rectum | glandular cells | Medium | Supported |
| salivary gland | glandular cells | Low | Supported |
| seminal vesicle | glandular cells | Medium | Supported |
| skeletal muscle | myocytes | Low | Supported |
| skin 1 | fibroblasts | Low | Supported |
| skin 1 | keratinocytes | Medium | Supported |
| skin 1 | melanocytes | Low | Supported |
| skin 2 | epidermal cells | Medium | Supported |
| small intestine | glandular cells | Medium | Supported |
| smooth muscle | smooth muscle cells | Medium | Supported |
| soft tissue 1 | fibroblasts | Medium | Supported |
| soft tissue 2 | fibroblasts | Low | Supported |
| soft tissue 2 | peripheral nerve | Low | Supported |
| spleen | cells in red pulp | Low | Supported |
| spleen | cells in white pulp | Low | Supported |
| stomach 1 | glandular cells | Medium | Supported |
| stomach 2 | glandular cells | Medium | Supported |
| testis | sertoli cells | Medium | Supported |
| thyroid gland | glandular cells | Medium | Supported |
| tonsil | germinal center cells | Medium | Supported |
| tonsil | non-germinal center cells | Medium | Supported |
| tonsil | squamous epithelial cells | Medium | Supported |
| urinary bladder | urothelial cells | High | Supported |
| vagina | squamous epithelial cells | Medium | Supported |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|