Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.3.1.48
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups;
histone acetyltransferase
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0000077 | DNA damage checkpoint signaling |
| Biological Process | GO:0071479 | cellular response to ionizing radiation |
| Biological Process | GO:0032922 | circadian regulation of gene expression |
| Biological Process | GO:0007623 | circadian rhythm |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway |
| Biological Process | GO:0009648 | photoperiodism |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| Biological Process | GO:0042753 | positive regulation of circadian rhythm |
| Biological Process | GO:0050729 | positive regulation of inflammatory response |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0006473 | protein acetylation |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0042752 | regulation of circadian rhythm |
| Biological Process | GO:0042634 | regulation of hair cycle |
| Biological Process | GO:0050796 | regulation of insulin secretion |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:2000074 | regulation of type B pancreatic cell development |
| Biological Process | GO:0051775 | response to redox state |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0007283 | spermatogenesis |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0070888 | E-box binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0004402 | histone acetyltransferase activity |
| Molecular Function | GO:0046983 | protein dimerization activity |
| Molecular Function | GO:0043565 | sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Cellular Component | GO:1990513 | CLOCK-BMAL transcription complex |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0033391 | chromatoid body |
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| InterPro
|
InterPro name |
|---|---|
| IPR000014 | PAS domain |
| IPR001067 | Nuclear translocator |
| IPR001610 | PAC motif |
| IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| IPR013767 | PAS fold |
| IPR035965 | PAS domain superfamily |
| IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
| IPR047230 | Circadian locomoter output cycles protein kaput-like |
| Pfam
|
Pfam name |
|---|---|
| PF00010 | Helix-loop-helix DNA-binding domain |
| PF00989 | PAS fold |
| PF14598 | PAS domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian gene expression | Leaf | R-HSA-400253 | Circadian Clock |
| R-HSA-1989781 | PPARA activates gene expression | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-3214847 | HATs acetylate histones | Leaf | R-HSA-4839726 | Chromatin organization |
| R-HSA-400253 | Circadian Clock | Root | R-HSA-400253 | Circadian Clock |
| R-HSA-9707616 | Heme signaling | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000250 | |
| Cytoplasm, cytosol | ECO:0000269 | PubMed:28985504 |
| Nucleus | ECO:0000269 | PubMed:14645221 |
| Nucleus | ECO:0000269 | PubMed:23160374 |
| Nucleus | ECO:0000269 | PubMed:28985504 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Supported |
| adrenal gland | glandular cells | Medium | Supported |
| appendix | glandular cells | Medium | Supported |
| appendix | lymphoid tissue | Low | Supported |
| bone marrow | hematopoietic cells | Medium | Supported |
| breast | adipocytes | Low | Supported |
| breast | glandular cells | Medium | Supported |
| breast | myoepithelial cells | Medium | Supported |
| bronchus | respiratory epithelial cells | Medium | Supported |
| caudate | glial cells | Low | Supported |
| caudate | neuronal cells | Medium | Supported |
| cerebellum | Purkinje cells | Medium | Supported |
| cerebellum | cells in granular layer | Medium | Supported |
| cerebellum | cells in molecular layer | Medium | Supported |
| cerebral cortex | endothelial cells | Low | Supported |
| cerebral cortex | glial cells | Low | Supported |
| cerebral cortex | neuronal cells | Medium | Supported |
| cerebral cortex | neuropil | Low | Supported |
| cervix | glandular cells | Low | Supported |
| cervix | squamous epithelial cells | Medium | Supported |
| colon | endothelial cells | Medium | Supported |
| colon | glandular cells | Medium | Supported |
| colon | peripheral nerve/ganglion | Medium | Supported |
| duodenum | glandular cells | Medium | Supported |
| endometrium 1 | cells in endometrial stroma | Low | Supported |
| endometrium 1 | glandular cells | Medium | Supported |
| endometrium 2 | cells in endometrial stroma | Medium | Supported |
| endometrium 2 | glandular cells | Medium | Supported |
| epididymis | glandular cells | Medium | Supported |
| esophagus | squamous epithelial cells | Medium | Supported |
| fallopian tube | glandular cells | Medium | Supported |
| gallbladder | glandular cells | Medium | Supported |
| heart muscle | cardiomyocytes | Medium | Supported |
| hippocampus | glial cells | Low | Supported |
| hippocampus | neuronal cells | Medium | Supported |
| kidney | cells in glomeruli | Medium | Supported |
| kidney | cells in tubules | Medium | Supported |
| liver | cholangiocytes | Low | Supported |
| liver | hepatocytes | Low | Supported |
| lung | alveolar cells type I | Low | Supported |
| lung | alveolar cells type II | Medium | Supported |
| lung | macrophages | Medium | Supported |
| lymph node | germinal center cells | Medium | Supported |
| lymph node | non-germinal center cells | Medium | Supported |
| nasopharynx | respiratory epithelial cells | Medium | Supported |
| oral mucosa | squamous epithelial cells | Medium | Supported |
| ovary | ovarian stroma cells | Medium | Supported |
| pancreas | exocrine glandular cells | Low | Supported |
| pancreas | pancreatic endocrine cells | Low | Supported |
| parathyroid gland | glandular cells | Medium | Supported |
| placenta | decidual cells | Medium | Supported |
| placenta | trophoblastic cells | Medium | Supported |
| prostate | glandular cells | Medium | Supported |
| rectum | glandular cells | Medium | Supported |
| salivary gland | glandular cells | Medium | Supported |
| seminal vesicle | glandular cells | Medium | Supported |
| skeletal muscle | myocytes | Medium | Supported |
| skin 1 | Langerhans | Medium | Supported |
| skin 1 | fibroblasts | Medium | Supported |
| skin 1 | keratinocytes | Medium | Supported |
| skin 1 | melanocytes | Medium | Supported |
| skin 2 | epidermal cells | Medium | Supported |
| small intestine | glandular cells | Low | Supported |
| smooth muscle | smooth muscle cells | Medium | Supported |
| soft tissue 1 | fibroblasts | Medium | Supported |
| soft tissue 1 | peripheral nerve | Low | Supported |
| soft tissue 2 | fibroblasts | Low | Supported |
| soft tissue 2 | peripheral nerve | Low | Supported |
| spleen | cells in red pulp | Low | Supported |
| spleen | cells in white pulp | Low | Supported |
| stomach 1 | glandular cells | Medium | Supported |
| stomach 2 | glandular cells | Medium | Supported |
| testis | Leydig cells | High | Supported |
| testis | elongated or late spermatids | Medium | Supported |
| testis | spermatogonia cells | Medium | Supported |
| thyroid gland | glandular cells | Medium | Supported |
| tonsil | germinal center cells | Medium | Supported |
| tonsil | non-germinal center cells | Medium | Supported |
| tonsil | squamous epithelial cells | Medium | Supported |
| urinary bladder | urothelial cells | Medium | Supported |
| vagina | squamous epithelial cells | Medium | Supported |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|