MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.2.2.-	Hydrolases; Glycosylases; Hydrolysing N-glycosyl compounds;
4.2.99.18	Lyases; Carbon-oxygen lyases; Other carbon-oxygen lyases; DNA-(apurinic or apyrimidinic site) lyase

Structure

PDB	Resolution (Å)	PDB name
1EBM	2.1	CRYSTAL STRUCTURE OF THE HUMAN 8-OXOGUANINE GLYCOSYLASE (HOGG1) BOUND TO A SUBSTRATE OLIGONUCLEOTIDE
1FN7	2.6	COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN
1HU0	2.35	CRYSTAL STRUCTURE OF AN HOGG1-DNA BOROHYDRIDE TRAPPED INTERMEDIATE COMPLEX
1KO9	2.15	Native Structure of the Human 8-oxoguanine DNA Glycosylase hOGG1
1LWV	2.3	Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-aminoguanine
1LWW	2.1	Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-bromoguanine
1LWY	2.01	hOgg1 Borohydride-Trapped Intermediate without 8-oxoguanine
1M3H	2.05	Crystal Structure of Hogg1 D268E Mutant with Product Oligonucleotide
1M3Q	1.9	Crystal Structure of hogg1 D268E Mutant with Base-Excised DNA and 8-aminoguanine
1N39	2.2	Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase
1N3A	2.2	Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase
1N3C	2.7	Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase
1YQK	2.5	Human 8-oxoguanine glycosylase crosslinked with guanine containing DNA
1YQL	2.6	Catalytically inactive hOGG1 crosslinked with 7-deaza-8-azaguanine containing DNA
1YQM	2.5	Catalytically inactive human 8-oxoguanine glycosylase crosslinked to 7-deazaguanine containing DNA
1YQR	2.43	Catalytically inactive human 8-oxoguanine glycosylase crosslinked to oxoG containing DNA
2I5W	2.6	Structure of hOGG1 crosslinked to DNA sampling a normal G adjacent to an oxoG
2NOB	2.1	Structure of catalytically inactive H270A human 8-oxoguanine glycosylase crosslinked to 8-oxoguanine DNA
2NOE	2.2	Structure of catalytically inactive G42A human 8-oxoguanine glycosylase complexed to 8-oxoguanine DNA
2NOF	2.35	Structure of Q315F human 8-oxoguanine glycosylase proximal crosslink to 8-oxoguanine DNA
2NOH	2.01	Structure of catalytically inactive Q315A human 8-oxoguanine glycosylase complexed to 8-oxoguanine DNA
2NOI	2.35	Structure of G42A human 8-oxoguanine glycosylase crosslinked to undamaged G-containing DNA
2NOL	2.57	Structure of catalytically inactive human 8-oxoguanine glycosylase distal crosslink to oxoG DNA
2NOZ	2.43	Structure of Q315F human 8-oxoguanine glycosylase distal crosslink to 8-oxoguanine DNA
2XHI	1.55	Separation-of-function mutants unravel the dual reaction mode of human 8-oxoguanine DNA glycosylase
3IH7	3.1	Crystal structure of catalytically active human 8-oxoguanine glycosylase distally crosslinked to guanine-containing DNA
3KTU	2.3	Structure of human 8-oxoGuanine Glycosylase 1 bound to fluorninated oxoG-containing DNA
5AN4	1.6	Crystal structure of the human 8-oxoguanine glycosylase (OGG1) processed with the CrystalDirect automated mounting and cryo-cooling technology
6RLW	2.0	Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with inhibitor TH5487
6W0M	2.37	Human 8-oxoguanine glycosylase crosslinked with oxoG lesion containing DNA
6W0R	2.35	Human 8-oxoguanine glycosylase interrogating fully intrahelical undamaged DNA
6W13	2.38	Human 8-oxoguanine glycosylase interrogating fully intrahelical oxoG lesion DNA
7AYY	2.0	Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with activator TH10785

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0002526	acute inflammatory response
Biological Process	GO:0007568	aging
Biological Process	GO:0006284	base-excision repair
Biological Process	GO:0006285	base-excision repair, AP site formation
Biological Process	GO:0071276	cellular response to cadmium ion
Biological Process	GO:0045007	depurination
Biological Process	GO:0045008	depyrimidination
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:1901291	negative regulation of double-strand break repair via single-strand annealing
Biological Process	GO:0006289	nucleotide-excision repair
Biological Process	GO:0006355	regulation of DNA-templated transcription
Biological Process	GO:0032355	response to estradiol
Biological Process	GO:0045471	response to ethanol
Biological Process	GO:0051593	response to folic acid
Biological Process	GO:0009416	response to light stimulus
Biological Process	GO:0006979	response to oxidative stress
Biological Process	GO:0009314	response to radiation
Biological Process	GO:0009410	response to xenobiotic stimulus
Molecular Function	GO:0034039	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
Molecular Function	GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Function	GO:0003684	damaged DNA binding
Molecular Function	GO:0004519	endonuclease activity
Molecular Function	GO:0008017	microtubule binding
Molecular Function	GO:0032357	oxidized purine DNA binding
Molecular Function	GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0016363	nuclear matrix
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0032991	protein-containing complex

InterPro / Pfam

InterPro	InterPro name
IPR003265	HhH-GPD domain
IPR004577	8-oxoguanine DNA-glycosylase
IPR011257	DNA glycosylase
IPR012904	8-oxoguanine DNA glycosylase, N-terminal
IPR023170	Helix-hairpin-helix, base-excision DNA repair, C-terminal

Pfam	Pfam name
PF00730	HhH-GPD superfamily base excision DNA repair protein
PF07934	8-oxoguanine DNA glycosylase, N-terminal domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-110328	Recognition and association of DNA glycosylase with site containing an affected pyrimidine	Leaf	R-HSA-73894	DNA Repair
R-HSA-110329	Cleavage of the damaged pyrimidine	Leaf	R-HSA-73894	DNA Repair
R-HSA-110330	Recognition and association of DNA glycosylase with site containing an affected purine	Leaf	R-HSA-73894	DNA Repair
R-HSA-110331	Cleavage of the damaged purine	Leaf	R-HSA-73894	DNA Repair
R-HSA-110357	Displacement of DNA glycosylase by APEX1	Leaf	R-HSA-73894	DNA Repair
R-HSA-5649702	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	Leaf	R-HSA-73894	DNA Repair
R-HSA-9656255	Defective OGG1 Substrate Binding	Leaf	R-HSA-1643685	Disease
R-HSA-9656256	Defective OGG1 Substrate Processing	Leaf	R-HSA-1643685	Disease
R-HSA-9657050	Defective OGG1 Localization	Leaf	R-HSA-1643685	Disease

Subcellular location

Location	ECO term	Pubmed
Mitochondrion
Nucleus
Nucleus matrix	ECO:0000269	PubMed:17148573
Nucleus speckle	ECO:0000269	PubMed:17148573
Nucleus, nucleoplasm	ECO:0000269	PubMed:17148573

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0003745	Sporadic
HP:0005584	Renal cell carcinoma

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Low	Approved
appendix	glandular cells	Medium	Approved
appendix	lymphoid tissue	Low	Approved
bone marrow	hematopoietic cells	Medium	Approved
breast	adipocytes	Low	Approved
breast	glandular cells	Medium	Approved
breast	myoepithelial cells	Low	Approved
bronchus	basal cells	Medium	Approved
bronchus	ciliated cells (cell body)	High	Approved
bronchus	goblet cells	High	Approved
caudate	glial cells	Low	Approved
caudate	neuronal cells	Low	Approved
cerebellum	Purkinje cells	Low	Approved
cerebellum	cells in granular layer	Low	Approved
cerebellum	cells in molecular layer	Low	Approved
cerebral cortex	endothelial cells	Low	Approved
cerebral cortex	glial cells	Low	Approved
cerebral cortex	neuronal cells	Low	Approved
cerebral cortex	neuropil	Medium	Approved
cervix	glandular cells	Low	Approved
cervix	squamous epithelial cells	Medium	Approved
colon	endothelial cells	Medium	Approved
colon	glandular cells	Medium	Approved
duodenum	glandular cells	Medium	Approved
endometrium 1	glandular cells	Low	Approved
endometrium 2	glandular cells	Low	Approved
epididymis	glandular cells	Medium	Approved
esophagus	squamous epithelial cells	Medium	Approved
fallopian tube	ciliated cells (cell body)	Medium	Approved
fallopian tube	ciliated cells (ciliary rootlets)	Low	Approved
fallopian tube	ciliated cells (tip of cilia)	Low	Approved
fallopian tube	non-ciliated cells	Medium	Approved
gallbladder	glandular cells	Medium	Approved
hippocampus	glial cells	Low	Approved
hippocampus	neuronal cells	Low	Approved
kidney	cells in glomeruli	Low	Approved
kidney	cells in tubules	Low	Approved
liver	hepatocytes	Medium	Approved
lung	alveolar cells	Low	Approved
lung	macrophages	Low	Approved
lymph node	germinal center cells	Medium	Approved
lymph node	non-germinal center cells	Medium	Approved
nasopharynx	basal cells	Medium	Approved
nasopharynx	ciliated cells (cell body)	High	Approved
nasopharynx	goblet cells	High	Approved
oral mucosa	squamous epithelial cells	Medium	Approved
ovary	follicle cells	Medium	Approved
ovary	ovarian stroma cells	Low	Approved
pancreas	exocrine glandular cells	Medium	Approved
parathyroid gland	glandular cells	Medium	Approved
placenta	decidual cells	Medium	Approved
placenta	trophoblastic cells	High	Approved
prostate	glandular cells	Low	Approved
rectum	glandular cells	Medium	Approved
salivary gland	glandular cells	Medium	Approved
seminal vesicle	glandular cells	Low	Approved
skeletal muscle	myocytes	Low	Approved
skin 1	Langerhans	Medium	Approved
skin 1	fibroblasts	Low	Approved
skin 1	keratinocytes	Medium	Approved
skin 1	melanocytes	High	Approved
skin 2	epidermal cells	Low	Approved
small intestine	glandular cells	Medium	Approved
soft tissue 1	chondrocytes	Low	Approved
soft tissue 1	fibroblasts	Medium	Approved
spleen	cells in red pulp	Medium	Approved
stomach 1	glandular cells	Low	Approved
stomach 2	glandular cells	Low	Approved
testis	Leydig cells	Medium	Approved
testis	cells in seminiferous ducts	Low	Approved
thyroid gland	glandular cells	Medium	Approved
tonsil	germinal center cells	Low	Approved
tonsil	non-germinal center cells	Medium	Approved
tonsil	squamous epithelial cells	High	Approved
urinary bladder	urothelial cells	Medium	Approved
vagina	squamous epithelial cells	Medium	Approved

Summary of O15527

Gene: OGG1, MMH, MUTM, OGH1
Protein: N-glycosylase/DNA lyase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of O15527

Gene: OGG1, MMH, MUTM, OGH1 Protein: N-glycosylase/DNA lyase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: OGG1, MMH, MUTM, OGH1
Protein: N-glycosylase/DNA lyase