MultifacetedProtDB - Bologna Biocomputing Group

Summary of O15527

Gene: OGG1, MMH, MUTM, OGH1
Protein: N-glycosylase/DNA lyase

Protein family
Protein sequence
Protein function

Catalytic activity

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EC number	EC number description
3.2.2.-	Hydrolases; Glycosylases; Hydrolysing N-glycosyl compounds;
4.2.99.18	Lyases; Carbon-oxygen lyases; Other carbon-oxygen lyases; DNA-(apurinic or apyrimidinic site) lyase

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Publications

Structure

Link to AlphaFold model

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PDB	Resolution (Å)	PDB name
1EBM	2.1	CRYSTAL STRUCTURE OF THE HUMAN 8-OXOGUANINE GLYCOSYLASE (HOGG1) BOUND TO A SUBSTRATE OLIGONUCLEOTIDE
1FN7	2.6	COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN
1HU0	2.35	CRYSTAL STRUCTURE OF AN HOGG1-DNA BOROHYDRIDE TRAPPED INTERMEDIATE COMPLEX
1KO9	2.15	Native Structure of the Human 8-oxoguanine DNA Glycosylase hOGG1
1LWV	2.3	Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-aminoguanine
1LWW	2.1	Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-bromoguanine
1LWY	2.01	hOgg1 Borohydride-Trapped Intermediate without 8-oxoguanine
1M3H	2.05	Crystal Structure of Hogg1 D268E Mutant with Product Oligonucleotide
1M3Q	1.9	Crystal Structure of hogg1 D268E Mutant with Base-Excised DNA and 8-aminoguanine
1N39	2.2	Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase

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GO term

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GO ontology	GO term	GO description
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0002526	acute inflammatory response
Biological Process	GO:0007568	aging
Biological Process	GO:0006284	base-excision repair
Biological Process	GO:0006285	base-excision repair, AP site formation
Biological Process	GO:0071276	cellular response to cadmium ion
Biological Process	GO:0045007	depurination
Biological Process	GO:0045008	depyrimidination
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:1901291	negative regulation of double-strand break repair via single-strand annealing

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InterPro / Pfam

Reactome

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Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-110328	Recognition and association of DNA glycosylase with site containing an affected pyrimidine	Leaf	R-HSA-73894	DNA Repair
R-HSA-110329	Cleavage of the damaged pyrimidine	Leaf	R-HSA-73894	DNA Repair
R-HSA-110330	Recognition and association of DNA glycosylase with site containing an affected purine	Leaf	R-HSA-73894	DNA Repair
R-HSA-110331	Cleavage of the damaged purine	Leaf	R-HSA-73894	DNA Repair
R-HSA-110357	Displacement of DNA glycosylase by APEX1	Leaf	R-HSA-73894	DNA Repair
R-HSA-5649702	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	Leaf	R-HSA-73894	DNA Repair
R-HSA-9656255	Defective OGG1 Substrate Binding	Leaf	R-HSA-1643685	Disease
R-HSA-9656256	Defective OGG1 Substrate Processing	Leaf	R-HSA-1643685	Disease
R-HSA-9657050	Defective OGG1 Localization	Leaf	R-HSA-1643685	Disease

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Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

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Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Low	Approved
appendix	glandular cells	Medium	Approved
appendix	lymphoid tissue	Low	Approved
bone marrow	hematopoietic cells	Medium	Approved
breast	adipocytes	Low	Approved
breast	glandular cells	Medium	Approved
breast	myoepithelial cells	Low	Approved
bronchus	basal cells	Medium	Approved
bronchus	ciliated cells (cell body)	High	Approved
bronchus	goblet cells	High	Approved

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Disease