Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 7QPG | 3.9 | Human RZZ kinetochore corona complex. |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0007030 | Golgi organization |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process | GO:0000132 | establishment of mitotic spindle orientation |
| Biological Process | GO:0051321 | meiotic cell cycle |
| Biological Process | GO:0007080 | mitotic metaphase plate congression |
| Biological Process | GO:0000070 | mitotic sister chromatid segregation |
| Biological Process | GO:0007094 | mitotic spindle assembly checkpoint signaling |
| Biological Process | GO:0034501 | protein localization to kinetochore |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0007096 | regulation of exit from mitosis |
| Biological Process | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| Molecular Function | GO:0019237 | centromeric DNA binding |
| Cellular Component | GO:0070939 | Dsl1/NZR complex |
| Cellular Component | GO:1990423 | RZZ complex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0005828 | kinetochore microtubule |
| Cellular Component | GO:0005811 | lipid droplet |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000922 | spindle pole |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-2467813 | Separation of Sister Chromatids | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-5663220 | RHO GTPases Activate Formins | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | Leaf | R-HSA-5653656 | Vesicle-mediated transport |
| R-HSA-68877 | Mitotic Prometaphase | Internal node | R-HSA-1640170 | Cell Cycle |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | Leaf | R-HSA-1640170 | Cell Cycle |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Chromosome, centromere, kinetochore | ECO:0000269 | PubMed:11590237 |
| Chromosome, centromere, kinetochore | ECO:0000269 | PubMed:15485811 |
| Chromosome, centromere, kinetochore | ECO:0000269 | PubMed:15824131 |
| Cytoplasm | ECO:0000269 | PubMed:15029241 |
| Cytoplasm, cytoskeleton, spindle | ECO:0000269 | PubMed:11590237 |
| Endoplasmic reticulum membrane | ECO:0000269 | PubMed:15029241 |
| Lipid droplet | ECO:0000269 | PubMed:30970241 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Enhanced |
| adrenal gland | glandular cells | High | Enhanced |
| appendix | glandular cells | High | Enhanced |
| appendix | lymphoid tissue | Medium | Enhanced |
| bone marrow | hematopoietic cells | Medium | Enhanced |
| breast | adipocytes | Low | Enhanced |
| breast | glandular cells | Medium | Enhanced |
| breast | myoepithelial cells | Medium | Enhanced |
| bronchus | respiratory epithelial cells | High | Enhanced |
| caudate | glial cells | Medium | Enhanced |
| caudate | neuronal cells | Medium | Enhanced |
| cerebellum | Purkinje cells - cytoplasm/membrane | Medium | Enhanced |
| cerebellum | Purkinje cells - dendrites | Medium | Enhanced |
| cerebellum | granular cells - cytoplasm/membrane | Medium | Enhanced |
| cerebellum | white matter cells - cytoplasm/membrane | Medium | Enhanced |
| cerebral cortex | endothelial cells | Medium | Enhanced |
| cerebral cortex | glial cells | Medium | Enhanced |
| cerebral cortex | neuronal cells | High | Enhanced |
| cerebral cortex | neuropil | Medium | Enhanced |
| cervix | glandular cells | Medium | Enhanced |
| cervix | squamous epithelial cells | Medium | Enhanced |
| colon | endothelial cells | Medium | Enhanced |
| colon | glandular cells | High | Enhanced |
| colon | peripheral nerve/ganglion | Low | Enhanced |
| duodenum | glandular cells | High | Enhanced |
| endometrium 1 | cells in endometrial stroma | Medium | Enhanced |
| endometrium 1 | glandular cells | High | Enhanced |
| endometrium 2 | cells in endometrial stroma | Low | Enhanced |
| endometrium 2 | glandular cells | Medium | Enhanced |
| epididymis | glandular cells | Medium | Enhanced |
| esophagus | squamous epithelial cells | High | Enhanced |
| fallopian tube | glandular cells | High | Enhanced |
| gallbladder | glandular cells | High | Enhanced |
| heart muscle | cardiomyocytes | Medium | Enhanced |
| hippocampus | glial cells | Medium | Enhanced |
| hippocampus | neuronal cells | High | Enhanced |
| kidney | cells in glomeruli | Medium | Enhanced |
| kidney | cells in tubules | High | Enhanced |
| liver | cholangiocytes | Medium | Enhanced |
| liver | hepatocytes | Medium | Enhanced |
| lung | alveolar cells type II | High | Enhanced |
| lung | macrophages | Medium | Enhanced |
| lymph node | germinal center cells | Medium | Enhanced |
| lymph node | non-germinal center cells | Medium | Enhanced |
| nasopharynx | respiratory epithelial cells | Medium | Enhanced |
| oral mucosa | squamous epithelial cells | Medium | Enhanced |
| ovary | follicle cells | High | Enhanced |
| ovary | ovarian stroma cells | Medium | Enhanced |
| pancreas | exocrine glandular cells | High | Enhanced |
| pancreas | pancreatic endocrine cells | High | Enhanced |
| parathyroid gland | glandular cells | Low | Enhanced |
| placenta | decidual cells | High | Enhanced |
| placenta | trophoblastic cells | Medium | Enhanced |
| prostate | glandular cells | High | Enhanced |
| rectum | glandular cells | High | Enhanced |
| salivary gland | glandular cells | High | Enhanced |
| seminal vesicle | glandular cells | Medium | Enhanced |
| skeletal muscle | myocytes | Low | Enhanced |
| skin 1 | Langerhans | Medium | Enhanced |
| skin 1 | fibroblasts | High | Enhanced |
| skin 1 | keratinocytes | Medium | Enhanced |
| skin 1 | melanocytes | Medium | Enhanced |
| skin 2 | epidermal cells | High | Enhanced |
| small intestine | glandular cells | High | Enhanced |
| smooth muscle | smooth muscle cells | Medium | Enhanced |
| soft tissue 1 | chondrocytes | Medium | Enhanced |
| soft tissue 1 | fibroblasts | Medium | Enhanced |
| soft tissue 1 | peripheral nerve | Low | Enhanced |
| soft tissue 2 | fibroblasts | Low | Enhanced |
| soft tissue 2 | peripheral nerve | Low | Enhanced |
| spleen | cells in red pulp | Medium | Enhanced |
| spleen | cells in white pulp | Medium | Enhanced |
| stomach 1 | glandular cells | Medium | Enhanced |
| stomach 2 | glandular cells | High | Enhanced |
| testis | Leydig cells | Medium | Enhanced |
| testis | elongated or late spermatids | Low | Enhanced |
| testis | pachytene spermatocytes | High | Enhanced |
| testis | round or early spermatids | High | Enhanced |
| testis | sertoli cells | Medium | Enhanced |
| thyroid gland | glandular cells | High | Enhanced |
| tonsil | germinal center cells | High | Enhanced |
| tonsil | non-germinal center cells | High | Enhanced |
| tonsil | squamous epithelial cells | High | Enhanced |
| urinary bladder | urothelial cells | Medium | Enhanced |
| vagina | squamous epithelial cells | Medium | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|