MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.7.10.2	Transferases; Transferring phosphorus-containing groups; Protein-tyrosine kinases; non-specific protein-tyrosine kinase
2.7.11.1	Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases; non-specific serine/threonine protein kinase

Structure

PDB	Resolution (Å)	PDB name
2N7Z		Solution structure of RIP2 CARD
2N83		p75NTR DD:RIP2 CARD
4C8B	2.75	Structure of the kinase domain of human RIPK2 in complex with ponatinib
5AR2	2.44	RIP2 Kinase Catalytic Domain (1 - 310)
5AR3	3.23	RIP2 Kinase Catalytic Domain (1 - 310) complex with AMP-PCP
5AR4	2.7	RIP2 Kinase Catalytic Domain (1 - 310) complex with SB-203580
5AR5	2.66	RIP2 Kinase Catalytic Domain (1 - 310) complex with Benzimidazole
5AR7	2.71	RIP2 Kinase Catalytic Domain (1 - 310) complex with Biaryl Urea
5AR8	2.79	RIP2 Kinase Catalytic Domain (1 - 310) complex with Biphenylsulfonamide
5J79	2.69	The identification and pharmacological characterization of 6-(tert-butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a highly potent and selective inhibitor of RIP2 Kinase, Compound 3 complex
5J7B	2.53	The identification and pharmacological characterization of 6-(tert-butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a highly potent and selective inhibitor of RIP2 Kinase, GSK583 complex
5NG0	2.0	Structure of RIP2K(L294F) with bound AMPPCP
5NG2	2.8	Structure of RIP2K(D146N) with bound Staurosporine
5NG3	2.6	Structure of inactive kinase RIP2K(K47R)
5W5J	2.85	Identification of potent and selective RIPK2 inhibitors for the treatment of inflammatory diseases
5W5O	2.89	Identification of potent and selective RIPK2 inhibitors for the treatment of inflammatory diseases.
5YRN	4.1	Structure of RIP2 CARD domain
6ES0	2.38	Crystal structure of the kinase domain of human RIPK2 in complex with the activation loop targeting inhibitor CS-R35
6FU5	3.26	Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP18
6GFJ	3.3	Structure of RIP2 CARD domain fused to crystallisable MBP tag
6GGS	3.94	Structure of RIP2 CARD filament
6HMX	2.53	RIP2 Kinase Catalytic Domain complex with N(4,5dimethyl1Hpyrazol3yl)7methoxy6(2methylpropane2sulfonyl)quinolin4amine
6RN8	2.69	RIP2 Kinase Catalytic Domain complex with 2(4[(1,3benzothiazol5yl)amino]6(2methylpropane2sulfonyl)quinazolin7yl)oxy)ethyl phosphate
6RNA	2.62	RIP2 Kinase Catalytic Domain complex with 2({4[(1,3benzothiazol5yl)amino]6(2methylpropane2sulfonyl)quinazolin7yl}oxy)ethan1ol
6S1F	3.11	Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP3
6SZE	2.94	RIP2 Kinase Catalytic Domain complex with 5-Amino-1-Phenylpyrazole-4-Carboxamide.
6SZJ	2.53	RIP2 Kinase Catalytic Domain complex with 5amino1tertbutyl3(3methoxyphenyl)1H pyrazole4carboxamide.
6UL8	2.68	RIP2 kinase catalytic domain complex with (5S,6S,8R)-2-(benzo[d]thiazol-5-yl)-6-hydroxy-4,5,6,7,8,9-hexahydro-5,8-methanopyrazolo[1,5-a][1,3]diazocine-3-carboxamide
7OBS	1.8	Crystal structure of 14-3-3 sigma in complex with RIPK2 phosphopeptide
7OBT	2.3	Crystal structure of 14-3-3 sigma in complex with RIPK2 phosphopeptide and stabilizer Fusicoccin-A
8AZA	3.15	Structure of RIP2K dimer bound to the XIAP BIR2 domain

GO term

GO ontology	GO term	GO description
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation
Biological Process	GO:0070371	ERK1 and ERK2 cascade
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling
Biological Process	GO:0007254	JNK cascade
Biological Process	GO:0050852	T cell receptor signaling pathway
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity
Biological Process	GO:0002250	adaptive immune response
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0071223	cellular response to lipoteichoic acid
Biological Process	GO:0071225	cellular response to muramyl dipeptide
Biological Process	GO:0071224	cellular response to peptidoglycan
Biological Process	GO:0019221	cytokine-mediated signaling pathway
Biological Process	GO:0050830	defense response to Gram-positive bacterium
Biological Process	GO:0033080	immature T cell proliferation in thymus
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0045087	innate immune response
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway
Biological Process	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway
Biological Process	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process	GO:0046330	positive regulation of JNK cascade
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity
Biological Process	GO:0045627	positive regulation of T-helper 1 cell differentiation
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response
Biological Process	GO:0043065	positive regulation of apoptotic process
Biological Process	GO:0032722	positive regulation of chemokine production
Biological Process	GO:0001961	positive regulation of cytokine-mediated signaling pathway
Biological Process	GO:0033092	positive regulation of immature T cell proliferation in thymus
Biological Process	GO:0032727	positive regulation of interferon-alpha production
Biological Process	GO:0032728	positive regulation of interferon-beta production
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production
Biological Process	GO:0032735	positive regulation of interleukin-12 production
Biological Process	GO:0032743	positive regulation of interleukin-2 production
Biological Process	GO:0032755	positive regulation of interleukin-6 production
Biological Process	GO:0060907	positive regulation of macrophage cytokine production
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
Biological Process	GO:0032092	positive regulation of protein binding
Biological Process	GO:0031398	positive regulation of protein ubiquitination
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production
Biological Process	GO:0032729	positive regulation of type II interferon production
Biological Process	GO:1904417	positive regulation of xenophagy
Biological Process	GO:0006468	protein phosphorylation
Biological Process	GO:0043330	response to exogenous dsRNA
Biological Process	GO:0070555	response to interleukin-1
Biological Process	GO:0070671	response to interleukin-12
Biological Process	GO:0070673	response to interleukin-18
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0034134	toll-like receptor 2 signaling pathway
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway
Biological Process	GO:0098792	xenophagy
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0050700	CARD domain binding
Molecular Function	GO:0004706	JUN kinase kinase kinase activity
Molecular Function	GO:0030274	LIM domain binding
Molecular Function	GO:0089720	caspase binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0106310	protein serine kinase activity
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Molecular Function	GO:0005102	signaling receptor binding
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0032991	protein-containing complex
Cellular Component	GO:0031982	vesicle

InterPro / Pfam

InterPro	InterPro name
IPR000719	Protein kinase domain
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR001315	CARD domain
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR011029	Death-like domain superfamily
IPR017322	Receptor-interacting serine/threonine-protein kinase 2
IPR042149	RIP2, CARD domain

Pfam	Pfam name
PF00619	Caspase recruitment domain
PF07714	Protein tyrosine and serine/threonine kinase

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-168638	NOD1/2 Signaling Pathway	Leaf	R-HSA-168256	Immune System
R-HSA-202424	Downstream TCR signaling	Leaf	R-HSA-168256	Immune System
R-HSA-209543	p75NTR recruits signalling complexes	Leaf	R-HSA-162582	Signal Transduction
R-HSA-445989	TAK1-dependent IKK and NF-kappa-B activation	Internal node	R-HSA-168256	Immune System
R-HSA-450302	activated TAK1 mediates p38 MAPK activation	Leaf	R-HSA-168256	Immune System
R-HSA-450321	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	Leaf	R-HSA-168256	Immune System
R-HSA-5689896	Ovarian tumor domain proteases	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-9020702	Interleukin-1 signaling	Internal node	R-HSA-168256	Immune System
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	Leaf	R-HSA-1643685	Disease

Subcellular location

Location	ECO term	Pubmed
Cytoplasm	ECO:0000269	PubMed:21887730
Endoplasmic reticulum	ECO:0000269	PubMed:28656966

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Low	Approved
appendix	glandular cells	Low	Approved
appendix	lymphoid tissue	Low	Approved
breast	glandular cells	High	Approved
breast	myoepithelial cells	Medium	Approved
bronchus	ciliated cells (cell body)	Medium	Approved
caudate	neuronal cells	Medium	Approved
cerebral cortex	neuronal cells	Low	Approved
cerebral cortex	neuropil	Low	Approved
cervix	glandular cells	Medium	Approved
colon	endothelial cells	Low	Approved
colon	glandular cells	Medium	Approved
colon	peripheral nerve/ganglion	Medium	Approved
duodenum	glandular cells	Medium	Approved
endometrium 1	glandular cells	High	Approved
endometrium 2	cells in endometrial stroma	Low	Approved
endometrium 2	glandular cells	Medium	Approved
epididymis	glandular cells	Medium	Approved
gallbladder	glandular cells	High	Approved
heart muscle	cardiomyocytes	Medium	Approved
hippocampus	neuronal cells	Low	Approved
kidney	cells in tubules	Medium	Approved
liver	cholangiocytes	Low	Approved
lung	macrophages	Medium	Approved
lymph node	germinal center cells	Medium	Approved
lymph node	non-germinal center cells	Low	Approved
oral mucosa	squamous epithelial cells	Low	Approved
pancreas	exocrine glandular cells	Medium	Approved
parathyroid gland	glandular cells	Medium	Approved
placenta	decidual cells	Low	Approved
placenta	trophoblastic cells	High	Approved
prostate	glandular cells	Medium	Approved
rectum	glandular cells	Medium	Approved
salivary gland	glandular cells	Medium	Approved
seminal vesicle	glandular cells	Medium	Approved
skeletal muscle	myocytes	Low	Approved
skin 1	keratinocytes	Low	Approved
skin 1	melanocytes	Medium	Approved
small intestine	glandular cells	Medium	Approved
smooth muscle	smooth muscle cells	Low	Approved
spleen	cells in white pulp	Low	Approved
stomach 1	glandular cells	Low	Approved
stomach 2	glandular cells	Low	Approved
testis	Leydig cells	Low	Approved
testis	elongated or late spermatids	Low	Approved
testis	pachytene spermatocytes	Low	Approved
testis	peritubular cells	Medium	Approved
testis	preleptotene spermatocytes	Medium	Approved
testis	round or early spermatids	Low	Approved
testis	sertoli cells	Low	Approved
testis	spermatogonia cells	Medium	Approved
thyroid gland	glandular cells	Medium	Approved
tonsil	germinal center cells	Medium	Approved
tonsil	non-germinal center cells	Low	Approved
tonsil	squamous epithelial cells	Low	Approved
urinary bladder	urothelial cells	Medium	Approved

Summary of O43353

Gene: RIPK2, CARDIAK, RICK, RIP2, UNQ277/PRO314/PRO34092
Protein: Receptor-interacting serine/threonine-protein kinase 2

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of O43353

Gene: RIPK2, CARDIAK, RICK, RIP2, UNQ277/PRO314/PRO34092 Protein: Receptor-interacting serine/threonine-protein kinase 2

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: RIPK2, CARDIAK, RICK, RIP2, UNQ277/PRO314/PRO34092
Protein: Receptor-interacting serine/threonine-protein kinase 2