Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
6.2.1.15
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases;
arachidonate—CoA ligase
6.2.1.3
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases;
long-chain-fatty-acid—CoA ligase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0060136 | embryonic process involved in female pregnancy |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0008610 | lipid biosynthetic process |
| Biological Process | GO:0006629 | lipid metabolic process |
| Biological Process | GO:0001676 | long-chain fatty acid metabolic process |
| Biological Process | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process |
| Biological Process | GO:0035336 | long-chain fatty-acyl-CoA metabolic process |
| Biological Process | GO:0032307 | negative regulation of prostaglandin secretion |
| Biological Process | GO:0030182 | neuron differentiation |
| Biological Process | GO:0030307 | positive regulation of cell growth |
| Biological Process | GO:0032024 | positive regulation of insulin secretion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0047676 | arachidonate-CoA ligase activity |
| Molecular Function | GO:0004467 | long-chain fatty acid-CoA ligase activity |
| Molecular Function | GO:0090433 | palmitoyl-CoA ligase activity |
| Molecular Function | GO:0031957 | very long-chain fatty acid-CoA ligase activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005811 | lipid droplet |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0044233 | mitochondria-associated endoplasmic reticulum membrane |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005778 | peroxisomal membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-434313 | Intracellular metabolism of fatty acids regulates insulin secretion | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-75876 | Synthesis of very long-chain fatty acyl-CoAs | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell membrane | ECO:0000269 | PubMed:24269233 |
| Endoplasmic reticulum membrane | ECO:0000269 | PubMed:24269233 |
| Microsome membrane | ECO:0000250 | |
| Mitochondrion outer membrane | ECO:0000250 | |
| Peroxisome membrane | ECO:0000250 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000083 | Renal insufficiency |
| HP:0000093 | Proteinuria |
| HP:0000233 | Thin vermilion border |
| HP:0000252 | Microcephaly |
| HP:0000272 | Malar flattening |
| HP:0000365 | Hearing impairment |
| HP:0000463 | Anteverted nares |
| HP:0000486 | Strabismus |
| HP:0000494 | Downslanted palpebral fissures |
| HP:0000545 | Myopia |
| HP:0000729 | Autistic behavior |
| HP:0000739 | Anxiety |
| HP:0000750 | Delayed speech and language development |
| HP:0000944 | Abnormal metaphysis morphology |
| HP:0001182 | Tapered finger |
| HP:0001249 | Intellectual disability |
| HP:0001252 | Hypotonia |
| HP:0001347 | Hyperreflexia |
| HP:0001423 | X-linked dominant inheritance |
| HP:0001595 | Abnormal hair morphology |
| HP:0001643 | Patent ductus arteriosus |
| HP:0001646 | Abnormal aortic valve morphology |
| HP:0002907 | Microscopic hematuria |
| HP:0004445 | Elliptocytosis |
| HP:0005280 | Depressed nasal bridge |
| HP:0010864 | Intellectual disability, severe |
| HP:0011069 | Supernumerary tooth |
| HP:0011463 | Childhood onset |
| HP:0012471 | Thick vermilion border |
| HP:0100820 | Glomerulopathy |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Supported |
| adrenal gland | glandular cells | Medium | Supported |
| appendix | germinal center cells | Low | Supported |
| breast | adipocytes | Low | Supported |
| breast | glandular cells | Low | Supported |
| breast | myoepithelial cells | Low | Supported |
| bronchus | respiratory epithelial cells | Medium | Supported |
| caudate | neuronal cells | Medium | Supported |
| cerebellum | GLUC cells - cytoplasm/membrane | Medium | Supported |
| cerebellum | Purkinje cells - cytoplasm/membrane | Low | Supported |
| cerebellum | molecular layer cells - cytoplasm/membrane | Medium | Supported |
| cerebellum | synaptic glomeruli - core | Low | Supported |
| cerebellum | white matter cells - cytoplasm/membrane | Low | Supported |
| cerebral cortex | neuronal cells | High | Supported |
| colon | mucosal lymphoid cells | Medium | Supported |
| duodenum | enterocytes | Low | Supported |
| endometrium 1 | glandular cells | Low | Supported |
| endometrium 2 | glandular cells | Medium | Supported |
| epididymis | glandular cells | Low | Supported |
| esophagus | squamous epithelial cells | Low | Supported |
| fallopian tube | glandular cells | Medium | Supported |
| gallbladder | glandular cells | Medium | Supported |
| heart muscle | cardiomyocytes | Low | Supported |
| hippocampus | neuronal cells | High | Supported |
| kidney | collecting ducts | Medium | Supported |
| kidney | distal tubules | Medium | Supported |
| liver | hepatocytes | Low | Supported |
| lung | alveolar cells type II | High | Supported |
| lung | macrophages | Medium | Supported |
| lymph node | germinal center cells | Low | Supported |
| lymph node | non-germinal center cells | Low | Supported |
| nasopharynx | respiratory epithelial cells | Medium | Supported |
| oral mucosa | squamous epithelial cells | Low | Supported |
| pancreas | exocrine glandular cells | Medium | Supported |
| pancreas | pancreatic endocrine cells | Low | Supported |
| parathyroid gland | glandular cells | Medium | Supported |
| placenta | decidual cells | Low | Supported |
| placenta | trophoblastic cells | Medium | Supported |
| prostate | glandular cells | Low | Supported |
| rectum | endothelial cells | Low | Supported |
| rectum | enterocytes | Low | Supported |
| rectum | fibroblasts | Medium | Supported |
| rectum | mucosal lymphoid cells | Medium | Supported |
| salivary gland | glandular cells | Low | Supported |
| seminal vesicle | glandular cells | Low | Supported |
| skeletal muscle | myocytes | Low | Supported |
| skin 1 | fibroblasts | Low | Supported |
| skin 1 | keratinocytes | Low | Supported |
| skin 2 | epidermal cells | Medium | Supported |
| small intestine | enterocytes | Low | Supported |
| smooth muscle | smooth muscle cells | Low | Supported |
| soft tissue 1 | fibroblasts | Low | Supported |
| soft tissue 1 | peripheral nerve | Low | Supported |
| soft tissue 2 | fibroblasts | Low | Supported |
| spleen | cells in red pulp | Low | Supported |
| stomach 1 | glandular cells | Medium | Supported |
| stomach 2 | glandular cells | Medium | Supported |
| testis | Leydig cells | Low | Supported |
| thyroid gland | glandular cells | Medium | Supported |
| tonsil | germinal center cells | Low | Supported |
| tonsil | squamous epithelial cells | Medium | Supported |
| urinary bladder | urothelial cells | Medium | Supported |
| vagina | squamous epithelial cells | Medium | Supported |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome | MONDO:0010263 | Q87 | chapter17, Congenital malformations, deformations and chromosomal abnormalities | OMIM:300194 | Orphanet:86818 |
| intellectual disability, x-linked 63 | MONDO:0010313 | F70 | chapter5, Mental and behavioural disorders | OMIM:300387 |