MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.4.1.-	Transferases; Glycosyltransferases; Hexosyltransferases;
2.4.1.275	Transferases; Glycosyltransferases; Hexosyltransferases; neolactotriaosylceramide β-1,4-galactosyltransferase
2.4.1.90	Transferases; Glycosyltransferases; Hexosyltransferases; N-acetyllactosamine synthase

GO ontology	GO term	GO description
Biological Process	GO:0005975	carbohydrate metabolic process
Biological Process	GO:0018146	keratan sulfate biosynthetic process
Biological Process	GO:0001572	lactosylceramide biosynthetic process
Biological Process	GO:0006643	membrane lipid metabolic process
Biological Process	GO:0006486	protein glycosylation
Molecular Function	GO:0003945	N-acetyllactosamine synthase activity
Molecular Function	GO:0035250	UDP-galactosyltransferase activity
Molecular Function	GO:0008378	galactosyltransferase activity
Molecular Function	GO:0046872	metal ion binding
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0000139	Golgi membrane
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0016020	membrane

InterPro	InterPro name
IPR003859	Beta-1,4-galactosyltransferase
IPR027791	Galactosyltransferase, C-terminal
IPR027995	Galactosyltransferase, N-terminal
IPR029044	Nucleotide-diphospho-sugar transferases

Pfam	Pfam name
PF02709	N-terminal domain of galactosyltransferase
PF13733	N-terminal region of glycosyl transferase group 7

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-2022854	Keratan sulfate biosynthesis	Leaf	R-HSA-1430728	Metabolism
R-HSA-975577	N-Glycan antennae elongation	Leaf	R-HSA-392499	Metabolism of proteins

Location	ECO term	Pubmed
Golgi apparatus membrane	ECO:0000269	PubMed:32827291
Secreted	ECO:0000269	PubMed:32827291

Tissue	Cell type	Expression level	Reliability
appendix	glandular cells	Medium	Approved
breast	myoepithelial cells	Low	Approved
bronchus	respiratory epithelial cells	Low	Approved
colon	glandular cells	Medium	Approved
duodenum	glandular cells	Medium	Approved
endometrium 1	glandular cells	Medium	Approved
endometrium 2	cells in endometrial stroma	Low	Approved
epididymis	glandular cells	Medium	Approved
esophagus	squamous epithelial cells	Low	Approved
gallbladder	glandular cells	Low	Approved
heart muscle	cardiomyocytes	Low	Approved
kidney	cells in tubules	Medium	Approved
liver	cholangiocytes	Low	Approved
liver	hepatocytes	Low	Approved
oral mucosa	squamous epithelial cells	Low	Approved
pancreas	exocrine glandular cells	Low	Approved
pancreas	pancreatic endocrine cells	Low	Approved
placenta	decidual cells	Medium	Approved
rectum	glandular cells	Medium	Approved
skin 1	fibroblasts	Low	Approved
skin 2	epidermal cells	Low	Approved
small intestine	glandular cells	Medium	Approved
smooth muscle	smooth muscle cells	Low	Approved
soft tissue 1	chondrocytes	Low	Approved
stomach 1	glandular cells	Low	Approved
testis	Leydig cells	Medium	Approved
testis	cells in seminiferous ducts	Low	Approved
urinary bladder	urothelial cells	Medium	Approved