MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1FYW	3.0	CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR2
1FYX	2.8	CRYSTAL STRUCTURE OF P681H MUTANT OF TIR DOMAIN OF HUMAN TLR2
1O77	3.2	CRYSTAL STRUCTURE OF THE C713S MUTANT OF THE TIR DOMAIN OF HUMAN TLR2
2Z7X	2.1	Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
2Z80	1.8	Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
6NIG	2.35	Crystal structure of the human TLR2-Diprovocim complex
8AR0		Solution structure of TLR2 transmembrane and cytoplasmic juxtamembrane regions

GO term

GO ontology	GO term	GO description
Biological Process	GO:0007252	I-kappaB phosphorylation
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0071221	cellular response to bacterial lipopeptide
Biological Process	GO:0071726	cellular response to diacyl bacterial lipopeptide
Biological Process	GO:0071223	cellular response to lipoteichoic acid
Biological Process	GO:0071727	cellular response to triacyl bacterial lipopeptide
Biological Process	GO:0071346	cellular response to type II interferon
Biological Process	GO:0032289	central nervous system myelin formation
Biological Process	GO:0050830	defense response to Gram-positive bacterium
Biological Process	GO:0051607	defense response to virus
Biological Process	GO:0042496	detection of diacyl bacterial lipopeptide
Biological Process	GO:0042495	detection of triacyl bacterial lipopeptide
Biological Process	GO:0006955	immune response
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0045087	innate immune response
Biological Process	GO:0007612	learning
Biological Process	GO:0006691	leukotriene metabolic process
Biological Process	GO:0014005	microglia development
Biological Process	GO:0001774	microglial cell activation
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0050765	negative regulation of phagocytosis
Biological Process	GO:0051964	negative regulation of synapse assembly
Biological Process	GO:0046209	nitric oxide metabolic process
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway
Biological Process	GO:1903974	positive regulation of cellular response to macrophage colony-stimulating factor stimulus
Biological Process	GO:0032722	positive regulation of chemokine production
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0050729	positive regulation of inflammatory response
Biological Process	GO:0032728	positive regulation of interferon-beta production
Biological Process	GO:0032733	positive regulation of interleukin-10 production
Biological Process	GO:0032735	positive regulation of interleukin-12 production
Biological Process	GO:0032741	positive regulation of interleukin-18 production
Biological Process	GO:0032755	positive regulation of interleukin-6 production
Biological Process	GO:0032757	positive regulation of interleukin-8 production
Biological Process	GO:1904466	positive regulation of matrix metallopeptidase secretion
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation
Biological Process	GO:0034123	positive regulation of toll-like receptor signaling pathway
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production
Biological Process	GO:0070542	response to fatty acid
Biological Process	GO:0001666	response to hypoxia
Biological Process	GO:0032868	response to insulin
Biological Process	GO:0032570	response to progesterone
Biological Process	GO:0009636	response to toxic substance
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
Biological Process	GO:0002224	toll-like receptor signaling pathway
Molecular Function	GO:0050135	NAD(P)+ nucleosidase activity
Molecular Function	GO:0061809	NAD+ nucleotidase, cyclic ADP-ribose generating
Molecular Function	GO:0035325	Toll-like receptor binding
Molecular Function	GO:0001540	amyloid-beta binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0001530	lipopolysaccharide binding
Molecular Function	GO:0001875	lipopolysaccharide immune receptor activity
Molecular Function	GO:0038187	pattern recognition receptor activity
Molecular Function	GO:0042834	peptidoglycan binding
Molecular Function	GO:0044877	protein-containing complex binding
Molecular Function	GO:0038023	signaling receptor activity
Molecular Function	GO:0004888	transmembrane signaling receptor activity
Molecular Function	GO:0042497	triacyl lipopeptide binding
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex
Cellular Component	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex
Cellular Component	GO:0044297	cell body
Cellular Component	GO:0042995	cell projection
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0045121	membrane raft
Cellular Component	GO:0030670	phagocytic vesicle membrane
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0043235	receptor complex
Cellular Component	GO:0030667	secretory granule membrane

InterPro	InterPro name
IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
IPR000483	Cysteine-rich flanking region, C-terminal
IPR001611	Leucine-rich repeat
IPR003591	Leucine-rich repeat, typical subtype
IPR017241	Toll-like receptor
IPR032675	Leucine-rich repeat domain superfamily
IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily

Pfam	Pfam name
PF01463	Leucine rich repeat C-terminal domain
PF01582	TIR domain
PF13855	Leucine rich repeat

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1236974	ER-Phagosome pathway	Leaf	R-HSA-168256	Immune System
R-HSA-1461957	Beta defensins	Leaf	R-HSA-168256	Immune System
R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	Internal node	R-HSA-168256	Immune System
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	Internal node	R-HSA-168256	Immune System
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	Internal node	R-HSA-168256	Immune System
R-HSA-5602498	MyD88 deficiency (TLR2/4)	Leaf	R-HSA-1643685	Disease
R-HSA-5603041	IRAK4 deficiency (TLR2/4)	Leaf	R-HSA-1643685	Disease
R-HSA-5686938	Regulation of TLR by endogenous ligand	Leaf	R-HSA-168256	Immune System
R-HSA-6798695	Neutrophil degranulation	Leaf	R-HSA-168256	Immune System
R-HSA-9637628	Modulation by Mtb of host immune system	Leaf	R-HSA-1643685	Disease
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	Leaf	R-HSA-1643685	Disease

Location	ECO term	Pubmed
Cytoplasmic vesicle, phagosome membrane	ECO:0000250
Membrane	ECO:0000250
Membrane raft	ECO:0000269	PubMed:16880211

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0001428	Somatic mutation
HP:0002715	Abnormality of the immune system
HP:0002891	Uterine leiomyosarcoma
HP:0005584	Renal cell carcinoma
HP:0006716	Hereditary nonpolyposis colorectal carcinoma
HP:0006740	Transitional cell carcinoma of the bladder
HP:0006753	Neoplasm of the stomach

Summary of O60603

Gene: TLR2, TIL4
Protein: Toll-like receptor 2

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of O60603

Gene: TLR2, TIL4 Protein: Toll-like receptor 2

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: TLR2, TIL4
Protein: Toll-like receptor 2