Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.7.7.50
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases;
mRNA guanylyltransferase
3.6.1.74
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides;
mRNA 5′-phosphatase
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006370 | 7-methylguanosine mRNA capping |
| Biological Process | GO:0006396 | RNA processing |
| Biological Process | GO:0006470 | protein dephosphorylation |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0008192 | RNA guanylyltransferase activity |
| Molecular Function | GO:0050355 | inorganic triphosphate phosphatase activity |
| Molecular Function | GO:0140818 | mRNA 5'-phosphatase activity |
| Molecular Function | GO:0004484 | mRNA guanylyltransferase activity |
| Molecular Function | GO:0004651 | polynucleotide 5'-phosphatase activity |
| Molecular Function | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| InterPro
|
InterPro name |
|---|---|
| IPR000340 | Dual specificity phosphatase, catalytic domain |
| IPR000387 | Tyrosine-specific protein phosphatases domain |
| IPR001339 | mRNA capping enzyme, adenylation domain |
| IPR012340 | Nucleic acid-binding, OB-fold |
| IPR013846 | mRNA capping enzyme, C-terminal |
| IPR016130 | Protein-tyrosine phosphatase, active site |
| IPR017074 | mRNA capping enzyme, bifunctional |
| IPR020422 | Dual specificity protein phosphatase domain |
| IPR029021 | Protein-tyrosine phosphatase-like |
| Pfam
|
Pfam name |
|---|---|
| PF00782 | Dual specificity phosphatase, catalytic domain |
| PF01331 | mRNA capping enzyme, catalytic domain |
| PF03919 | mRNA capping enzyme, C-terminal domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | Leaf | R-HSA-1643685 | Disease |
| R-HSA-72086 | mRNA Capping | Leaf | R-HSA-8953854 | Metabolism of RNA |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Nucleus | ECO:0000250 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Approved |
| adrenal gland | glandular cells | Low | Approved |
| bone marrow | hematopoietic cells | Low | Approved |
| breast | glandular cells | Low | Approved |
| breast | myoepithelial cells | Low | Approved |
| bronchus | respiratory epithelial cells | Low | Approved |
| cerebral cortex | endothelial cells | Medium | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cerebral cortex | neuropil | Low | Approved |
| cervix | glandular cells | Medium | Approved |
| cervix | squamous epithelial cells | Low | Approved |
| colon | endothelial cells | Medium | Approved |
| duodenum | glandular cells | Low | Approved |
| endometrium 1 | glandular cells | Low | Approved |
| endometrium 2 | glandular cells | Low | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | Low | Approved |
| fallopian tube | glandular cells | Low | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | High | Approved |
| hippocampus | glial cells | Low | Approved |
| hippocampus | neuronal cells | Low | Approved |
| kidney | cells in tubules | Low | Approved |
| liver | hepatocytes | High | Approved |
| lung | macrophages | Low | Approved |
| lymph node | germinal center cells | Low | Approved |
| nasopharynx | respiratory epithelial cells | Low | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| pancreas | pancreatic endocrine cells | Low | Approved |
| placenta | decidual cells | High | Approved |
| placenta | trophoblastic cells | High | Approved |
| prostate | glandular cells | Low | Approved |
| rectum | glandular cells | Low | Approved |
| salivary gland | glandular cells | Low | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | Medium | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 1 | melanocytes | High | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | Low | Approved |
| smooth muscle | smooth muscle cells | Low | Approved |
| soft tissue 1 | peripheral nerve | Low | Approved |
| stomach 1 | glandular cells | High | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | High | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | germinal center cells | Low | Approved |
| tonsil | squamous epithelial cells | Low | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|