Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.7.11.1
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
non-specific serine/threonine protein kinase
3.1.26.-
Hydrolases;
Acting on ester bonds;
Endoribonucleases producing 5'-phosphomonoesters;
PDB | Resolution (Å) | PDB name |
---|---|---|
2HZ6 | 3.1 | The crystal structure of human IRE1-alpha luminal domain |
3P23 | 2.7 | Crystal structure of the Human kinase and RNase domains in complex with ADP |
4U6R | 2.5 | Crystal structure of human IRE1 cytoplasmic domains in complex with a sulfonamide inhibitor. |
4YZ9 | 2.463 | Crystal Structure of human phosphorylated IRE1alpha in complex with a type III kinase inhibitor (GSK2850163A) |
4YZC | 2.494 | Crystal structure of pIRE1alpha in complex with staurosporine |
4YZD | 3.102 | Crystal Structure of human phosphorylated IRE1alpha in complex with ADP-Mg |
4Z7G | 2.6 | Crystal structure of human IRE1 cytoplasmic kinase-RNase region - apo |
4Z7H | 2.9 | Crystal structure of human IRE1 cytoplasmic kinase-RNase region - complex with imidazopyridine compound 3 |
5HGI | 2.584 | Crystal structure of apo human IRE1 alpha |
6HV0 | 2.73 | IRE1 kinase/RNase in complex with imidazo[1,2-b]pyridazin-8-amine compound 33 |
6HX1 | 2.14 | IRE1 ALPHA IN COMPLEX WITH imidazo[1,2-b]pyridazin-8-amine compound 2 |
6SHC | 3.55 | Crystal structure of human IRE1 luminal domain Q105C |
6URC | 2.2 | Crystal structure of IRE1a in complex with compound 18 |
6W39 | 1.736 | Structure of unphosphorylated IRE1 in complex with G-1749 |
6W3A | 2.606 | Structure of unphosphorylated IRE1 in complex with G-7658 |
6W3B | 2.57 | Structure of apo unphosphorylated IRE1 |
6W3C | 2.3 | Structure of phosphorylated apo IRE1 |
6W3E | 2.737 | Structure of phosphorylated IRE1 in complex with G-0701 |
6W3K | 2.08 | Structure of unphosphorylated human IRE1 bound to G-9807 |
6XDB | 2.45 | Crystal structure of IRE1a in complex with G-6904 |
6XDD | 2.4 | Crystal structure of IRE1 in complex with G-3053 |
6XDF | 2.54 | Crystal structure of IRE1a in complex with G-4100 |
7BMK | 1.85 | ATP-Competitive Partial Antagonists-'PAIR's-Rheostatically Modulate IRE1alpha's Kinase Helix-alphaC to Segregate its RNase-Mediated Biological Outputs |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0036498 | IRE1-mediated unfolded protein response |
Biological Process | GO:0071333 | cellular response to glucose stimulus |
Biological Process | GO:0070301 | cellular response to hydrogen peroxide |
Biological Process | GO:0034620 | cellular response to unfolded protein |
Biological Process | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
Biological Process | GO:0001935 | endothelial cell proliferation |
Biological Process | GO:1901142 | insulin metabolic process |
Biological Process | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
Biological Process | GO:0006402 | mRNA catabolic process |
Biological Process | GO:0006379 | mRNA cleavage |
Biological Process | GO:0098787 | mRNA cleavage involved in mRNA processing |
Biological Process | GO:0070054 | mRNA splicing, via endonucleolytic cleavage and ligation |
Biological Process | GO:0036289 | peptidyl-serine autophosphorylation |
Biological Process | GO:1990579 | peptidyl-serine trans-autophosphorylation |
Biological Process | GO:0043507 | positive regulation of JUN kinase activity |
Biological Process | GO:0033120 | positive regulation of RNA splicing |
Biological Process | GO:1900103 | positive regulation of endoplasmic reticulum unfolded protein response |
Biological Process | GO:1904707 | positive regulation of vascular associated smooth muscle cell proliferation |
Biological Process | GO:0046777 | protein autophosphorylation |
Biological Process | GO:0006468 | protein phosphorylation |
Biological Process | GO:0016241 | regulation of macroautophagy |
Biological Process | GO:0034976 | response to endoplasmic reticulum stress |
Molecular Function | GO:0043531 | ADP binding |
Molecular Function | GO:0005524 | ATP binding |
Molecular Function | GO:0030544 | Hsp70 protein binding |
Molecular Function | GO:0051879 | Hsp90 protein binding |
Molecular Function | GO:0004521 | RNA endonuclease activity |
Molecular Function | GO:0019899 | enzyme binding |
Molecular Function | GO:0042802 | identical protein binding |
Molecular Function | GO:0000287 | magnesium ion binding |
Molecular Function | GO:0005161 | platelet-derived growth factor receptor binding |
Molecular Function | GO:0042803 | protein homodimerization activity |
Molecular Function | GO:0106310 | protein serine kinase activity |
Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
Molecular Function | GO:0051082 | unfolded protein binding |
Cellular Component | GO:1990597 | AIP1-IRE1 complex |
Cellular Component | GO:1990630 | IRE1-RACK1-PP2A complex |
Cellular Component | GO:1990604 | IRE1-TRAF2-ASK1 complex |
Cellular Component | GO:1990332 | Ire1 complex |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005783 | endoplasmic reticulum |
Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
Cellular Component | GO:0005739 | mitochondrion |
Cellular Component | GO:0005637 | nuclear inner membrane |
InterPro | InterPro name |
---|---|
IPR000719 | Protein kinase domain |
IPR008271 | Serine/threonine-protein kinase, active site |
IPR010513 | KEN domain |
IPR011009 | Protein kinase-like domain superfamily |
IPR011047 | Quinoprotein alcohol dehydrogenase-like superfamily |
IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
IPR018391 | Pyrrolo-quinoline quinone beta-propeller repeat |
IPR038357 | KEN domain superfamily |
IPR045133 | Serine/threonine-protein kinase/endoribonuclease IRE1/2-like |
Pfam | Pfam name |
---|---|
PF00069 | Protein kinase domain |
PF06479 | Ribonuclease 2-5A |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-381070 | IRE1alpha activates chaperones | Internal node | R-HSA-8953897 | Cellular responses to stimuli |
Location | ECO term | Pubmed |
---|---|---|
Endoplasmic reticulum membrane | ECO:0000269 | PubMed:9637683 |