Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2CQ0 | solution structure of RNA binding domain in eukaryotic translation initiation factor 3 subunit 4 | |
| 2MJC | Zn-binding domain of eukaryotic translation initiation factor 3, subunit G | |
| 5K0Y | 5.8 | m48S late-stage initiation complex, purified from rabbit reticulocytes lysates, displaying eIF2 ternary complex and eIF3 i and g subunits relocated to the intersubunit face |
| 6YBS | 3.1 | Structure of a human 48S translational initiation complex - head |
| 6ZMW | 3.7 | Structure of a human 48S translational initiation complex |
| 7QP6 | 4.7 | Structure of the human 48S initiation complex in open state (h48S AUG open) |
| 7QP7 | 3.7 | Structure of the human 48S initiation complex in closed state (h48S AUG closed) |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0001732 | formation of cytoplasmic translation initiation complex |
| Biological Process | GO:0006413 | translational initiation |
| Biological Process | GO:0075525 | viral translational termination-reinitiation |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003743 | translation initiation factor activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016282 | eukaryotic 43S preinitiation complex |
| Cellular Component | GO:0033290 | eukaryotic 48S preinitiation complex |
| Cellular Component | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| InterPro
|
InterPro name |
|---|---|
| IPR000504 | RNA recognition motif domain |
| IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| IPR017334 | Eukaryotic translation initiation factor 3 subunit G |
| IPR024675 | Eukaryotic translation initiation factor 3 subunit G, N-terminal |
| IPR034240 | eIF3G, RNA recognition motif |
| IPR035979 | RNA-binding domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00076 | RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
| PF12353 | Eukaryotic translation initiation factor 3 subunit G |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-72649 | Translation initiation complex formation | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-72689 | Formation of a pool of free 40S subunits | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | Leaf | R-HSA-392499 | Metabolism of proteins |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000255 | |
| Cytoplasm, perinuclear region | ECO:0000255 | PubMed:17094969 |
| Nucleus | ECO:0000255 | PubMed:17094969 |