Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.3.2.-
Transferases;
Acyltransferases;
Aminoacyltransferases;
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1V66 | Solution structure of human p53 binding domain of PIAS-1 |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0045444 | fat cell differentiation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0033235 | positive regulation of protein sumoylation |
| Biological Process | GO:0016925 | protein sumoylation |
| Biological Process | GO:0007259 | receptor signaling pathway via JAK-STAT |
| Biological Process | GO:0042127 | regulation of cell population proliferation |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0061665 | SUMO ligase activity |
| Molecular Function | GO:0019789 | SUMO transferase activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Cellular Component | GO:0016605 | PML body |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-3108214 | SUMOylation of DNA damage response and repair proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-3232118 | SUMOylation of transcription factors | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-3232142 | SUMOylation of ubiquitinylation proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-3899300 | SUMOylation of transcription cofactors | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-4090294 | SUMOylation of intracellular receptors | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-4551638 | SUMOylation of chromatin organization proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | Leaf | R-HSA-73894 | DNA Repair |
| R-HSA-877312 | Regulation of IFNG signaling | Leaf | R-HSA-168256 | Immune System |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Nucleus speckle | ECO:0000269 | PubMed:12393906 |
| Nucleus speckle | ECO:0000269 | PubMed:9177271 |
| Nucleus, PML body | ECO:0000250 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | High | Supported |
| adrenal gland | glandular cells | High | Supported |
| appendix | glandular cells | High | Supported |
| appendix | lymphoid tissue | High | Supported |
| bone marrow | hematopoietic cells | High | Supported |
| breast | adipocytes | High | Supported |
| breast | glandular cells | High | Supported |
| breast | myoepithelial cells | Medium | Supported |
| bronchus | basal cells | Medium | Supported |
| bronchus | ciliated cells (cell body) | Low | Supported |
| bronchus | goblet cells | High | Supported |
| caudate | glial cells | High | Supported |
| caudate | neuronal cells | High | Supported |
| cerebellum | cells in granular layer | High | Supported |
| cerebellum | cells in molecular layer | High | Supported |
| cerebral cortex | endothelial cells | High | Supported |
| cerebral cortex | glial cells | High | Supported |
| cerebral cortex | neuronal cells | High | Supported |
| cervix | glandular cells | High | Supported |
| cervix | squamous epithelial cells | High | Supported |
| colon | endothelial cells | High | Supported |
| colon | glandular cells | High | Supported |
| colon | peripheral nerve/ganglion | Medium | Supported |
| duodenum | glandular cells | High | Supported |
| endometrium 1 | cells in endometrial stroma | High | Supported |
| endometrium 1 | glandular cells | High | Supported |
| endometrium 2 | cells in endometrial stroma | High | Supported |
| endometrium 2 | glandular cells | High | Supported |
| epididymis | glandular cells | High | Supported |
| esophagus | squamous epithelial cells | High | Supported |
| fallopian tube | ciliated cells (cell body) | High | Supported |
| gallbladder | glandular cells | High | Supported |
| heart muscle | cardiomyocytes | High | Supported |
| hippocampus | glial cells | High | Supported |
| hippocampus | neuronal cells | High | Supported |
| kidney | cells in glomeruli | Medium | Supported |
| kidney | cells in tubules | Medium | Supported |
| liver | cholangiocytes | Medium | Supported |
| liver | hepatocytes | Medium | Supported |
| lung | alveolar cells type I | High | Supported |
| lung | alveolar cells type II | High | Supported |
| lung | endothelial cells | High | Supported |
| lung | macrophages | High | Supported |
| lymph node | germinal center cells | High | Supported |
| lymph node | non-germinal center cells | High | Supported |
| nasopharynx | basal cells | High | Supported |
| nasopharynx | ciliated cells (cell body) | Medium | Supported |
| nasopharynx | goblet cells | Medium | Supported |
| oral mucosa | squamous epithelial cells | Medium | Supported |
| ovary | ovarian stroma cells | High | Supported |
| pancreas | exocrine glandular cells | High | Supported |
| pancreas | pancreatic endocrine cells | High | Supported |
| parathyroid gland | glandular cells | High | Supported |
| placenta | decidual cells | Medium | Supported |
| placenta | trophoblastic cells | High | Supported |
| prostate | glandular cells | Medium | Supported |
| rectum | glandular cells | High | Supported |
| salivary gland | glandular cells | High | Supported |
| seminal vesicle | glandular cells | High | Supported |
| skeletal muscle | myocytes | High | Supported |
| skin 1 | Langerhans | High | Supported |
| skin 1 | fibroblasts | High | Supported |
| skin 1 | keratinocytes | High | Supported |
| skin 1 | melanocytes | High | Supported |
| skin 2 | epidermal cells | High | Supported |
| small intestine | glandular cells | High | Supported |
| smooth muscle | smooth muscle cells | Low | Supported |
| soft tissue 1 | chondrocytes | High | Supported |
| soft tissue 1 | fibroblasts | High | Supported |
| soft tissue 1 | peripheral nerve | Medium | Supported |
| soft tissue 2 | fibroblasts | High | Supported |
| soft tissue 2 | peripheral nerve | High | Supported |
| spleen | cells in red pulp | High | Supported |
| spleen | cells in white pulp | High | Supported |
| stomach 1 | glandular cells | Medium | Supported |
| stomach 2 | glandular cells | High | Supported |
| testis | pachytene spermatocytes | Medium | Supported |
| testis | preleptotene spermatocytes | Medium | Supported |
| testis | round or early spermatids | Medium | Supported |
| testis | spermatogonia cells | High | Supported |
| thyroid gland | glandular cells | High | Supported |
| tonsil | germinal center cells | High | Supported |
| tonsil | non-germinal center cells | High | Supported |
| tonsil | squamous epithelial cells | High | Supported |
| urinary bladder | urothelial cells | High | Supported |
| vagina | squamous epithelial cells | High | Supported |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| nephronophthisis | MONDO:0019005 | Q61 | chapter17, Congenital malformations, deformations and chromosomal abnormalities | OMIMPS:256100 | Orphanet:655 |