Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 3KFV | 2.8 | Crystal structure of the SH3-kinase fragment of tight junction protein 3 (TJP3) in apo-form |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0045216 | cell-cell junction organization |
| Biological Process | GO:0090557 | establishment of endothelial intestinal barrier |
| Biological Process | GO:0035633 | maintenance of blood-brain barrier |
| Biological Process | GO:1905605 | positive regulation of blood-brain barrier permeability |
| Biological Process | GO:0150105 | protein localization to cell-cell junction |
| Molecular Function | GO:0050839 | cell adhesion molecule binding |
| Cellular Component | GO:0005923 | bicellular tight junction |
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| InterPro
|
InterPro name |
|---|---|
| IPR001452 | SH3 domain |
| IPR001478 | PDZ domain |
| IPR005417 | Tight junction protein ZO |
| IPR005420 | Tight junction protein ZO-3 |
| IPR008144 | Guanylate kinase-like domain |
| IPR008145 | Guanylate kinase/L-type calcium channel beta subunit |
| IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| IPR036028 | SH3-like domain superfamily |
| IPR036034 | PDZ superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00595 | PDZ domain |
| PF00625 | Guanylate kinase |
| PF07653 | Variant SH3 domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell junction, tight junction | ECO:0000269 | PubMed:21411630 |
| Cell junction, tight junction | ECO:0000269 | PubMed:23608536 |
| Cell membrane | ECO:0000269 | PubMed:21411630 |
| Nucleus | ECO:0000269 | PubMed:23608536 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Medium | Enhanced |
| appendix | endocrine cells | Medium | Enhanced |
| appendix | enterocytes | Medium | Enhanced |
| appendix | enterocytes - Microvilli | High | Enhanced |
| appendix | goblet cells | Medium | Enhanced |
| breast | glandular cells | Medium | Enhanced |
| bronchus | respiratory epithelial cells | Medium | Enhanced |
| cerebral cortex | endothelial cells | Medium | Enhanced |
| cerebral cortex | neuronal cells | Low | Enhanced |
| cervix | glandular cells | Medium | Enhanced |
| colon | endocrine cells | Medium | Enhanced |
| colon | endothelial cells | Low | Enhanced |
| colon | enterocytes | Medium | Enhanced |
| colon | enterocytes - Microvilli | High | Enhanced |
| colon | goblet cells | Medium | Enhanced |
| colon | mucosal lymphoid cells | Low | Enhanced |
| duodenum | endocrine cells | Medium | Enhanced |
| duodenum | enterocytes | Medium | Enhanced |
| duodenum | enterocytes - Microvilli | High | Enhanced |
| duodenum | glands of Brunner | Low | Enhanced |
| duodenum | goblet cells | Medium | Enhanced |
| duodenum | paneth cells | Medium | Enhanced |
| endometrium 1 | glandular cells | Medium | Enhanced |
| endometrium 2 | glandular cells | Medium | Enhanced |
| epididymis | glandular cells | Medium | Enhanced |
| esophagus | squamous epithelial cells | Low | Enhanced |
| fallopian tube | glandular cells | Medium | Enhanced |
| gallbladder | glandular cells | Medium | Enhanced |
| heart muscle | cardiomyocytes | Low | Enhanced |
| kidney | cells in tubules | Low | Enhanced |
| liver | cholangiocytes | Low | Enhanced |
| liver | hepatocytes | Low | Enhanced |
| lung | alveolar cells | Low | Enhanced |
| lymph node | non-germinal center cells | Low | Enhanced |
| nasopharynx | respiratory epithelial cells | Low | Enhanced |
| oral mucosa | squamous epithelial cells | Low | Enhanced |
| pancreas | exocrine glandular cells | Medium | Enhanced |
| pancreas | pancreatic endocrine cells | Low | Enhanced |
| placenta | cytotrophoblasts | Medium | Enhanced |
| prostate | glandular cells | Low | Enhanced |
| rectum | endocrine cells | Medium | Enhanced |
| rectum | endothelial cells | Low | Enhanced |
| rectum | enterocytes | Medium | Enhanced |
| rectum | enterocytes - Gradient | Ascending | Enhanced |
| rectum | enterocytes - Microvilli | High | Enhanced |
| rectum | goblet cells | Medium | Enhanced |
| rectum | mucosal lymphoid cells | Low | Enhanced |
| salivary gland | glandular cells | Medium | Enhanced |
| seminal vesicle | glandular cells | Medium | Enhanced |
| skeletal muscle | myocytes | Low | Enhanced |
| skin 2 | epidermal cells | Low | Enhanced |
| small intestine | endocrine cells | Medium | Enhanced |
| small intestine | enterocytes | Medium | Enhanced |
| small intestine | enterocytes - Microvilli | High | Enhanced |
| small intestine | goblet cells | Medium | Enhanced |
| smooth muscle | smooth muscle cells | Low | Enhanced |
| stomach 1 | glandular cells | Medium | Enhanced |
| stomach 2 | glandular cells | Medium | Enhanced |
| testis | pachytene spermatocytes | Medium | Enhanced |
| testis | round or early spermatids | Medium | Enhanced |
| testis | spermatogonia cells | Medium | Enhanced |
| thyroid gland | glandular cells | Medium | Enhanced |
| tonsil | squamous epithelial cells | Low | Enhanced |
| urinary bladder | urothelial cells | Medium | Enhanced |
| vagina | squamous epithelial cells | Medium | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|