Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
3.2.2.-
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds;
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2MOE | Solution structure of MBD4 methyl-cytosine binding domain bound to methylated DNA | |
| 3IHO | 2.7 | The C-terminal glycosylase domain of human MBD4 |
| 4DK9 | 2.76 | Crystal Structure of MBD4 Catalytic Domain Bound to Abasic DNA |
| 4E9E | 1.9 | Structure of the glycosylase domain of MBD4 |
| 4E9F | 1.79 | Structure of the glycosylase domain of MBD4 bound to AP site containing DNA |
| 4E9G | 2.35 | structure of the glycosylase domain of MBD4 bound to thymine containing DNA |
| 4E9H | 3.0 | structure of glycosylase domain of MBD4 bound to 5hmU containing DNA |
| 4EA4 | 2.0 | Structure of the glycosylase domain of MBD4 bound to 5hmU-containing DNA |
| 4EA5 | 2.14 | Structure of the glycoslyase domain of MBD4 bound to a 5hmU containing DNA |
| 4LG7 | 2.5 | Crystal structure MBD4 MBD domain in complex with methylated CpG DNA |
| 4OFA | 1.55 | Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding domain protein 4: Implications for roles of Arg468 in mismatch recognition and catalysis |
| 4OFE | 2.15 | Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding domain protein 4: Implications for roles of Arg468 in mismatch recognition and catalysis |
| 4OFH | 2.22 | Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding domain protein 4: Implications for roles of Arg468 in mismatch recognition and catalysis |
| 5CHZ | 1.83 | Structure of wild-type human MBD4 bound to a G:T mismatch |
| 6VJW | 2.02 | Crystal structure of WT hMBD4 complexed with T:G mismatch DNA |
| 7KZ0 | 1.57 | Human MBD4 glycosylase domain bound to DNA containing substrate analog 2'-deoxy-pseudouridine |
| 7KZ1 | 1.62 | Human MBD4 glycosylase domain bound to DNA containing an abasic site |
| 7KZG | 1.68 | Human MBD4 glycosylase domain bound to DNA containing oxacarbenium-ion analog 1-aza-2'-deoxyribose |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0045008 | depyrimidination |
| Molecular Function | GO:0019104 | DNA N-glycosylase activity |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0004520 | DNA endonuclease activity |
| Molecular Function | GO:0008263 | pyrimidine-specific mismatch base pair DNA N-glycosylase activity |
| Molecular Function | GO:0003696 | satellite DNA binding |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected pyrimidine | Leaf | R-HSA-73894 | DNA Repair |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | Leaf | R-HSA-73894 | DNA Repair |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | Leaf | R-HSA-73894 | DNA Repair |
| HPO ID
|
HPO name |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0002858 | Meningioma |
| HP:0003003 | Colon cancer |
| HP:0003581 | Adult onset |
| HP:0003596 | Middle age onset |
| HP:0003621 | Juvenile onset |
| HP:0004808 | Acute myeloid leukemia |
| HP:0005227 | Adenomatous colonic polyposis |
| HP:0007716 | Uveal melanoma |
| HP:0011462 | Young adult onset |
| HP:0030075 | Ductal carcinoma in situ |
| HP:0031919 | Juvenile type ovarian granulosa cell tumor |
| HP:0100008 | Schwannoma |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| melanoma, uveal, susceptibility to, 1 | MONDO:0011695 | C69 | chapter2, Neoplasms | OMIM:606660 | |
| tumor predisposition syndrome 2 | MONDO:0859267 | - | - | OMIM:619975 |