MultifacetedProtDB - Bologna Biocomputing Group

Catalytic activity

EC number	EC number description
2.7.1.25	Transferases; Transferring phosphorus-containing groups; Phosphotransferases with an alcohol group as acceptor; adenylyl-sulfate kinase
2.7.7.4	Transferases; Transferring phosphorus-containing groups; Nucleotidyltransferases; sulfate adenylyltransferase

Publications

PDB	Resolution (Å)	PDB name
2AX4	2.5	Crystal structure of the kinase domain of human 3'-phosphoadenosine 5'-phosphosulphate synthetase 2
7FH3	1.8	Crystal structure of the ATP sulfurylase domain of human PAPSS2
7FHA	2.0	Crystal structure of the ATP sulfurylase domain of human PAPSS2 in complex with APS

GO ontology	GO term	GO description
Biological Process	GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
Biological Process	GO:0007596	blood coagulation
Biological Process	GO:0060348	bone development
Biological Process	GO:0042445	hormone metabolic process
Biological Process	GO:0016310	phosphorylation
Biological Process	GO:0000103	sulfate assimilation
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004020	adenylylsulfate kinase activity
Molecular Function	GO:0016779	nucleotidyltransferase activity
Molecular Function	GO:0004781	sulfate adenylyltransferase (ATP) activity
Cellular Component	GO:0005829	cytosol

InterPro	InterPro name
IPR002650	Sulphate adenylyltransferase
IPR002891	Adenylyl-sulfate kinase
IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
IPR015947	PUA-like superfamily
IPR024951	Sulphate adenylyltransferase catalytic domain
IPR025980	ATP-sulfurylase PUA-like domain
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-174362	Transport and synthesis of PAPS	Leaf	R-HSA-1430728	Metabolism
R-HSA-2408550	Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	Leaf	R-HSA-1430728	Metabolism
R-HSA-3560796	Defective PAPSS2 causes SEMD-PA	Leaf	R-HSA-1643685	Disease

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000869	Secondary amenorrhea
HP:0000926	Platyspondyly
HP:0001007	Hirsutism
HP:0001061	Acne
HP:0001156	Brachydactyly
HP:0002651	Spondyloepimetaphyseal dysplasia
HP:0002751	Kyphoscoliosis
HP:0002979	Bowing of the legs
HP:0003301	Irregular vertebral endplates
HP:0004322	Short stature
HP:0004626	Lumbar scoliosis
HP:0009816	Lower limb undergrowth
HP:0012411	Premature pubarche

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	High	Enhanced
appendix	enterocytes	Low	Enhanced
appendix	enterocytes - Gradient	Ascending	Enhanced
appendix	goblet cells	Low	Enhanced
cartilage	chondrocytes	High	Enhanced
caudate	neuronal cells	Low	Enhanced
colon	enterocytes	Medium	Enhanced
colon	enterocytes - Gradient	Ascending	Enhanced
colon	goblet cells	Medium	Enhanced
duodenum	enterocytes	Medium	Enhanced
duodenum	enterocytes - Gradient	Ascending	Enhanced
gallbladder	glandular cells	High	Enhanced
kidney	collecting ducts	Low	Enhanced
kidney	distal tubules	Medium	Enhanced
kidney	proximal tubules (cell body)	Low	Enhanced
lymph node	germinal center cells	Low	Enhanced
pancreas	pancreatic endocrine cells	Low	Enhanced
parathyroid gland	glandular cells	Low	Enhanced
placenta	decidual cells	High	Enhanced
rectum	enterocytes	High	Enhanced
rectum	enterocytes - Gradient	Ascending	Enhanced
rectum	goblet cells	Medium	Enhanced
small intestine	enterocytes	Medium	Enhanced
small intestine	enterocytes - Gradient	Ascending	Enhanced
smooth muscle	smooth muscle cells	Low	Enhanced
stomach 2	glandular cells	Low	Enhanced
testis	Leydig cells	High	Enhanced
thyroid gland	glandular cells	Medium	Enhanced

Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM	Orphanet
autosomal recessive brachyolmia	MONDO:0018662	Q76	chapter17, Congenital malformations, deformations and chromosomal abnormalities		Orphanet:448242
spondyloepimetaphyseal dysplasia, papss2 type	MONDO:0019666	Q77	chapter17, Congenital malformations, deformations and chromosomal abnormalities	OMIM:612847	Orphanet:93282