Structure
GO term
GO ontology
| GO term | GO description |
|---|---|---|
| Biological Process | GO:0006501 | C-terminal protein lipidation |
| Biological Process | GO:0006914 | autophagy |
| Biological Process | GO:0000422 | autophagy of mitochondrion |
| Biological Process | GO:0071455 | cellular response to hyperoxia |
| Biological Process | GO:0006995 | cellular response to nitrogen starvation |
| Biological Process | GO:0009267 | cellular response to starvation |
| Biological Process | GO:0051607 | defense response to virus |
| Biological Process | GO:0044805 | late nucleophagy |
| Biological Process | GO:0016236 | macroautophagy |
| Biological Process | GO:0034727 | piecemeal microautophagy of the nucleus |
Showing 1 to 10 of 28 entries
InterPro / Pfam
| InterPro
| InterPro name |
|---|---|
| IPR000594 | THIF-type NAD/FAD binding fold |
| IPR006285 | Ubiquitin-like modifier-activating enzyme Atg7 |
| IPR032197 | Ubiquitin-like modifier-activating enzyme Atg7, N-terminal |
| IPR035985 | Ubiquitin-activating enzyme |
| IPR042522 | Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 1 |
| IPR042523 | Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 2 |
| IPR045886 | ThiF/MoeB/HesA family |
Showing 1 to 7 of 7 entries
Reactome
| Reactome
| Reactome Name | Node type
| Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1632852 | Macroautophagy | Internal node | R-HSA-9612973 | Autophagy |
| R-HSA-6798695 | Neutrophil degranulation | Leaf | R-HSA-168256 | Immune System |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | Leaf | R-HSA-1643685 | Disease |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | Leaf | R-HSA-168256 | Immune System |
Showing 1 to 4 of 4 entries
Subcellular location
| Location
| ECO term
| Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000250 | |
| Preautophagosomal structure | ECO:0000250 |
Showing 1 to 2 of 2 entries
Interactor | Variant | Drug
Phenotype
| HPO ID
| HPO name |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000212 | Gingival overgrowth |
| HP:0000218 | High palate |
| HP:0000276 | Long face |
| HP:0000278 | Retrognathia |
| HP:0000319 | Smooth philtrum |
| HP:0000486 | Strabismus |
| HP:0000488 | Retinopathy |
| HP:0000508 | Ptosis |
| HP:0000544 | External ophthalmoplegia |
Showing 1 to 10 of 42 entries
Tissue and cell type
| Tissue
| Cell type
| Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Supported |
| adrenal gland | glandular cells | Medium | Supported |
| appendix | glandular cells | Low | Supported |
| appendix | lymphoid tissue | Low | Supported |
| breast | glandular cells | Medium | Supported |
| breast | myoepithelial cells | Medium | Supported |
| bronchus | respiratory epithelial cells | Low | Supported |
| caudate | glial cells | Medium | Supported |
| cerebellum | Purkinje cells | Medium | Supported |
| cerebral cortex | endothelial cells | Low | Supported |
Showing 1 to 10 of 64 entries
Disease
| Disease name | MONDO ID
| ICD10
| ICD10 chapter
| OMIM
| Orphanet
|
|---|---|---|---|---|---|
| muscular dystrophy, congenital hearing loss, and ovarian insufficiency syndrome | MONDO:0859189 | - | - | OMIM:619518 | |
| spinocerebellar ataxia, autosomal recessive 31 | MONDO:0030323 | - | - | OMIM:619422 |
Showing 1 to 2 of 2 entries