Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
1.1.1.363
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor;
glucose-6-phosphate dehydrogenase [NAD(P)+]
1.1.1.47
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor;
glucose 1-dehydrogenase [NAD(P)+]
3.1.1.31
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
6-phosphogluconolactonase
PDB | Resolution (Å) | PDB name |
---|
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006006 | glucose metabolic process |
Biological Process | GO:0009051 | pentose-phosphate shunt, oxidative branch |
Biological Process | GO:2000064 | regulation of cortisol biosynthetic process |
Biological Process | GO:0097305 | response to alcohol |
Biological Process | GO:0031667 | response to nutrient levels |
Molecular Function | GO:0017057 | 6-phosphogluconolactonase activity |
Molecular Function | GO:0050661 | NADP binding |
Molecular Function | GO:0030246 | carbohydrate binding |
Molecular Function | GO:0047934 | glucose 1-dehydrogenase (NAD+) activity |
Molecular Function | GO:0047935 | glucose 1-dehydrogenase (NADP+) activity |
Molecular Function | GO:0047936 | glucose 1-dehydrogenase NAD(P) activity |
Molecular Function | GO:0004345 | glucose-6-phosphate dehydrogenase activity |
Cellular Component | GO:0005783 | endoplasmic reticulum |
Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
Cellular Component | GO:0005739 | mitochondrion |
InterPro | InterPro name |
---|---|
IPR001282 | Glucose-6-phosphate dehydrogenase |
IPR005900 | 6-phosphogluconolactonase, DevB-type |
IPR006148 | Glucosamine/galactosamine-6-phosphate isomerase |
IPR019796 | Glucose-6-phosphate dehydrogenase, active site |
IPR022674 | Glucose-6-phosphate dehydrogenase, NAD-binding |
IPR022675 | Glucose-6-phosphate dehydrogenase, C-terminal |
IPR036291 | NAD(P)-binding domain superfamily |
IPR037171 | NagB/RpiA transferase-like |
Pfam | Pfam name |
---|---|
PF00479 | Glucose-6-phosphate dehydrogenase, NAD binding domain |
PF01182 | Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase |
PF02781 | Glucose-6-phosphate dehydrogenase, C-terminal domain |
Location | ECO term | Pubmed |
---|---|---|
Endoplasmic reticulum lumen | ECO:0000305 | PubMed:18628520 |
HPO ID | HPO name |
---|---|
HP:0000007 | Autosomal recessive inheritance |
HP:0000789 | Infertility |
HP:0000826 | Precocious puberty |
HP:0000876 | Oligomenorrhea |
HP:0001007 | Hirsutism |
HP:0001061 | Acne |
HP:0001513 | Obesity |
HP:0001596 | Alopecia |
HP:0003581 | Adult onset |
HP:0003596 | Middle age onset |
HP:0003621 | Juvenile onset |
HP:0025710 | Late young adult onset |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
cortisone reductase deficiency 1 | MONDO:0011503 | E25 | chapter4, Endocrine, nutritional and metabolic diseases | OMIM:604931 |