MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
2KLL		Solution structure of human interleukin-33
4KC3	3.2702	Cytokine/receptor binary complex

GO term

GO ontology	GO term	GO description
Biological Process	GO:0071260	cellular response to mechanical stimulus
Biological Process	GO:0051607	defense response to virus
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway
Biological Process	GO:0010467	gene expression
Biological Process	GO:0038172	interleukin-33-mediated signaling pathway
Biological Process	GO:0030225	macrophage differentiation
Biological Process	GO:0002282	microglial cell activation involved in immune response
Biological Process	GO:0061518	microglial cell proliferation
Biological Process	GO:0002826	negative regulation of T-helper 1 type immune response
Biological Process	GO:0002638	negative regulation of immunoglobulin production
Biological Process	GO:0106015	negative regulation of inflammatory response to wounding
Biological Process	GO:0002686	negative regulation of leukocyte migration
Biological Process	GO:0120042	negative regulation of macrophage proliferation
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0032689	negative regulation of type II interferon production
Biological Process	GO:0150145	positive regulation of CD80 production
Biological Process	GO:0150142	positive regulation of CD86 production
Biological Process	GO:0045345	positive regulation of MHC class I biosynthetic process
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process
Biological Process	GO:0010186	positive regulation of cellular defense response
Biological Process	GO:0032722	positive regulation of chemokine production
Biological Process	GO:0001819	positive regulation of cytokine production
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0002639	positive regulation of immunoglobulin production
Biological Process	GO:0050729	positive regulation of inflammatory response
Biological Process	GO:0032736	positive regulation of interleukin-13 production
Biological Process	GO:0032753	positive regulation of interleukin-4 production
Biological Process	GO:0032754	positive regulation of interleukin-5 production
Biological Process	GO:0032755	positive regulation of interleukin-6 production
Biological Process	GO:0043032	positive regulation of macrophage activation
Biological Process	GO:0150078	positive regulation of neuroinflammatory response
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production
Biological Process	GO:0002830	positive regulation of type 2 immune response
Biological Process	GO:0006606	protein import into nucleus
Biological Process	GO:0051930	regulation of sensory perception of pain
Biological Process	GO:0042092	type 2 immune response
Biological Process	GO:0042060	wound healing
Molecular Function	GO:0005125	cytokine activity
Molecular Function	GO:0002112	interleukin-33 receptor binding
Cellular Component	GO:0005694	chromosome
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0043231	intracellular membrane-bounded organelle
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0030133	transport vesicle

InterPro / Pfam

InterPro	InterPro name
IPR026145	Interleukin-33

Pfam	Pfam name
PF15095	Interleukin 33

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1257604	PIP3 activates AKT signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-5689880	Ub-specific processing proteases	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9014843	Interleukin-33 signaling	Leaf	R-HSA-168256	Immune System

Subcellular location

Location	ECO term	Pubmed
Chromosome	ECO:0000269	PubMed:17185418
Cytoplasm	ECO:0000269	PubMed:32272059
Cytoplasmic vesicle, secretory vesicle	ECO:0000269	PubMed:22215666
Nucleus	ECO:0000269	PubMed:12819012
Nucleus	ECO:0000269	PubMed:17185418
Nucleus	ECO:0000269	PubMed:18787100
Nucleus	ECO:0000269	PubMed:18836528
Nucleus	ECO:0000269	PubMed:21734074
Secreted	ECO:0000269	PubMed:19465481

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Low	Supported
appendix	lymphoid tissue	Medium	Supported
bone marrow	hematopoietic cells	Medium	Supported
breast	adipocytes	Medium	Supported
breast	myoepithelial cells	Medium	Supported
bronchus	respiratory epithelial cells	High	Supported
caudate	glial cells	Low	Supported
cerebellum	cells in granular layer	Low	Supported
cerebral cortex	endothelial cells	Medium	Supported
cervix	glandular cells	High	Supported
cervix	squamous epithelial cells	Medium	Supported
colon	endothelial cells	High	Supported
endometrium	ciliated epithelial cells	High	Supported
endometrium	endothelial cells	High	Supported
endometrium	nonciliated glandular epithelial cells	High	Supported
endometrium	nonciliated luminal epithelial cells	High	Supported
endometrium	stromal fibroblasts	Medium	Supported
endometrium 1	cells in endometrial stroma	High	Supported
endometrium 1	glandular cells	High	Supported
endometrium 2	cells in endometrial stroma	High	Supported
endometrium 2	glandular cells	High	Supported
esophagus	squamous epithelial cells	Medium	Supported
heart muscle	cardiomyocytes	Low	Supported
hippocampus	glial cells	Low	Supported
hippocampus	neuronal cells	Low	Supported
lung	macrophages	Low	Supported
lymph node	non-germinal center cells	Medium	Supported
nasopharynx	respiratory epithelial cells	High	Supported
pancreas	exocrine glandular cells	Medium	Supported
prostate	glandular cells	Low	Supported
salivary gland	glandular cells	Medium	Supported
skeletal muscle	myocytes	Medium	Supported
skin 1	cells in basal layer	Medium	Supported
skin 1	cells in spinous layer	Medium	Supported
skin 1	endothelial cells	High	Supported
skin 1	fibrohistiocytic cells	High	Supported
skin 1	lymphocytes	High	Supported
skin 2	cells in basal layer	Medium	Supported
skin 2	cells in spinous layer	Medium	Supported
skin 2	endothelial cells	High	Supported
skin 2	fibrohistiocytic cells	High	Supported
skin 2	lymphocytes	High	Supported
smooth muscle	smooth muscle cells	Medium	Supported
soft tissue 1	fibroblasts	Medium	Supported
soft tissue 2	fibroblasts	Medium	Supported
spleen	cells in red pulp	Medium	Supported
spleen	cells in white pulp	Medium	Supported
stomach 1	glandular cells	High	Supported
stomach 2	glandular cells	High	Supported
testis	Leydig cells	Low	Supported
tonsil	non-germinal center cells	Medium	Supported
urinary bladder	urothelial cells	Low	Supported
vagina	squamous epithelial cells	Medium	Supported

Disease

Summary of O95760

Gene: IL33, C9orf26, IL1F11, NFHEV
Protein: Interleukin-33

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of O95760

Gene: IL33, C9orf26, IL1F11, NFHEV Protein: Interleukin-33

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: IL33, C9orf26, IL1F11, NFHEV
Protein: Interleukin-33