Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.7.11.1
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
non-specific serine/threonine protein kinase
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0000082 | G1/S transition of mitotic cell cycle |
| Biological Process | GO:0000086 | G2/M transition of mitotic cell cycle |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0051220 | cytoplasmic sequestering of protein |
| Biological Process | GO:0035329 | hippo signaling |
| Biological Process | GO:0009755 | hormone-mediated signaling pathway |
| Biological Process | GO:0001827 | inner cell mass cell fate commitment |
| Biological Process | GO:0001828 | inner cell mass cellular morphogenesis |
| Biological Process | GO:0030216 | keratinocyte differentiation |
| Biological Process | GO:0060644 | mammary gland epithelial cell differentiation |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity |
| Biological Process | GO:1900181 | negative regulation of protein localization to nucleus |
| Biological Process | GO:0018105 | peptidyl-serine phosphorylation |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:0030833 | regulation of actin filament polymerization |
| Biological Process | GO:0033146 | regulation of intracellular estrogen receptor signaling pathway |
| Biological Process | GO:0046620 | regulation of organ growth |
| Biological Process | GO:0043254 | regulation of protein-containing complex assembly |
| Biological Process | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:2000058 | regulation of ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0000819 | sister chromatid segregation |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0030331 | nuclear estrogen receptor binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005815 | microtubule organizing center |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000922 | spindle pole |
| InterPro
|
InterPro name |
|---|---|
| IPR000719 | Protein kinase domain |
| IPR000961 | AGC-kinase, C-terminal |
| IPR008271 | Serine/threonine-protein kinase, active site |
| IPR009060 | UBA-like superfamily |
| IPR011009 | Protein kinase-like domain superfamily |
| IPR015940 | Ubiquitin-associated domain |
| IPR042706 | Serine/threonine-protein kinase LATS1, catalytic domain |
| Pfam
|
Pfam name |
|---|---|
| PF00069 | Protein kinase domain |
| PF00627 | UBA/TS-N domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-2028269 | Signaling by Hippo | Leaf | R-HSA-162582 | Signal Transduction |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | ECO:0000269 | PubMed:10518011 |
| Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body | ECO:0000269 | PubMed:10518011 |
| Cytoplasm, cytoskeleton, spindle | ECO:0000269 | PubMed:10518011 |
| Midbody | ECO:0000269 | PubMed:10518011 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Approved |
| adrenal gland | glandular cells | High | Approved |
| appendix | glandular cells | Medium | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | adipocytes | Medium | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Medium | Approved |
| bronchus | respiratory epithelial cells | Medium | Approved |
| caudate | glial cells | Low | Approved |
| caudate | neuronal cells | Medium | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in granular layer | Medium | Approved |
| cerebellum | cells in molecular layer | Low | Approved |
| cerebral cortex | endothelial cells | Medium | Approved |
| cerebral cortex | glial cells | Medium | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cerebral cortex | neuropil | Low | Approved |
| cervix | glandular cells | Low | Approved |
| cervix | squamous epithelial cells | Medium | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | Medium | Approved |
| colon | peripheral nerve/ganglion | Medium | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | glandular cells | High | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | Medium | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | High | Approved |
| heart muscle | cardiomyocytes | High | Approved |
| hippocampus | glial cells | Low | Approved |
| hippocampus | neuronal cells | Low | Approved |
| kidney | cells in glomeruli | Low | Approved |
| kidney | cells in tubules | High | Approved |
| liver | hepatocytes | High | Approved |
| lung | alveolar cells | Low | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | non-germinal center cells | Low | Approved |
| nasopharynx | respiratory epithelial cells | Medium | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| ovary | follicle cells | Medium | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| pancreas | pancreatic endocrine cells | Low | Approved |
| parathyroid gland | glandular cells | Medium | Approved |
| placenta | trophoblastic cells | High | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | Medium | Approved |
| skin 1 | fibroblasts | Medium | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 1 | melanocytes | Medium | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | Medium | Approved |
| smooth muscle | smooth muscle cells | High | Approved |
| soft tissue 1 | chondrocytes | Medium | Approved |
| soft tissue 1 | fibroblasts | Medium | Approved |
| soft tissue 1 | peripheral nerve | Low | Approved |
| soft tissue 2 | fibroblasts | Medium | Approved |
| stomach 1 | glandular cells | High | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | Medium | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | germinal center cells | Low | Approved |
| tonsil | non-germinal center cells | Low | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| plasma cell myeloma | MONDO:0009693 | C90 | chapter2, Neoplasms | OMIM:254500 | Orphanet:29073 |
| plasma cell myeloma | MONDO:0009693 | C90 | chapter2, Neoplasms | OMIM:254500 | Orphanet:314701 |
| plasma cell myeloma | MONDO:0009693 | C90 | chapter2, Neoplasms | OMIM:254500 | Orphanet:85443 |
| al amyloidosis | MONDO:0019438 | E85 | chapter4, Endocrine, nutritional and metabolic diseases | Orphanet:85443 |