Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0051276 | chromosome organization |
| Biological Process | GO:0045143 | homologous chromosome segregation |
| Biological Process | GO:0007283 | spermatogenesis |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Molecular Function | GO:0004869 | cysteine-type endopeptidase inhibitor activity |
| Molecular Function | GO:0140677 | molecular function activator activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-2467813 | Separation of Sister Chromatids | Leaf | R-HSA-1640170 | Cell Cycle |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| appendix | glandular cells | Low | Enhanced |
| appendix | lymphoid tissue | Medium | Enhanced |
| bone marrow | hematopoietic cells | Medium | Enhanced |
| breast | glandular cells | Medium | Enhanced |
| bronchus | respiratory epithelial cells | Medium | Enhanced |
| cervix | glandular cells | Medium | Enhanced |
| cervix | squamous epithelial cells | Medium | Enhanced |
| colon | glandular cells | Low | Enhanced |
| duodenum | glandular cells | Low | Enhanced |
| endometrium 1 | glandular cells | Low | Enhanced |
| endometrium 2 | glandular cells | Low | Enhanced |
| epididymis | glandular cells | Low | Enhanced |
| esophagus | squamous epithelial cells | Medium | Enhanced |
| fallopian tube | glandular cells | Low | Enhanced |
| gallbladder | glandular cells | Low | Enhanced |
| liver | hepatocytes | Low | Enhanced |
| lymph node | germinal center cells | High | Enhanced |
| lymph node | non-germinal center cells | Low | Enhanced |
| nasopharynx | respiratory epithelial cells | Medium | Enhanced |
| oral mucosa | squamous epithelial cells | Medium | Enhanced |
| pancreas | exocrine glandular cells | Low | Enhanced |
| placenta | trophoblastic cells | Low | Enhanced |
| rectum | glandular cells | Low | Enhanced |
| seminal vesicle | glandular cells | Medium | Enhanced |
| skin 1 | cells in basal layer | Medium | Enhanced |
| skin 1 | cells in spinous layer | Medium | Enhanced |
| skin 1 | hair follicles | Medium | Enhanced |
| skin 2 | cells in basal layer | Medium | Enhanced |
| skin 2 | cells in spinous layer | Medium | Enhanced |
| small intestine | glandular cells | Low | Enhanced |
| spleen | cells in red pulp | Low | Enhanced |
| spleen | cells in white pulp | Low | Enhanced |
| testis | Leydig cells | Low | Enhanced |
| testis | pachytene spermatocytes | High | Enhanced |
| testis | preleptotene spermatocytes | Low | Enhanced |
| tonsil | germinal center cells | High | Enhanced |
| tonsil | non-germinal center cells | Low | Enhanced |
| tonsil | squamous epithelial cells | Low | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
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