MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
1.16.3.1	Oxidoreductases; Oxidizing metal ions; With oxygen as acceptor; ferroxidase

PDB	Resolution (Å)	PDB name
1KCW	3.0	X-RAY CRYSTAL STRUCTURE OF HUMAN CERULOPLASMIN AT 3.0 ANGSTROMS
2J5W	2.8	Ceruloplasmin revisited: structural and functional roles of various metal cation binding sites
4EJX	4.69	Structure of ceruloplasmin-myeloperoxidase complex
4ENZ	2.6	Structure of human ceruloplasmin at 2.6 A resolution

GO ontology	GO term	GO description
Biological Process	GO:0006825	copper ion transport
Biological Process	GO:0006879	intracellular iron ion homeostasis
Biological Process	GO:0006826	iron ion transport
Molecular Function	GO:0005507	copper ion binding
Molecular Function	GO:0004322	ferroxidase activity
Molecular Function	GO:0016491	oxidoreductase activity
Molecular Function	GO:0051087	protein-folding chaperone binding
Cellular Component	GO:0072562	blood microparticle
Cellular Component	GO:0005788	endoplasmic reticulum lumen
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005765	lysosomal membrane
Cellular Component	GO:0005886	plasma membrane

InterPro	InterPro name
IPR001117	Multicopper oxidase, second cupredoxin domain
IPR002355	Multicopper oxidase, copper-binding site
IPR008972	Cupredoxin
IPR011706	Multicopper oxidase, C-terminal
IPR011707	Multicopper oxidase, N-terminal
IPR033138	Multicopper oxidases, conserved site
IPR045087	Multicopper oxidase

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-425410	Metal ion SLC transporters	Internal node	R-HSA-382551	Transport of small molecules
R-HSA-5619049	Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)	Leaf	R-HSA-1643685	Disease
R-HSA-5619060	Defective CP causes aceruloplasminemia (ACERULOP)	Leaf	R-HSA-1643685	Disease
R-HSA-8957275	Post-translational protein phosphorylation	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-917937	Iron uptake and transport	Internal node	R-HSA-382551	Transport of small molecules

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000273	Facial grimacing
HP:0000473	Torticollis
HP:0000546	Retinal degeneration
HP:0000608	Macular degeneration
HP:0000639	Nystagmus
HP:0000643	Blepharospasm
HP:0000707	Abnormality of the nervous system
HP:0000726	Dementia
HP:0000741	Apathy
HP:0000819	Diabetes mellitus
HP:0001251	Ataxia
HP:0001260	Dysarthria
HP:0001300	Parkinsonism
HP:0001332	Dystonia
HP:0001337	Tremor
HP:0001394	Cirrhosis
HP:0001395	Hepatic fibrosis
HP:0001635	Congestive heart failure
HP:0001903	Anemia
HP:0002063	Rigidity
HP:0002066	Gait ataxia
HP:0002070	Limb ataxia
HP:0002071	Abnormality of extrapyramidal motor function
HP:0002072	Chorea
HP:0002168	Scanning speech
HP:0002304	Akinesia
HP:0002354	Memory impairment
HP:0002396	Cogwheel rigidity
HP:0003281	Increased circulating ferritin concentration
HP:0003581	Adult onset
HP:0004305	Involuntary movements
HP:0004840	Hypochromic microcytic anemia
HP:0005505	Refractory anemia
HP:0007703	Abnormality of retinal pigmentation
HP:0010837	Decreased circulating ceruloplasmin concentration
HP:0010994	Abnormal corpus striatum morphology
HP:0011967	Decreased circulating copper concentration
HP:0012090	Abnormal pancreas morphology
HP:0012179	Craniofacial dystonia
HP:0012379	Abnormal circulating enzyme concentration or activity
HP:0012465	Elevated hepatic iron concentration
HP:0012675	Iron accumulation in brain
HP:0012696	Abnormal thalamic MRI signal intensity
HP:0025498	Aceruloplasminemia
HP:0040303	Decreased serum iron
HP:0100321	Abnormal dentate nucleus morphology
HP:0100543	Cognitive impairment