MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.7.10.1	Transferases; Transferring phosphorus-containing groups; Protein-tyrosine kinases; receptor protein-tyrosine kinase

Structure

PDB	Resolution (Å)	PDB name
2GS7	2.6	Crystal Structure of the inactive EGFR kinase domain in complex with AMP-PNP
2EB3	2.84	Crystal structure of mutated EGFR kinase domain (L858R) in complex with AMPPNP
6B3S	2.8	Crystal structure of the Fab fragment of necitumumab (Fab11F8) in complex with domain III from a cetuximab resistant variant of EGFR (sEGFRd3-S468R)
5HCY	2.46	EGFR kinase domain mutant TMLR with 3-carboxamide azaindole compound 13
3QWQ	2.75	Crystal structure of the extracellular domain of the epidermal growth factor receptor in complex with an adnectin
8A2D	1.11	EGFR kinase domain (L858R/V948R) in complex with 2-[4-(difluoromethyl)-6-[2-[4-[[4-(hydroxymethyl)-1-piperidyl]methyl]phenyl]ethynyl]-7-methyl-indazol-2-yl]-2-spiro[6,7-dihydropyrrolo[1,2-c]imidazole-5,1'-cyclopropane]-1-yl-N-thiazol-2-yl-acetamide
3W2P	2.05	EGFR Kinase domain T790M/L858R mutant with compound 2
5GTZ	2.999	Crystal structure of EGFR 696-1022 T790M in complex with JTS-1-39
7SZ0	3.3	Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF. tips-juxtaposed conformation
7KY0	3.1	Inactive conformation of EGFR (T790M/V948R) kinase in complex with BI-4020
5SX4	2.8	Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3.
4TKS	3.2017	Native-SAD phasing for human EGFR kinase domain.
7SZ7	3.4	Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha. tips-juxtaposed conformation
3GT8	2.955	Crystal structure of the inactive EGFR kinase domain in complex with AMP-PNP
2ITT	2.73	Crystal structure of EGFR kinase domain L858R mutation in complex with AEE788
6TFU	2.0	Crystal Structure of EGFR T790M/V948R in Complex with Covalent Pyrrolopyrimidine 14d
7T4J	2.2	Crystal Structure of EGFR_D770_N771insNPG/V948R in complex with TAK-788
6LUB	2.315	Crystal Structure of EGFR(L858R/T790M/C797S) in complex with CH7233163
3G5V	2.001	Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR
5CAV	2.73	EGFR kinase domain with compound 41a
7JXL	2.4	EGFR kinase (T790M/V948R) in complex with AZ5104
4RJ8	2.5	EGFR kinase (T790M/L858R) with inhibitor compound 8
3LZB	2.7	EGFR kinase domain complexed with an imidazo[2,1-b]thiazole inhibitor
1IVO	3.3	Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.
7SYE	3.3	Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF. tips-separated conformation
6S8A	2.6	Crystal Structure of EGFR-T790M/C797S in Complex with Covalent Pyrrolopyrimidine 19h
3VRP	1.52	Crystal structure of the tyrosine kinase binding domain of Cbl-c in complex with phospho-EGFR peptide
4I20	3.34	Crystal structure of monomeric (V948R) primary oncogenic mutant L858R EGFR kinase domain
7VRE	2.507	The crystal structure of EGFR T790M/C797S with the inhibitor HCD2892
2ITV	2.47	Crystal structure of EGFR kinase domain L858R mutation in complex with AMP-PNP
3P0Y	1.8	anti-EGFR/HER3 Fab DL11 in complex with domain III of EGFR extracellular region
6S9D	2.67	EGFR-KINASE IN COMPLEX WITH COMPOUND 6
5CNO	1.55	Crystal structure of the EGFR kinase domain mutant V924R
5HIC	2.6	EGFR kinase domain mutant TMLR with a imidazopyridinyl-aminopyrimidine inhibitor
4WKQ	1.85	1.85 angstrom structure of EGFR kinase domain with gefitinib
3GOP	2.8	Crystal structure of the EGF receptor juxtamembrane and kinase domains
8A2A	1.43	EGFR kinase domain in complex with 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[6-[2-[4-[[4-(hydroxymethyl)-1-piperidyl]methyl]phenyl]ethynyl]-1-oxo-4-(trifluoromethyl)isoindolin-2-yl]-N-thiazol-2-yl-acetamide (form 2)
7JXQ	1.83	EGFR kinase (T790M/V948R) in complex with allosteric inhibitor JBJ-09-063
7LFR	3.2	Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with spermine
4JR3	2.7	Crystal structure of EGFR kinase domain in complex with compound 3g
3W2O	2.35	EGFR Kinase domain T790M/L858R Mutant with TAK-285
7TVD	2.96	Crystal structure of the kinase domain of EGFR exon-19 (del-747-749) mutant
6Z4D	2.0	Crystal Structure of EGFR-T790M/V948R in Complex with Mavelertinib and EAI001
6TG0	1.5	Crystal Structure of EGFR T790M/V948R in Complex with Covalent Pyrrolopyrimidine 21a
5X2A	1.85	Crystal structure of EGFR 696-1022 T790M/V948R in complex with SKLB(3)
5Y25	3.102	EGFR kinase domain mutant (T790M/L858R) with covalent ligand NS-062
7SZ5	3.6	Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha tips-separated conformation
7SZ1	3.4	Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF. tips-separated conformation
5X2F	2.2	Crystal structure of EGFR 696-1022 T790M/V948R in complex with SKLB(6)
3OB2	2.1	Crystal structure of c-Cbl TKB domain in complex with double phosphorylated EGFR peptide
6LUD	2.05	Crystal Structure of EGFR(L858R/T790M/C797S) in complex with Osimertinib
5XWD	2.894	Crystal structure of the complex of 059-152-Fv and EGFR-ECD
5X28	2.952	Crystal structure of EGFR 696-1022 L858R in complex with SKLB(6)
3VJO	2.64	Crystal structure of the wild-type EGFR kinase domain in complex with AMPPNP.
3UG1	2.75	Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in the apo form
7U98	3.42	EGFR(T790M/V948R) in complex with a macrocyclic inhibitor
6JX4	2.531	Crystal structure of EGFR 696-1022 T790M in complex with AZD9291 prepared by soaking
3NJP	3.304	The Extracellular and Transmembrane Domain Interfaces in Epidermal Growth Factor Receptor Signaling
4ZAU	2.8	AZD9291 complex with wild type EGFR
6V66	1.79	EGFR(T790M/V948R) in complex with LN2899
5CZI	2.6	EGFR L858R MUTANT IN COMPLEX WITH A SHC PEPTIDE SUBSTRATE
6V6K	2.2	EGFR(T790M/V948R) in complex with LN2057
7JXK	3.1	EGFR kinase (T790M/V948R) in complex with PF-06747775 and JBJ-04-125-02
2JIT	3.1	Crystal structure of EGFR kinase domain T790M mutation
3W33	1.7	EGFR kinase domain complexed with compound 19b
4WRG	1.9	1.9 angstrom structure of EGFR kinase domain
7JXW	2.5	EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-09-063
7LFS	3.5	Crystal structure of the epidermal growth factor receptor extracellular region with A265V mutation in complex with epiregulin
5HG8	1.42	EGFR (L858R, T790M, V948R) in complex with N-[3-({2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)phenyl]prop-2-enamide
4RJ6	2.7	EGFR kinase (T790M/L858R) with inhibitor compound 4
6V5N	2.4	EGFR(T790M/V948R) in complex with LN2084
4RJ5	3.1	EGFR kinase (T790M/L858R) with inhibitor compound 5
7U99	2.5	EGFR kinase in complex with a macrocyclic inhibitor
6JWL	2.551	Crystal structure of EGFR 696-1022 L858R in complex with AZD9291
5XGM	2.952	Crystal structure of EGFR 696-1022 T790M in complex with Go6976
4RJ4	2.78	EGFR kinase (T790M/L858R) with inhibitor compound 6
5EDR	2.6	EGFR kinase (T790M/L858R) with inhibitor compound 27: ~{N}-(1~{H}-indazol-3-yl)-7,7-dimethyl-2-(2-methylpyrazol-3-yl)-5~{H}-furo[3,4-d]pyrimidin-4-amine
5CAS	2.1	EGFR kinase domain mutant TMLR with compound 41a
4LRM	3.526	EGFR D770_N771insNPG in complex with PD168393
6V5P	2.3	EGFR(T790M/V948R) in complex with LN2725
6TG1	1.6	Crystal Structure of EGFR T790M/V948R in Complex with Covalent Pyrrolopyrimidine 21b
7K1H	2.602	EGFR L858R/V948R in complex with osimertinib and allosteric inhibitor JBJ-09-063
4KRM	2.655	Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 3.5
3UG2	2.5	Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in complex with gefitinib
6S9C	2.73	EGFR-KINASE IN COMPLEX WITH COMPOUND 5
5SX5	2.5	Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3 mutant S468R.
4I21	3.37	Crystal structure of L858R + T790M EGFR kinase domain in complex with MIG6 peptide
3BEL	2.3	X-ray structure of EGFR in complex with oxime inhibitor
7ER2	2.662	Crystal structure of EGFR 696-1022 T790M/C797S in complex with LS_2_40
5CZH	2.8	EGFR L858R MUTANT IN COMPLEX WITH AN OPTIMAL PEPTIDE SUBSTRATE
5HG7	1.85	EGFR (L858R, T790M, V948R) in complex with 1-{(3R,4R)-3-[5-Chloro-2-(1-methyl-1H-pyrazol-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxymethyl]-4-methoxy-pyrrolidin-1-yl}propenone (PF-06459988)
7A6K	2.0	Crystal Structure of EGFR-T790M/V948R in Complex with TAK-788
5CAL	2.7	EGFR kinase domain mutant TMLR with compound 24
8HGO	3.31	The EGF-bound EGFR/HER2 ectodomain complex
5EDQ	2.8	EGFR kinase (T790M/L858R) with inhibitor compound 15: ~{N}-(7-chloranyl-1~{H}-indazol-3-yl)-7,7-dimethyl-2-(1~{H}-pyrazol-4-yl)-5~{H}-furo[3,4-d]pyrimidin-4-amine
3C09	3.2	Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR
7SI1	1.6	Crystal structure of apo EGFR kinase domain
4R5S	3.001	Crystal structure of EGFR 696-1022 L858R in complex with FIIN-3
7LEN	2.9	Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with trehalose
6WAK	2.4	A crystal structure of EGFR(T790M/V948R) in complex with LN3754
5FEE	2.7	EGFR kinase domain T790M mutant in complex with a covalent aminobenzimidazole inhibitor.
7OM4	6.05	Nanobody EgB4 bound to the full extracellular EGFR-EGF complex
5YU9	1.95	Crystal structure of EGFR 696-1022 T790M in complex with Ibrutinib
6WXN	1.76	EGFR(T790M/V948R) in complex with LN3844
6JXT	2.307	Crystal structure of EGFR 696-1022 WT in complex with AZD9291 prepared by cocrystallization
5EM7	2.81	EGFR kinase domain mutant TMLR with pyridone compound 13: 4-[(2-methoxyphenyl)amino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide
4JQ7	2.73	Crystal structure of EGFR kinase domain in complex with compound 2a
3VJN	2.34	Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in complex with AMPPNP.
1XKK	2.4	EGFR kinase domain complexed with a quinazoline inhibitor- GW572016
6TFV	1.5	Crystal Structure of EGFR T790M/V948R in Complex with Covalent Pyrrolopyrimidine 18b
5WB7	2.941	Crystal structure of the epidermal growth factor receptor extracellular region in complex with epiregulin
8A2B	1.69	EGFR kinase domain (L858R/V948R) in complex with 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[6-[2-[4-[[4-(hydroxymethyl)-1-piperidyl]methyl]phenyl]ethynyl]-1-oxo-4-(trifluoromethyl)isoindolin-2-yl]-N-thiazol-2-yl-acetamide
5HG5	1.52	EGFR (L858R, T790M, V948R) in complex with N-{3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}prop-2-enamide
6JRX	2.201	EGFR T790M/C797S in complex with compound 6i
2EB2	2.5	Crystal structure of mutated EGFR kinase domain (G719S)
5HCX	2.6	EGFR kinase domain mutant TMLR with azabenzimidazole compound 7
1Z9I		A Structural Model for the Membrane-Bound Form of the Juxtamembrane Domain of the Epidermal Growth Factor Receptor
7LGS	3.1	Structure of EGFR_D770_N771insNPG/V948R in complex with covalent inhibitor Osimertinib.
5Y9T	3.25	Crystal Structure of EGFR T790M mutant in complex with naquotinib
5CAQ	2.5	EGFR kinase domain mutant TMLR with compound 33
5XGN	3.0	Crystal structure of EGFR 696-1022 T790M/C797S in complex with Go6976
5X2C	2.05	Crystal structure of EGFR 696-1022 T790M/V948R in complex with SKLB(5)
4HJO	2.75	Crystal structure of the inactive EGFR tyrosine kinase domain with erlotinib
5EM6	2.78	EGFR kinase domain mutant TMLR with pyridone compound 19: 4-[(2-azanylpyrimidin-4-yl)amino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide
5X26	2.951	Crystal structure of EGFR 696-1022 L858R in complex with SKLB(3)
2ITP	2.74	Crystal structure of EGFR kinase domain G719S mutation in complex with AEE788
2ITY	3.42	Crystal structure of EGFR kinase domain in complex with Iressa
5UGC	1.58	Crystal structure of the EGFR kinase domain (L858R, T790M, V948R) in complex with a covalent inhibitor N-[(3R,4R)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-9-methyl-9H-purin-2-yl}pyrrolidin-3-yl]propanamide
7UKW	2.6	EGFR(T790M/V948R) in complex with Lazertinib (YH25448)
3W2Q	2.2	EGFR kinase domain T790M/L858R mutant with HKI-272
2ITQ	2.68	Crystal structure of EGFR kinase domain G719S mutation in complex with AFN941
7T4I	2.61	Crystal Structure of wild type EGFR in complex with TAK-788
8D76	2.4	Crystal Structure of EGFR LRTM with compound 24
6JX0	2.53	Crystal structure of EGFR 696-1022 T790M in complex with AZD9291 prepared by co-crystallization
7K1I	3.202	EGFR kinase (L858R/V948R) in complex with allosteric inhibitor JBJ-09-063
7U9A	2.6	EGFR in complex with a macrocyclic inhibitor
2GS6	2.6	Crystal Structure of the active EGFR kinase domain in complex with an ATP analog-peptide conjugate
5C8N	2.401	EGFR kinase domain mutant TMLR with compound 23
8A27	1.07	EGFR kinase domain in complex with 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[6-[2-[4-[[4-(hydroxymethyl)-1-piperidyl]methyl]phenyl]ethynyl]-1-oxo-4-(trifluoromethyl)isoindolin-2-yl]-N-thiazol-2-yl-acetamide
6WA2	2.4	Crystal structure of EGFR(T790M/V948R) in complex with LN3753
3POZ	1.5	EGFR Kinase domain complexed with tak-285
7JXM	2.192	EGFR kinase (T790M/V948R) in complex with osimertinib and EAI045
5GTY	3.14	Crystal structure of EGFR 696-1022 T790M in complex with LXX-6-26
5UWD	3.06	Crystal structure of EGFR kinase domain (L858R, T790M, V948R) in complex with the covalent inhibitor CO-1686
5JEB	3.298	Crystal structure of EGFR tyrosine kinase domain with novel inhibitor of active state of HER2
2RGP	2.0	Structure of EGFR in complex with hydrazone, a potent dual inhibitor
6XL4	2.06	EGFR(T790M/V948R) in complex with AZD9291 and DDC4002
5CNN	1.9	Crystal structure of the EGFR kinase domain mutant I682Q
1MOX	2.5	Crystal Structure of Human Epidermal Growth Factor Receptor (residues 1-501) in complex with TGF-alpha
4G5P	3.17	Crystal structure of EGFR kinase T790M in complex with BIBW2992
4ZJV	2.7	crystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein
4RJ7	2.55	EGFR kinase (T790M/L858R) with inhibitor compound 1
7A6J	2.0	Crystal Structure of EGFR-T790M/V948R in Complex with Poziotinib
2RF9	3.5	Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide
4JQ8	2.83	Crystal structure of EGFR kinase domain in complex with compound 4b
2J5E	3.1	Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 13-jab
5WB8	3.0	Crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen
5HIB	2.85	EGFR kinase domain mutant TMLR with a pyrazolopyrimidine inhibitor
5CAU	2.25	EGFR kinase domain mutant TMLR with compound 41b
5UG8	1.46	Crystal structure of the EGFR kinase domain (L858R, T790M, V948R) in complex with a covalent inhibitor N-[(3R,4R)-4-fluoro-1-{6-[(1-methyl-1H-pyrazol-4-yl)amino]-9-(propan-2-yl)-9H-purin-2-yl}pyrrolidin-3-yl]propanamide
4RIY	2.981	Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-E909G mutation
6S89	2.701	Crystal Structure of EGFR-T790M/C797S in Complex with Covalent Pyrrolopyrimidine 19g
2ITU	2.8	Crystal structure of EGFR kinase domain L858R mutation in complex with AFN941
5C8M	2.9	EGFR kinase domain mutant TMLR with compound 17
4I1Z	3.0	Crystal structure of the monomeric (V948R) form of the gefitinib/erlotinib resistant EGFR kinase domain L858R+T790M
7VRA	2.41	The crystal structure of EGFR T790M/C797S with the inhibitor HC5476
2GS2	2.8	Crystal Structure of the active EGFR kinase domain
6DUK	2.2	EGFR with an allosteric inhibitor
6VHN	2.4	Wild type EGFR in complex with LN2057
3W32	1.8	EGFR kinase domain complexed with compound 20a
2ITO	3.25	Crystal structure of EGFR kinase domain G719S mutation in complex with Iressa
6V6O	2.1	EGFR(T790M/V948R) in complex with LN2380
4LI5	2.64	EGFR-K IN COMPLEX WITH N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxy-phenyl] Prop-2-enamide
6TFY	1.7	Crystal Structure of EGFR T790M/V948R in Complex with Covalent Pyrrolopyrimidine 18c
5HCZ	2.62	EGFR kinase domain mutant TMLR with 3-azetidinyl azaindazole compound 21
6JRJ	2.943	The structure of co-crystals of 8r-B-EGFR T790M/C797S complex
6TFW	2.0	Crystal Structure of EGFR T790M/V948R in Complex with Covalent Pyrrolopyrimidine 18d
2ITW	2.88	Crystal structure of EGFR kinase domain in complex with AFN941
5XDL	2.7	Crystal structure of EGFR 696-1022 L858R in complex with CO-1686
1M14	2.6	Tyrosine Kinase Domain from Epidermal Growth Factor Receptor
4UV7	2.1	The complex structure of extracellular domain of EGFR and GC1118A
3BUO	2.6	Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor'
1NQL	2.8	Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.
6S9B	3.25	EGFR-KINASE IN COMPLEX WITH COMPOUND 1
7A6I	2.4	Crystal Structure of EGFR-T790M/V948R in Complex with LDC8201
2RFE	2.9	Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide
2ITX	2.98	Crystal structure of EGFR kinase domain in complex with AMP-PNP
6P8Q	1.9	EGFR in complex with a dihydrodibenzodiazepinone allosteric inhibitor.
5J9Y	2.8	EGFR-T790M in complex with pyrazolopyrimidine inhibitor 1b
3VRR	2.0	Crystal structure of the tyrosine kinase binding domain of Cbl-c (PL mutant) in complex with phospho-EGFR peptide
5UGB	2.53	Crystal structure of the EGFR kinase domain in complex with 4-(4-{[2-{[(3S)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9H-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium
5UG9	1.33	Crystal structure of the EGFR kinase domain (L858R, T790M, V948R) in complex with a covalent inhibitor N-[(3R,4R)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-9-(propan-2-yl)-9H-purin-2-yl}pyrrolidin-3-yl]propanamide
5UGA	1.82	Crystal structure of the EGFR kinase domain (L858R, T790M, V948R) in complex with 4-(4-{[2-{[(3S)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9H-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium
5X2K	3.201	Crystal structure of EGFR 696-1022 T790M in complex with WZ4003
5CAN	2.8	EGFR kinase domain mutant TMLR with compound 27
4ZSE	1.97	Crystal structure of EGFR 696-1022 T790M/V948R, crystal form II
4RIX	3.1	Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-Q790R mutation
7OXB	2.56	Crystal structure of EGFR double mutant (T790M/L858R) in complex with compound 6.
7LTX	2.3	EGFR (T790M/V948R) in complex with quinazolinone allosteric inhibitor
5LV6		N-terminal motif dimerization of EGFR transmembrane domain in bicellar environment
5CAO	2.6	EGFR kinase domain mutant TMLR with compound 29
2ITN	2.47	Crystal structure of EGFR kinase domain G719S mutation in complex with AMP-PNP
6P1D	2.4	Crystal structure of EGFR with mutant-selective dihydrodibenzodiazepinone allosteric inhibitor
5ZWJ	2.9	Crystal structure of EGFR 675-1022 T790M/C797S/V948R in complex with EAI045
2RFD	3.6	Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide
6D8E	2.537	Discovery of a Highly Potent and Broadly Effective EGFR and HER2 Exon 20 Insertion Mutant Inhibitor
4I24	1.8	Structure of T790M EGFR kinase domain co-crystallized with dacomitinib
5ZTO	2.649	Crystal structure of EGFR 696-1022 T790M/C797S in complex with D3003
7LG8	2.93	EGFR (T79M/V948R) in complex with naquotinib and an allosteric inhibitor
5CAP	2.4	EGFR kinase domain mutant TMLR with compound 30
3G5Y	1.59	Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR
2ITZ	2.8	Crystal structure of EGFR kinase domain L858R mutation in complex with Iressa
5GMP	2.797	Crystal structure of EGFR 696-1022 T790M in complex with XTF-262
4LL0	4.0	EGFR L858R/T790M in complex with PD168393
3B2U	2.58	Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8
6VHP	3.6	Wild type EGFR in complex with LN2899
7SYD	3.1	Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF tips-juxtaposed conformation
7B85	2.5	Crystal Structure of EGFR-WT in Complex with TAK-788
6P1L	2.8	Crystal structure of EGFR in complex with EAI045
2JIV	3.5	Crystal structure of EGFR kinase domain T790M mutation in compex with HKI-272
4R3P	2.905	Crystal structures of EGFR in complex with Mig6
7JXP	2.16	EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-04-125-02
5GNK	1.796	Crystal structure of EGFR 696-988 T790M in complex with LXX-6-34
6TFZ	1.8	Crystal Structure of EGFR T790M/V948R in Complex with Covalent Pyrrolopyrimidine 19
5EM8	2.8	EGFR kinase domain with pyridone compound 13: 4-[(2-methoxyphenyl)amino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide
7AEI	2.65	Studies Towards a Reversible EGFR C797S Triple Mutant Inhibitor Series
2M20		EGFR transmembrane - juxtamembrane (TM-JM) segment in bicelles: MD guided NMR refined structure.
4I22	1.71	Structure of the monomeric (V948R)gefitinib/erlotinib resistant double mutant (L858R+T790M) EGFR kinase domain co-crystallized with gefitinib
5U8L	1.6	Crystal structure of EGFR kinase domain in complex with a sulfonyl fluoride probe XO44
4WD5	3.3	Crystal structure of EGFR 696-1022 T790M in complex with QL-X138
4KRO	3.054	Nanobody/VHH domain EgA1 in complex with the extracellular region of EGFR
3W2S	1.9	EGFR kinase domain with compound4
7UKV	2.4	Wild type EGFR in complex with Lazertinib (YH25448)
2J5F	3.0	Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 34-jab
1YY9	2.605	Structure of the extracellular domain of the epidermal growth factor receptor in complex with the Fab fragment of cetuximab/Erbitux/IMC-C225
6JRK	2.796	The structure of co-crystals of 8r-B-EGFR WT complex
4UIP	2.95	The complex structure of extracellular domain of EGFR with Repebody (rAC1).
4RIW	3.1	Crystal structure of an EGFR/HER3 kinase domain heterodimer
2M0B		Homodimeric transmembrane domain of the human receptor tyrosine kinase ErbB1 (EGFR, HER1) in micelles
5X27	2.952	Crystal structure of EGFR 696-1022 L858R in complex with SKLB(5)
3W2R	2.05	EGFR Kinase domain T790M/L858R mutant with compound 4
4KRL	2.849	Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 6.0
8D73	2.17	Crystal Structure of EGFR LRTM with compound 7
5HG9	2.15	EGFR (L858R, T790M, V948R) in complex with 1-[(3R,4R)-3-[({2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-(trifluoromethyl)pyrrolidin-1-yl]prop-2-en-1-one
2J6M	3.1	Crystal structure of EGFR kinase domain in complex with AEE788
7AEM	2.65	Studies Towards a Reversible EGFR C797S Triple Mutant Inhibitor Series
8HGS	3.81	The EGF-bound EGFR ectodomain homodimer
5C8K	3.0	EGFR kinase domain mutant TMLR with compound 1
7KXZ	2.4	Active conformation of EGFR kinase in complex with BI-4020
7JXI	3.0	EGFR kinase (T790M/V948R) in complex with PF-06747775
5FEQ	3.4	EGFR KINASE DOMAIN IN COMPLEX WITH A COVALENT AMINOBENZIMIDAZOLE
8HGP	4.53	The EREG-bound EGFR/HER2 ectodomain complex
4G5J	2.8	Crystal structure of EGFR kinase in complex with BIBW2992
2N5S		Spatial structure of EGFR transmembrane and juxtamembrane domains in DPC micelles
5J9Z	2.5	EGFR-T790M in complex with pyrazolopyrimidine inhibitor 1a
4KRP	2.823	Nanobody/VHH domain 9G8 in complex with the extracellular region of EGFR
3IKA	2.9	Crystal Structure of EGFR 696-1022 T790M Mutant Covalently Binding to WZ4002
3B2V	3.3	Crystal structure of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8
1M17	2.6	Epidermal Growth Factor Receptor tyrosine kinase domain with 4-anilinoquinazoline inhibitor erlotinib
6JZ0	2.86	Crystal structure of EGFR kinase domain in complex with compound 78
5EDP	2.9	EGFR kinase (T790M/L858R) apo
3PFV	2.27	Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide
2JIU	3.05	Crystal structure of EGFR kinase domain T790M mutation in complex with AEE788
5FED	2.651	EGFR kinase domain in complex with a covalent aminobenzimidazole inhibitor.
5EM5	2.65	EGFR kinase domain mutant TMLR with pyridone compound 2: 4-[2-(4-chlorophenyl)ethylamino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide
6Z4B	2.5	Crystal Structure of EGFR-T790M/V948R in Complex with Osimertinib and EAI045
5XDK	2.346	Crystal structure of EGFR 696-1022 T790M in complex with CO-1686
3OP0	2.52	Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide
5D41	2.31	EGFR kinase domain in complex with mutant selective allosteric inhibitor
4LQM	2.5	EGFR L858R in complex with PD168393
2KS1		Heterodimeric association of Transmembrane domains of ErbB1 and ErbB2 receptors Enabling Kinase Activation
6ARU	3.2	Structure of Cetuximab Fab mutant in complex with EGFR extracellular domain
7A2A	1.9	Crystal Structure of EGFR-T790M/V948R in Complex with Spebrutinib and EAI001
4JRV	2.8	Crystal structure of EGFR kinase domain in complex with compound 4c
4I23	2.8	Crystal structure of the wild-type EGFR kinase domain in complex with dacomitinib (soaked)
6VH4	2.8	Wild type EGFR in complex with LN2380
4R3R	3.25	Crystal structures of EGFR in complex with Mig6

GO term

GO ontology	GO term	GO description
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway
Biological Process	GO:0007202	activation of phospholipase C activity
Biological Process	GO:0000902	cell morphogenesis
Biological Process	GO:0007166	cell surface receptor signaling pathway
Biological Process	GO:0098609	cell-cell adhesion
Biological Process	GO:0071230	cellular response to amino acid stimulus
Biological Process	GO:0071276	cellular response to cadmium ion
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus
Biological Process	GO:0071392	cellular response to estradiol stimulus
Biological Process	GO:0034614	cellular response to reactive oxygen species
Biological Process	GO:0021795	cerebral cortex cell migration
Biological Process	GO:0048546	digestive tract morphogenesis
Biological Process	GO:0001892	embryonic placenta development
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway
Biological Process	GO:0050673	epithelial cell proliferation
Biological Process	GO:0061029	eyelid development in camera-type eye
Biological Process	GO:0001942	hair follicle development
Biological Process	GO:0007611	learning or memory
Biological Process	GO:0060571	morphogenesis of an epithelial fold
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:1905208	negative regulation of cardiocyte differentiation
Biological Process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
Biological Process	GO:0042177	negative regulation of protein catabolic process
Biological Process	GO:0022008	neurogenesis
Biological Process	GO:0001503	ossification
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation
Biological Process	GO:0045739	positive regulation of DNA repair
Biological Process	GO:0045740	positive regulation of DNA replication
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
Biological Process	GO:0043406	positive regulation of MAP kinase activity
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway
Biological Process	GO:0030307	positive regulation of cell growth
Biological Process	GO:0030335	positive regulation of cell migration
Biological Process	GO:0008284	positive regulation of cell population proliferation
Biological Process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation
Biological Process	GO:0048146	positive regulation of fibroblast proliferation
Biological Process	GO:0033674	positive regulation of kinase activity
Biological Process	GO:1902895	positive regulation of miRNA transcription
Biological Process	GO:0010750	positive regulation of nitric oxide mediated signal transduction
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation
Biological Process	GO:0042327	positive regulation of phosphorylation
Biological Process	GO:0051897	positive regulation of protein kinase B signaling
Biological Process	GO:1900020	positive regulation of protein kinase C activity
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane
Biological Process	GO:0001934	positive regulation of protein phosphorylation
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0046777	protein autophosphorylation
Biological Process	GO:0051205	protein insertion into membrane
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade
Biological Process	GO:0046328	regulation of JNK cascade
Biological Process	GO:0050999	regulation of nitric-oxide synthase activity
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation
Biological Process	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling
Biological Process	GO:0070141	response to UV-A
Biological Process	GO:0007435	salivary gland morphogenesis
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0051117	ATPase binding
Molecular Function	GO:0004709	MAP kinase kinase kinase activity
Molecular Function	GO:0051015	actin filament binding
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0003690	double-stranded DNA binding
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0048408	epidermal growth factor binding
Molecular Function	GO:0005006	epidermal growth factor receptor activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0019900	kinase binding
Molecular Function	GO:0019903	protein phosphatase binding
Molecular Function	GO:0030296	protein tyrosine kinase activator activity
Molecular Function	GO:0004713	protein tyrosine kinase activity
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity
Molecular Function	GO:0004888	transmembrane signaling receptor activity
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Molecular Function	GO:0001618	virus receptor activity
Cellular Component	GO:0000139	Golgi membrane
Cellular Component	GO:0070435	Shc-EGFR complex
Cellular Component	GO:0009925	basal plasma membrane
Cellular Component	GO:0016323	basolateral plasma membrane
Cellular Component	GO:0030054	cell junction
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0030669	clathrin-coated endocytic vesicle membrane
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0031901	early endosome membrane
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0005768	endosome
Cellular Component	GO:0010008	endosome membrane
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0097708	intracellular vesicle
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0045121	membrane raft
Cellular Component	GO:0097489	multivesicular body, internal vesicle lumen
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0032991	protein-containing complex
Cellular Component	GO:0043235	receptor complex
Cellular Component	GO:0032587	ruffle membrane

InterPro / Pfam

InterPro	InterPro name
IPR000494	Receptor L-domain
IPR000719	Protein kinase domain
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR006211	Furin-like cysteine-rich domain
IPR006212	Furin-like repeat
IPR008266	Tyrosine-protein kinase, active site
IPR009030	Growth factor receptor cysteine-rich domain superfamily
IPR011009	Protein kinase-like domain superfamily
IPR016245	Tyrosine protein kinase, EGF/ERB/XmrK receptor
IPR017441	Protein kinase, ATP binding site
IPR020635	Tyrosine-protein kinase, catalytic domain
IPR032778	Growth factor receptor domain 4
IPR036941	Receptor L-domain superfamily

Pfam	Pfam name
PF00757	Furin-like cysteine rich region
PF01030	Receptor L domain
PF07714	Protein tyrosine and serine/threonine kinase
PF14843	Growth factor receptor domain IV

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1227986	Signaling by ERBB2	Internal node	R-HSA-162582	Signal Transduction
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	Leaf	R-HSA-1643685	Disease
R-HSA-1236394	Signaling by ERBB4	Internal node	R-HSA-162582	Signal Transduction
R-HSA-1250196	SHC1 events in ERBB2 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-1251932	PLCG1 events in ERBB2 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-1257604	PIP3 activates AKT signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-177929	Signaling by EGFR	Internal node	R-HSA-162582	Signal Transduction
R-HSA-179812	GRB2 events in EGFR signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-180292	GAB1 signalosome	Leaf	R-HSA-162582	Signal Transduction
R-HSA-180336	SHC1 events in EGFR signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-182971	EGFR downregulation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-1963640	GRB2 events in ERBB2 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-1963642	PI3K events in ERBB2 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-212718	EGFR interacts with phospholipase C-gamma	Leaf	R-HSA-162582	Signal Transduction
R-HSA-2179392	EGFR Transactivation by Gastrin	Leaf	R-HSA-162582	Signal Transduction
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	Leaf	R-HSA-1643685	Disease
R-HSA-445144	Signal transduction by L1	Leaf	R-HSA-1266738	Developmental Biology
R-HSA-5637810	Constitutive Signaling by EGFRvIII	Leaf	R-HSA-1643685	Disease
R-HSA-5638303	Inhibition of Signaling by Overexpressed EGFR	Leaf	R-HSA-1643685	Disease
R-HSA-5673001	RAF/MAP kinase cascade	Internal node	R-HSA-162582	Signal Transduction
R-HSA-6785631	ERBB2 Regulates Cell Motility	Leaf	R-HSA-162582	Signal Transduction
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-8847993	ERBB2 Activates PTK6 Signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	Leaf	R-HSA-5653656	Vesicle-mediated transport
R-HSA-8856828	Clathrin-mediated endocytosis	Internal node	R-HSA-5653656	Vesicle-mediated transport
R-HSA-8857538	PTK6 promotes HIF1A stabilization	Leaf	R-HSA-162582	Signal Transduction
R-HSA-8863795	Downregulation of ERBB2 signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-9009391	Extra-nuclear estrogen signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-9013507	NOTCH3 Activation and Transmission of Signal to the Nucleus	Internal node	R-HSA-162582	Signal Transduction
R-HSA-9609690	HCMV Early Events	Leaf	R-HSA-1643685	Disease
R-HSA-9634638	Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9664565	Signaling by ERBB2 KD Mutants	Leaf	R-HSA-1643685	Disease
R-HSA-9665348	Signaling by ERBB2 ECD mutants	Leaf	R-HSA-1643685	Disease
R-HSA-9665686	Signaling by ERBB2 TMD/JMD mutants	Leaf	R-HSA-1643685	Disease

Subcellular location

Location	ECO term	Pubmed
Cell membrane	ECO:0000269	PubMed:17182860
Cell membrane	ECO:0000269	PubMed:20462955
Cell membrane	ECO:0000269	PubMed:23589287
Cell membrane	ECO:0000269	PubMed:27153536
Cell membrane	ECO:0000269	PubMed:2790960
Endoplasmic reticulum membrane	ECO:0000269	PubMed:27153536
Endosome	ECO:0000269	PubMed:17182860
Endosome	ECO:0000269	PubMed:27153536
Endosome membrane
Golgi apparatus membrane
Nucleus	ECO:0000269	PubMed:17115032
Nucleus	ECO:0000269	PubMed:17909029
Nucleus	ECO:0000269	PubMed:20551055
Nucleus	ECO:0000269	PubMed:20674546
Nucleus membrane
Secreted

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000498	Blepharitis
HP:0000527	Long eyelashes
HP:0000822	Hypertension
HP:0001428	Somatic mutation
HP:0001508	Failure to thrive
HP:0001561	Polyhydramnios
HP:0001680	Coarctation of aorta
HP:0001712	Left ventricular hypertrophy
HP:0001805	Onychogryposis
HP:0001944	Dehydration
HP:0002013	Vomiting
HP:0003212	Increased circulating IgE level
HP:0003577	Congenital onset
HP:0003765	Psoriasiform dermatitis
HP:0005208	Secretory diarrhea
HP:0005406	Recurrent bacterial skin infections
HP:0006519	Alveolar cell carcinoma
HP:0006532	Recurrent pneumonia
HP:0008396	Chronic monilial nail infection
HP:0010783	Erythema
HP:0011131	Perianal dermatitis
HP:0011228	Horizontal eyebrow
HP:0011354	Generalized abnormality of skin
HP:0012390	Anal fissure
HP:0025085	Bloody diarrhea
HP:0025092	Epidermal acanthosis
HP:0030078	Lung adenocarcinoma
HP:0030358	Non-small cell lung carcinoma
HP:0031123	Recurrent gastroenteritis
HP:0040181	Chapped lip
HP:0040189	Scaling skin
HP:0100038	Slow-growing scalp hair
HP:0100501	Recurrent bronchiolitis
HP:0200034	Papule
HP:0200039	Pustule
HP:0410017	Otitis externa

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Low	Enhanced
appendix	glandular cells	Low	Enhanced
breast	adipocytes	Low	Enhanced
breast	glandular cells	Low	Enhanced
breast	myoepithelial cells	Low	Enhanced
bronchus	basal cells	High	Enhanced
bronchus	ciliated cells (cell body)	Medium	Enhanced
bronchus	ciliated cells (ciliary rootlets)	Medium	Enhanced
bronchus	ciliated cells (tip of cilia)	Low	Enhanced
caudate	glial cells	Low	Enhanced
cervix	glandular cells	Low	Enhanced
cervix	squamous epithelial cells	Medium	Enhanced
colon	glandular cells	Low	Enhanced
duodenum	glandular cells	Low	Enhanced
endometrium 1	cells in endometrial stroma	Low	Enhanced
endometrium 1	glandular cells	Low	Enhanced
endometrium 2	cells in endometrial stroma	Low	Enhanced
endometrium 2	glandular cells	Low	Enhanced
epididymis	glandular cells	Medium	Enhanced
esophagus	squamous epithelial cells	Medium	Enhanced
fallopian tube	ciliated cells (cell body)	Medium	Enhanced
fallopian tube	non-ciliated cells	Medium	Enhanced
gallbladder	glandular cells	Medium	Enhanced
heart muscle	cardiomyocytes	Low	Enhanced
kidney	bowman's capsule	Medium	Enhanced
kidney	collecting ducts	Medium	Enhanced
kidney	distal tubules	Medium	Enhanced
kidney	proximal tubules (cell body)	Medium	Enhanced
liver	cholangiocytes	Medium	Enhanced
liver	hepatocytes	Low	Enhanced
lung	alveolar cells	Low	Enhanced
lung	macrophages	Low	Enhanced
lymph node	germinal center cells	Low	Enhanced
nasopharynx	basal cells	High	Enhanced
nasopharynx	ciliated cells (cell body)	Medium	Enhanced
nasopharynx	goblet cells	High	Enhanced
oral mucosa	squamous epithelial cells	Medium	Enhanced
ovary	follicle cells	Low	Enhanced
ovary	ovarian stroma cells	Low	Enhanced
pancreas	exocrine glandular cells	Medium	Enhanced
parathyroid gland	glandular cells	Low	Enhanced
placenta	cytotrophoblasts	High	Enhanced
placenta	decidual cells	Medium	Enhanced
placenta	hofbauer cells	High	Enhanced
placenta	syncytiotrophoblasts - cell body	High	Enhanced
placenta	syncytiotrophoblasts - microvilli	High	Enhanced
prostate	glandular cells	Medium	Enhanced
rectum	glandular cells	Medium	Enhanced
salivary gland	glandular cells	Low	Enhanced
seminal vesicle	glandular cells	Medium	Enhanced
skeletal muscle	myocytes	Low	Enhanced
skin 1	cells in basal layer	Medium	Enhanced
skin 1	cells in spinous layer	Low	Enhanced
skin 1	fibrohistiocytic cells	High	Enhanced
skin 2	cells in basal layer	Medium	Enhanced
skin 2	cells in spinous layer	Medium	Enhanced
skin 2	fibrohistiocytic cells	High	Enhanced
small intestine	glandular cells	Low	Enhanced
smooth muscle	smooth muscle cells	Low	Enhanced
stomach 1	glandular cells	Low	Enhanced
stomach 2	glandular cells	Low	Enhanced
testis	Leydig cells	Medium	Enhanced
testis	pachytene spermatocytes	Medium	Enhanced
testis	round or early spermatids	Medium	Enhanced
thyroid gland	glandular cells	Medium	Enhanced
tonsil	germinal center cells	Low	Enhanced
tonsil	squamous epithelial cells	Medium	Enhanced
urinary bladder	urothelial cells	Medium	Enhanced
vagina	squamous epithelial cells	Medium	Enhanced

Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM	Orphanet
brain stem glioma	MONDO:0002911	C71	chapter2, Neoplasms
squamous cell lung carcinoma	MONDO:0005097	C34	chapter2, Neoplasms
non-small cell lung carcinoma	MONDO:0005233	C34	chapter2, Neoplasms		Orphanet:488201
colorectal neoplasm	MONDO:0005335	K63	chapter11, Diseases of the digestive system
esophageal squamous cell carcinoma	MONDO:0005580	C15	chapter2, Neoplasms		Orphanet:99977
cowden syndrome 1	MONDO:0008021	Q85	chapter17, Congenital malformations, deformations and chromosomal abnormalities	OMIM:158350	Orphanet:2969
cowden syndrome 1	MONDO:0008021	Q85	chapter17, Congenital malformations, deformations and chromosomal abnormalities	OMIM:158350	Orphanet:65285
prostate cancer	MONDO:0008315	C61	chapter2, Neoplasms
head and neck squamous cell carcinoma	MONDO:0010150	C76	chapter2, Neoplasms	OMIM:275355	Orphanet:67037
inflammatory skin and bowel disease- neonatal- 2	MONDO:0014481	D84	chapter3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	OMIM:616069
glioblastoma	MONDO:0018177	C71	chapter2, Neoplasms		Orphanet:360

Summary of P00533

Gene: EGFR, ERBB, ERBB1, HER1
Protein: Epidermal growth factor receptor

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P00533

Gene: EGFR, ERBB, ERBB1, HER1 Protein: Epidermal growth factor receptor

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: EGFR, ERBB, ERBB1, HER1
Protein: Epidermal growth factor receptor