| 1MU8 |
2.0 |
thrombin-hirugen_l-378,650 |
| 1Z8I |
2.0 |
Crystal structure of the thrombin mutant G193A bound to PPACK |
| 5AFZ |
1.53 |
Thrombin in complex with (2R)-2-(benzylsulfonylamino)-N-(2-((4- carbamimidoylphenyl)methylamino)-2-oxo-propyl)-3-phenyl-propanamide |
| 1C4V |
2.1 |
SELECTIVE NON ELECTROPHILIC THROMBIN INHIBITORS WITH CYCLOHEXYL MOIETIES. |
| 1JOU |
1.8 |
Crystal Structure of Native S195A Thrombin with an Unoccupied Active Site |
| 1RD3 |
2.5 |
2.5A Structure of Anticoagulant Thrombin Variant E217K |
| 6EO9 |
1.84 |
Crystal structure of thrombin in complex with a novel glucose-conjugated potent inhibitor |
| 1NU9 |
2.2 |
Staphylocoagulase-Prethrombin-2 complex |
| 1QUR |
2.0 |
HUMAN ALPHA-THROMBIN IN COMPLEX WITH BIVALENT, BENZAMIDINE-BASED SYNTHETIC INHIBITOR |
| 4MLF |
2.2 |
Crystal structure for the complex of thrombin mutant D102N and hirudin |
| 3QLP |
2.14 |
X-ray structure of the complex between human alpha thrombin and a modified thrombin binding aptamer (mTBA) |
| 3PO1 |
1.65 |
Thrombin in complex with Benzothiazole Guanidine |
| 1NRS |
2.4 |
CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES |
| 1C5O |
1.9 |
STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR |
| 4E06 |
3.196 |
Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism |
| 1G37 |
2.0 |
CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH BCH-10556 AND EXOSITE-DIRECTED PEPTIDE |
| 1DWE |
3.0 |
Crystallographic analysis at 3.0-Angstroms resolution of the binding to human thrombin of four active site-directed inhibitors |
| 3NXP |
2.2 |
Crystal structure of human prethrombin-1 |
| 3D49 |
1.5 |
Thrombin Inhibition |
| 1K22 |
1.93 |
HUMAN THROMBIN-INHIBITOR COMPLEX |
| 1IHS |
2.0 |
CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN ALPHA-THROMBIN AND NON-HYDROLYZABLE BIFUNCTIONAL INHIBITORS, HIRUTONIN-2 AND HIRUTONIN-6 |
| 6EO8 |
1.94 |
Crystal structure of thrombin in complex with a novel glucose-conjugated potent inhibitor |
| 3EGK |
2.2 |
KNOBLE Inhibitor |
| 2ZF0 |
2.2 |
Exploring Thrombin S1 Pocket |
| 2BVR |
1.25 |
Human thrombin complexed with fragment-based small molecules occupying the S1 pocket |
| 1K21 |
1.86 |
HUMAN THROMBIN-INHIBITOR COMPLEX |
| 1NU7 |
2.2 |
Staphylocoagulase-Thrombin Complex |
| 3DT0 |
2.4 |
Understanding Thrombin Inhibition |
| 2PKS |
2.5 |
Thrombin in complex with inhibitor |
| 4UFG |
1.65 |
Thrombin in complex with (2R)-2-(benzylsulfonylamino)-N-((1S)-2-((4- carbamimidoylphenyl)methylamino)-1-methyl-2-oxo-ethyl)-N-methyl-3- phenyl-propanamide ethane |
| 1O2G |
1.58 |
Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors |
| 1NRO |
3.1 |
CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES |
| 5Z5W |
|
VFR12 in complex with LPS micelles |
| 1TA6 |
1.9 |
Crystal structure of thrombin in complex with compound 14b |
| 5AFY |
1.12 |
Thrombin in complex with 3-chloro-benzamide |
| 1GJ5 |
1.73 |
SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN |
| 4AYY |
2.6 |
Human thrombin - inhibitor complex |
| 2BXU |
2.8 |
Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-P2-Linker |
| 1HXF |
2.1 |
HUMAN THROMBIN COMPLEX WITH HIRUDIN VARIANT |
| 2ZHF |
1.98 |
Exploring thrombin S3 pocket |
| 2GDE |
2.0 |
Thrombin in complex with inhibitor |
| 1EOL |
2.1 |
Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures |
| 3SV2 |
1.3 |
Human Thrombin In Complex With UBTHR105 |
| 5TO3 |
2.34 |
Crystal structure of thrombin mutant W215A/E217A fused to EGF456 of thrombomodulin via a 31-residue linker and bound to PPACK |
| 3GIS |
2.4 |
Crystal Structure of Na-free Thrombin in Complex with Thrombomodulin |
| 1VR1 |
1.9 |
Specifity for Plasminogen Activator Inhibitor-1 |
| 1G30 |
2.0 |
THROMBIN INHIBITOR COMPLEX |
| 1A61 |
2.2 |
THROMBIN COMPLEXED WITH A BETA-MIMETIC THIAZOLE-CONTAINING INHIBITOR |
| 3T5F |
1.45 |
Human Thrombin In Complex With MI340 |
| 2ANK |
2.46 |
orally active thrombin inhibitors in complex with thrombin and an exosite decapeptide |
| 1XMN |
1.85 |
Crystal structure of thrombin bound to heparin |
| 4UFE |
1.593 |
Thrombin in complex with (2R)-2-(benzylsulfonylamino)-N-(2-((4- carbamimidoylphenyl)methylamino)-2-oxo-butyl)-3-phenyl-propanamide |
| 3LU9 |
1.8 |
Crystal structure of human thrombin mutant S195A in complex with the extracellular fragment of human PAR1 |
| 1NY2 |
2.3 |
Human alpha thrombin inhibited by RPPGF and hirugen |
| 4HZH |
3.3 |
Structure of recombinant Gla-domainless prothrombin mutant S525A |
| 4O03 |
3.38 |
Crystal structure of Ca2+ bound prothrombin deletion mutant residues 146-167 |
| 2GP9 |
1.87 |
Crystal structure of the slow form of thrombin in a self-inhibited conformation |
| 3QGN |
2.1 |
The allosteric E*-E equilibrium is a key property of the trypsin fold |
| 1D6W |
2.0 |
STRUCTURE OF THROMBIN COMPLEXED WITH SELECTIVE NON-ELECTROPHILIC INHIBITORS HAVING CYCLOHEXYL MOIETIES AT P1 |
| 1A3B |
1.8 |
COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG1 |
| 2JH5 |
2.5 |
Human Thrombin Hirugen Inhibitor complex |
| 3U8R |
1.47 |
Human thrombin complexed with D-Phe-Pro-D-Arg-Ile |
| 3P70 |
2.55 |
Structural basis of thrombin-mediated factor V activation: essential role of the hirudin-like sequence Glu666-Glu672 for processing at the heavy chain-B domain junction |
| 5EDK |
3.214 |
Crystal structure of prothrombin deletion mutant residues 146-167 ( Form II ). |
| 2ZHQ |
1.96 |
Thrombin Inhibition |
| 5DO4 |
1.859 |
Thrombin-RNA aptamer complex |
| 1MU6 |
1.99 |
Crystal Structure of Thrombin in Complex with L-378,622 |
| 6C2W |
4.12 |
Crystal structure of human prothrombin mutant S101C/A470C |
| 3R3G |
1.75 |
Structure of human thrombin with residues 145-150 of murine thrombin. |
| 4E7R |
2.25 |
Thrombin in complex with 3-amidinophenylalanine inhibitor |
| 3EQ0 |
1.53 |
Thrombin Inhibitor |
| 1HAO |
2.8 |
COMPLEX OF HUMAN ALPHA-THROMBIN WITH A 15MER OLIGONUCLEOTIDE GGTTGGTGTGGTTGG (BASED ON NMR MODEL OF DNA) |
| 4H6T |
2.4 |
Crystal structure of prethrombin-2 mutant E14eA/D14lA/E18A/S195A |
| 3HTC |
2.3 |
THE STRUCTURE OF A COMPLEX OF RECOMBINANT HIRUDIN AND HUMAN ALPHA-THROMBIN |
| 1TOM |
1.8 |
ALPHA-THROMBIN COMPLEXED WITH HIRUGEN |
| 5AF9 |
1.18 |
Thrombin in complex with 4-Methoxy-N-(2-pyridinyl)benzamide |
| 3RMM |
1.58 |
Human Thrombin in complex with MI332 |
| 4UEH |
1.16 |
Thrombin in complex with benzamidine |
| 2C8W |
1.96 |
thrombin inhibitors |
| 1SL3 |
1.81 |
crystal structue of Thrombin in complex with a potent P1 heterocycle-Aryl based inhibitor |
| 2R2M |
2.1 |
2-(2-Chloro-6-Fluorophenyl)Acetamides as Potent Thrombin Inhibitors |
| 1P8V |
2.6 |
CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A |
| 1DWB |
3.16 |
CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS |
| 3JZ2 |
2.4 |
Crystal structure of human thrombin mutant N143P in E* form |
| 2ZGX |
1.8 |
Thrombin Inhibition |
| 1KTS |
2.4 |
Thrombin Inhibitor Complex |
| 1T4U |
2.0 |
Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin |
| 3QDZ |
2.8 |
Crystal structure of the human thrombin mutant D102N in complex with the extracellular fragment of human PAR4. |
| 1THR |
2.3 |
STRUCTURES OF THROMBIN COMPLEXES WITH A DESIGNED AND A NATURAL EXOSITE INHIBITOR |
| 1A46 |
2.12 |
THROMBIN COMPLEXED WITH HIRUGEN AND A BETA-STRAND MIMETIC INHIBITOR |
| 4THN |
2.5 |
THE CRYSTAL STRUCTURE OF ALPHA-THROMBIN-HIRUNORM IV COMPLEX REVEALS A NOVEL SPECIFICITY SITE RECOGNITION MODE. |
| 3DHK |
1.73 |
Bisphenylic Thrombin Inhibitors |
| 1NT1 |
2.0 |
thrombin in complex with selective macrocyclic inhibitor |
| 5E8E |
1.9 |
Crystal structure of thrombin bound to an exosite 1-specific IgA Fab |
| 1EB1 |
1.8 |
Complex structure of human thrombin with N-methyl-arginine inhibitor |
| 6EO6 |
1.69 |
X-ray structure of the complex between human alpha-thrombin and modified 15-mer DNA aptamer containing 5-(3-(2-(1H-indol-3-yl)acetamide-N-yl)-1-propen-1-yl)-2'-deoxyuridine residue |
| 1A4W |
1.8 |
CRYSTAL STRUCTURES OF THROMBIN WITH THIAZOLE-CONTAINING INHIBITORS: PROBES OF THE S1' BINDING SITE |
| 1C5N |
1.5 |
STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR |
| 1PPB |
1.92 |
THE REFINED 1.9 ANGSTROMS CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN: INTERACTION WITH D-PHE-PRO-ARG CHLOROMETHYLKETONE AND SIGNIFICANCE OF THE TYR-PRO-PRO-TRP INSERTION SEGMENT |
| 1GJ4 |
1.81 |
SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN |
| 1HDT |
2.6 |
STRUCTURE OF A RETRO-BINDING PEPTIDE INHIBITOR COMPLEXED WITH HUMAN ALPHA-THROMBIN |
| 4RKJ |
1.7 |
Crystal structure of thrombin mutant S195T (free form) |
| 4DII |
2.05 |
X-ray structure of the complex between human alpha thrombin and thrombin binding aptamer in the presence of potassium ions |
| 5CMX |
2.98 |
X-ray structure of the complex between human alpha thrombin and a duplex/quadruplex 31-mer DNA aptamer |
| 1AY6 |
1.8 |
THROMBIN INHIBITOR FROM THEONALLA, CYCLOTHEANAMIDE-BASED MACROCYCLIC TRIPEPTIDE MOTIF |
| 2A0Q |
1.9 |
Structure of thrombin in 400 mM potassium chloride |
| 1YPJ |
1.78 |
Thrombin Inhibitor Complex |
| 2C8Z |
2.14 |
thrombin inhibitors |
| 1MH0 |
2.8 |
Crystal structure of the anticoagulant slow form of thrombin |
| 3SI3 |
1.55 |
Human Thrombin In Complex With UBTHR103 |
| 3S7H |
1.9 |
Structure of thrombin mutant Y225P in the E* form |
| 1DWC |
3.0 |
CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS |
| 4AYV |
2.8 |
Human thrombin - inhibitor complex |
| 2FEQ |
2.44 |
orally active thrombin inhibitors |
| 1YPK |
1.78 |
Thrombin Inhibitor Complex |
| 3EE0 |
2.75 |
Crystal Structure of the W215A/E217A Mutant of Human Thrombin (space group P2(1)2(1)2(1)) |
| 3C27 |
2.182 |
Cyanofluorophenylacetamides as Orally Efficacious Thrombin Inhibitors |
| 5L6N |
1.627 |
Disulfated madanin-thrombin complex |
| 3S7K |
1.9 |
Structure of thrombin mutant Y225P in the E form |
| 2ZFR |
1.85 |
Exploring thrombin S3 pocket |
| 1H8D |
1.4 |
X-ray structure of the human alpha-thrombin complex with a tripeptide phosphonate inhibitor. |
| 4UD9 |
1.124 |
Thrombin in complex with 5-chlorothiophene-2-carboxamide |
| 1LHC |
1.95 |
HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D)PHE-PRO-BOROARG-OH |
| 2V3H |
1.79 |
Thrombin with 3-cycle no F |
| 2A2X |
2.44 |
Orally Active Thrombin Inhibitors in Complex with Thrombin Inh12 |
| 1NRQ |
3.5 |
CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES |
| 1T4V |
2.0 |
Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin |
| 3VXE |
1.25 |
Human alpha-thrombin-Bivalirudin complex at PD5.0 |
| 1Z8J |
2.0 |
Crystal structure of the thrombin mutant G193P bound to PPACK |
| 2BDY |
1.61 |
thrombin in complex with inhibitor |
| 3RM0 |
1.34 |
Human Thrombin in complex with MI354 |
| 1LHE |
2.25 |
HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D)PHE-PRO-BORO-N-BUTYL-AMIDINO-GLYCINE-OH |
| 1C1V |
1.98 |
RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
| 4LZ1 |
1.65 |
X-ray structure of the complex between human thrombin and the TBA deletion mutant lacking thymine 12 nucleobase |
| 1GHV |
1.85 |
A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE |
| 1A2C |
2.1 |
Structure of thrombin inhibited by AERUGINOSIN298-A from a BLUE-GREEN ALGA |
| 1D3T |
3.0 |
CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH BENZO[B]THIOPHENE INHIBITOR 1 |
| 3F68 |
1.75 |
Thrombin Inhibition |
| 1D4P |
2.07 |
CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH 5-AMIDINOINDOLE-4-BENZYLPIPERIDINE INHIBITOR |
| 1YPM |
1.85 |
X-ray crystal structure of thrombin inhibited by synthetic cyanopeptide analogue RA-1014 |
| 2UUJ |
1.32 |
Thrombin-hirugen-gw473178 ternary complex at 1.32A resolution |
| 1TMB |
2.3 |
MOLECULAR BASIS FOR THE INHIBITION OF HUMAN ALPHA-THROMBIN BY THE MACROCYCLIC PEPTIDE CYCLOTHEONAMIDE A |
| 1D3Q |
2.9 |
CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH BENZO[B]THIOPHENE INHIBITOR 2 |
| 4DY7 |
2.8 |
Crystal structures of protease nexin-1 in complex with S195A thrombin |
| 3QTV |
1.63 |
Thrombin Inhibition by Pyridin Derivatives |
| 1XM1 |
2.3 |
Nonbasic Thrombin Inhibitor Complex |
| 1BCU |
2.0 |
ALPHA-THROMBIN COMPLEXED WITH HIRUGEN AND PROFLAVIN |
| 1LHF |
2.4 |
HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D)PHE-PRO-BORO-HOMOLYS-OH |
| 6V5T |
2.1 |
Crystal structure of human prethrombin-2 with tryptophans replaced by 5-F-tryptophan |
| 4UFD |
1.429 |
Thrombin in complex with 4-(((1-((2S)-1-((2R)-2-(benzylsulfonylamino)- 3-phenyl-propanoyl)pyrrolidin-2-yl)-1-oxo-ethyl)amino)methyl) benzamidine |
| 1B7X |
2.1 |
STRUCTURE OF HUMAN ALPHA-THROMBIN Y225I MUTANT BOUND TO D-PHE-PRO-ARG-CHLOROMETHYLKETONE |
| 3SQH |
2.2 |
Crystal structure of prethrombin-2 mutant S195A in the the open form |
| 3SHC |
1.9 |
Human Thrombin In Complex With UBTHR101 |
| 2C90 |
2.25 |
thrombin inhibitors |
| 1HBT |
2.0 |
Human alpha-thrombin complexed with a peptidyl pyridinium methyl ketone containing bivalent inhibitor |
| 4RKO |
1.84 |
Crystal structure of thrombin mutant S195T bound with PPACK |
| 3PMH |
3.2 |
Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct alpha-Thrombin Sites |
| 2BVS |
1.4 |
Human thrombin complexed with fragment-based small molecules occupying the S1 pocket |
| 1QJ7 |
2.2 |
Novel Covalent Active Site Thrombin Inhibitors |
| 1FPH |
2.5 |
THE INTERACTION OF THROMBIN WITH FIBRINOGEN: A STRUCTURAL BASIS FOR ITS SPECIFICITY |
| 5JDU |
1.7 |
Crystal structure for human thrombin mutant D189A |
| 1BHX |
2.3 |
X-RAY STRUCTURE OF THE COMPLEX OF HUMAN ALPHA THROMBIN WITH THE INHIBITOR SDZ 229-357 |
| 3RLW |
1.69 |
Human Thrombin in complex with MI328 |
| 1RIW |
2.04 |
Thrombin in complex with natural product inhibitor Oscillarin |
| 1QJ6 |
2.2 |
Novel Covalent Active Site Thrombin Inhibitors |
| 2ZDA |
1.73 |
Exploring Thrombin S1 pocket |
| 1BMM |
2.6 |
HUMAN ALPHA-THROMBIN COMPLEXED WITH [S-(R*,R*)]-4-[(AMINOIMINOMETHYL)AMINO]-N-[[1-[3-HYDROXY-2-[(2-NAPHTHALENYLSULFONYL)AMINO]-1-OXOPROPYL]-2-PYRROLIDINYL] METHYL]BUTANAMIDE (BMS-186282) |
| 4BAN |
1.87 |
Thrombin in complex with inhibitor |
| 3VXF |
1.602 |
X/N Joint refinement of Human alpha-thrombin-Bivalirudin complex PD5 |
| 3GIC |
1.55 |
Structure of thrombin mutant delta(146-149e) in the free form |
| 5EW2 |
3.59 |
Human thrombin sandwiched between two DNA aptamers: HD22 and HD1-deltaT12 |
| 2C8X |
2.17 |
thrombin inhibitors |
| 1CA8 |
2.1 |
Thrombin inhibitors with rigid tripeptidyl aldehydes |
| 3K65 |
1.85 |
Crystal Structure of Prethombin-2/Fragment-2 Complex |
| 3BIU |
2.3 |
Human thrombin-in complex with UB-THR10 |
| 5AHG |
1.24 |
Thrombin in complex with ((4-chlorophenyl)sulfamoyl))diemethylamine |
| 1GHX |
1.65 |
A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE |
| 5A2M |
1.4 |
Thrombin Inhibitor |
| 4YES |
1.5 |
Thrombin in complex with (S)-(4-chloro-2-((1-(5-methyl-1H-pyrrole-2-carbonyl)pyrrolidine-2-carboxamido)methyl)phenyl)methanaminium |
| 5GDS |
2.1 |
HIRUNORMS ARE TRUE HIRUDIN MIMETICS. THE CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN:HIRUNORM V COMPLEX |
| 8KME |
2.1 |
CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN INHIBITED WITH SEL2770. |
| 4UDW |
1.16 |
Thrombin in complex with 1-(2R)-2-amino-3-phenyl-propanoyl-N-(2, 5dichlorophenyl)methylpyrrolidine-2-carboxamide |
| 1TQ7 |
2.4 |
Crystal structure of the anticoagulant thrombin mutant W215A/E217A bound to PPACK |
| 1YPL |
1.85 |
X-ray crystal structure of thrombin inhibited by synthetic cyanopeptide analogue RA-1008 |
| 2HGT |
2.2 |
STRUCTURE OF THE HIRUGEN AND HIRULOG 1 COMPLEXES OF ALPHA-THROMBIN |
| 1C4Y |
2.7 |
SELECTIVE NON-ELECTROPHILIC THROMBIN INHIBITORS |
| 1ZGV |
2.2 |
Thrombin in complex with an oxazolopyridine inhibitor 2 |
| 3UWJ |
1.5 |
Human Thrombin In Complex With MI353 |
| 1TB6 |
2.5 |
2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex |
| 2ZNK |
1.8 |
Thrombin Inhibition |
| 3RMN |
1.78 |
Human Thrombin in complex with MI341 |
| 1ABJ |
2.4 |
STRUCTURE OF THE HIRULOG 3-THROMBIN COMPLEX AND NATURE OF THE S' SUBSITES OF SUBSTRATES AND INHIBITORS |
| 1SR5 |
3.1 |
ANTITHROMBIN-ANHYDROTHROMBIN-HEPARIN TERNARY COMPLEX STRUCTURE |
| 1DWD |
3.0 |
CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS |
| 3JZ1 |
1.6 |
Crystal structure of human thrombin mutant N143P in E:Na+ form |
| 2C93 |
2.2 |
thrombin inhibitors |
| 4BAO |
1.87 |
Thrombin in complex with inhibitor |
| 3BV9 |
1.8 |
Structure of Thrombin Bound to the Inhibitor FM19 |
| 1TQ0 |
2.8 |
Crystal structure of the potent anticoagulant thrombin mutant W215A/E217A in free form |
| 1HAG |
2.0 |
THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK-THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN |
| 1AE8 |
2.0 |
HUMAN ALPHA-THROMBIN INHIBITION BY EOC-D-PHE-PRO-AZALYS-ONP |
| 3RLY |
1.51 |
Human Thrombin in complex with MI329 |
| 1NM6 |
1.8 |
thrombin in complex with selective macrocyclic inhibitor at 1.8A |
| 1HUT |
2.9 |
THE STRUCTURE OF ALPHA-THROMBIN INHIBITED BY A 15-MER SINGLE-STRANDED DNA APTAMER |
| 1NZQ |
2.18 |
D-Phe-Pro-Arg-Type Thrombin Inhibitor |
| 2ZHE |
2.1 |
Exploring thrombin S3 pocket |
| 1AFE |
2.0 |
HUMAN ALPHA-THROMBIN INHIBITION BY CBZ-PRO-AZALYS-ONP |
| 2ANM |
2.4 |
Ternary complex of an orally active thrombin inhibitor with human thrombin and a c-terminal hirudin derived exo-sit inhibitor |
| 1THP |
2.1 |
STRUCTURE OF HUMAN ALPHA-THROMBIN Y225P MUTANT BOUND TO D-PHE-PRO-ARG-CHLOROMETHYLKETONE |
| 1EOJ |
2.1 |
Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures |
| 3DA9 |
1.8 |
Crystal structure of thrombin in complex with inhibitor |
| 5EDM |
2.2 |
Crystal structure of prothrombin deletion mutant residues 154-167 ( Form I ) |
| 4AZ2 |
2.6 |
Human thrombin - inhibitor complex |
| 1AI8 |
1.85 |
HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH THE EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROMPG |
| 1TMU |
2.5 |
Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms |
| 1OOK |
2.3 |
Crystal Structure of the Complex of Platelet Receptor GPIb-alpha and Human alpha-Thrombin |
| 1HXE |
2.1 |
SERINE PROTEASE |
| 1GHY |
1.85 |
A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE |
| 4UE7 |
1.129 |
Thrombin in complex with 1-amidinopiperidine |
| 7KME |
2.1 |
CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN INHIBITED WITH SEL2711. |
| 3P17 |
1.43 |
Thrombin Inhibition by Pyridin Derivatives |
| 1C4U |
2.1 |
SELECTIVE NON ELECTROPHILIC THROMBIN INHIBITORS WITH CYCLOHEXYL MOIETIES. |
| 3B23 |
2.4 |
Crystal structure of thrombin-variegin complex: Insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors |
| 2JH0 |
1.7 |
Human Thrombin Hirugen Inhibitor complex |
| 1SB1 |
1.9 |
Novel Non-Covalent Thrombin Inhibitors Incorporating P1 4,5,6,7-Tetrahydrobenzothiazole Arginine Side Chain Mimetics |
| 1A3E |
1.85 |
COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG2 |
| 4DT7 |
1.9 |
Crystal structure of thrombin bound to the activation domain QEDQVDPRLIDGKMTRRGDS of protein C |
| 4BAH |
1.94 |
Thrombin in complex with inhibitor |
| 2ZIQ |
1.65 |
Thrombin Inhibition |
| 1C1U |
1.75 |
RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
| 4BAK |
1.94 |
Thrombin in complex with inhibitor |
| 1HAP |
2.8 |
COMPLEX OF HUMAN ALPHA-THROMBIN WITH A 15MER OLIGONUCLEOTIDE GGTTGGTGTGGTTGG (BASED ON X-RAY MODEL OF DNA) |
| 4DIH |
1.8 |
X-ray structure of the complex between human alpha thrombin and thrombin binding aptamer in the presence of sodium ions |
| 4HFP |
2.4 |
Structure of thrombin mutant S195a bound to the active site inhibitor argatroban |
| 2UUK |
1.39 |
Thrombin-hirugen-gw420128 ternary complex at 1.39A resolution |
| 1D9I |
2.3 |
STRUCTURE OF THROMBIN COMPLEXED WITH SELECTIVE NON-ELECTOPHILIC INHIBITORS HAVING CYCLOHEXYL MOIETIES AT P1 |
| 2ZI2 |
1.65 |
Thrombin Inhibition |
| 2CF9 |
1.79 |
Complex of recombinant human thrombin with an inhibitor |
| 1C5L |
1.47 |
STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR |
| 1BMN |
2.8 |
HUMAN ALPHA-THROMBIN COMPLEXED WITH [S-(R*,R*)]-1-(AMINOIMINOMETHYL)-N-[[1-[N-[(2-NAPHTHALENYLSULFONYL)-L-SERYL]-PYRROLIDINYL]METHYL]-3-PIPERIDENECARBOXAMIDE (BMS-189090) |
| 1TBZ |
2.3 |
HUMAN THROMBIN WITH ACTIVE SITE N-METHYL-D PHENYLALANYL-N-[5-(AMINOIMINOMETHYL)AMINO]-1-{{BENZOTHIAZOLYL)CARBONYL] BUTYL]-L-PROLINAMIDE TRIFLUROACETATE AND EXOSITE-HIRUGEN |
| 2AFQ |
1.93 |
1.9 angstrom crystal structure of wild-type human thrombin in the sodium free state |
| 1W7G |
1.65 |
Alpha-thrombin complex with sulfated hirudin (residues 54-65) and L- Arginine template inhibitor CS107 |
| 6BJR |
6.0 |
Crystal structure of prothrombin mutant S101C/A470C |
| 1VZQ |
1.54 |
Complex of thrombin with designed inhibitor 7165 |
| 1H8I |
1.75 |
X-ray crystal structure of human alpha-thrombin with a tripeptide phosphonate inhibitor. |
| 3QTO |
1.52 |
Thrombin Inhibition by Pyridin Derivatives |
| 3HAT |
2.5 |
ACTIVE SITE MIMETIC INHIBITION OF THROMBIN |
| 2ZG0 |
1.75 |
Exploring thrombin S3 pocket |
| 2ZC9 |
1.58 |
Thrombin in complex with Inhibitor |
| 1OYT |
1.67 |
COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR |
| 3B9F |
1.6 |
1.6 A structure of the PCI-thrombin-heparin complex |
| 2PW8 |
1.84 |
Crystal structure of sulfo-hirudin complexed to thrombin |
| 1SG8 |
2.3 |
Crystal structure of the procoagulant fast form of thrombin |
| 1HGT |
2.2 |
STRUCTURE OF THE HIRUGEN AND HIRULOG 1 COMPLEXES OF ALPHA-THROMBIN |
| 5MLS |
1.62 |
Thrombin Mutant A190S in complex with (S)-1-(D-phenylalanyl)-N-(3-chlorobenzyl)pyrrolidine-2-carboxamide |
| 1UVS |
2.8 |
BOVINE THROMBIN--BM51.1011 COMPLEX |
| 4NZQ |
2.807 |
Crystal structure of Ca2+-free prothrombin deletion mutant residues 146-167 |
| 1JWT |
2.5 |
CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH A NOVEL BICYCLIC LACTAM INHIBITOR |
| 1HAI |
2.4 |
THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK-THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN |
| 1SGI |
2.3 |
Crystal structure of the anticoagulant slow form of thrombin |
| 1DIT |
2.3 |
COMPLEX OF A DIVALENT INHIBITOR WITH THROMBIN |
| 1ABI |
2.3 |
STRUCTURE OF THE HIRULOG 3-THROMBIN COMPLEX AND NATURE OF THE S' SUBSITES OF SUBSTRATES AND INHIBITORS |
| 4AX9 |
1.9 |
Human thrombin complexed with Napsagatran, RO0466240 |
| 2CF8 |
1.3 |
Complex of recombinant human thrombin with an inhibitor |
| 5JZY |
1.27 |
Thrombin in complex with (S)-1-((R)-2-amino-3-cyclohexylpropanoyl)-N-(4-carbamimidoylbenzyl)pyrrolidine-2-carboxamide |
| 4BAQ |
1.89 |
Thrombin in complex with inhibitor |
| 4E05 |
2.304 |
Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism |
| 2C8Y |
2.2 |
thrombin inhibitors |
| 1TWX |
2.4 |
Crystal structure of the thrombin mutant D221A/D222K |
| 2ZFQ |
1.8 |
Exploring thrombin S3 pocket |
| 2HNT |
2.5 |
CRYSTALLOGRAPHIC STRUCTURE OF HUMAN GAMMA-THROMBIN |
| 2BXT |
1.83 |
Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-P2-Linker |
| 1WAY |
2.02 |
Active site thrombin inhibitors |
| 1ZGI |
2.2 |
thrombin in complex with an oxazolopyridine inhibitor 21 |
| 1DX5 |
2.3 |
Crystal structure of the thrombin-thrombomodulin complex |
| 1QJ1 |
2.0 |
Novel Covalent Active Site Thrombin Inhibitors |
| 3RM2 |
1.23 |
Human Thrombin in complex with MI003 |
| 3E6P |
2.1 |
Crystal structure of human meizothrombin desF1 |
| 1C1W |
1.9 |
RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES |
| 5Z5X |
|
HVF18 in complex with LPS micelles |
| 4UFF |
1.55 |
Thrombin in complex with (2R)-2-(benzylsulfonylamino)-N-(2-((4- carbamimidoylphenyl)methylamino)-2-oxo-ethyl)-N-methyl-3-phenyl- propanamide |
| 2THF |
2.1 |
STRUCTURE OF HUMAN ALPHA-THROMBIN Y225F MUTANT BOUND TO D-PHE-PRO-ARG-CHLOROMETHYLKETONE |
| 1NRN |
3.1 |
CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES |
| 1TA2 |
2.3 |
Crystal structure of thrombin in complex with compound 1 |
| 1AWH |
3.0 |
NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT |
| 1YPE |
1.81 |
Thrombin Inhibitor Complex |
| 2PGB |
1.54 |
Inhibitor-free human thrombin mutant C191A-C220A |
| 1ZRB |
1.9 |
Thrombin in complex with an azafluorenyl inhibitor 23b |
| 1QBV |
1.8 |
CRYSTAL STRUCTURE OF THROMBIN COMPLEXED WITH AN GUANIDINE-MIMETIC INHIBITOR |
| 5GIM |
2.09 |
Crystal structure of thrombin-avathrin complex |
| 3QWC |
1.75 |
Thrombin Inhibition by Pyridin Derivatives |
| 6EO7 |
2.24 |
X-ray structure of the complex between human alpha-thrombin and modified 15-mer DNA aptamer containing 5-(3-(acetamide-N-yl)-1-propen-1-yl)-2'-deoxyuridine residue |
| 1HLT |
3.0 |
THE STRUCTURE OF A NONADECAPEPTIDE OF THE FIFTH EGF DOMAIN OF THROMBOMODULIN COMPLEXED WITH THROMBIN |
| 1JMO |
2.2 |
Crystal Structure of the Heparin Cofactor II-S195A Thrombin Complex |
| 2ZDV |
1.72 |
Exploring Thrombin S1 pocket |
| 1D3D |
2.04 |
CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH BENZOTHIOPHENE INHIBITOR 4 |
| 7TPP |
4.1 |
Cryo-em structure of human prothrombin:prothrombinase at 4.1 Angstrom resolution |
| 1QHR |
2.2 |
NOVEL COVALENT ACTIVE SITE THROMBIN INHIBITORS |
| 4HTC |
2.3 |
THE REFINED STRUCTURE OF THE HIRUDIN-THROMBIN COMPLEX |
| 3U69 |
1.55 |
Unliganded wild-type human thrombin |
| 2CN0 |
1.3 |
Complex of Recombinant Human Thrombin with a Designed Inhibitor |
| 1BTH |
2.3 |
STRUCTURE OF THROMBIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR |
| 1FPC |
2.3 |
ACTIVE SITE MIMETIC INHIBITION OF THROMBIN |
| 4BOH |
2.595 |
Madanins (MEROPS I53) are cleaved by thrombin and factor Xa |
| 1B5G |
2.07 |
HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN |
| 5EW1 |
2.95 |
Human thrombin sandwiched between two DNA aptamers: HD22 and HD1-deltaT3 |
| 1UMA |
2.0 |
ALPHA-THROMBIN (HIRUGEN) COMPLEXED WITH NA-(N,N-DIMETHYLCARBAMOYL)-ALPHA-AZALYSINE |
| 4H6S |
2.19 |
Crystal structure of thrombin mutant E14eA/D14lA/E18A/S195A |
| 1Z71 |
1.8 |
thrombin and P2 pyridine N-oxide inhibitor complex structure |
| 1KTT |
2.1 |
Thrombin inhibitor complex |
| 3BIV |
1.8 |
Human thrombin-in complex with UB-THR11 |
| 4CH8 |
1.75 |
High-salt crystal structure of a thrombin-GpIbalpha peptide complex |
| 3RMO |
1.4 |
Human Thrombin in complex with MI004 |
| 1DM4 |
2.5 |
SER195ALA MUTANT OF HUMAN THROMBIN COMPLEXED WITH FIBRINOPEPTIDE A (7-16) |
| 1AWF |
2.2 |
NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT |
| 1LHD |
2.35 |
HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D)PHE-PRO-BOROLYS-OH |
| 1AIX |
2.1 |
HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROVAL |
| 1TMT |
2.2 |
CHANGES IN INTERACTIONS IN COMPLEXES OF HIRUDIN DERIVATIVES AND HUMAN ALPHA-THROMBIN DUE TO DIFFERENT CRYSTAL FORMS |
| 1GHW |
1.75 |
A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE |
| 3P6Z |
1.7 |
Structural basis of thrombin mediated factor V activation: essential role of the hirudin-like sequence Glu666-Glu672 for processing at the heavy chain-B domain junction |
| 4RN6 |
3.0 |
Structure of prethrombin-2 mutant s195a bound to the active site inhibitor argatroban |
| 3TU7 |
2.49 |
Human alpha-thrombin complexed with N-(methylsulfonyl)-D-phenylalanyl-N-((1-carbamimidoyl-4-piperidinyl)methyl)-l-prolinamide (BMS-189664) |
| 1DOJ |
1.7 |
Crystal structure of human alpha-thrombin*RWJ-51438 complex at 1.7 A |
| 1LHG |
2.25 |
HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D)PHE-PRO-BOROORNITHINE-OH |
| 1THS |
2.2 |
STRUCTURES OF THROMBIN COMPLEXES WITH A DESIGNED AND A NATURAL EXOSITE INHIBITOR |
| 4CH2 |
1.6 |
Low-salt crystal structure of a thrombin-GpIbalpha peptide complex |
| 1D3P |
2.1 |
CRYSTAL STRUCTURE OF HUMAN APLHA-THROMBIN IN COMPLEX WITH BENZO[B]THIOPHENE INHIBITOR 3 |
| 3BEI |
1.55 |
Crystal structure of the slow form of thrombin in a self_inhibited conformation |
| 2BVX |
3.2 |
Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-P2-Linker |
| 2B5T |
2.1 |
2.1 Angstrom structure of a nonproductive complex between antithrombin, synthetic heparin mimetic SR123781 and two S195A thrombin molecules |
| 1NRP |
3.0 |
CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES |
| 3BF6 |
2.5 |
Thrombin:suramin complex |
| 1MUE |
2.0 |
Thrombin-Hirugen-L405,426 |
| 1HAH |
2.3 |
THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK-THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN |
| 1O5G |
1.75 |
Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA) |
| 3U8T |
1.861 |
Human thrombin complexed with D-Phe-Pro-D-Arg-Cys |
| 5MJT |
1.4 |
Thrombin Mutant A190S in complex with (S) -1 - ((R) -2-amino-3,3-diphenylpropanoyl) -N- (3-chlorobenzyl) pyrrolidine-2-carboxamide |
| 2HWL |
2.4 |
Crystal structure of thrombin in complex with fibrinogen gamma' peptide |
| 3BEF |
2.2 |
Crystal structure of thrombin bound to the extracellular fragment of PAR1 |
| 3UTU |
1.55 |
High affinity inhibitor of human thrombin |
| 3RML |
1.53 |
Human Thrombin in complex with MI331 |
| 2ZO3 |
1.7 |
Bisphenylic Thrombin Inhibitors |
| 1BB0 |
2.1 |
THROMBIN INHIBITORS WITH RIGID TRIPEPTIDYL ALDEHYDES |
| 1YPG |
1.8 |
Thrombin Inhibitor Complex |
| 3DD2 |
1.9 |
Crystal structure of an RNA aptamer bound to human thrombin |
| 2ZGB |
1.6 |
Thrombin Inhibition |
| 1WBG |
2.2 |
Active site thrombin inhibitors |
| 1AHT |
1.6 |
CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH HIRUGEN AND P-AMIDINOPHENYLPYRUVATE AT 1.6 ANGSTROMS RESOLUTION |
| 4LOY |
1.77 |
Crystal Structure Analysis of thrombin in complex with compound D57, 5-Chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2- oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1- yl)-3-oxopropyl]amide (SAR107375) |
| 2FES |
2.42 |
Orally active thrombin inhibitors |
| 1SFQ |
1.91 |
Fast form of thrombin mutant R(77a)A bound to PPACK |
| 3HKJ |
2.6 |
Crystal structure of human thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1 |
| 2JH6 |
2.21 |
Human Thrombin Hirugen Inhibitor complex |
| 4BAM |
1.88 |
Thrombin in complex with inhibitor |
| 2HPP |
3.3 |
Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human ppack-thrombin |
| 3SI4 |
1.27 |
Human Thrombin In Complex With UBTHR104 |
| 2ZHW |
2.02 |
Exploring thrombin S3 pocket |
| 2UUF |
1.26 |
Thrombin-hirugen binary complex at 1.26A resolution |
| 1IHT |
2.1 |
CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN ALPHA-THROMBIN AND NON-HYDROLYZABLE BIFUNCTIONAL INHIBITORS, HIRUTONIN-2 AND HIRUTONIN-6 |
| 1E0F |
3.1 |
Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor |
| 4I7Y |
2.4 |
Crystal Structure of Human Alpha Thrombin in Complex with a 27-mer Aptamer Bound to Exosite II |
| 4LXB |
1.61 |
Crystal Structure Analysis of thrombin in complex with compound D58 |
| 2HPQ |
3.3 |
Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human ppack-thrombin |
| 1SHH |
1.55 |
Slow form of Thrombin Bound with PPACK |
| 1AD8 |
2.0 |
COMPLEX OF THROMBIN WITH AND INHIBITOR CONTAINING A NOVEL P1 MOIETY |
| 2PGQ |
1.8 |
Human thrombin mutant C191A-C220A in complex with the inhibitor PPACK |
| 2ZFP |
2.25 |
Thrombin Inibition |
| 2V3O |
1.79 |
Thrombin with 3-cycle with F |
| 3SHA |
1.52 |
Human Thrombin In Complex With UBTHR97 |
| 2H9T |
2.4 |
Crystal structure of human alpha-thrombin in complex with suramin |
| 3DUX |
1.6 |
Understanding Thrombin Inhibition |
| 1NRR |
2.4 |
Crystallographic structures of Thrombin complexed with Thrombin receptor peptides: Existence of expected and novel binding modes |
| 2ZFF |
1.47 |
Exploring Thrombin S1-pocket |
| 1A5G |
2.06 |
HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN |
| 3C1K |
1.84 |
Crystal structure of thrombin in complex with inhibitor 15 |
| 3SQE |
1.9 |
Crystal structure of prethrombin-2 mutant S195A in the alternative form |
| 2OD3 |
1.75 |
Human thrombin chimera with human residues 184a, 186, 186a, 186b, 186c and 222 replaced by murine thrombin equivalents. |
| 1DE7 |
2.0 |
INTERACTION OF FACTOR XIII ACTIVATION PEPTIDE WITH ALPHA-THROMBIN: CRYSTAL STRUCTURE OF THE ENZYME-SUBSTRATE COMPLEX |
| 3LDX |
2.246 |
Discovery and Clinical Evaluation of RWJ-671818, a Thrombin Inhibitor with an Oxyguanidine P1 Motif |
| 3U8O |
1.28 |
Human thrombin complexed with D-Phe-Pro-D-Arg-D-Thr |
| 5JFD |
1.46 |
Thrombin in complex with (S)-N-(2-(aminomethyl)-5-chlorobenzyl)-1-((benzylsulfonyl)-D-arginyl)pyrrolidine-2-carboxamide |
| 1NO9 |
1.9 |
Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies. |
| 4LZ4 |
2.56 |
X-ray structure of the complex between human thrombin and the TBA deletion mutant lacking thymine 3 nucleobase |
| 3U98 |
1.45 |
Human Thrombin In Complex With MI001 |
| 3U9A |
1.58 |
Human Thrombin In Complex With MI330 |
| 2A45 |
3.65 |
Crystal structure of the complex between thrombin and the central E region of fibrin |
| 1BA8 |
1.8 |
THROMBIN INHIBITOR WITH A RIGID TRIPEPTIDYL ALDEHYDES |
| 1G32 |
1.9 |
THROMBIN INHIBITOR COMPLEX |
| 1O0D |
2.44 |
Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor |
| 5NHU |
1.45 |
HUMAN ALPHA THROMBIN COMPLEXED WITH ANOPHELES GAMBIAE cE5 ANTICOAGULANT |
| 3QX5 |
1.35 |
Thrombin Inhibition by Pyridin Derivatives |
| 5MM6 |
1.29 |
Thrombin Mutant A190S in complex with (S)-1-(D-phenylalanyl)-N-(4-carbamimidoylbenzyl)pyrrolidine-2-carboxamide |
