Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.5.4.4
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines;
adenosine deaminase
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006196 | AMP catabolic process |
| Biological Process | GO:0044209 | AMP salvage |
| Biological Process | GO:0042100 | B cell proliferation |
| Biological Process | GO:0032263 | GMP salvage |
| Biological Process | GO:0048541 | Peyer's patch development |
| Biological Process | GO:0042110 | T cell activation |
| Biological Process | GO:0033077 | T cell differentiation in thymus |
| Biological Process | GO:0050852 | T cell receptor signaling pathway |
| Biological Process | GO:0006154 | adenosine catabolic process |
| Biological Process | GO:0046085 | adenosine metabolic process |
| Biological Process | GO:0000255 | allantoin metabolic process |
| Biological Process | GO:0046632 | alpha-beta T cell differentiation |
| Biological Process | GO:0043605 | amide catabolic process |
| Biological Process | GO:0019722 | calcium-mediated signaling |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0046059 | dAMP catabolic process |
| Biological Process | GO:0046061 | dATP catabolic process |
| Biological Process | GO:0006157 | deoxyadenosine catabolic process |
| Biological Process | GO:0048566 | embryonic digestive tract development |
| Biological Process | GO:0002314 | germinal center B cell differentiation |
| Biological Process | GO:0002467 | germinal center formation |
| Biological Process | GO:0043103 | hypoxanthine salvage |
| Biological Process | GO:0046103 | inosine biosynthetic process |
| Biological Process | GO:0050900 | leukocyte migration |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0048286 | lung alveolus development |
| Biological Process | GO:0002901 | mature B cell apoptotic process |
| Biological Process | GO:0070254 | mucus secretion |
| Biological Process | GO:0060169 | negative regulation of adenosine receptor signaling pathway |
| Biological Process | GO:0050728 | negative regulation of inflammatory response |
| Biological Process | GO:0002686 | negative regulation of leukocyte migration |
| Biological Process | GO:0002906 | negative regulation of mature B cell apoptotic process |
| Biological Process | GO:0070256 | negative regulation of mucus secretion |
| Biological Process | GO:0060407 | negative regulation of penile erection |
| Biological Process | GO:0070244 | negative regulation of thymocyte apoptotic process |
| Biological Process | GO:0043084 | penile erection |
| Biological Process | GO:0001890 | placenta development |
| Biological Process | GO:0030890 | positive regulation of B cell proliferation |
| Biological Process | GO:0033089 | positive regulation of T cell differentiation in thymus |
| Biological Process | GO:0050862 | positive regulation of T cell receptor signaling pathway |
| Biological Process | GO:0046638 | positive regulation of alpha-beta T cell differentiation |
| Biological Process | GO:0050850 | positive regulation of calcium-mediated signaling |
| Biological Process | GO:0002636 | positive regulation of germinal center formation |
| Biological Process | GO:0010460 | positive regulation of heart rate |
| Biological Process | GO:0045987 | positive regulation of smooth muscle contraction |
| Biological Process | GO:0032261 | purine nucleotide salvage |
| Biological Process | GO:0043101 | purine-containing compound salvage |
| Biological Process | GO:0033632 | regulation of cell-cell adhesion mediated by integrin |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0010035 | response to inorganic substance |
| Biological Process | GO:0014074 | response to purine-containing compound |
| Biological Process | GO:0006939 | smooth muscle contraction |
| Biological Process | GO:0070242 | thymocyte apoptotic process |
| Biological Process | GO:0001829 | trophectodermal cell differentiation |
| Biological Process | GO:0046111 | xanthine biosynthetic process |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
| Molecular Function | GO:0046936 | 2'-deoxyadenosine deaminase activity |
| Molecular Function | GO:0004000 | adenosine deaminase activity |
| Molecular Function | GO:0019239 | deaminase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Cellular Component | GO:0070161 | anchoring junction |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0060205 | cytoplasmic vesicle lumen |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-74217 | Purine salvage | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-9734735 | Defective ADA disrupts (deoxy)adenosine deamination | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9755088 | Ribavirin ADME | Leaf | R-HSA-9748784 | Drug ADME |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell junction | ECO:0000269 | PubMed:11772392 |
| Cell membrane | ECO:0000269 | PubMed:11772392 |
| Cell membrane | ECO:0000269 | PubMed:8101391 |
| Cytoplasm | ECO:0000250 | |
| Cytoplasmic vesicle lumen | ECO:0000250 | |
| Lysosome | ECO:0000269 | PubMed:8452534 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000100 | Nephrotic syndrome |
| HP:0000246 | Sinusitis |
| HP:0000403 | Recurrent otitis media |
| HP:0000821 | Hypothyroidism |
| HP:0000907 | Anterior rib cupping |
| HP:0000926 | Platyspondyly |
| HP:0000944 | Abnormal metaphysis morphology |
| HP:0000958 | Dry skin |
| HP:0000969 | Edema |
| HP:0000988 | Skin rash |
| HP:0000989 | Pruritus |
| HP:0001019 | Erythroderma |
| HP:0001072 | Thickened skin |
| HP:0001270 | Motor delay |
| HP:0001442 | Somatic mosaicism |
| HP:0001508 | Failure to thrive |
| HP:0001596 | Alopecia |
| HP:0001744 | Splenomegaly |
| HP:0001831 | Short toe |
| HP:0001880 | Eosinophilia |
| HP:0001888 | Lymphopenia |
| HP:0001890 | Autoimmune hemolytic anemia |
| HP:0001903 | Anemia |
| HP:0001945 | Fever |
| HP:0001954 | Recurrent fever |
| HP:0001967 | Diffuse mesangial sclerosis |
| HP:0001973 | Autoimmune thrombocytopenia |
| HP:0001974 | Leukocytosis |
| HP:0002014 | Diarrhea |
| HP:0002028 | Chronic diarrhea |
| HP:0002090 | Pneumonia |
| HP:0002099 | Asthma |
| HP:0002240 | Hepatomegaly |
| HP:0002644 | Abnormal pelvic girdle bone morphology |
| HP:0002665 | Lymphoma |
| HP:0002716 | Lymphadenopathy |
| HP:0002718 | Recurrent bacterial infections |
| HP:0002720 | Decreased circulating IgA level |
| HP:0002728 | Chronic mucocutaneous candidiasis |
| HP:0002788 | Recurrent upper respiratory tract infections |
| HP:0002841 | Recurrent fungal infections |
| HP:0002849 | Absence of lymph node germinal center |
| HP:0002850 | Decreased circulating total IgM |
| HP:0002960 | Autoimmunity |
| HP:0003212 | Increased circulating IgE level |
| HP:0003593 | Infantile onset |
| HP:0003623 | Neonatal onset |
| HP:0004332 | Abnormal lymphocyte morphology |
| HP:0004429 | Recurrent viral infections |
| HP:0004430 | Severe combined immunodeficiency |
| HP:0005354 | Lack of T cell function |
| HP:0005359 | Aplasia of the thymus |
| HP:0005365 | Severe B lymphocytopenia |
| HP:0005368 | Abnormality of humoral immunity |
| HP:0005390 | Recurrent opportunistic infections |
| HP:0005403 | T lymphocytopenia |
| HP:0005424 | Absent specific antibody response |
| HP:0006532 | Recurrent pneumonia |
| HP:0007549 | Desquamation of skin soon after birth |
| HP:0008348 | Decreased circulating IgG2 level |
| HP:0010444 | Pulmonary insufficiency |
| HP:0010976 | B lymphocytopenia |
| HP:0011123 | Inflammatory abnormality of the skin |
| HP:0012191 | B-cell lymphoma |
| HP:0012393 | Allergy |
| HP:0025379 | Anti-thyroid peroxidase antibody positivity |
| HP:0030273 | Reduced red cell adenosine deaminase level |
| HP:0030813 | Absent tonsils |
| HP:0031164 | Growth arrest lines |
| HP:0031233 | Horizontal inferior border of scapula |
| HP:0100646 | Thyroiditis |
| HP:0100806 | Sepsis |
| HP:0100840 | Aplasia/Hypoplasia of the eyebrow |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| duodenum | enterocytes | Medium | Enhanced |
| duodenum | enterocytes - Microvilli | Medium | Enhanced |
| small intestine | enterocytes - Microvilli | Low | Enhanced |
| stomach 1 | glandular cells | Low | Enhanced |
| stomach 2 | glandular cells | Low | Enhanced |
| testis | Leydig cells | Low | Enhanced |
| testis | round or early spermatids | Medium | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency | MONDO:0007064 | D81 | chapter3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | OMIM:102700 | Orphanet:277 |
| severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-positive | MONDO:0011086 | D81 | chapter3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | OMIM:601457 | Orphanet:331206 |
| omenn syndrome | MONDO:0011338 | D81 | chapter3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | OMIM:603554 | Orphanet:39041 |