MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
4.2.1.1	Lyases; Carbon-oxygen lyases; Hydro-lyases; carbonic anhydrase
4.2.1.69	Lyases; Carbon-oxygen lyases; Hydro-lyases; cyanamide hydratase

Structure

PDB	Resolution (Å)	PDB name
3OYS	1.538	Human Carbonic Anhydrase II complexed with 2-{[4-AMINO-3-(3-HYDROXYPROP-1-YN-1-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL]METHYL}-5-METHYL-3-(2-METHYLPHENYL)QUINAZOLIN-4(3H)-ONE
5NY1	1.1	Carbonic Anhydrase II Inhibitor RA10
2HNC	1.55	Crystal structure of the human carbonic anhydrase II in complex with the 5-amino-1,3,4-thiadiazole-2-sulfonamide inhibitor.
4PZH	1.06	Crystal structure of human carbonic anhydrase isozyme II with 2,3,5,6-tetrafluoro-4[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
4Q07	1.15	Crystal structure of chimeric carbonic anhydrase IX with inhibitor
4HT0	1.6	Crystal structure of human carbonic anhydrase isozyme II with the inhibitor.
3P3J	1.6	Human carbonic anhydrase II in complex with p-(5-ruthenocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide
1CNW	2.0	SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS
6ECZ	2.21	Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
5LL4	1.12	Crystal structure of human carbonic anhydrase isozyme II with 4-(1H-benzimidazol-1-ylacetyl)benzenesulfonamide
5FDI	1.85	Crystal structure of Human Carbonic Anhydrase II with the anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog.
6RKN	0.959	Human Carbonic Anhydrase II in complex with a fluorinated Benzenesulfonamide.
3M1W	1.38	Carbonic Anhyrdase II mutant W5CH64C with closed disulfide bond in complex with sulfate
1XEV	2.2	Crystal structure of human carbonic anhydrase II in a new crystal form
1BNT	2.15	CARBONIC ANHYDRASE II INHIBITOR
7OYR	1.15	Carbonic anhydrase II in complex with Hit3-t4 (MH181)
3V2J	1.699	Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II
4K0S	1.802	Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with acetazolamide
4E3G	1.55	Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
4Q08	1.07	Crystal structure of chimeric carbonic anhydrase XII with inhibitor
5JQ0	1.4	Crystal structure of human carbonic anhydrase II in complex with Benzoxaborole at pH=8.7
3HKQ	1.7	Human carbonic anhydrase II in complex with 1-S-D-Galactopyranosylsulfonamide
1CVF	2.25	STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE
5TY1	1.6	Identification of a New Zinc Binding Chemotype by Fragment Screening
4ZWX	1.696	Engineered Carbonic Anhydrase IX mimic in complex with glucosyl sulfamate inhibitor
1H9Q	2.2	H119Q CARBONIC ANHYDRASE II
5JEP	1.19	Human carbonic anhydrase II (T199S) complexed with benzo[d]thiazole-2-sulfonamide
4ITP	1.697	Structure of human carbonic anhydrase II bound to a benzene sulfonamide
3RZ5	1.65	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
4YGN	1.23	NaI--Interactions between Hofmeister Anions and the Binding Pocket of a Protein
6SFU	1.04	Human Carbonic Anhydrase II in complex with a furan-containing benzenesulfonamide
2NWO	1.7	Structural and kinetic effect of hydrophobic mutations in the active site of human carbonic anhydrase II
3OKU	1.45	Human Carbonic Anhydrase II in complex with 2-Ethylestrone-3-O-sulfamate
5JQT	1.36	Crystal structure of human carbonic anhydrase II in complex with Benzoxaborole at pH 7.4
6IC2	1.15	Polypharmacology of Epacadostat: a Potent and Selective Inhibitor of the Tumor Associated Carbonic Anhydrases IX and XII
6WQ9	1.305	Carbonic Anhydrase II Complexed with 3-((2-((Naphthalen-2-ylmethyl)(4-sulfamoylphenethyl)amino)-2-oxoethyl)(phenethyl)amino)propanoic acid
6RHK	1.44	The crystal structure of human carbonic anhydrase II in complex with 4-(3-benzylimidazolidine-1-carbonyl)benzenesulfonamide
3T82	2.002	Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates
4Q7W	1.45	Crystal structure of 1-hydroxy-6-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II
1RZC	1.9	X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
2NXS	1.8	Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
6I2F	1.198	Human Carbonic Anhydrase II in complex with 4-Propoxybenzenesulfonamide
3D8W	1.7	Use of a carbonic Anhydrase II, IX Active-site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
6T4N	1.4	Human Carbonic anhydrase II bound by 2,4,6-trimethylbenzenesulfonamide
1ZSC	1.8	CARBONIC ANHYDRASE II MUTANT E117Q, HOLO FORM
5JG5	1.19	Human carbonic anhydrase II (V121T/F131Y) complexed with benzo[d]thiazole-2-sulfonamide
5DSR	1.3	Structure of CO2 released apo-form of human carbonic anhydrase II with 10 min warming
6RVF	2.07	Crystal structure of hCA II in complex with Urea, N-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-N'-phenyl
6B59	1.638	Carbonic anhydrase II in complex with nitrogenous base-bearing benezenesulfonamide
3V3G	1.5581	Kinetic and structural studies of thermostabilized mutants of HCA II.
3DBU	1.7	Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
6KM3	1.15	Human Carbonic Anhydrase II native 00 atm CO2
6YOI	1.2	Meta-Carborane di-propyl-sulfonamide in complex with CA IX mimic
3MHL	1.9	Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-methoxy-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide
2CA2	1.9	CRYSTALLOGRAPHIC STUDIES OF INHIBITOR BINDING SITES IN HUMAN CARBONIC ANHYDRASE II. A PENTACOORDINATED BINDING OF THE SCN-ION TO THE ZINC AT HIGH P*H
2CBB	1.67	STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES
1ZSA	2.5	CARBONIC ANHYDRASE II MUTANT E117Q, APO FORM
1BNN	2.3	CARBONIC ANHYDRASE II INHIBITOR
4M2U	1.999	Carbonic Anhydrase II in complex with Dorzolamide
6SG0	1.13	Atomic resolution structure of Human Carbonic Anhydrase II in complex with furosemide
5TY8	1.45	Identification of a New Zinc Binding Chemotype by Fragment Screening
4YVY	1.45	Crystal structure of human carbonic anhydrase II in complex with hydroxylamine-O-sulfonamide, a molecule incorporating two zinc-binding groups.
3SAX	1.1	Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(5-ethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide
4KNJ	2.0	Crystal structure of human carbonic anhydrase isozyme II with 2-Chloro-4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide
1CAK	1.9	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
3T83	1.8	Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates
3KWA	2.0	Polyamines inhibit carbonic anhydrases
1CVH	2.3	STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE
6B4D	1.196	Crystal structure of human carbonic anhydrase II in complex with a heteroaryl-pyrazole carboxylic acid derivative.
6RVK	1.58	Crystal structure of hCA II in complex with Urea, N-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-N'-(phenylmethyl)-
6QEB		Assessment of a large enzyme-drug complex by proton-detected solid-state NMR without deuteration
6SYB	1.6	Crystal structure of carbonic anhydrase 2 with (3aR,4S,9bS)-4-(2-chloro-4-hydroxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
6KM2	0.9	Human Carbonic Anhydrase II V143I variant 15 atm CO2
3RG3	1.903	Crystal structure of the W5E mutant of human carbonic anhydrase II
7RNZ	1.3	Carbonic Anhydrase II in complex with 4-ureido benzenesulfonamide derivative
4FL7	1.85	The crystal structure of human carbonic anhydrase II in complex with N-(Hydroxy)-benzamide
5N24	1.5	Crystal structure of human carbonic anhydrase II in complex with the inhibitor b4'-Cyano-biphenyl-4-sulfonic acid amide
3V5G	1.5	Crystal structure of human carbonic anhydrase II in complex with the 4-sulfamido-benzenesulfonamide inhibitor
1KWQ	2.6	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 2000-07
4Z1E	2.01	Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)
6SBH	0.95	Human Carbonic Anhydrase II in complex with 4-pentylbenzenesulfonamide.
5AML	1.36	Three dimensional structure of human carbonic anhydrase II in complex with 2-(But-2-yn-1-ylsulfamoyl)-4-sulfamoylbenzoic acid
1FQM	2.0	X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
5FNJ	1.67	Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
5U0D	1.59	Identification of a New Zinc Binding Chemotype by Fragment Screening
5TYA	1.5	Identification of a New Zinc Binding Chemotype by Fragment Screening
6Q3O	2.23	PROTEIN-AROMATIC FOLDAMER COMPLEX CRYSTAL STRUCTURE
6E91	1.8	CA IX mimic Complexed with Steroidal Sulfamate Compound STX 2484
1UGF	2.0	HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY THR (A65T)
5E28	1.3	Crystal structure of human carbonic anhydrase II in complex with the 4-(4-aminophenyl)benzenesulfonamide inhibitor
3RZ1	1.51	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
2WEG	1.1	Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors
3R17	1.7	hCarbonic anhydrase II bound to N-(2-fluoro.4-sulfamoylphenyl)-2-(thiophen-2-yl) acetamide
1ZFK	1.56	carbonic anhydrase II in complex with N-4-sulfonamidphenyl-N'-4-methylbenzosulfonylurease as sulfonamide inhibitor
3DVD	1.6	X-ray crystal structure of mutant N62D of human Carbonic Anhydrase II
4Q8X	1.55	Crystal structure of 1-hydroxy-5-(trifluoromethyl)pyridine-2(1H)-thione bound to human carbonic anhydrase II
6SAC	1.02	N-terminal expression tag remainder of human Carbonic Anhydrase II covalently modified by fragment
1BN3	2.2	CARBONIC ANHYDRASE II INHIBITOR
2HD6	1.8	Crystal structure of the human carbonic anhydrase II in complex with a hypoxia-activatable sulfonamide.
1I90	2.0	CARBONIC ANHYDRASE II COMPLEXED WITH AL-8520 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 4-AMINO-3,4-DIHYDRO-2-(3-METHOXYPROPYL)-, 1,1-DIOXIDE, (R)
4E3H	1.5	Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
2FMZ	1.6	Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine, structure with D-Phenylalanine.
6SG6	0.98	Human Carbonic Anhydrase II in complex with furan-containing benzenesulfonamide
6Q9T	2.68	Protein-aromatic foldamer complex crystal structure
3SBH	1.65	Crystal structure of human carbonic anhydrase isozyme II with 4-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide
7ORQ	1.43	crystal structure of human carbonic anhydrase II in complex with 4-((3-(butylselanyl)-2-hydroxypropyl)selanyl)benzenesulfonamide
6U4Q	1.306	Carbonic anhydrase 2 in complex with SB4197
2NXR	1.7	Structural effects of hydrophobic mutations on the active site of human carbonic anhydrase II
6YHB	1.65	Crystal structure of chimeric carbonic anhydrase XII with 4-[(4,6-dimethylpyrimidin-2-yl)thio]-2,3,5,6-tetrafluorobenzenesulfonamide
4ZWZ	1.62	Engineered Carbonic Anhydrase IX mimic in complex with a glucosyl sulfamate inhibitor
4R59	1.65	A Carbonic Anhydrase IX Mimic in Complex with a Carbohydrate-Based Sulfamate
6LV1	1.2	Co- Carbonic Anhydrase II pH 7.8 0 atm CO2
4CAC	2.2	REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION
3KOK	1.5	Crystal structure of cobalt (II) human carbonic anhydrase II at pH 8.5
1CIL	1.6	THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS
5EHV	1.208	human carbonic anhydrase II in complex with ligand
4K1Q	1.699	Structure of hCAIX mimic (hCAII with 5 mutations in active site)
3L14	1.22	Human Carbonic Anhydrase II complexed with Althiazide
6YZR	1.2	Carborane nido-butyl-sulfonamide in complex with CA II
1CRA	1.9	THE COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND THE AROMATIC INHIBITOR 1,2,4-TRIAZOLE
4KUV	1.35	Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(4-chlorophenylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor
3RYX	1.6	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
5L6T	2.65	CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER
3HFP	2.098	Crystal structure of teh complex between CA II and the activator MAI
7SV8	1.388	Carbonic Anhydrase IX-mimic Complexed with 3-((2-((Furan-2-ylmethyl)(4-sulfamoylphenethyl)amino)-2-oxoethyl)(phenethyl)amino)propanoic acid
1ZSB	2.0	CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE
1IF7	1.98	Carbonic Anhydrase II Complexed With (R)-N-(3-Indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide
4R5B	1.5	Human Carbonic Anhydrase II in Complex with a Carbohydrate-Based Sulfamate
1CVC	2.3	REDESIGNING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF A HIS2ASP-ZN2+ METAL COORDINATION POLYHEDRON
1YO2	1.8	Proton Transfer from His200 in Human Carbonic Anhydrase II
5T71	1.3	Human carboanhydrase F131C_C206S double mutant in complex with SA-2
7JO3	1.454	Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)pivalamide
1YDB	1.9	STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II
3V3J	1.63	Kinetic and structural studies of thermostabilized mutants of HCA II.
1DCB	2.1	STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH
6T7U	1.2	Carborane inhibitor of Carbonic Anhydrase IX
5SZ6	1.15	Carbonic anhydrase IX-mimic in complex with 4-(3-formylphenyl)-benzenesulfonamide
3MHI	1.7	Crystal structure of human carbonic anhydrase isozyme II with 4-{[(5-nitro-6-oxo-1,6-dihydro-4-pyrimidinyl)amino]methyl}benzenesulfonamide
3SAP	1.75	Crystal structure of human carbonic anhydrase isozyme II with 4-{[(5-butyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide
1OKN	2.4	CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKN INHIBITOR 4-SULFONAMIDE-[1-(4-N-(5-FLUORESCEIN THIOUREA)BUTANE)]
1CAJ	1.9	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
3P44	2.2	Human carbonic anhydrase II in complex with p-(4-ruthenocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide
3R16	1.6	Human CAII bound to N-(4-sulfamoylphenyl)-2-(thiophen-2-yl) acetamide
8C0Q	1.67	Crystal structure of human carbonic anhydrase II in complex with a coumarin derivative.
4KUY	1.65	Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(o-tolylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor
6OTK	1.123	Carbonic Anhydrase IX mimic complexed with ureido benzene sulfonamide MB10-596B
1OQ5	1.5	CARBONIC ANHYDRASE II IN COMPLEX WITH NANOMOLAR INHIBITOR
7QSI	1.304	human Carbonic Anhydrase II in complex with indoline-1-sulfonamide
5SZ7	1.776	Carbonic anhydrase IX-mimic in complex with 4-(3-quinolinyl)-benzenesulfonamide
3NJ9	2.0	Crystal structure of carbonic anhydrase II in complex with a Nir inhibitor
6YH6	1.4	Crystal structure of chimeric carbonic anhydrase XII with 2-(Cyclooctylamino)-3,5,6-trifluorobenzenesulfonamide
6NLV	1.794	Selective inhibition of carbonic anhydrase IX activity, using compound SLC-149, displays limited anticancer effects in breast cancer cell lines
3MMF	1.5	Crystal structure of human carbonic anhydrase II in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor
6SEY	1.23	Human Carbonic Anhydrase II in complex with aliphatically substituted benzenesulfonamide
8FQY	1.466	Carbonic Anhydrase II in complex with the alkyl urea 3h
4QJM	1.75	Crystal structure of human carbonic anhydrase isozyme II with inhibitor
2Q1B	1.7	Carbonic Anhydrase II in Complex with Saccharin
6SB7	1.09	Human Carbonic Anhydrase II in complex with fragment.
4E5Q	1.7024	Human Carbonic Anhydrase II in complex with cyanate
3RYV	1.2	Carbonic Anhydrase complexed with N-ethyl-4-sulfamoylbenzamide
5NXW	1.1	Carbonic Anhydrase II Inhibitor RA9
1XQ0	1.76	Structure of human carbonic anhydrase II with 4-[(3-bromo-4-O-sulfamoylbenzyl)(4-cyanophenyl)amino]-4H-[1,2,4]-triazole
1FSN	2.0	X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
1TH9	1.63	Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
6KM0	0.93	Human Carbonic Anhydrase II V143I variant 07 atm CO2
7JNR	1.443	Carbonic Anhydrase II Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)propionamide
2CBC	1.88	STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES
1BNM	2.6	CARBONIC ANHYDRASE II INHIBITOR
2QP6	1.45	The crystal structure of the complex of hcaII with a bioreductive antitumor derivative
1G1D	2.04	CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE
1CAH	1.88	STRUCTURE OF COBALT CARBONIC ANHYDRASE COMPLEXED WITH BICARBONATE
5DOG	1.7	Crystal structure of human carbonic anhydrase isozyme II with 2-(Benzylamino)-3,5,6-trifluoro-4-[(2-phenylethyl)thio]benzene- sulfonamide
4GL1	1.5	Structure of H64A/N62L/N67L Human Carbonic Anhydrase II triple mutant
4QY3	1.5	THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH AN ORTHO-SUBSTITUTED BENZOIC ACID
3T5U	1.75	Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide
6BBS	2.0	Joint X-ray/neutron structure of human carbonic anhydrase II in complex with brinzolamide
5WEX	1.26	Discovery of new selenoureido analogs of 4-(4-fluorophenylureido) benzenesulfonamides as carbonic anhydrase inhibitors
4QSI	1.95	Crystal structure of human carbonic anhydrase isozyme II with 5-{[(4-tert-buthyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}-2-chlorobenzenesulfonamide
4YXU	1.08	Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (4).
7AES	1.4	Human carbonic anhydrase II in complex with 2,3,5,6-tetrafluoro-N-methyl-4-propylsulfanyl-benzenesulfonamide
3M5S	1.4	Carbonic Anhydrase II mutant H64C in complex with carbonate
1UGA	2.0	HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY PHE (A65F)
6SD7	1.05	Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide and its dimer
5NXI	1.16	Carbonic Anhydrase II Inhibitor RA2
7K6X	1.76	Carbonic Anhydrase IX mimic complexed with 4-(2-(3-(3,5-dimethylphenyl)ureido)ethylsulfonamido)benzenesulfonamide
1CNB	2.35	COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES
7NZR	1.284	Crystal structure of chimeric carbonic anhydrase VA with 2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)sulfanyl]benzenesulfonamide
6XXT	1.05	The crystal structure of hCA II in complex with a 4-(4-aroylpiperazine-1-carbonyl)benzenesulfonamide derivative.
6LVA	1.2	Cu- Carbonic Anhydrase II pH 7.8 20 atm CO2
3GZ0	1.26	Apo-human carbonic anhydrase II revisited: Implications of the loss of a metal in protein structure, stability and solvent network
1CAY	2.1	WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE
5CLU	1.55	THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH A SACCHARINE DERIVATIVE
6T4P	1.75	Human Carbonic anhydrase II bound by napthalene-1-sulfonamide
6HXD	1.119	Human Carbonic Anhydrase II in complex with 4-Butylbenzenesulfonamide
3P58	1.49	Human Carbonic Anhydrase in complex with Benzyl (Methyl) Carbamodithoic Acid
3HKN	1.8	Human carbonic anhydrase II in complex with (2,3,4,6-Tetra-O-acetyl-beta-D-galactopyranosyl) -(1-4)-1,2,3,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosylsulfonamide
5NEA	1.3	Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(2-methyl-1,3-oxazol-5-yl)benzene-1-sulfonammide
1FQR	2.0	X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
7M26	1.3	Human carbonic anhydrase II in complex with pioglitazone
2CBD	1.67	STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES
6UGZ	1.306	Human Carbonic Anhydrase IX-mimic complexed with SB4-208
6OUJ	1.466	Carbonic Anhydrase II complexed with benzene sulfonamide MB11-689A
1YO1	1.7	Proton Transfer from His200 in Human Carbonic Anhydrase II
1HEA	2.0	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) (HCA II) (E.C.4.2.1.1) MUTANT WITH LEU 198 REPLACED BY ARG (L198R)
3NB5	1.8	Human carbonic anhydrase II in complex with 2-(3-chloro-4-hydroxyphenyl)-N-(4-sulfamoylphenethyl)acetamide
6LUZ	1.2	Zn- Carbonic Anhydrase II pH 11.0 20 atm CO2
5DOH	1.05	Crystal structure of human carbonic anhydrase isozyme II with 2-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide
3D9Z	1.65	Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
3M96	1.4	Crystal structure of human carbonic anhydrase isozyme II with 5-{[(5-bromo-1H-benzimidazol-2-yl)sulfanyl]acetyl}-2-chlorobenzenesulfonamide
4QK1	1.599	Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - K170P
3DC9	1.6	Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
4FRC	0.98	Carbonic Anhydrase II in complex with N'-sulfamoylpyrrolidine-1-carboximidamide
3MWO	1.4	Human carbonic anhydrase II in a doubled monoclinic cell: a re-determination
6G3Q	1.01	Crystal structure of human carbonic anhydrase II in complex with the inhibitor famotidine
6CJV	1.547	Carbonic anhydrase IX-mimic in complex with sucralose
5TFX	1.5	New method for synthesis of benzoxazole amide inhibitors of carbonic anhydrase
1TG3	1.8	Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
3RYJ	1.39	Carbonic Anhydrase complexed with 4-sulfamoyl-N-(2,2,2-trifluoroethyl)benzamide
3RYY	1.16	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
2CBE	1.82	STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES
6YZQ	1.04	Carborane closo-butyl-sulfonamide in complex with CA II
4Q8Y	1.45	Crystal structure of 2-hydroxyisoquinoline-1(2H)-thione bound to human carbonic anhydrase II
6UGQ	1.305	Human Carbonic Anhydrase IX-mimic complexed with SB4-206
3MZC	1.498	Human carbonic ahydrase II in complex with a benzenesulfonamide inhibitor
6ROE	0.939	Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide
4YGJ	1.1	NaBr--Interactions between Hofmeister Anions and the Binding Pocket of a Protein
1RAZ	1.9	THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE
6KM6	1.15	Human Carbonic Anhydrase II native 15 atm CO2
1AM6	2.0	CARBONIC ANHYDRASE II INHIBITOR: ACETOHYDROXAMATE
6YO2	1.2	Meta-Carborane propyl-sulfonamide in complex with CA IX mimic
2CBA	1.54	STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES
7NTB	1.7	Crystal structure of human carbonic anhydrase with a benzophenone-derivative
6OTP	1.466	Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB10-586B
6T4O	1.133	Human Carbonic anhydrase II bound by 3,5-dimethylbenzenesulfonamide
6SBL	0.94	Human Carbonic Anhydrase II in complex with 4-hexylbenzenesulfonamide
2WEO	1.4	Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors
4XE1	1.8	Human carbonic anhydrase II in complex with 6-SULFAMOYL-SACCHARIN
1HEC	2.0	STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II
5JEH	1.13	Human carbonic anhydrase II (L198A) complexed with benzo[d]thiazole-2-sulfonamide
3MHC	1.698	Crystal structure of human cabonic anhydrase II in adduct with an adamantyl analogue of acetazolamide in a novel hydrophobic binding pocket
5G01	1.4	An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C
7JNZ	1.289	Carbonic Anhydrase II Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)cyclohexanecarboxamide
6UH0	1.306	Human Carbonic Anhydrase 2 in complex with SB4-202
4QEF	1.469	Human Carbonic Anhydrase II V207I - cyanate inhibitor complex
4M2R	1.993	Human Carbonic Anhydrase II in complex with Brinzolamide
6YZL	1.2	Closo-carborane methyl-sulfonamide in complex with CA IX mimic
1IF6	2.09	Carbonic Anhydrase II Complexed With 3,5-difluorobenzenesulfonamide
7OK8	1.43	Crystal structure of human carbonic anhydrase II with 4-((2-hydroxy-3-(phenylselanyl)propyl)thio)benzenesulfonamide
1FQN	2.0	X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
6OUI	1.528	Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB11-710A
5DSM	1.3	Structure of CO2 released holo-form of human carbonic anhydrase II with 25 min warming
7OYQ	1.15	Carbonic anhydrase II in complex with Hit3-t2 (MH174)
1T9N	2.0	Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
5EKJ	1.129	Human Carbonic Anhydrase II complexed with a two-faced guest
2POV	1.6	The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-chloro-benzene-1,3-disulfonamide
5FLR	1.68	Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
4HEY	1.45	Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
6FJJ	1.5	Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (saccharin).
5EOI	1.8	Crystal structure of copper bound human Carbonic anhydrase II
1BCD	1.9	X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE
6YZT	1.05	Closo-carborane propyl-sulfonamide in complex with CA II
2NXT	1.15	Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
1TTM	1.95	Human carbonic anhydrase II complexed with 667-coumate
5TI0	1.42	Crystal Structure of 2-Hydroxycyclohepta-2,4,6-triene-1-thione bound to human carbonic anhydrase 2 L198G
3N4B	1.6	Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor
3DV7	1.7	Role of Hydrophilic Residues in Proton Transfer During Catalysis by Human Carbonic Anhydrase II (N62A)
6RM1	1.68	Human Carbonic Anhydrase II in complex with fragment.
5N25	1.4	Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-Pyridin-3-yl-benzenesulfonamide
7K6J	1.755	Carbonic Anhydrase II complexed with 4-(2-(3-(4-methylphenyl)ureido)ethylsulfonamido)benzenesulfonamide
1YDA	2.1	STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II
5N1R	1.3	Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4'-Pyrazol-1-ylmethyl-biphenyl-4-sulfonamide
6EDA	1.879	Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
1IF4	1.93	Carbonic Anhydrase II Complexed With 4-fluorobenzenesulfonamide
1G52	1.8	CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE
6GM9	1.089	Human Carbonic Anhydrase II in complex with 4-Methylbenzenesulfonamide
4Q8Z	1.5	Crystal structure of 1-hydroxy-4-methylpyridin-2(1H)-one bound to human carbonic anhydrase II
4ITO	1.162	Human CA II inhibition by novel sulfonamide
2NNG	1.2	Structure of inhibitor binding to Carbonic Anhydrase II
5THJ	1.5	Crystal Structure of 2-hydroxycyclohepta-2,4,6-trien-1-one bound to human carbonic anhydrase 2
2NWZ	1.8	Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II
6YZN	0.95	Closo-carborane butyl-sulfonamide in complex with CA IX mimic
1G53	1.94	CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE
5SZ2	1.63	Carbonic anhydrase II in complex with 4-(3-formylphenyl)-benzenesulfonamide
3P5A	1.49	Human Carbonic Anhydrase complexed with Sodium morpholinocarbodithioate
5EH8	1.381	human carbonic anhydrase II in complex with ligand
3HKU	1.8	Human carbonic anhydrase II in complex with topiramate
1I9O	1.86	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4-TRIFLUOROPHENYL)METHYL]-BENZAMIDE
5E2K	1.4	Crystal structure of human carbonic anhydrase II in complex with the 4-(3-aminophenyl)benzenesulfonamide inhibitor
3ZP9	1.31	Human Carbonic Anhydrase II as a Scaffold for an Artificial Transfer Hydrogenase
1G3Z	1.86	CARBONIC ANHYDRASE II (F131V)
5GMN	1.8	Crystal structure of human carbonic anhydrase II in complex with polmacoxib
6SDH	1.04	Human Carbonic Anhydrase II in complex with an inhibitor soaked at a concentration of 5 mM
4KNI	1.8	Crystal structure of human carbonic anhydrase isozyme II with 2-Chloro-4-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide
6BCC	1.8	Joint X-ray/neutron structure of human carbonic anhydrase II in complex with ethoxzolamide
1I9M	1.84	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4-DIFLUOROPHENYL)METHYL]-BENZAMIDE
6YKH	1.1	Metala-Carborane di-ethyl-sulfonamide (cis isomer) in complex with CA IX mimic
4MDG	1.35	Closo Carborane Carbonic Anhydrase Inhibitor
4E4A	1.45	Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
7JO2	1.307	Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)isobutyramide
3KNE	1.35	Carbonic Anhydrase II H64C mutant in complex with an in situ formed triazole
5JEG	1.19	Human carbonic anhydrase II (V121I) complexed with benzo[d]thiazole-2-sulfonamide
1CAM	1.7	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
8CA2	2.4	ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
2FOU	0.99	Human Carbonic Anhydrase II complexed with two-prong inhibitors
4BF1	1.35	Three dimensional structure of human carbonic anhydrase II in complex with 5-(1-naphthalen-1-yl-1,2,3-triazol-4-yl)thiophene-2-sulfonamide
5SZ3	1.689	Carbonic anhydrase II in complex with 4-(3-quinolinyl)-benzenesulfonamide
5LJQ	1.05	Crystal structure of human carbonic anhydrase II in complex with the 4-(4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl)benzenesulfonamide inhibitor
4QTL	1.8	Crystal structure of human carbonic anhydrase isozyme II with inhibitor
1I9N	1.86	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,5-DIFLUOROPHENYL)METHYL]-BENZAMIDE
6RRI	1.097	Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide
3F8E	2.0	Coumarins are a novel class of suicide carbonic anhydrase inhibitors
6YZJ	1.2	Closo-carborane ethyl-sulfonamide in complex with CA IX mimic
2OSM	1.6	Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study
6SAY	0.95	Human Carbonic Anhydrase II in complex with fragment.
6H33	1.58	The crystal structure of human carbonic anhydrase II in complex with 4-(4-phenyl)-4-hydroxy-1-piperidine-1-carbonyl)benzenesulfonamide.
3RZ8	1.7	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
6OE1	1.45	Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects
6SDS	1.26	HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A SULFONAMIDE INHIBITOR
5J8Z	1.7	Human carbonic anhydrase II in complex with ligand
8FAU	1.44	Masking thiol reactivity with thioamide-based MBPs- carbonic anhydrase II complexed with 4-phenylthiazole-2(3H)-thione
7U5X	1.04	Crystal Structure Analysis of human Carbonic anhydrase 2
4MLX	1.65	Structure of a bidentate 3-hydroxy-4H-pyran-4-thione ligand bound to hCAII
5FNH	1.66	Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
7ASJ	1.43	Crystal structure for the complex of human carbonic anhydrase II and 3-(3-methyl-3-phenethylureido)benzenesulfonamide
7BHH	1.4	4-(2-(3-(4-iodophenyl)selenoureido)ethyl)benzenesulfonamide in complex with Carbonic Anhydrase II
7K6L	1.655	Carbonic Anhydrase II complexed with 4-(2-(3-(4-fluorophenyl)ureido)ethylsulfonamido)benzenesulfonamide
1OKM	2.2	CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKM INHIBITOR 4-SULFONAMIDE-[1-(4-AMINOBUTANE)]BENZAMIDE
6PEA	1.36	High Resolution Apo Carbonic Anhydrase II
4JS6	1.55	Crystal structure of inhibitor-free hCAII H94D
3M2X	1.87	Carbonic Anhydrase II in complex with novel sulfonamide inhibitor
6YH7	1.12	Crystal structure of chimeric carbonic anhydrase XII with 3-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
6B5A	1.622	Carbonic anhydrase IX-mimic in complex with nitrogenous base-bearing benezenesulfonamide
4HEW	1.6984	Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
4FPT	0.98	Carbonic Anhydrase II in complex with ethyl (2Z,4R)-2-(sulfamoylimino)-1,3-thiazolidine-4-carboxylate
1G0E	1.6	SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH 4-METHYLIMIDAZOLE
1CIN	2.1	THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS
1CVB	2.4	STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II
1CNH	2.05	X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
1G54	1.86	CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE
3CA2	2.0	CRYSTALLOGRAPHIC STUDIES OF INHIBITOR BINDING SITES IN HUMAN CARBONIC ANHYDRASE II. A PENTACOORDINATED BINDING OF THE SCN-ION TO THE ZINC AT HIGH P*H
3S78	1.98	The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
1TEU	2.0	Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
6OUF	1.358	Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB11-707A
6UGO	1.457	Human Carbonic Anhydrase IX-mimic complexed with SB4-205
4G0C	2.0	Neutron structure of acetazolamide-bound human carbonic anhydrase II reveal molecular details of drug binding.
5FDC	1.75	Crystal structure of Human Carbonic Anhydrase II in complex with the anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog.
4ZAO	1.8	Genetically engineered Carbonic anhydrase IX
3D92	1.1	Human carbonic anhydrase II bound with substrate carbon dioxide
1G4J	1.84	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE
6LV6	1.2	Ni- Carbonic Anhydrase II pH 7.8 20 atm CO2
4RH2	1.3	Crystal structure of human carbonic anhydrase II in complex with 2-(6-hydroxy-3-Oxo-3H-xanthen-9-yl)-5-{3-1-(4-sulfamoyl-phenyl)-1h-[1,2,3]triazol-4-ylmethyl-thioureido}-benzoic acid
1G48	1.86	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE
2ABE	2.0	Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators
4RUX	1.14	Crystal structure of human Carbonic Anhydrase II in complex with 4-(allyloxy)benzenesulfonamide
4L5U	2.05	The structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II
1HEB	2.0	STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II
4JSZ	1.9	Benzenesulfonamide bound to hCAII H94C
4L5V	1.63	The structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II
6YZP	1.35	Carborane nido-hexyl-sulfonamide in complex with CA IX mimic
2NNS	1.03	Structure of inhibitor binding to Carbonic Anhydrase II
6FJI	1.6	Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (apo).
6QL3	1.35	Crystal structure of chimeric carbonic anhydrase VI with 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
5BNL	2.0	Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins
6R6J	1.55	Crystal structure of human carbonic anhydrase isozyme II with 2-(benzenesulfonyl)-4-chloro-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide
4RUZ	1.63	Crystal structure of human Carbonic Anhydrase II in complex with 4-ethoxybenzenesulfonamide
6SAS	1.1	Human Carbonic Anhydrase II in complex with fragment.
6S9G	1.14	Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide
5YUJ	1.25	CO2 release in human carbonic anhydrase II crystals: reveal histidine 64 and solvent dynamics
2QO8	1.4	Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor
7RRF	1.45	Carbonic Anhydrase IX-mimic in complex with Beta-Galactose_2C
7NZU	1.24	Crystal structure of chimeric carbonic anhydrase VA with 3-(benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
6ZR8	1.79	The crystal structure of 2-(4-Benzhydrylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide in complex with human carbonic anhydrase II
3PO6	1.47	Crystal structure of human carbonic anhydrase II with 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide
6RRG	1.127	Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide
3S8X	1.3	Crystal structure of human carbonic anhydrase isozyme II with 4-{[(4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide
7QRK	1.428	Human Carbonic Anhydrase II in complex with N-(2-aminophenyl)-4-((2-oxo-2-((4-sulfamoylphenethyl)amino)ethyl)amino)benzamide
5OGO	0.99	Crystal structure of chimeric carbonic anhydrase I with 3-(Benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
1RZE	1.9	X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
7A6V	2.0	Human Carbonic Anhydrase II in complex with 4-(3-(3-phenoxypropyl)thioureido)benzenesulfonamide
7K6T	1.759	Carbonic Anhydrase IX mimic complexed with 4-(2-(3-phenylureido)ethylsulfonamido)benzenesulfonamide
3K7K	1.9	Crystal structure of the complex between Carbonic Anhydrase II and anions
5YUI	1.2	CO2 release in human carbonic anhydrase II crystals: reveal histidine 64 and solvent dynamics
5MJN	1.17	Three dimensional structure of human carbonic anhydrase II in complex with 5-[(4Chlorobenzyl)sulfanyl]thiophene-2-sulfonamide
6YPW	1.1	Crystal structure for the complex of human carbonic anhydrase II and 4-((1-(2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)-1H-1,2,3-triazol-4-yl)methoxy)benzenesulfonamide
5WGP	1.53	Human Carbonic Anhydrase IX-mimic complexed with AceK
7QSE	1.428	human Carboni Anhydrase II in complex with N-(2-aminophenyl)-4-((2-oxo-2-((4-sulfamoylbenzyl)amino)ethyl)amino)benzamide
3KIG	1.39	Mutant carbonic anhydrase II in complex with an azide and an alkyne
5DRS	1.1	Crystal structure of human carbonic anhydraseisozyme II with 3-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
6KLZ	0.9	Human Carbonic Anhydrase II V143I variant 00 atm CO2
6I0W	1.04	Human Carbonic Anhydrase II in complex with 4-Methoxybenzenesulfonamide
6YZO	1.5	Carborane closo-hexyl-sulfonamide in complex with CA IX mimic
6UGN	1.406	Human Carbonic Anhydrase 2 complexed with SB4-205
1CNJ	1.8	X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
1BNQ	2.4	CARBONIC ANHYDRASE II INHIBITOR
3RJ7	1.2	Human carbonic anhydrase II complexed with its inhibitor rhenium(I)triscarbonyl-cyclopentadienyl-carboxy-4-aminomethylbenzene-sulfonamide
1TG9	1.9	Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
5AMG	1.55	Three dimensional structure of human carbonic anhydrase II in complex with 2-(Pentylsulfamoyl)-4-sulfamoylbenzoic acid
3U45	1.699	Human Carbonic Anhydrase II V143A
2AW1	1.46	Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II selective inhibitor Celecoxib
6HR3	1.02	Human Carbonic Anhydrase II in complex with 4-Propylbenzenesulfonamide
1RZD	1.9	X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
5C8I	1.56	Joint X-ray/neutron structure of Human Carbonic Anhydrase II in complex with Methazolamide
4FVO	1.05	Carbonic Anhydrase II in complex with N-[(2E)-3,4-dihydroquinazolin-2(1H)-ylidene]sulfuric diamide
4KAP	1.45	The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand
3RZ7	1.8	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
1BNW	2.25	CARBONIC ANHYDRASE II INHIBITOR
8B29	1.7	Human carbonic anhydrase II containing 6-fluorotryptophanes.
6RG4	1.25	Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(2-benzyl-4-methylpiperazin-1-yl)benzenesulfonamide
1OKL	2.1	CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKL INHIBITOR 5-DIMETHYLAMINO-NAPHTHALENE-1-SULFONAMIDE
1G46	1.84	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE
6YO7	1.17	Ortho-Carborane di-propyl-sulfonamide in complex with CA IX mimic
4YXO	1.06	Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (3).
5LJT	1.0	Crystal structure of human carbonic anhydrase II in complex with the 4-((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)benzenesulfonamide inhibitor
7AEQ	1.5	Human carbonic anhydrase II in complex with 2,3,5,6-tetrafluoro-4-(2-hydroxyethylsulfanyl)-N-methyl-benzenesulfonamide
3T85	2.4	Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates
1CNK	2.15	X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
5G0B	1.55	An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C
6YHC	1.28	Crystal structure of chimeric carbonic anhydrase XII with 3-(benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
5FLO	1.66	Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
1LGD	1.9	Crystal Structure Analysis of HCA II Mutant T199P in Complex with Bicarbonate
1I9P	1.92	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4,6-TRIFLUOROPHENYL)METHYL]-BENZAMIDE
2VVB	1.66	Human carbonic anhydrase II in complex with bicarbonate
4MO8	1.85	The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide
7OYP	1.05	Carbonic anhydrase II in complex with Hit3-t1 (MH172)
6I3E	1.07	Human Carbonic Anhydrase II in complex with 4-Butylbenzenesulfonamide
3M1Q	1.69	Carbonic Anhydrase II mutant W5C-H64C with opened disulfide bond
2WEH	2.09	Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors
6CA2	2.5	ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
4FVN	1.05	Carbonic Anhydrase II in complex with N-(tetrahydropyrimidin-2(1H)-ylidene)sulfuric diamide
1AVN	2.0	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH THE HISTAMINE ACTIVATOR
5EKM	1.33	Human Carbonic Anhydrase II complexed with a two-faced guest
1ZE8	2.0	Carbonic anhydrase II in complex with a membrane-impermeant sulfonamide inhibitor
6YQT	1.5	CRYSTAL STRUCTURE OF HUMAN CA II IN COMPLEX WITH A SULFONAMIDE DERIVATIVE OF 2-MERCAPTOBENZOXAZOLE
6WQ7	1.304	Carbonic Anhydrase II Complexed with 2-((3-Aminopropyl)(phenethyl)amino)-N-(4-fluorobenzyl)-N-(4-sulfamoylphenethyl)acetamide
6LV5	1.2	Ni- Carbonic Anhydrase II pH 7.8 0 atm CO2
5LLE	1.9	Crystal structure of human carbonic anhydrase isozyme II with 4-(1-Adamantylamino)-2,3,5,6-tetrafluorobenzenesulfonamide
2HKK	1.9	Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms
1CVA	2.25	STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II
3KS3	0.9	High resolution structure of Human Carbonic Anhydrase II at 0.9 A
6H2Z	1.94	The crystal structure of human carbonic anhydrase II in complex with 4-(4-phenylpiperidine-1-carbonyl)benzenesulfonamide.
5E2R	1.6	The crystal structure of the human carbonic anhydrase II in complex with a 1,1'-biphenyl-4-sulfonamide inhibitor
3K2F	1.98	Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma
4MTY	1.0	Structure at 1A resolution of a helical aromatic foldamer-protein complex.
4CQ0	1.45	Cyclic secondary sulfonamides: unusually good inhibitors of cancer- related carbonic anhydrase enzymes
3NI5	2.1	Carbonic anhydrase inhibitor: C1 family
2Q38	1.95	Carbonic Anhydrase II in complex with Saccharin at 1.95 Angstrom
3MNA	1.5	The crystal structure of human carbonic anhydrase Ii in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor
7BG5	1.428	4-(2-(3-(4-iodophenyl)ureido)ethyl)benzenesulfonamide in complex with Carbonic Anhydrase II
4Q9Y	1.55	Crystal structure of 3-methylthiophenol bound to human carbonic anhydrase II
6GXB	1.35	Carbonic Anhydrase CAIX mimic in complex with inhibitor JS13
6GOT	1.56	Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(phenethylthio)benzenesulfonamide
5BRU	1.6	Catalytic Improvement of an Artificial Metalloenzyme by Computational Design
3KON	1.5	Crystal structure of cobalt (II) human carbonic anhydrase II at pH 11.0
2NNO	1.01	Structure of inhibitor binding to Carbonic Anhydrase II
5CA2	2.1	CONFORMATIONAL MOBILITY OF HIS-64 IN THE THR-200 (RIGHT ARROW) SER MUTANT OF HUMAN CARBONIC ANHYDRASE II
1DCA	2.2	STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH
5FLT	1.67	Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
6ROB	0.929	Human Carbonic Anhydrase II in complex with 4-cyanobenzenesulfonamide
2EZ7	2.0	Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII and XIV with L- and D-histidine and crystallographic analysis of their adducts with isoform II: engineering proton transfer processes within the active site of an enzyme
6LUV	1.2	apo- Carbonic Anhydrase II pH 7.8 20 atm CO2
4K0T	1.78	Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with chlorzolamide
5NXP	1.25	Carbonic Anhydrase II Inhibitor RA7
7SV1	1.559	Carbonic Anhydrase IX-mimic Complexed with 3-((2-((Naphthalen-2-ylmethyl)(4-sulfamoylphenethyl)amino)-2-oxoethyl)(phenethyl)amino)propanoic acid
2F14	1.71	Tne Crystal Structure of the Human Carbonic Anhydrase II in Complex with a Fluorescent Inhibitor
3OIM	1.45	Human Carbonic anhydrase II bound by 2-Ethylestradiol 3-O-sulfamate
1CNY	2.3	SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS
5L9E	2.9	CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER
1CAZ	1.9	WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE
7OYN	0.98	Carbonic anhydrase II in complex with Hit3 (MH57)
3V3F	2.0	Kinetic and structural studies of thermostabilized mutants of HCA II.
5A6H	1.57	Synthesis, carbonic anhydrase inhibition and protein X-ray structure of the unusual natural product primary sulfonamide Psammaplin C
3DVB	1.7	X-ray crystal structure of mutant N62V human Carbonic Anhydrase II
1CNC	2.2	COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES
6GXE	1.3	Carbonic Anhydrase CAIX mimic in complex with inhibitor JS14
5Y2S	0.9	7.0 atm CO2-pressurized human carbonic anhydrase II
2HL4	1.55	Crystal structure analysis of human carbonic anhydrase II in complex with a benzenesulfonamide derivative
12CA	2.4	ALTERING THE MOUTH OF A HYDROPHOBIC POCKET. STRUCTURE AND KINETICS OF HUMAN CARBONIC ANHYDRASE II MUTANTS AT RESIDUE VAL-121
3RYZ	1.37	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
5FLP	1.71	Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
4Q49	1.8	Room temperature neutron crystal structure of apo human carbonic anhydrase at pH 7.5
7RRE	1.44	Carbonic Anhydrase II in complex with Beta-Galactose-2C
3IBI	1.93	The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor
3N2P	1.648	Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor
7JO1	1.499	Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)butyramide
3HLJ	1.44	Crystal structure of human carbonic anhydrase isozyme II with 3-methylthiobenzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamide
6UFC	1.325	Carbonic anhydrase 2 with inhibitor (2Z)-2-[(4-methoxyphenyl)methylidene]-3-oxo-N-(4-sulfamoylphenyl)butanamide (11d/D4)
2OSF	1.6	Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study
5FNM	1.59	Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
7NZX	1.33	Crystal structure of chimeric carbonic anhydrase VA with 2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
4BCW	1.5	Carbonic anhydrase IX mimic in complex with (E)-2-(5-bromo-2- hydroxyphenyl)ethenesulfonic acid
1CAN	1.9	CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS
5SZ1	1.55	Carbonic anhydrase II in complex with 4-(2-methylphenyl)-benzenesulfonamide
1FR4	1.6	X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
6QL2	1.3	Crystal structure of chimeric carbonic anhydrase VI with ethoxzolamide.
3TVN	1.497	Human Carbonic Anhydrase II Proton Transfer Mutant
5L6K	1.7	Crystal Structure of Human Carbonic Anhydrase II in Complex with a Quinoline Oligoamide Foldamer
6ODZ	1.3	Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects
6RH4	0.948	Human Carbonic Anhydrase II in complex with 4-Nitrobenzenesulfonamide.
3RGE	2.096	Crystal structure of the W5H mutant of human carbonic anhydrase II
1YDD	2.1	STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II
7JOB	1.381	Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)cyclohexanecarboxamide
8FR2	1.307	Carbonic Anhydrase IX-mimic in complex with the alkyl urea compound 3h
3QYK	1.469	Human Carbonic Anhydrase II complexed with triple ring benzene sulfonamide inhibitor
6OE0	1.3	Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects
5JES	1.205	Human carbonic anhydrase II (V121T) complexed with benzo[d]thiazole-2-sulfonamide
5EH5	1.207	human carbonic anhydrase II in complex with ligand
6C7X	1.5	Carbonic anhydrase 2 in complex with 2-chloro-5'-O-sulfamoyladenosine
3P3H	1.5	Human carbonic anhydrase II in complex with p-(5-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide
4ZWY	1.5	Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor
3P55	2.0	Human carbonic anhydrase II in complex with p-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide
1Z9Y	1.66	carbonic anhydrase II in complex with furosemide as sulfonamide inhibitor
6S9Z	0.95	Expression tag modified N-terminus of human Carbonic Anhydrase II covalently linked to fragment
2FMG	1.6	Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine and crystallographic analysis of their adducts with isozyme II: sterospecific recognition within the active site of an enzyme and its consequences for the drug design, structure with L-phenylalanine
3EFI	1.75	Carbonic anhydrase activators: Kinetic and X-ray crystallographic study for the interaction of d- and l-tryptophan with the mammalian isoforms I-XIV
3RG4	1.5	Crystal structure of the W5F mutant of human carbonic anhydrase II
1TB0	2.0	Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
1ZH9	1.7	carbonic anhydrase II in complex with N-4-Methyl-1-piperazinyl-N'-(p-sulfonamide)phenylthiourea as sulfonamide inhibitor
1LG5	1.75	Crystal Structure Analysis of the HCA II Mutant T199P in complex with beta-mercaptoethanol
6U4T	1.356	Carbonic anhydrase 9 in complex with SB4197
2X7U	2.12	Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.
6XWZ	1.38	Carbonic Anhydrase II-mediated hydrolysis of selenolester
6LUW	1.2	Zn- Carbonic Anhydrase II pH 7.8 0 atm CO2
4YGL	1.51	NaClO4--Interactions between Hofmeister Anions and the Binding Pocket of a Protein
3OKV	1.45	Human Carbonic Anhydrase II A65S, N67Q (CA IX mimic) bound with 2-Ethylestrone 3-O-sulfamate
6SBM	0.95	Human Carbonic Anhydrase II in complex with 4-(pentyloxy)benzenesulfonamide
3S72	1.6	The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
1I9L	1.93	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(4-FLUOROPHENYL)METHYL]-BENZAMIDE
1UGD	2.0	HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY SER (A65S)
1I91	2.0	CARBONIC ANHYDRASE II COMPLEXED WITH AL-6619 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-HYDROXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE
2X7S	1.64	Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.
5SZ5	1.274	Carbonic anhydrase IX-mimic in complex with 4-(2-methylphenyl)-benzenesulfonamide
2FOS	1.1	Human Carbonic Anhydrase II complexed with two-prong inhibitors
6RMY	1.5	Human Carbonic anhydrase II mutant T199V bound by 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
3P4V	2.0	Human carbonic anhydrase II in complex with (+)-Xylariamide A
1ZGE	1.65	carbonic anhydrase II in complex with p-Sulfonamido-o,o'-dichloroaniline as sulfonamide inhibitor
1FSR	2.0	X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
7U5W	1.13	Crystal Structure Analysis of human Carbonic anhydrase 2
3V3H	1.85	Kinetic and structural studies of thermostabilized mutants of HCA II.
6LV8	1.2	Ni- Carbonic Anhydrase II pH 11.0 20 atm CO2
4Y0J	2.0	H/D exchanged human carbonic anhydrase II pH 6 room temperature neutron crystal structure.
4Q06	1.15	Crystal structure of chimeric carbonic anhydrase IX with inhibitor
3M40	1.6	Crystal structure of human carbonic anhydrase isozyme II with 4-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]benzenesulfonamide
7QGY	1.5	Human carbonic anhydrase II in complex with 3-((5-(ethoxycarbonyl)-4-methylthiazol-2-yl)(4-sulfamoylphenyl)amino)propanoic acid
1HCA	2.3	UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II.
4Q99	1.5	Crystal structure of 2-mercapto-4-methylphenol bound to human carbonic anhydrase II
3SBI	1.4	Crystal structure of human carbonic anhydrase isozyme II with 4-[(2-pyrimidinylsulfanyl)acetyl]benzenesulfonamide
5JE7	1.15	Human carbonic anhydrase II (F131Y) complexed with benzo[d]thiazole-2-sulfonamide
2VVA	1.56	Human carbonic anhydrase in complex with CO2
6H29	1.46	HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BENZYL CARBAMATE
1LZV	2.3	Site-Specific Mutant (Tyr7 replaced with His) of Human Carbonic Anhydrase II
6EQU	1.65	X-Ray crystal structure of the human carbonic anhydrase II adduct with a membrane-impermeant inhibitor
2H15	1.9	Carbonic anhydrase inhibitors: Clashing with Ala65 as a means of designing isozyme-selective inhibitors that show low affinity for the ubiquitous isozyme II
1BIC	1.9	CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3-
6OUD	1.256	Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB11-694B
3BL1	2.1	Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited old leads for new applications
2EU3	1.6	Human Carbonic anhydrase II in complex with novel inhibitors
6LV9	1.2	Cu- Carbonic Anhydrase II pH 7.8 0 atm CO2
7ONV	1.04	Carbonic anhydrase II mutant (I91C) dually binding an IrCp* complex to generate an artificial transfer hydrogenase (ATHase)
5JGS	1.11	Human carbonic anhydrase II (F131Y/L198A) complexed with benzo[d]thiazole-2-sulfonamide
3M5T	1.95	Fragment tethered to Carbonic Anhydrase II H64C mutant
6OUM	1.559	Carbonic Anhydrase IX mimic complexed with benzene sulfonamide MB10-580B
5BRW	1.4	Catalytic Improvement of an Artificial Metalloenzyme by Computational Design
4KUW	1.55	Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(4-fluorophenylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor
3V3I	1.73	Kinetic and structural studies of thermostabilized mutants of HCA II.
2FNK	1.8	Activation of Human Carbonic Anhydrase II by exogenous proton donors
8EYL	1.18	Human Carbonic Anhydrase II with Tert-butyl (2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)carbamate
3U47	1.6	Human Carbonic Anhydrase II V143L
5WLV	1.4	Carbonic Anhydrase II in complex with aryloxy-2-hydroxypropylammine sulfonamide
4MDM	1.55	Nido-Carborane Carbonic Anhydrase Inhibitor
4E3F	1.5	Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
6EEA	1.63	Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
2H4N	1.9	H94N CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE
5T75	1.5	Human carbonic anhydrase II G132C_C206S double mutant in complex with SA-2
3V2M	1.471	Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II
1I9Q	1.8	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(3,4,5-TRIFLUOROPHENYL)METHYL]-BENZAMIDE
3MNI	1.75	Human Carbonic Anhydrase II Mutant K170D
1RZB	1.8	X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
4IWZ	1.598	structure of hCAII in complex with an acetazolamide derivative
1BN1	2.1	CARBONIC ANHYDRASE II INHIBITOR
7M24	1.3	Human carbonic anhydrase II in complex with (R)-rosiglitazone
2GD8	1.46	Crystal structure analysis of the human carbonic anhydrase II in complex with a 2-substituted estradiol bis-sulfamate
6RIG	0.999	Human Carbonic Anhydrase II in complex with 4-Hydroxybenzenesulfonamide
7NZW	1.45	Crystal structure of chimeric carbonic anhydrase VA with 4-[(4,6-dimethylpyrimidin-2-yl)thio]-2,3,5,6-tetrafluorobenzenesulfonamide
4Z1N	1.47	Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)
6YZW	1.03	Carborane closo-hexyl-sulfonamide in complex with CA II
6UX1	1.36	Carbonic Anhydrase II Complexed with Salicylic Acid
6OUK	1.498	Carbonic Anhydrase II complexed with benzene sulfonamide MB10-580B
3S75	1.5	The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
7R1X	1.35	human Carbonic Anhydrase II in complex with 4-oxo-N-(4-sulfamoylphenethyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-2-carbothioamide
4IDR	1.6	Human Carbonic Anhydrase II Proton Transfer Double Mutant
3F4X	1.9	Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules make the difference
1FSQ	2.0	X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
5Y2R	1.0	2.5 atm CO2-pressurized human carbonic anhydrase II
5L3O	1.98	Crystal Structure of Human Carbonic Anhydrase II in Complex with a Quinoline Oligoamide Foldamer
7BI5	1.74	Human CA II in complex with benzyl alcohol
6QL1	1.42	Crystal structure of chimeric carbonic anhydrase VI with 4-[(4,6-dimethylpyrimidin-2-yl)thio]-2,3,5,6-tetrafluorobenzenesulfonamide
4Q6D	1.12	Crystal structure of human carbonic anhydrase isozyme II with 4-[(Z)-azepan-1-yldiazenyl]benzenesulfonamide
4Q81	1.55	Crystal structure of 1-hydroxy-4,6-dimethylpyridine-2(1H)-thione bound to human carbonic anhydrase II
1CVD	2.2	STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE
1BV3	1.85	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH UREA
3MYQ	1.35	Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-[(1H-imidazo[4,5-c]quinolin-2-ylsulfanyl)acetyl]benzenesulfonamide
4L5W	1.7	Structural implications of the secondary CO2 binding pocket in human carbonic anhydrase II
6LV7	1.2	Ni- Carbonic Anhydrase II pH 11.0 0 atm CO2
4DZ9	1.491	hCA II in complex with novel sulfonamide inhibitors Set D
7NZT	1.35	Crystal structure of chimeric carbonic anhydrase VA with 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
5DSQ	1.5	Structure of CO2 released apo-form of human carbonic anhydrase II with 3 min warming
1A42	2.25	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE
7Q0C	1.12	Mimic carbonic anhydrase IX in complex with Methyl 2-chloro-4-(cyclohexylsulfanyl)-5-sulfamoylbenzoate
6LUX	1.2	Zn- Carbonic Anhydrase II pH 7.8 20 atm CO2
5U0G	1.54	Identification of a New Zinc Binding Chemotype by Fragment Screening
6CEH	1.43	Design, Synthesis, X-ray and Biological Activities of Selenides Bearing the Benzenesulfonamide Moiety as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology
5NXG	1.2	Carbonic Anhydrase II Inhibitor RA1
1I8Z	1.93	CARBONIC ANHYDRASE II COMPLEXED WITH AL-6629 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-METHOXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE
4JSA	1.5	Benzenesulfonamide complexed with hCAII H94D
2GEH	2.0	N-Hydroxyurea, a versatile zinc binding function in the design of metalloenzyme inhibitors
6YZV	1.65	Closo-carborane ethyl-sulfonamide in complex with CA II
6RW1	1.7	Crystal structure of hCA II in complex with Urea, N-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-N'-(phenylmethyl)-
6KM4	1.15	Human Carbonic Anhydrase II native 07 atm CO2
3DCS	1.8	Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
6NM0	1.44	Selective inhibition of carbonic anhydrase IX activity, using compound SLC-149, displays limited anticancer effects in breast cancer cell lines
6YMB	2.5	MicroED structure of human carbonic anhydrase II
1LG6	2.2	Crystal Structure Analysis of HCA II Mutant T199P in Complex with Thiocyanate
3MNK	1.75	Human Carbonic Anhydrase II Mutant K170H
1CA2	2.0	REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION
1YDC	1.95	STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II
5DSP	1.4	Structure of CO2 released apo-form of human carbonic anhydrase II with 40 sec warming
4Z1J	1.27	Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)
6SYS	1.3	Crystal structure of (3aR,4S,9bS)-4-(4-hydroxyphenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide with carbonic anhydrase 2
1CCT	2.2	STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY
3M1K	1.35	Carbonic Anhydrase in complex with fragment
4RFC	1.645	Human carbonic anhydrase II in complex with tert-butyl 4-(4-sulfamoylphenoxy)butylcarbamate
1TEQ	2.0	Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
2AX2	1.5	Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II
4M2W	1.658	Genetically engineered Carbonic Anhydrase IX in complex with Dorzolamide
7JNW	1.292	Carbonic Anhydrase II Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)isobutyramide
6VJ3	1.35	Carbonic Anhydrase II in complex with pyrimidine-based inhibitor
4JSS	1.5	Human carbonic anhydrase II H94D bound to a bidentate inhibitor
4PXX	1.851	Crystal structure of a highly thermal stabilized variant of Human Carbonic Anhydrase II
6LV4	1.2	Co- Carbonic Anhydrase II pH 11.0 20 atm CO2
3S9T	1.3	Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide
7QGZ	1.13	Human carbonic anhydrase II in complex with Methyl 3-((4-methylthiazol-2-yl)(4-sulfamoylphenyl)amino)propanoate
3HKT	2.36	Human carbonic anhydrase II in complex with alpha-D-Glucopyranosyl-(1->4)-1-thio-beta-D-glucopyranosylsulfonamide
7NZS	1.5	Crystal structure of chimeric carbonic anhydrase VA with 2,3,5,6-tetrafluoro-4-(propylsulfanyl)benzenesulfonamide
3B4F	1.89	Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
1CAL	2.2	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
1CA3	2.3	UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II.
3N0N	1.5	Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor
6EEH	1.629	Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
4ZX0	1.6	Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor
5DSK	1.3	Structure of CO2 released holo-form of human carbonic anhydrase II with 3 min warming
5O07	1.8	The crystal structure of the human carbonic anhydrase II in complex with a nitroimidazole sulfamate inhibitor
3HS4	1.1	Human carbonic anhydrase II complexed with acetazolamide
5NXO	1.2	Carbonic Anhydrase II Inhibitor RA6
6UFB	1.67	Carbonic anhydrase 2 with inhibitor (2Z)-2-benzylidene-3-oxo-N-(4-sulfamoylphenyl)butanamide (11a/D1)
5JG3	1.21	Human carbonic anhydrase II (121T/N67Q) complexed with benzo[d]thiazole-2-sulfonamide
2NNV	1.1	Structure of inhibitor binding to Carbonic Anhydrase II
5EHW	1.392	human carbonic anhydrase II in complex with ligand
5LLC	1.1	Crystal structure of human carbonic anhydrase isozyme II with 3-(Methylamino)-2,5,6-trifluoro-4-[(2-phenylethyl)sulfonyl]benzenesulfonamide
5NYA	1.2	Carbonic Anhydrase II Inhibitor RA13
5NEE	1.7	Crystal structure of human carbonic anhydrase II in complex with the inhibitor 5-[2-(morpholine-4-carbonyl)1,3-oxazol-5-yl)]thiophene-2-sulfonammide
3S74	1.4	The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
4YGK	1.5	NaSCN--Interactions between Hofmeister Anions and the Binding Pocket of a Protein
6LV3	1.2	Co- Carbonic Anhydrase II pH 11.0 0 atm CO2
2FOQ	1.25	Human Carbonic Anhydrase II complexed with two-prong inhibitors
7MU3	1.35	human carbonic anhydrase 9 mimic with compound
6YJ3	1.55	Metala-Carborane di-propyl-sulfonamide
2HOC	2.1	Crystal structure of the human carbonic anhydrase II in complex with the 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide inhibitor
3EFT	1.85	Crystal structure of the complex between Carbonic Anhydrase II and a spin-labeled sulfonamide incorporating TEMPO moiety
5EH7	1.425	human carbonic anhydrase II in complex with ligand
7JNX	1.286	Carbonic Anhydrase II Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)pivalamide
6SDL	1.08	Human Carbonic Anhydrase II in complex with (R)-N-(3-(1H-indol-1-yl)-2-methylpropyl)-4-sulfamoylbenzamide
5W8B	1.601	Carbonic anhydrase II in complex with activating histamine pyridinium derivative
1KWR	2.25	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 0134-36
7QZX	1.24	Human Carbonic Anhydrase II in complex with 4-oxo-N-(4-sulfamoylphenethyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-2-carboxamide
3M98	1.5	Crystal structure of human carbonic anhydrase isozyme II with 5-(1H-benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide
7JNV	1.49	Carbonic Anhydrase II Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)butyramide
7Q0E	1.3	Human Carbonic Anhydrase II in complex with Methyl 2-(benzenesulfonyl)-4-chloro-5-sulfamoylbenzoate
5LL8	1.03	Human Carbonic Anhydrase II in complex with aliphatic Benzenesulfonamide inhibitor.
1UGC	2.0	HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY HIS (A65H)
6OTO	1.496	Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB9-561B
1LUG	0.95	Full Matrix Error Analysis of Carbonic Anhydrase
4K13	1.6	Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with dorzolamide
6C7W	1.28	Carbonic anhydrase 2 in complex with [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE inhibitor
3PYK	1.3	Human Carbonic Anhydrase II as Host for Pianostool Complexes Bearing a Sulfonamide Anchor
3TVO	1.6	Human Carbonic Anhydrase II Proton Transfer Double Mutant
6OTM	1.307	Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB10-586B
4E3D	1.6	Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
6YZU	1.0	Carborane nido-pentyl-sulfonamide in complex with CA II
6YZX	1.1	Carborane nido-hexyl-sulfonamide in complex with CA II
6OTI	2.0	Carbonic Anhydrase IX mimic complexed with ureic benzene sulfonamide MB9-561B
5U0E	1.27	Identification of a New Zinc Binding Chemotype by Fragment Screening
7QGX	1.19	Human carbonic anhydrase II in complex with 3-((5-chloro-4-(4-chlorophenyl)thiazol-2-yl)(4-sulfamoylphenyl)amino)propanoic acid
5THN	1.33	Crystal Structure of 2-Hydroxycyclohepta-2,4,6-triene-1-thione bound to human carbonic anhydrase 2
1IF8	1.94	Carbonic Anhydrase II Complexed With (S)-N-(3-Indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide
1CCS	2.35	STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY
3DCW	1.5	Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
6RJJ	1.056	Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide
6RS5	1.07	Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide
1THK	1.8	Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
1BNV	2.4	CARBONIC ANHYDRASE II INHIBITOR
2POU	1.6	The crystal structure of the human carbonic anhydrase II in complex with 4,5-dichloro-benzene-1,3-disulfonamide
4LHI	1.6	Crystal structure of human carbonic anhydrase isozyme II with 5-(phenylsulfonyl)thiophene-2-sulfonamide
6RIT	1.007	Human Carbonic Anhydrase II in complex with 2-Fluorobenzenesulfonamide
3U7C	0.93	crystal structure of the V143I mutant of human carbonic anhydrase II
3M1J	1.8	The crystal structure of a NAMI A-Carbonic Anhydrase II adduct discloses the mode of action of this novel anticancer metallodrug
4Q83	1.55	Crystal structure of 1-hydroxy-3-(trifluoromethyl)pyridine-2(1H)-thione bound to human carbonic anhydrase II
6XVH	1.8	carbonic anhydrase with bound arylsulfonamide- boronic acid
5NY3	1.4	Carbonic Anhydrase II Inhibitor RA11
6E92	1.772	CA IX mimic Complexed with Steroidal Sulfamate Compound STX 2845
6YH4	1.3	Crystal structure of chimeric carbonic anhydrase XII with 2,3,5,6-Tetrafluoro-4-(propylthio)benzenesulfonamide
6RMP	1.22	Human Carbonic Anhydrase II in complex with fragment.
3DD8	1.9	Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD-486019 with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
5T74	1.2	Human carboanhydrase F131C_C206S double mutant in complex with 14
1EOU	2.1	CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH AN ANTICONVULSANT SUGAR SULFAMATE
6T9Z	1.12	Nidocarborane inhibitor of Carbonic Anhydrase IX
1UGG	2.2	HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY SER (A65S)-ORTHORHOMBIC FORM
6RFH	0.969	Human Carbonic Anhydrase II in complex with 4-Carboxybenzenesulfonamide
7NH6	1.28	Crystal structure of human carbonic anhydrase II with 3-(3-((1-(2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)-1H-1,2,3-triazol-4-yl)methyl)ureido)benzenesulfonamide
3U3A	1.549	structure of Human Carbonic Anhydrase II V143I
2FNM	1.8	Activation of human carbonic anhdyrase II by exogenous proton donors
6KM5	1.151	Human Carbonic Anhydrase II native 13 atm CO2
2WEJ	1.45	Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors
5FLS	1.67	Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
6YHA	1.25	Crystal structure of chimeric carbonic anhydrase XII with 2,3,5,6-Tetrafluoro-4-(propylthio)benzenesulfonamide
5N1S	1.3	Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(1H-Indol-2-yl)-benzenesulfonamide
4ZX1	1.501	Engineered Carbonic Anhydrase IX mimic in complex with a glucosyl sulfamate inhibitor
6RHJ	1.44	Crystal structure of human carbonic anhydrase isozyme II with 4-(4-benzyl-1,4-diazepane-1-carbonyl)benzenesulfonamide
6WKA	1.34	human carbonic anhydrase II bound to an inhibitor modified with azidothymidine
5SZ0	1.63	Carbonic anhydrase II in complex with 4-(phenyl)-benzenesulfonamide
3OIK	1.5	Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol 3,17-O,O-bis-sulfamate
7JO0	1.607	Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)propionamide
3M2Y	1.17	Carbonic Anhydrase II in complex with novel sulfonamide inhibitor
3M3X	1.68	Crystal structure of human carbonic anhydrase isozyme II with 4-{2-[N-(6-methoxy-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide
7ORP	1.43	crystal structure of human carbonic anhydrase II in complex with 4-((2-hydroxy-3-((3,4,5-trimethoxyphenyl)tellanyl)propyl)selanyl)benzenesulfonamide
6YOK	1.25	Para-Carborane di-propyl-sulfonamide in complex with CA IX mimic
3DVC	1.6	X-ray crystal structure of mutant N62T of human Carbonic Anhydrase II
1CNI	1.8	X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
6OTQ	1.467	Carbonic Anhydrase II complexed with ureic benzene sulfonamide MB10-596B
6LV2	1.2	Co- Carbonic Anhydrase II pH 7.8 20 atm CO2
5JN3	1.6	Carbonic Anhydrase IX-mimic IN Complex WITH U-F
1HED	2.0	STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II
3C7P	1.7	Crystal structure of human carbonic anhydrase II in complex with STX237
1G45	1.83	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE
9CA2	2.8	ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
3V7X	1.03	Complex of human carbonic anhydrase II with N-[2-(3,4-dimethoxyphenyl)ethyl]-4-sulfamoylbenzamide
4DZ7	1.491	hCA II in complex with novel sulfonamide inhibitors Set D
3MNH	1.65	Human Carbonic Anhydrase II Mutant K170A
8FAL	1.37	Masking thiol reactivity with thioamide-based MBPs- carbonic anhydrase II complexed with benzo[d]thiazole-2(3H)-thione
6RG3	1.32	Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(2-benzylpiperazin-1-yl)benzenesulfonamide
4JSW	1.9	Human carbonic anhydrase II H94C
2EU2	1.15	Human Carbonic Anhydrase II in complex with novel inhibitors
7K6U	1.605	Carbonic Anhydrase IX mimic complexed with 4-(2-(3-(4-methylphenyl)ureido)ethylsulfonamido)benzenesulfonamide
6UFD	1.48	Carbonic anhydrase 2 with inhibitor (2Z)-3-oxo-N-(4-sulfamoylphenyl)-2-[(thiophen-2-yl)methylidene]butanamide (11g/D7)
6E8X	1.6	CA IX mimic Complexed with Steroidal Sulfamate Compound STX 140
4QSB	1.4	Crystal structure of human carbonic anhydrase isozyme II with 3-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}benzenesulfonamide
8DJ9	1.54	Carbonic Anhydrase II in complex with Ibuprofen
3IBN	2.2	The crystal structure of the human carbonic anhydrase II in complex with an aliphatic bis-sulfamate inhibitor
4PQ7	1.85	The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor
6YZK	0.99	Carborane closo-pentyl-sulfonamide in complex with CA IX mimic
4Q7P	1.65	Crystal Structure of 1-hydroxy-3-methylpyridine-2(1H)-thione bound to hCAII
3IBL	1.55	The crystal structure of the human carbonic anhydrase II in complex with an aliphatic bis-sulfamate inhibitor
6HZX	2.91	Protein-aromatic foldamer complex crystal structure
5DSL	1.45	Structure of CO2 released holo-form of human carbonic anhydrase II with 10 min warming
2Q1Q	1.9	Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
6YKC	1.2	Metala-Carborane di-ethyl-sulfonamide (trans isomer) in complex with CA IX mimic
6MBV	1.695	Carbonic Anhydrase II in complex with Nicotinic Acid
5DSO	1.4	Structure of CO2 bound apo-form of human carbonic anhydrase II with 0 sec (no) warming
6ROF	1.5	Human Carbonic anhydrase II mutant T199V bound by 2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide
1G4O	1.96	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-PHENYLMETHYLBENZAMIDE
3MHM	1.5	Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-benzylamino-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide
3M5E	1.7	Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]methyl}benzenesulfonamide
1CNG	1.9	X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
5EIJ	1.99	Carbonic Anhydrase II in complex with Sulfonamide Inhibitor
3K34	0.9	Human carbonic anhydrase II with a sulfonamide inhibitor
4QSA	1.501	Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-4-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}benzenesulfonamide
6EEO	1.719	Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
6D1L	1.4	Design, synthesis, and X-ray of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects
4Z1K	1.35	Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)
1FR7	1.5	X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
6HD2		Active-site conformational dynamics of carbonic anhydrase II under native conditions: An NMR perspective
5WLU	1.39	Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide
3OYQ	1.47	Structure of Human Carbonic Anhydrase II complexed with 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE
1CIM	2.1	THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS
6RSZ	1.089	Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide
6RQI	0.95	Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide
5FNI	1.6	Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
4Q87	1.55	Crystal structure of 1-hydroxy-4-(trifluoromethyl)pyridine-2(1H)-thione bound to human carbonic anhydrase II
4QK3	1.345	Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - [delta]230-240
5L70	2.2	CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER
3DC3	1.7	Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
6VKG	1.37	Human carbonic anhydrase IX mimic with Epacadostat bound
8FR1	2.0	Carbonic Anhydrase IX in complex with the alkyl urea compound 3g
6OUE	1.415	Carbonic Anhydrase II complexed with benzene sulfonamide MB11-707A
5E2S	1.5	Crystal structure of human carbonic anhydrase II in complex with the 4-(2-iso-propylphenyl)benzenesulfonamide inhibitor
3VBD	1.05	Complex of human carbonic anhydrase II with 4-(6-methoxy-3,4-dihydroisoquinolin-1-yl)benzenesulfonamide
1FQL	2.0	X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
5NXM	1.25	Carbonic Anhydrase II Inhibitor RA1
3M2Z	1.7	Fragment tethered to Carbonic Anhydrase II H64C mutant
6YO4	1.7	Para-Carborane propyl-sulfonamide in complex with CA IX mimic
5NXV	1.1	Carbonic Anhydrase II Inhibitor RA8
4MLT	2.0	Structure of a monodentate 3-hydroxy-4H-pyran-4-thione ligand bound to hCAII
7YWT	1.106	human Carbonic Anhydrase II in complex with 4-oxo-N-(4-sulfamoylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-2-carboxamide
5JDV	1.34	Human carbonic anhydrase II (F131W) complexed with benzo[d]thiazole-2-sulfonamide
3BL0	1.9	Carbonic anhydrase inhibitors. Interaction of 2-N,N-Dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
7K6Z	1.657	Carbonic Anhydrase IX mimic complexed with 4-(2-(3-(4-fluorophenyl)ureido)ethylsulfonamido)benzenesulfonamide
1XPZ	2.02	Structure of human carbonic anhydrase II with 4-[4-O-sulfamoylbenzyl)(4-cyanophenyl)amino]-4H-[1,2,4]-triazole
6RMX	1.6	Human Carbonic anhydrase II mutant T199V bound by 2-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide
4RIV	1.631	A Carbonic Anhydrase IX Mimic in Complex with Saccharin
1CAI	1.8	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
6RNP	1.07	Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide
4HBA	1.762	Structural and Catalytic Characterization of a Thermal and Acid Stable Variant of Human Carbonic Anhydrase II Containing an Engineered Disulfide Bond
4RIU	1.651	A Carbonic Anhydrase IX Mimic in Complex with a Saccharin-Based Inhibitor
5BYI	1.15	Human carbonic anhydrase II with an azobenzene inhibitor (1d)
4KV0	1.55	Crystal structure of human carbonic anhydrase II in complex with the 5-(3-tosylureido)pyridine-2-sulfonamide inhibitor
6HQX	1.097	Human Carbonic Anhydrase II in complex with 4-Ethylbenzenesulfonamide
2WD3	1.8	Highly Potent First Examples of Dual Aromatase-Steroid Sulfatase Inhibitors based on a Biphenyl Template
1TE3	2.0	Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
6UZU	1.5	Carbonic Anhydrase IX-mimic In Complex WITH U-CH3
6S03	1.38	Carbonic Anhydrase CAIX mimic in complex with inhibitor I39LT379
3ML2	1.8	Human carbonic anhydsase II in complex with an aryl sulfonamide inhibitor
4Q6E	1.12	Crystal structure of human carbonic anhydrase isozyme II with 4-{[3-(3,5-Dimethyl-1H-pyrazol-1-yl)-3-oxopropyl]amino}benzene-1-sulfonamide
3CYU	1.7	Human Carbonic Anhydrase II complexed with Cryptophane biosensor and xenon
7SUY	1.405	Carbonic Anhydrase IX-mimic Complexed with 2-((3-Aminopropyl)(phenethyl)amino)-N-(4-fluorobenzyl)-N-(4-sulfamoylphenethyl)acetamide
5FNL	1.59	Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
6RZX	1.0	Carbonic Anhydrase CAIX mimic in complex with inhibitor FBSA
5JN7	1.517	Carbonic Anhydrase II In Complex WITH U-CH3
6SDJ	1.02	Human Carbonic Anhydrase II in complex with (R)-1-aminopropan-2-ol
6G6T	1.12	Crystal structure of human carbonic anhydrase isozyme II with N-butyl-2,4-dichloro-5-sulfamoyl-benzamide
1TBT	2.0	Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
5WG7	1.45	Human Carbonic Anhydrase II complexed with AceK
6PGX	1.36	Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity
2WD2	1.49	A chimeric microtubule disruptor with efficacy on a taxane resistant cell line
5EHE	1.5	Crystal structure of human carbonic anhydrase isozyme II with 3-(benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
1CAO	1.9	CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS
4K0Z	1.799	Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with methazolamide
8EMU	1.13	Human Carbonic Anhydrase II Heterobifunctional Degraders
6YRI	1.6	THE CRYSTAL STRUCTURE OF THE COMPLEX OF HCAII WITH CAFFEIC ACID
1BNU	2.15	CARBONIC ANHYDRASE II INHIBITOR
6OUB	1.418	Carbonic Anhydrase II complexed with benzene sulfonamide MB11-694B
5N0D	1.7	Crystal structure of human carbonic anhydrase II in complex with (R)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1H-2-carbonyl)benzenesulfonamide.
5LLH	1.9	Crystal structure of human carbonic anhydrase isozyme II with 4-(1,3-Benzothiazol-2-ylthio)-2,3,5,6-tetrafluorobenzenesulfonamide
3KOI	1.64	Crystal structure of cobalt (III) human carbonic anhydrase II at pH 6.0
1CVE	2.25	STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE
2O4Z	2.1	Crystal structure of the Carbonic Anhydrase II complexed with hydroxysulfamide inhibitor
6H3Q	1.31	Crystal structure of human carbonic anhydrase II in complex with the 4-(5-(chloromethyl)-1,3-selenazol-2-yl)benzenesulfonamide
4WL4	1.1	Crystal structure of human carbonic anhydrase II in complex with the 6-hydroxy-chromene-2-thione inhibitor
5OGP	1.1	Metalacarborane inhibitors of Carbonic Anhydrase IX
4PYX	1.8	Crystal structure of human carbonic anhydrase isozyme II with inhibitor
5LMD	1.7	The crystal structure of hCA II in complex with a benzoxaborole inhibitor
3N3J	1.5	Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor
7RNY	1.29	Carbonic Anhydrase II in complex with 3-ureido benzenesulfonamide derivative
5N0E	1.75	Crystal structure of human carbonic anhydrase II in complex with (S)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1H-2-carbonyl)benzenesulfonamide.
6H34	1.55	The crystal structure of human carbonic anhydrase II in complex with 4-[(4-fluorophenyl)methyl]-1-piperazinyl]benzenesulfonamide.
3RLD	1.5	Crystal structure of the Y7I mutant of human carbonic anhydrase II
5FNG	2.05	Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
4HEZ	1.3446	Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
6T81	0.98	Human Carbonic anhydrase II bound by 2-Naphthalenesulfonamide.
3TMJ	2.0	Joint X-ray/neutron structure of human carbonic anhydrase II at pH 7.8
2POW	1.75	The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide
4Q09	1.2	Crystal structure of chimeric carbonic anhydrase XII with inhibitor
4QIY	1.3	Crystal structure of human carbonic anhydrase isozyme II with inhibitor
4E49	1.45	Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
6RG5	1.089	Human Carbonic Anhydrase II in complex with 4-(2-hydroxyethyl)benzenesulfonamide
3OIL	1.5	Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol 3-O-sulfamate
6PDV	1.23	Cu-Carbonic Anhydrase II, A Nitrite Reductase
4RN4	1.53	Human Carbonic anhydrases II in complex with a acetazolamide derivative comprising one hydrophobic and one hydrophilic tail moiety
6LUY	1.2	Zn- Carbonic Anhydrase II pH 11.0 0 atm CO2
6GDC	1.079	Human Carbonic Anhydrase II in complex with Benzenesulfonamide
3MNU	1.8	Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron containing aromatic sulfamide with mammalian isoforms I-XV
3P5L	1.498	Human Carbonic Anhydrase complexed with sodium 4-cyano-4-phenylpiperidine-1-carbodithioate
5YUK	1.45	CO2 release in human carbonic anhydrase II crystals: reveal histidine 64 and solvent dynamics
2FNN	1.8	Activation of human carbonic anhydrase II by exogenous proton donors
5WLR	1.49	Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide
8EXG	1.99	Human Carbonic Anhydrase II bound N-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)-4-sulfamoylbenzamide
6T5C	1.22	Human Carbonic anhydrase II bound by anthracene-9-sulfonamide
6LUU	1.2	apo- Carbonic Anhydrase II pH 7.8 0 atm CO2
4M2V	1.718	Genetically engineered Carbonic Anhydrase IX in complex with Brinzolamide
4ILX	1.6	Structure of human carbonic anhydrase II in complex with an adamantyl sulfonamide inhibitor
3S77	1.86	The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
1CCU	2.25	STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY
1IF5	2.0	Carbonic Anhydrase II Complexed With 2,6-difluorobenzenesulfonamide
5JGT	1.1	Human carbonic anhydrase II (F131Y/L198A) complexed with 1,3-thiazole-2-sulfonamide
3S76	1.6	The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
6H6S	1.45	Sad phasing on nickel-substituted human carbonic anhydrase II
4N0X	1.63	Room temperature crystal structure of human carbonic anhydrase II in complex with thiophene-2-sulfonamide
3DCC	1.6	Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
6EBE	1.88	Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
3DD0	1.48	Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
4QK2	1.519	Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - E234P
1UGE	1.9	HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY LEU (A65L)
1ZFQ	1.55	carbonic anhydrase II in complex with ethoxzolamidphenole as sulfonamide inhibitor
6MBY	1.496	Carbonic Anhydrase II in complex with Ferulic Acid
4FU5	0.98	Carbonic Anhydrase II in complex with N-[(2Z)-1,3-oxazolidin-2-ylidene]sulfuric diamide
5TY9	1.53	Identification of a New Zinc Binding Chemotype by Fragment Screening
1MOO	1.05	Site Specific Mutant (H64A) of Human Carbonic Anhydrase II at high resolution
3S73	1.75	The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
6R6F	1.2	Crystal structure of human carbonic anhydrase isozyme II with 4-chloro-2-cyclohexylsulfanyl-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide
3FFP	1.81	X ray structure of the complex between carbonic anhydrase II and LC inhibitors
4LP6	2.15	Crystal Structure of Human Carbonic Anhydrase II in complex with a quinoline oligoamide foldamer
7NH8	1.369	Crystal structure of human carbonic anhydrase II with N-((1-(6-((3aR,7R,7aS)-7-hydroxy-2,2-dimethyltetrahydro-[1,3]dioxolo[4,5-c]pyridin-5(4H)-yl)hexyl)-1H-1,2,3-triazol-4-yl)methyl)-4-sulfamoylbenzamide
5FNK	1.59	Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
8C0R	1.56	Crystal structure of human carbonic anhydrase II in complex with a coumarin derivative.
6YQU	1.478	CRYSTAL STRUCTURE OF HUMAN CA II IN COMPLEX WITH 2-MERCAPTOBENZOXAZOLE
6OUH	1.449	Carbonic Anhydrase II mimic complexed with benzene sulfonamide MB11-710A
1IF9	2.0	Carbonic Anhydrase II Complexed With N-[2-(1H-Indol-5-yl)-butyl]-4-sulfamoyl-benzamide
3OY0	1.6	Human Carbonic Anhydrase II complexed with 1-(4-(4-(2-(ISOPROPYLSULFONYL)PHENYLAMINO)-1H-PYRROLO[2,3-B]PYRIDIN-6-YLAMINO)-3-METHOXYPHENYL)PIPERIDIN-4-OL
5WLT	1.57	Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide
3M14	1.38	Carbonic Anhydrase II in complex with novel sulfonamide inhibitor
7OYO	1.03	Carbonic anhydrase II in complex with Hit4 (MH70)
3M67	1.8	Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-[(6,7-dihydro-1H-[1,4]dioxino[2,3-f]benzimidazol-2-ylsulfanyl)acetyl]benzenesulfonamide
7OYM	0.98	Carbonic anhydrase II in complex with Hit2 (MH65)
1YO0	1.8	Proton Transfer from His200 in Human Carbonic Anhydrase II
5G0C	1.28	An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C
3IEO	2.0	The coumarin-binding site in carbonic anhydrase: the antiepileptic lacosamide as an example
4Q78	1.0	Structure-assisted design of carborane-based inhibitors of carbonic anhydrase
7CA2	2.4	ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
6E8P	1.9	CA IX mimic Complexed with Steroidal Sulfamate Compound STX 49
6RVL	1.72	Crystal structure of hCA II with Urea, N-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-?N'-phenyl-
7QBH	1.223	Selenocarbamates as a novel prodrug-based approach towards Carbonic Anhydrase inhibition (hCA II)
6SX9	1.43	Crystal structure of carbonic anhydrase 2 with 4-(2-chlorophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
3PJJ	1.8	Synthetic Dimer of Human Carbonic Anhydrase II
1UGB	2.0	HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY GLY (A65G)
6YH5	1.2	Crystal structure of chimeric carbonic anhydrase XII with 2-Chloro-4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide
5NY6	1.1	Carbonic Anhydrase II Inhibitor RA12
3S71	1.25	The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
6YZS	1.05	Carborane closo-pentyl-sulfonamide in complex with CA II
6SFQ	1.0	Atomic resolution structure of human Carbonic Anhydrase II in complex with (R)-5-phenyloxazolidine-2,4-dione
4RUY	1.14	Crystal structure of human Carbonic Anhydrase II in complex with 4-propoxybenzenesulfonamide
4Q7S	1.8	Crystal Structure of 1-hydroxy-4-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II
1XEG	1.81	Crystal structure of human carbonic anhydrase II complexed with an acetate ion
8FR4	1.123	Carbonic Anhydrase IX-mimic in complex with the alkyl urea compound 3j
6KM1	1.05	Human Carbonic Anhydrase II V143I variant 13 atm CO2
6BC9	1.8	Joint X-ray/neutron structure of human carbonic anhydrase II in complex with dorzolamide
2FOV	1.15	Human Carbonic Anhydrase II complexed with two-prong inhibitors
8EXC	1.9	Human Carbonic Anhydrase II bound tert-butyl (3-(4-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propoxy)butoxy)propyl)carbamate
6RL9	1.0	Human Carbonic Anhydrase II in complex with 4-Aminobenzenesulfonamide
5JMZ	1.9	Carbonic Anhydrase IX-mimic IN Complex WITH U-NO2
2NWY	1.65	Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II
6UGP	1.306	Human Carbonic Anhydrase 2 complexed with SB4-206
4HF3	1.1476	Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
6WQ4	1.35	Carbonic Anhydrase II Complexed with 2-((2-Cyanoethyl)(phenethyl)amino)-N-phenethyl-N-(4-sulfamoylphenethyl)acetamide
3KKX	2.0	Neutron structure of human carbonic anhydrase II
2QOA	1.6	Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor
2ILI	1.05	Refine atomic structure of human carbonic anhydrase II
5TXY	1.206	Identification of a New Zinc Binding Chemotype of by Fragment Screening on human carbonic anhydrase
4YXI	0.96	Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (2).
4RFD	1.631	Human carbonic anhydrase II in complex with 4-(4-sulfamoyl-phenoxy)-butylammonium
6I1U	1.08	Human Carbonic Anhydrase II in complex with 4-Ethoxybenzenesulfonamide
3MNJ	1.75	Human Carbonic Anhydrase II Mutant K170E
5VGY	1.39	Identification of a New Zinc Binding Chemotype by Fragment Screening
5EKH	1.34	Human Carbonic Anhydrase II complexed with a two-faced guest
1H4N	2.0	H94N CARBONIC ANHYDRASE II COMPLEXED WITH TRIS
5CAC	2.2	REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION
4BF6	1.82	Three dimensional structure of human carbonic anhydrase II in complex with 5-(1-(3-Cyanophenyl)-1H-1,2,3-triazol-4-yl)thiophene-2- sulfonamide
4ZWI	1.6	Surface Lysine Acetylated Human Carbonic Anhydrase II in Complex with a Sulfamate-Based Inhibitor
6YH9	1.55	Crystal structure of chimeric carbonic anhydrase XII with 2,3,6-trifluoro-5-{[(1R,2S)-2-hydroxy-1,2-diphenylethyl]amino}-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
6YZM	1.5	Carborane nido-pentyl-sulfonamide in complex with CA IX mimic
5G03	1.35	An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C
6UGR	1.307	Human Carbonic Anhydrase 2 complexed with SB4-208
4N16	1.54	Structure of cholate bound to human carbonic anhydrase II
7K6K	1.306	Carbonic Anhydrase II complexed with 4-(2-(3-(3,5-dimethylphenyl)ureido)ethylsulfonamido)benzenesulfonamide
6WQ8	1.405	Carbonic Anhydrase II Complexed with 3-((2-((Furan-2-ylmethyl)(4-sulfamoylphenethyl)amino)-2-oxoethyl)(phenethyl)amino)propanoic acid
5TH4	1.47	Crystal Structure of 1-hydroxypyridine-2(1H)-thione bound to human carbonic anhydrase 2 L198G
4CA2	2.1	ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
4YWP	1.45	Sucrose Binding Site in genetically engineered Carbonic anhydrase IX
6SDI	1.03	Human Carbonic Anhydrase II in complex with an inhibitor soaked at a concentration of 0.01 mM
4Q7V	1.6	Crystal structure of 1-hydroxy-5-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II
6HX5	1.44	Selenols: a new class of Carbonic Anhydrase inhibitors
5M78	1.077	Human Carbonic Anhydrase II in complex with fragment-like inhibitor.
3T84	2.0	Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates
5ULN	1.35	Synthesis of novel seleno ureido containing compounds as SLC-0111 analogs. Investigations on carbonic anhydrases activity, glutathione peroxidase and X-ray crystallography
4FIK	1.2	Human carbonic anhydrase II H64A complexed with thioxolone hydrolysis products
6D1M	1.21	Design, synthesis, and X-ray of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects
4Z0Q	1.45	Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)
3CAJ	1.8	Crystal structure of the human carbonic anhydrase II in complex with ethoxzolamide
3RZ0	1.798	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase
5OGN	1.1	Metalacarborane inhibitors of Carbonic Anhydrase IX
3T5Z	1.65	Crystal structure of the human carbonic anhydrase II in complex with N-methoxy-benzenesulfonamide
1RZA	1.9	X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES
4R5A	1.64	A Carbonic Anhydrase IX Mimic in Complex with a Carbohydrate-Based Sulfamate
4PYY	1.75	Crystal structure of human carbonic anhydrase isozyme II with inhibitor
3MHO	1.15	Crystal structure of human carbonic anhydrase isozyme II with 4-[N-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]benzenesulfonamide
5U0F	1.21	Identification of a New Zinc Binding Chemotype by Fragment Screening
5THI	1.5	Crystal Structure of 2-hydroxycyclohepta-2,4,6-trien-1-one bound to human carbonic anhydrase 2 L198G
2X7T	1.89	Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.
8FQZ	1.467	Carbonic Anhydrase II in complex with the alkyl urea 3j
4WW6	1.06	Crystal structure of human carbonic anhydrase isozyme II with 2,3,5,6-Tetrafluoro-4-(propylthio)benzenesulfonamide
5AMD	1.5	Three dimensional structure of human carbonic anhydrase II in complex with 2-((2-Phenylethyl)sulfamoyl)-4-sulfamoylbenzoic acid
6WQ5	1.304	Carbonic Anhydrase II Complexed with 2-((3-Aminopropyl)(phenethyl)amino)-N-(furan-2-ylmethyl)-N-(4-sulfamoylphenethyl)acetamide
8FQX	1.496	Carbonic Anhydrase II in complex with the alkyl ureas 3g
6GCY	1.3	Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (saccharin-sugar conjugate complex)
5LLG	1.12	Crystal structure of human carbonic anhydrase isozyme II with 4-Propylthiobenzenesulfonamide
7K6I	1.406	Carbonic Anhydrase II complexed with 4-(2-(3-phenylureido)ethylsulfonamido)benzenesulfonamide
7M23	1.3	Human carbonic anhydrase II in complex with troglitazone
5BRV	1.6	Catalytic Improvement of an Artificial Metalloenzyme by Computational Design
6Z04	1.05	Nido-carborane butyl-sulfonamide in complex with CA IX mimic
1G0F	1.6	SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMAN CARBONIC ANHYDRASE II
1BN4	2.1	CARBONIC ANHYDRASE II INHIBITOR
1MUA	1.7	STRUCTURE AND ENERGETICS OF A NON-PROLINE CIS-PEPTIDYL LINKAGE IN AN ENGINEERED PROTEIN
5T72	1.3	Human carboanhydrase F131C_C206S double mutant in complex with 2
2NWP	1.8	Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
3DAZ	1.6	Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
1F2W	1.9	THE MECHANISM OF CYANAMIDE HYDRATION CATALYZED BY CARBONIC ANHYDRASE II REVEALED BY CRYOGENIC X-RAY DIFFRACTION
5FLQ	1.7	Native state mass spectrometry, surface plasmon resonance and X-ray crystallography correlate strongly as a fragment screening combination
1HVA	2.3	ENGINEERING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF THE HIS-94-> CYS APOENZYME IN A NEW CRYSTALLINE FORM
1CNX	1.9	SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS
1RAY	1.8	THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE
3M04	1.4	Carbonic Anhydrase II in complex with novel sulfonamide inhibitor
4YX4	1.01	Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (1).
3IBU	1.41	The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor
1H9N	1.85	H119N CARBONIC ANHYDRASE II
7AGN	1.15	Human carbonic anhydrase II in complex with 4-(2-aminoethylsulfanyl)-2,3,5,6-tetrafluoro-N-methyl-benzenesulfonamide
5ZXW	1.316	Crystal structure of human carbonic anhydrase II crystallized by ammonium sulfate
7SUW	1.456	Carbonic Anhydrase IX-mimic with 2-((3-Aminopropyl)(phenethyl)amino)-N-(furan-2-ylmethyl)-N-(4-sulfamoylphenethyl)acetamide
4YYT	1.07	Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (5).
6YH8	1.2	Crystal structure of chimeric carbonic anhydrase XII with 2-[(1S)-1,2,3,4-Tetrahydronapthalen-1-ylamino)-3,5,6-trifluorobenzenesulfonamide
5LVS	1.42	Self-assembled protein-aromatic foldamer complexes with 2:3 and 2:2:1 stoichiometries
5UMC	2.15	Synthesis of novel seleno ureido containing compounds as SLC-0111 analogs. Investigations on carbonic anhydrases activity, glutathione peroxidase and X-ray crystallography
3IGP	1.65	Structure of inhibitor binding to Carbonic Anhydrase II
7QNV	1.278	human carbonic anhydrase II bound to 3-methylbenzoselenoate
4Q90	1.54	Crystal structure of 4-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II
7BFA	1.6	4-(2-(3-(4-iodophenyl)thioureido)ethyl)benzenesulfonamide in complex with Carbonic Anhydrase II
6YMA	2.5	MicroED structure of acetazolamide-bound human carbonic anhydrase II
7JOC	1.385	Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)adamantanecarboxamide
6YOL	1.15	Meta-Nidocarborane propyl-sulfonamide in complex with CA IX mimic
3BET	1.85	Crystal structure of the human carbonic anhydrase II in complex with STX 641 at 1.85 angstroms resolution
3M2N	1.65	Crystal structure of human carbonic anhydrase isozyme II with 4-{2-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide
3D93	1.1	Apo Human carbonic anhydrase II bound with substrate carbon dioxide
5SZ4	1.6	Carbonic anhydrase IX-mimic in complex with 4-(phenyl)-benzenesulfonamide
4MDL	1.516	Meta Carborane Carbonic Anhydrase Inhibitor
1ZGF	1.75	carbonic anhydrase II in complex with trichloromethiazide as sulfonamide inhibitor

GO term

GO ontology	GO term	GO description
Biological Process	GO:0038166	angiotensin-activated signaling pathway
Biological Process	GO:0015670	carbon dioxide transport
Biological Process	GO:0002009	morphogenesis of an epithelium
Biological Process	GO:0070050	neuron cellular homeostasis
Biological Process	GO:0032849	positive regulation of cellular pH reduction
Biological Process	GO:2001150	positive regulation of dipeptide transmembrane transport
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic
Biological Process	GO:2001225	regulation of chloride transport
Biological Process	GO:0051453	regulation of intracellular pH
Biological Process	GO:0044070	regulation of monoatomic anion transport
Biological Process	GO:0046903	secretion
Molecular Function	GO:0004064	arylesterase activity
Molecular Function	GO:0004089	carbonate dehydratase activity
Molecular Function	GO:0018820	cyanamide hydratase activity
Molecular Function	GO:0008270	zinc ion binding
Cellular Component	GO:0045177	apical part of cell
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0043209	myelin sheath
Cellular Component	GO:0005886	plasma membrane

InterPro / Pfam

InterPro	InterPro name
IPR001148	Alpha carbonic anhydrase domain
IPR018338	Carbonic anhydrase, alpha-class, conserved site
IPR023561	Carbonic anhydrase, alpha-class
IPR036398	Alpha carbonic anhydrase domain superfamily

Pfam	Pfam name
PF00194	Eukaryotic-type carbonic anhydrase

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1237044	Erythrocytes take up carbon dioxide and release oxygen	Leaf	R-HSA-382551	Transport of small molecules
R-HSA-1247673	Erythrocytes take up oxygen and release carbon dioxide	Leaf	R-HSA-382551	Transport of small molecules
R-HSA-1475029	Reversible hydration of carbon dioxide	Leaf	R-HSA-1430728	Metabolism

Subcellular location

Location	ECO term	Pubmed
Cell membrane	ECO:0000269	PubMed:15990874
Cytoplasm	ECO:0000269	PubMed:15990874

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000126	Hydronephrosis
HP:0000160	Narrow mouth
HP:0000164	Abnormality of the dentition
HP:0000179	Thick lower lip vermilion
HP:0000218	High palate
HP:0000248	Brachycephaly
HP:0000278	Retrognathia
HP:0000347	Micrognathia
HP:0000400	Macrotia
HP:0000405	Conductive hearing impairment
HP:0000479	Abnormal retinal morphology
HP:0000505	Visual impairment
HP:0000572	Visual loss
HP:0000592	Blue sclerae
HP:0000648	Optic atrophy
HP:0000689	Dental malocclusion
HP:0000692	Tooth malposition
HP:0000767	Pectus excavatum
HP:0000787	Nephrolithiasis
HP:0000867	Secondary hyperparathyroidism
HP:0001105	Retinal atrophy
HP:0001249	Intellectual disability
HP:0001263	Global developmental delay
HP:0001293	Cranial nerve compression
HP:0001328	Specific learning disability
HP:0001357	Plagiocephaly
HP:0001433	Hepatosplenomegaly
HP:0001508	Failure to thrive
HP:0001562	Oligohydramnios
HP:0001873	Thrombocytopenia
HP:0001876	Pancytopenia
HP:0001882	Leukopenia
HP:0001903	Anemia
HP:0001942	Metabolic acidosis
HP:0001947	Renal tubular acidosis
HP:0001978	Extramedullary hematopoiesis
HP:0001999	Abnormal facial shape
HP:0002049	Proximal renal tubular acidosis
HP:0002092	Pulmonary arterial hypertension
HP:0002135	Basal ganglia calcification
HP:0002240	Hepatomegaly
HP:0002273	Tetraparesis
HP:0002514	Cerebral calcification
HP:0002518	Abnormal periventricular white matter morphology
HP:0002684	Thickened calvaria
HP:0002757	Recurrent fractures
HP:0002870	Obstructive sleep apnea
HP:0002901	Hypocalcemia
HP:0003034	Diaphyseal sclerosis
HP:0003148	Elevated serum acid phosphatase
HP:0003236	Elevated circulating creatine kinase concentration
HP:0004322	Short stature
HP:0004437	Cranial hyperostosis
HP:0004445	Elliptocytosis
HP:0005461	Craniofacial disproportion
HP:0005528	Bone marrow hypocellularity
HP:0006335	Persistence of primary teeth
HP:0006641	Prominent floating ribs
HP:0006824	Cranial nerve paralysis
HP:0007807	Optic nerve compression
HP:0008153	Periodic hypokalemic paresis
HP:0008341	Distal renal tubular acidosis
HP:0010864	Intellectual disability, severe
HP:0011002	Osteopetrosis
HP:0011220	Prominent forehead
HP:0012181	Entrapment neuropathy
HP:0012370	Prominence of the zygomatic bone
HP:0012379	Abnormal circulating enzyme concentration or activity
HP:0030812	Enlarged tonsils

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
appendix	endocrine cells	High	Enhanced
appendix	enterocytes	High	Enhanced
appendix	enterocytes - Gradient	Ascending	Enhanced
appendix	enterocytes - Microvilli	High	Enhanced
appendix	goblet cells	High	Enhanced
bone marrow	hematopoietic cells	Medium	Enhanced
breast	glandular cells	Medium	Enhanced
caudate	glial cells	High	Enhanced
cerebellum	granular cells - nucleus	High	Enhanced
cerebellum	molecular layer cells - nucleus	High	Enhanced
cerebellum	processes in granular layer	High	Enhanced
cerebellum	processes in white matter	High	Enhanced
cerebellum	synaptic glomeruli - capsule	High	Enhanced
cerebellum	white matter cells - nucleus	High	Enhanced
cerebral cortex	endothelial cells	Low	Enhanced
cerebral cortex	glial cells	High	Enhanced
cerebral cortex	neuropil	Low	Enhanced
colon	endocrine cells	High	Enhanced
colon	enterocytes	High	Enhanced
colon	enterocytes - Gradient	Ascending	Enhanced
colon	enterocytes - Microvilli	High	Enhanced
colon	goblet cells	High	Enhanced
duodenum	endocrine cells	High	Enhanced
duodenum	enterocytes	High	Enhanced
duodenum	enterocytes - Gradient	Ascending	Enhanced
duodenum	enterocytes - Microvilli	High	Enhanced
duodenum	goblet cells	High	Enhanced
gallbladder	glandular cells	High	Enhanced
hippocampus	glial cells	High	Enhanced
kidney	collecting ducts	High	Enhanced
kidney	distal tubules	High	Enhanced
kidney	proximal tubules (cell body)	Medium	Enhanced
liver	cholangiocytes	High	Enhanced
liver	hepatocytes	Medium	Enhanced
lung	macrophages	Low	Enhanced
pancreas	exocrine glandular cells	Medium	Enhanced
rectum	endocrine cells	High	Enhanced
rectum	enterocytes	High	Enhanced
rectum	enterocytes - Gradient	Ascending	Enhanced
rectum	enterocytes - Microvilli	High	Enhanced
rectum	goblet cells	High	Enhanced
salivary gland	glandular cells	High	Enhanced
seminal vesicle	glandular cells	High	Enhanced
skin 1	cells in granular layer	Low	Enhanced
stomach 1	glandular cells	High	Enhanced
stomach 2	glandular cells	High	Enhanced

Summary of P00918

Gene: CA2
Protein: Carbonic anhydrase 2

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P00918

Gene: CA2 Protein: Carbonic anhydrase 2

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: CA2
Protein: Carbonic anhydrase 2