Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
PDB | Resolution (Å) | PDB name |
---|---|---|
1D2B | THE MMP-INHIBITORY, N-TERMINAL DOMAIN OF HUMAN TISSUE INHIBITOR OF METALLOPROTEINASES-1 (N-TIMP-1), SOLUTION NMR, 29 STRUCTURES | |
1OO9 | Orientation in Solution of MMP-3 Catalytic Domain and N-TIMP-1 from Residual Dipolar Couplings | |
1UEA | 2.8 | MMP-3/TIMP-1 COMPLEX |
2J0T | 2.54 | Crystal Structure of the Catalytic Domain of MMP-1 in Complex with the Inhibitory Domain of TIMP-1 |
3MA2 | 2.05 | Complex membrane type-1 matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase-1 (TIMP-1) |
3V96 | 1.9 | Complex of matrix metalloproteinase-10 catalytic domain (MMP-10cd) with tissue inhibitor of metalloproteinases-1 (TIMP-1) |
6MAV | 2.37 | Complex of tissue inhibitor of metalloproteinase-1 (TIMP-1) mutant L34G with matrix metalloproteinase-3 catalytic domain (MMP-3cd) |
6N9D | 2.67 | Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/L133P/L151C/G154A) with matrix metalloproteinase-3 catalytic domain (MMP-3cd) |
7S7L | 2.34 | Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66S/E67Y/L133N/S155L) with matrix metalloproteinase-3 catalytic domain (MMP-3cd) |
7S7M | 3.0 | Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66D/T98G/P131S/Q153N) with matrix metalloproteinase-3 catalytic domain (MMP-3cd) |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0007568 | aging |
Biological Process | GO:0051216 | cartilage development |
Biological Process | GO:0001775 | cell activation |
Biological Process | GO:0071492 | cellular response to UV-A |
Biological Process | GO:0002248 | connective tissue replacement involved in inflammatory response wound healing |
Biological Process | GO:0043066 | negative regulation of apoptotic process |
Biological Process | GO:0043086 | negative regulation of catalytic activity |
Biological Process | GO:0010951 | negative regulation of endopeptidase activity |
Biological Process | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis |
Biological Process | GO:1905049 | negative regulation of metallopeptidase activity |
Biological Process | GO:1901164 | negative regulation of trophoblast cell migration |
Biological Process | GO:0008284 | positive regulation of cell population proliferation |
Biological Process | GO:2001044 | regulation of integrin-mediated signaling pathway |
Biological Process | GO:0034097 | response to cytokine |
Biological Process | GO:0009725 | response to hormone |
Biological Process | GO:0043434 | response to peptide hormone |
Molecular Function | GO:0005125 | cytokine activity |
Molecular Function | GO:0008083 | growth factor activity |
Molecular Function | GO:0008191 | metalloendopeptidase inhibitor activity |
Molecular Function | GO:0030414 | peptidase inhibitor activity |
Molecular Function | GO:0002020 | protease binding |
Molecular Function | GO:0008270 | zinc ion binding |
Cellular Component | GO:0005604 | basement membrane |
Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0031012 | extracellular matrix |
Cellular Component | GO:0005576 | extracellular region |
Cellular Component | GO:0005615 | extracellular space |
Cellular Component | GO:0031093 | platelet alpha granule lumen |
InterPro | InterPro name |
---|---|
IPR001134 | Netrin domain |
IPR001820 | Protease inhibitor I35 (TIMP) |
IPR008993 | Tissue inhibitor of metalloproteinases-like, OB-fold |
IPR027465 | Proteinase inhibitor I35b (TIMP), C-terminal |
IPR030490 | Tissue inhibitor of metalloproteinase, conserved site |
Pfam | Pfam name |
---|---|
PF00965 | Tissue inhibitor of metalloproteinase |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-114608 | Platelet degranulation | Leaf | R-HSA-109582 | Hemostasis |
R-HSA-1592389 | Activation of Matrix Metalloproteinases | Leaf | R-HSA-1474244 | Extracellular matrix organization |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-6783783 | Interleukin-10 signaling | Leaf | R-HSA-168256 | Immune System |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | Leaf | R-HSA-168256 | Immune System |
R-HSA-8957275 | Post-translational protein phosphorylation | Leaf | R-HSA-392499 | Metabolism of proteins |
Location | ECO term | Pubmed |
---|---|---|
Secreted | ECO:0000269 | PubMed:1730286 |
Secreted | ECO:0000269 | PubMed:24635319 |
Secreted | ECO:0000269 | PubMed:3010309 |
Secreted | ECO:0000269 | PubMed:3839290 |
Secreted | ECO:0000269 | PubMed:3903517 |
Secreted | ECO:0000269 | PubMed:8541540 |