MultifacetedProtDB - Bologna Biocomputing Group

Summary of P02649

Gene: APOE
Protein: Apolipoprotein E

Protein family
Protein sequence
Protein function

Catalytic activity

The protein has not catalytic activity

Publications

Structure

Link to AlphaFold model

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PDB	Resolution (Å)	PDB name
1B68	2.0	APOLIPOPROTEIN E4 (APOE4), 22K FRAGMENT
1BZ4	1.85	APOLIPOPROTEIN E3 (APO-E3), TRUNCATION MUTANT 165
1EA8	1.95	Apolipoprotein E3 22kD fragment LYS146GLU mutant
1GS9	1.7	Apolipoprotein E4, 22k domain
1H7I	1.9	Apolipoprotein E3 22kD fragment LYS146GLN mutant
1LE2	3.0	STRUCTURAL BASIS FOR ALTERED FUNCTION IN THE COMMON MUTANTS OF HUMAN APOLIPOPROTEIN-E
1LE4	2.5	STRUCTURAL BASIS FOR ALTERED FUNCTION IN THE COMMON MUTANTS OF HUMAN APOLIPOPROTEIN-E
1LPE	2.25	THREE-DIMENSIONAL STRUCTURE OF THE LDL RECEPTOR-BINDING DOMAIN OF HUMAN APOLIPOPROTEIN E
1NFN	1.8	APOLIPOPROTEIN E3 (APOE3)
1NFO	2.0	APOLIPOPROTEIN E2 (APOE2, D154A MUTATION)

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GO term

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GO ontology	GO term	GO description
Biological Process	GO:0097113	AMPA glutamate receptor clustering
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway
Biological Process	GO:0097114	NMDA glutamate receptor clustering
Biological Process	GO:0042982	amyloid precursor protein metabolic process
Biological Process	GO:0048844	artery morphogenesis
Biological Process	GO:0019934	cGMP-mediated signaling
Biological Process	GO:0006707	cholesterol catabolic process
Biological Process	GO:0033344	cholesterol efflux
Biological Process	GO:0042632	cholesterol homeostasis
Biological Process	GO:0008203	cholesterol metabolic process

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InterPro / Pfam

Reactome

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Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1251985	Nuclear signaling by ERBB4	Leaf	R-HSA-162582	Signal Transduction
R-HSA-3000480	Scavenging by Class A Receptors	Leaf	R-HSA-5653656	Vesicle-mediated transport
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	Internal node	R-HSA-74160	Gene expression (Transcription)
R-HSA-8957275	Post-translational protein phosphorylation	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-8963888	Chylomicron assembly	Leaf	R-HSA-382551	Transport of small molecules
R-HSA-8963901	Chylomicron remodeling	Leaf	R-HSA-382551	Transport of small molecules
R-HSA-8964026	Chylomicron clearance	Leaf	R-HSA-382551	Transport of small molecules
R-HSA-8964058	HDL remodeling	Leaf	R-HSA-382551	Transport of small molecules
R-HSA-9029569	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Leaf	R-HSA-162582	Signal Transduction

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Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

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Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	High	Enhanced
bone marrow	hematopoietic cells	Low	Enhanced
caudate	glial cells	High	Enhanced
caudate	neuronal cells	High	Enhanced
cerebellum	Bergmann glia - cytoplasm/membrane	Medium	Enhanced
cerebellum	Purkinje cells - cytoplasm/membrane	Low	Enhanced
cerebellum	granular cells - cytoplasm/membrane	Medium	Enhanced
cerebellum	granular cells - nucleus	Medium	Enhanced
cerebellum	molecular layer - neuropil	Low	Enhanced
cerebellum	molecular layer cells - cytoplasm/membrane	High	Enhanced

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Disease