Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
PDB | Resolution (Å) | PDB name |
---|---|---|
1BH7 | A LOW ENERGY STRUCTURE FOR THE FINAL CYTOPLASMIC LOOP OF BAND 3, NMR, MINIMIZED AVERAGE STRUCTURE | |
1BNX | STRUCTURAL STUDIES ON THE EFFECTS OF THE DELETION IN THE RED CELL ANION EXCHANGER (BAND3, AE1) ASSOCIATED WITH SOUTH EAST ASIAN OVALOCYTOSIS. | |
1BTQ | THE SOLUTION STRUCTURES OF THE FIRST AND SECOND TRANSMEMBRANE-SPANNING SEGMENTS OF BAND 3 | |
1BTR | THE SOLUTION STRUCTURES OF THE FIRST AND SECOND TRANSMEMBRANE-SPANNING SEGMENTS OF BAND 3 | |
1BTS | THE SOLUTION STRUCTURES OF THE FIRST AND SECOND TRANSMEMBRANE-SPANNING SEGMENTS OF BAND 3 | |
1BTT | THE SOLUTION STRUCTURES OF THE FIRST AND SECOND TRANSMEMBRANE-SPANNING SEGMENTS OF BAND 3 | |
1BZK | STRUCTURAL STUDIES ON THE EFFECTS OF THE DELETION IN THE RED CELL ANION EXCHANGER (BAND3, AE1) ASSOCIATED WITH SOUTH EAST ASIAN OVALOCYTOSIS. | |
1HYN | 2.6 | CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF HUMAN ERYTHROCYTE BAND-3 PROTEIN |
2BTA | NMR STUDY OF N-TERMINAL HUMAN BAND 3 PEPTIDE, RESIDUES 1-15 | |
2BTB | NMR STUDY OF N-TERMINAL HUMAN BAND 3 PEPTIDE, RESIDUES 1-15 | |
3BTB | NMR SOLUTION STRUCTURE OF A BAND 3 PEPTIDE INHIBITOR BOUND TO GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, 20 STRUCTURES | |
4KY9 | 2.23 | Structural and Functional Analysis of a Putative Substrate Access Tunnel in the Cytosolic Domain of Human Anion Exchanger 1 |
4YZF | 3.5 | Crystal structure of the anion exchanger domain of human erythrocyte Band 3 |
7TVZ | 3.6 | Cryo-EM structure of human band 3-protein 4.2 complex in diagonal conformation |
7TW0 | 4.6 | Cryo-EM structure of human band 3-protein 4.2 complex in vertical conformation |
7TW1 | 4.6 | Cryo-EM structure of human band 3-protein 4.2 complex (B2P2vertical) |
7TW2 | 4.8 | Cryo-EM structure of human band 3 dimer from red blood cell |
7TW3 | 4.4 | Cryo-EM structure of human ankyrin complex (B2P1A1) from red blood cell |
7TW5 | 5.7 | Cryo-EM structure of human ankyrin complex (B2P1A2) from red blood cell |
7TW6 | 5.6 | Cryo-EM structure of human ankyrin complex (B4P1A1) from red blood cell |
7UZ3 | 2.35 | Band 3-Glycophorin A complex, outward facing |
7UZU | 2.3 | Ankyrin-1 (N-terminal region of membrane binding domain, local refinement from consensus reconstruction; bound to N-terminal peptide from band 3) |
7UZV | 2.5 | Cytoplasmic domains of Band 3-I (local refinement from consensus reconstruction of ankyrin complexes) |
7V07 | 2.8 | Band 3-I-TM local refinement from erythrocyte ankyrin-1 complex consensus reconstruction |
7V0K | 2.4 | Consensus refinement of human erythrocyte ankyrin-1 complex (Composite map) |
7V0M | 2.7 | Local refinement of ankyrin-1 (N-terminal half), class 1 of erythrocyte ankyrin-1 complex |
7V0T | 2.7 | Local refinement of Band 3-I cytoplasmic domains, class 1 of erythrocyte ankyrin-1 complex |
7V0U | 3.0 | Local refinement of Band 3-II cytoplasmic domains, class 1 of erythrocyte ankyrin-1 complex |
7V0Y | 3.0 | Local refinement of Band 3-III cytoplasmic domains, class 1 of erythrocyte ankyrin-1 complex |
7V19 | 3.3 | Local refinement of Band 3-II transmembrane domains, class 1 of erythrocyte ankyrin-1 complex |
8CRQ | 3.2 | Local refinement of Band 3-I transmembrane domains, class 1 of erythrocyte ankyrin-1 complex |
8CRR | 3.0 | Local refinement of Band 3-III transmembrane domains, class 1 of erythrocyte ankyrin-1 complex |
8CRT | 3.0 | Local refinement of Rh trimer, glycophorin B and Band3-III transmembrane region, class 1a of erythrocyte ankyrin-1 complex |
8CS9 | 2.74 | Composite reconstruction of Class 1 of the erythrocyte ankyrin-1 complex |
8CSL | 25.0 | Sub-tomogram averaging of erythrocyte ankyrin-1 complex |
8CSV | 2.7 | Local refinement of Anykyrin-1 (N-terminal half of membrane binding domain) in Class 2 of erythrocyte ankyrin-1 complex |
8CSY | 2.7 | Local refinement of cytoplasmic domains of band3-I in class 2 of erythrocyte ankyrin-1 complex |
8CT3 | 3.3 | Local refinement of band3-I transmembrane region from class 2 of erythrocyte ankyrin-1 complex |
8CTE | 2.9 | Class 2 of erythrocyte ankyrin-1 complex (Composite map) |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0015701 | bicarbonate transport |
Biological Process | GO:0007596 | blood coagulation |
Biological Process | GO:1902476 | chloride transmembrane transport |
Biological Process | GO:0006821 | chloride transport |
Biological Process | GO:0048821 | erythrocyte development |
Biological Process | GO:0006873 | intracellular monoatomic ion homeostasis |
Biological Process | GO:0006820 | monoatomic anion transport |
Biological Process | GO:1904539 | negative regulation of glycolytic process through fructose-6-phosphate |
Biological Process | GO:0051354 | negative regulation of oxidoreductase activity |
Biological Process | GO:0035811 | negative regulation of urine volume |
Biological Process | GO:0045852 | pH elevation |
Biological Process | GO:0017121 | plasma membrane phospholipid scrambling |
Biological Process | GO:0072659 | protein localization to plasma membrane |
Biological Process | GO:0051453 | regulation of intracellular pH |
Biological Process | GO:0055085 | transmembrane transport |
Molecular Function | GO:0030506 | ankyrin binding |
Molecular Function | GO:0015106 | bicarbonate transmembrane transporter activity |
Molecular Function | GO:0015108 | chloride transmembrane transporter activity |
Molecular Function | GO:0140900 | chloride:bicarbonate antiporter activity |
Molecular Function | GO:0030492 | hemoglobin binding |
Molecular Function | GO:0008509 | monoatomic anion transmembrane transporter activity |
Molecular Function | GO:0042803 | protein homodimerization activity |
Molecular Function | GO:0043495 | protein-membrane adaptor activity |
Molecular Function | GO:0005452 | solute:inorganic anion antiporter activity |
Cellular Component | GO:0030018 | Z disc |
Cellular Component | GO:0016323 | basolateral plasma membrane |
Cellular Component | GO:0072562 | blood microparticle |
Cellular Component | GO:0030863 | cortical cytoskeleton |
Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0005886 | plasma membrane |
InterPro | InterPro name |
---|---|
IPR001717 | Anion exchange protein |
IPR002977 | Anion exchange protein 1 |
IPR003020 | Bicarbonate transporter, eukaryotic |
IPR011531 | Bicarbonate transporter-like, transmembrane domain |
IPR013769 | Band 3 cytoplasmic domain |
IPR016152 | Phosphotransferase/anion transporter |
IPR018241 | Anion exchange, conserved site |
Pfam | Pfam name |
---|---|
PF00955 | HCO3- transporter family |
PF07565 | Band 3 cytoplasmic domain |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | Leaf | R-HSA-382551 | Transport of small molecules |
R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | Leaf | R-HSA-382551 | Transport of small molecules |
R-HSA-425381 | Bicarbonate transporters | Leaf | R-HSA-382551 | Transport of small molecules |
R-HSA-5619050 | Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) | Leaf | R-HSA-1643685 | Disease |
Location | ECO term | Pubmed |
---|---|---|
Basolateral cell membrane | ECO:0000269 | PubMed:7506871 |
Cell membrane | ECO:0000269 | PubMed:10926824 |
Cell membrane | ECO:0000269 | PubMed:24121512 |
Cell membrane | ECO:0000269 | PubMed:26542571 |
Cell membrane | ECO:0000269 | PubMed:7506871 |
HPO ID | HPO name |
---|---|
HP:0000006 | Autosomal dominant inheritance |
HP:0000007 | Autosomal recessive inheritance |
HP:0000121 | Nephrocalcinosis |
HP:0000787 | Nephrolithiasis |
HP:0000952 | Jaundice |
HP:0000969 | Edema |
HP:0000980 | Pallor |
HP:0001046 | Intermittent jaundice |
HP:0001081 | Cholelithiasis |
HP:0001251 | Ataxia |
HP:0001254 | Lethargy |
HP:0001324 | Muscle weakness |
HP:0001433 | Hepatosplenomegaly |
HP:0001508 | Failure to thrive |
HP:0001510 | Growth delay |
HP:0001723 | Restrictive cardiomyopathy |
HP:0001744 | Splenomegaly |
HP:0001878 | Hemolytic anemia |
HP:0001901 | Polycythemia |
HP:0001903 | Anemia |
HP:0001907 | Thromboembolism |
HP:0001923 | Reticulocytosis |
HP:0001930 | Nonspherocytic hemolytic anemia |
HP:0001942 | Metabolic acidosis |
HP:0001945 | Fever |
HP:0001972 | Macrocytic anemia |
HP:0001978 | Extramedullary hematopoiesis |
HP:0001981 | Schistocytosis |
HP:0001997 | Gout |
HP:0002027 | Abdominal pain |
HP:0002039 | Anorexia |
HP:0002240 | Hepatomegaly |
HP:0002748 | Rickets |
HP:0002749 | Osteomalacia |
HP:0002756 | Pathologic fracture |
HP:0002900 | Hypokalemia |
HP:0002901 | Hypocalcemia |
HP:0002904 | Hyperbilirubinemia |
HP:0003259 | Elevated circulating creatinine concentration |
HP:0003265 | Neonatal hyperbilirubinemia |
HP:0003270 | Abdominal distention |
HP:0003281 | Increased circulating ferritin concentration |
HP:0003326 | Myalgia |
HP:0003573 | Increased total bilirubin |
HP:0003621 | Juvenile onset |
HP:0004322 | Short stature |
HP:0004444 | Spherocytosis |
HP:0004445 | Elliptocytosis |
HP:0004446 | Stomatocytosis |
HP:0004804 | Congenital hemolytic anemia |
HP:0004918 | Hyperchloremic metabolic acidosis |
HP:0005502 | Increased red cell osmotic fragility |
HP:0005518 | Increased mean corpuscular volume |
HP:0005525 | Spontaneous hemolytic crises |
HP:0008341 | Distal renal tubular acidosis |
HP:0010972 | Anemia of inadequate production |
HP:0011042 | Abnormal blood potassium concentration |
HP:0011462 | Young adult onset |
HP:0011900 | Hypofibrinogenemia |
HP:0012431 | Episodic fatigue |
HP:0020063 | Increased hemoglobin concentration |
HP:0025066 | Decreased mean corpuscular volume |
HP:0025143 | Chills |
HP:0025435 | Increased circulating lactate dehydrogenase concentration |
HP:0025548 | Increased mean corpuscular hemoglobin concentration |
HP:0030036 | Isothenuria |
HP:0030242 | Portal vein thrombosis |
HP:0030950 | Pulmonary venous hypertension |
HP:0031033 | Impaired urinary acidification |
HP:0040186 | Maculopapular exanthema |
HP:0100724 | Hypercoagulability |
HP:0200042 | Skin ulcer |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
renal tubular acidosis | MONDO:0001909 | N25 | chapter14, Diseases of the genitourinary system | ||
southeast asian ovalocytosis | MONDO:0008165 | D58 | chapter3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | OMIM:166900 | Orphanet:98868 |
autosomal dominant distal renal tubular acidosis | MONDO:0008368 | N25 | chapter14, Diseases of the genitourinary system | OMIM:179800 | Orphanet:93608 |
cryohydrocytosis | MONDO:0008494 | D58 | chapter3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | OMIM:185020 | Orphanet:398088 |
renal tubular acidosis, distal, 4, with hemolytic anemia | MONDO:0012700 | N25 | chapter14, Diseases of the genitourinary system | OMIM:611590 | Orphanet:93610 |
hereditary spherocytosis type 4 | MONDO:0012981 | D58 | chapter3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | OMIM:612653 | |
dehydrated hereditary stomatocytosis | MONDO:0017910 | D58 | chapter3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Orphanet:3202 |