MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1AIN	2.5	CRYSTAL STRUCTURE OF HUMAN ANNEXIN I AT 2.5 ANGSTROMS RESOLUTION
1BO9		NMR SOLUTION STRUCTURE OF DOMAIN 1 OF HUMAN ANNEXIN I
1QLS	2.3	S100C (S100A11),OR CALGIZZARIN, IN COMPLEX WITH ANNEXIN I N-TERMINUS
5VFW		An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease

GO term

GO ontology	GO term	GO description
Biological Process	GO:0032508	DNA duplex unwinding
Biological Process	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Biological Process	GO:0031532	actin cytoskeleton reorganization
Biological Process	GO:0002250	adaptive immune response
Biological Process	GO:0046632	alpha-beta T cell differentiation
Biological Process	GO:0050482	arachidonic acid secretion
Biological Process	GO:0007166	cell surface receptor signaling pathway
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus
Biological Process	GO:0070301	cellular response to hydrogen peroxide
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus
Biological Process	GO:0031018	endocrine pancreas development
Biological Process	GO:0042063	gliogenesis
Biological Process	GO:0071621	granulocyte chemotaxis
Biological Process	GO:0070365	hepatocyte differentiation
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0045087	innate immune response
Biological Process	GO:0030073	insulin secretion
Biological Process	GO:0030216	keratinocyte differentiation
Biological Process	GO:0051179	localization
Biological Process	GO:0002548	monocyte chemotaxis
Biological Process	GO:0014839	myoblast migration involved in skeletal muscle regeneration
Biological Process	GO:0045629	negative regulation of T-helper 2 cell differentiation
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0045920	negative regulation of exocytosis
Biological Process	GO:0032717	negative regulation of interleukin-8 production
Biological Process	GO:1900138	negative regulation of phospholipase A2 activity
Biological Process	GO:0042119	neutrophil activation
Biological Process	GO:0097350	neutrophil clearance
Biological Process	GO:0001780	neutrophil homeostasis
Biological Process	GO:0018149	peptide cross-linking
Biological Process	GO:0006909	phagocytosis
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
Biological Process	GO:0042102	positive regulation of T cell proliferation
Biological Process	GO:0045627	positive regulation of T-helper 1 cell differentiation
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis
Biological Process	GO:0032743	positive regulation of interleukin-2 production
Biological Process	GO:0033031	positive regulation of neutrophil apoptotic process
Biological Process	GO:0031394	positive regulation of prostaglandin biosynthetic process
Biological Process	GO:0031340	positive regulation of vesicle fusion
Biological Process	GO:0090303	positive regulation of wound healing
Biological Process	GO:0070459	prolactin secretion
Biological Process	GO:0030850	prostate gland development
Biological Process	GO:0008360	regulation of cell shape
Biological Process	GO:0046883	regulation of hormone secretion
Biological Process	GO:0050727	regulation of inflammatory response
Biological Process	GO:0032652	regulation of interleukin-1 production
Biological Process	GO:0002685	regulation of leukocyte migration
Biological Process	GO:0010165	response to X-ray
Biological Process	GO:0032355	response to estradiol
Biological Process	GO:0070555	response to interleukin-1
Biological Process	GO:0043434	response to peptide hormone
Biological Process	GO:0007165	signal transduction
Molecular Function	GO:0098641	cadherin binding involved in cell-cell adhesion
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0005544	calcium-dependent phospholipid binding
Molecular Function	GO:0048306	calcium-dependent protein binding
Molecular Function	GO:0008289	lipid binding
Molecular Function	GO:0019834	phospholipase A2 inhibitor activity
Molecular Function	GO:0005543	phospholipid binding
Molecular Function	GO:0005102	signaling receptor binding
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0016324	apical plasma membrane
Cellular Component	GO:0016323	basolateral plasma membrane
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0062023	collagen-containing extracellular matrix
Cellular Component	GO:0001533	cornified envelope
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0031901	early endosome membrane
Cellular Component	GO:0005768	endosome
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0031232	extrinsic component of external side of plasma membrane
Cellular Component	GO:0019898	extrinsic component of membrane
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0016328	lateral plasma membrane
Cellular Component	GO:0031514	motile cilium
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0001891	phagocytic cup
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0042383	sarcolemma
Cellular Component	GO:0031982	vesicle

InterPro / Pfam

InterPro	InterPro name
IPR001464	Annexin
IPR002388	Annexin A1
IPR018252	Annexin repeat, conserved site
IPR018502	Annexin repeat
IPR037104	Annexin superfamily

Pfam	Pfam name
PF00191	Annexin

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-416476	G alpha (q) signalling events	Internal node	R-HSA-162582	Signal Transduction
R-HSA-418594	G alpha (i) signalling events	Internal node	R-HSA-162582	Signal Transduction
R-HSA-444473	Formyl peptide receptors bind formyl peptides and many other ligands	Leaf	R-HSA-162582	Signal Transduction
R-HSA-445355	Smooth Muscle Contraction	Leaf	R-HSA-397014	Muscle contraction
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	Leaf	R-HSA-168256	Immune System

Subcellular location

Location	ECO term	Pubmed
Apical cell membrane	ECO:0000250
Basolateral cell membrane	ECO:0000250
Cell membrane	ECO:0000269	PubMed:10772777
Cell membrane	ECO:0000269	PubMed:19625660
Cell membrane	ECO:0000269	PubMed:25664854
Cell projection, cilium	ECO:0000250
Cell projection, phagocytic cup	ECO:0000250
Cytoplasm	ECO:0000269	PubMed:10772777
Cytoplasm	ECO:0000269	PubMed:17008549
Cytoplasm	ECO:0000269	PubMed:19625660
Cytoplasmic vesicle membrane	ECO:0000250
Cytoplasmic vesicle, secretory vesicle lumen	ECO:0000269	PubMed:10772777
Early endosome	ECO:0000250
Endosome membrane	ECO:0000250
Lateral cell membrane	ECO:0000250
Membrane	ECO:0000269	PubMed:17008549
Membrane	ECO:0000269	PubMed:2532504
Membrane	ECO:0000269	PubMed:8557678
Nucleus	ECO:0000269	PubMed:10772777
Nucleus	ECO:0000269	PubMed:19625660
Secreted	ECO:0000269	PubMed:17008549
Secreted	ECO:0000269	PubMed:19625660
Secreted	ECO:0000269	PubMed:25664854
Secreted, extracellular exosome	ECO:0000269	PubMed:25664854
Secreted, extracellular space	ECO:0000269	PubMed:25664854

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Enhanced
appendix	lymphoid tissue	Medium	Enhanced
bone marrow	hematopoietic cells	High	Enhanced
breast	glandular cells	Medium	Enhanced
breast	myoepithelial cells	Medium	Enhanced
bronchus	respiratory epithelial cells	High	Enhanced
cerebral cortex	endothelial cells	Medium	Enhanced
cervix	glandular cells	Medium	Enhanced
cervix	squamous epithelial cells	High	Enhanced
colon	endothelial cells	Medium	Enhanced
endometrium 1	glandular cells	Medium	Enhanced
endometrium 2	glandular cells	Medium	Enhanced
epididymis	glandular cells	Medium	Enhanced
esophagus	squamous epithelial cells	High	Enhanced
fallopian tube	glandular cells	High	Enhanced
kidney	bowman's capsule	High	Enhanced
lung	alveolar cells type II	Medium	Enhanced
lung	macrophages	High	Enhanced
lymph node	non-germinal center cells	Medium	Enhanced
nasopharynx	respiratory epithelial cells	High	Enhanced
oral mucosa	squamous epithelial cells	High	Enhanced
placenta	decidual cells	High	Enhanced
placenta	trophoblastic cells	High	Enhanced
prostate	glandular cells	High	Enhanced
salivary gland	glandular cells	Medium	Enhanced
seminal vesicle	glandular cells	Medium	Enhanced
skin 1	cells in basal layer	Medium	Enhanced
skin 1	eccrine glands	High	Enhanced
skin 1	endothelial cells	Low	Enhanced
skin 1	fibrohistiocytic cells	High	Enhanced
skin 1	langerhans cells	Medium	Enhanced
skin 1	lymphocytes	High	Enhanced
skin 1	melanocytes	High	Enhanced
skin 1	sebaceous glands	Medium	Enhanced
skin 2	cells in basal layer	Medium	Enhanced
skin 2	cells in corneal layer	Low	Enhanced
skin 2	cells in granular layer	Low	Enhanced
skin 2	cells in spinous layer	Low	Enhanced
skin 2	endothelial cells	Low	Enhanced
skin 2	fibrohistiocytic cells	High	Enhanced
skin 2	langerhans cells	Medium	Enhanced
skin 2	lymphocytes	High	Enhanced
skin 2	melanocytes	High	Enhanced
soft tissue 1	chondrocytes	Medium	Enhanced
soft tissue 1	fibroblasts	High	Enhanced
soft tissue 1	peripheral nerve	Low	Enhanced
soft tissue 2	chondrocytes	Low	Enhanced
soft tissue 2	fibroblasts	Medium	Enhanced
soft tissue 2	peripheral nerve	Low	Enhanced
spleen	cells in red pulp	High	Enhanced
spleen	cells in white pulp	Low	Enhanced
thyroid gland	glandular cells	Low	Enhanced
tonsil	non-germinal center cells	Medium	Enhanced
tonsil	squamous epithelial cells	High	Enhanced
urinary bladder	urothelial cells	Medium	Enhanced
vagina	squamous epithelial cells	Medium	Enhanced

Disease

Summary of P04083

Gene: ANXA1, ANX1, LPC1
Protein: Annexin A1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P04083

Gene: ANXA1, ANX1, LPC1 Protein: Annexin A1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: ANXA1, ANX1, LPC1
Protein: Annexin A1