MultifacetedProtDB - Bologna Biocomputing Group

Catalytic activity

EC number	EC number description
2.3.1.43	Transferases; Acyltransferases; Transferring groups other than aminoacyl groups; phosphatidylcholine—sterol O-acyltransferase
3.1.1.47	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; 1-alkyl-2-acetylglycerophosphocholine esterase

Publications

PDB	Resolution (Å)	PDB name
4X96	8.69	Low resolution crystal structure of Lecithin:Cholesterol Acyltransferase (LCAT; residues 21-397)
4XWG	2.65	Crystal Structure of LCAT (C31Y) in complex with Fab1
4XX1	3.6	Low resolution structure of LCAT in complex with Fab1
5BV7	2.45	Crystal structure of human LCAT (L4F, N5D) in complex with Fab of an agonistic antibody
5TXF	3.1	Crystal structure of Lecithin:cholesterol acyltransferase (LCAT) in a closed conformation
6MVD	3.1	Crystal structure of Lecithin:cholesterol acyltransferase (LCAT) in complex with isopropyl dodec-11-enylfluorophosphonate (IDFP) and a small molecule activator

GO ontology	GO term	GO description
Biological Process	GO:0042632	cholesterol homeostasis
Biological Process	GO:0008203	cholesterol metabolic process
Biological Process	GO:0030301	cholesterol transport
Biological Process	GO:0034375	high-density lipoprotein particle remodeling
Biological Process	GO:0042158	lipoprotein biosynthetic process
Biological Process	GO:0006656	phosphatidylcholine biosynthetic process
Biological Process	GO:0046470	phosphatidylcholine metabolic process
Biological Process	GO:0006644	phospholipid metabolic process
Biological Process	GO:0090107	regulation of high-density lipoprotein particle assembly
Biological Process	GO:0046688	response to copper ion
Biological Process	GO:0051384	response to glucocorticoid
Biological Process	GO:0043691	reverse cholesterol transport
Biological Process	GO:0034372	very-low-density lipoprotein particle remodeling
Molecular Function	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity
Molecular Function	GO:0034186	apolipoprotein A-I binding
Molecular Function	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity
Molecular Function	GO:0004623	phospholipase A2 activity
Molecular Function	GO:0047179	platelet-activating factor acetyltransferase activity
Molecular Function	GO:0004771	sterol esterase activity
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0034364	high-density lipoprotein particle

InterPro	InterPro name
IPR003386	Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase
IPR029058	Alpha/Beta hydrolase fold

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000083	Renal insufficiency
HP:0000093	Proteinuria
HP:0000505	Visual impairment
HP:0001084	Corneal arcus
HP:0001681	Angina pectoris
HP:0001744	Splenomegaly
HP:0001878	Hemolytic anemia
HP:0001895	Normochromic anemia
HP:0002155	Hypertriglyceridemia
HP:0002240	Hepatomegaly
HP:0002621	Atherosclerosis
HP:0002716	Lymphadenopathy
HP:0003141	Increased LDL cholesterol concentration
HP:0003233	Decreased HDL cholesterol concentration
HP:0003362	Increased VLDL cholesterol concentration
HP:0003581	Adult onset
HP:0003651	Foam cells
HP:0007759	Opacification of the corneal stroma
HP:0007957	Corneal opacity
HP:0025433	Decreased lecithin cholesterol acyl transferase level

Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM	Orphanet
fish eye disease	MONDO:0007620	E78	chapter4, Endocrine, nutritional and metabolic diseases	OMIM:136120	Orphanet:79292
norum disease	MONDO:0009515	E78	chapter4, Endocrine, nutritional and metabolic diseases	OMIM:245900	Orphanet:79293