Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
1.2.1.12
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor;
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
2.6.99.-
Transferases;
Transferring nitrogenous groups;
Transferring other nitrogenous groups;
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1U8F | 1.75 | Crystal Structure Of Human Placental Glyceraldehyde-3-Phosphate Dehydrogenase At 1.75 Resolution |
| 1ZNQ | 2.5 | Crystal Structure of Human Liver GAPDH |
| 3GPD | 3.5 | TWINNING IN CRYSTALS OF HUMAN SKELETAL MUSCLE D-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE |
| 4WNC | 1.99 | Crystal structure of human wild-type GAPDH at 1.99 angstroms resolution |
| 4WNI | 2.3 | Crystal structure of the T229K mutant of human GAPDH at 2.3 angstroems resolution |
| 6ADE | 3.15 | Crystal structure of phosphorylated mutant of glyceraldehyde 3-phosphate dehydrogenase from human placenta at 3.15A resolution |
| 6IQ6 | 2.29 | Crystal structure of GAPDH |
| 6M61 | 1.8245 | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) with inhibitor heptelidic acid |
| 6YND | 1.525 | GAPDH purified from the supernatant of HEK293F cells: crystal form 1 of 4. |
| 6YNE | 1.853 | GAPDH purified from the supernatant of HEK293F cells: crystal form 2 of 4. |
| 6YNF | 2.394 | GAPDH purified from the supernatant of HEK293F cells: crystal form 3 of 4. |
| 6YNH | 2.621 | GAPDH purified from the supernatant of HEK293F cells: crystal form 4 of 4 |
| 8DNS | 3.22 | Human Brain Glyceraldehyde 3-phosphate dehydrogenase |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide |
| Biological Process | GO:0071346 | cellular response to type II interferon |
| Biological Process | GO:0050832 | defense response to fungus |
| Biological Process | GO:0006006 | glucose metabolic process |
| Biological Process | GO:0006096 | glycolytic process |
| Biological Process | GO:0051873 | killing by host of symbiont cells |
| Biological Process | GO:0031640 | killing of cells of another organism |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0010951 | negative regulation of endopeptidase activity |
| Biological Process | GO:0017148 | negative regulation of translation |
| Biological Process | GO:0051402 | neuron apoptotic process |
| Biological Process | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation |
| Biological Process | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| Biological Process | GO:0001819 | positive regulation of cytokine production |
| Biological Process | GO:0032481 | positive regulation of type I interferon production |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0016241 | regulation of macroautophagy |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0050661 | NADP binding |
| Molecular Function | GO:0019828 | aspartic-type endopeptidase inhibitor activity |
| Molecular Function | GO:0097718 | disordered domain specific binding |
| Molecular Function | GO:0004365 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0035605 | peptidyl-cysteine S-nitrosylase activity |
| Cellular Component | GO:0097452 | GAIT complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
| Cellular Component | GO:0005811 | lipid droplet |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0031982 | vesicle |
| InterPro
|
InterPro name |
|---|---|
| IPR006424 | Glyceraldehyde-3-phosphate dehydrogenase, type I |
| IPR020828 | Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain |
| IPR020829 | Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain |
| IPR020830 | Glyceraldehyde 3-phosphate dehydrogenase, active site |
| IPR020831 | Glyceraldehyde/Erythrose phosphate dehydrogenase family |
| IPR036291 | NAD(P)-binding domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00044 | Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain |
| PF02800 | Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-70171 | Glycolysis | Internal node | R-HSA-1430728 | Metabolism |
| R-HSA-70263 | Gluconeogenesis | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm, cytoskeleton | ECO:0000250 | |
| Cytoplasm, cytosol | ECO:0000269 | PubMed:12829261 |
| Cytoplasm, perinuclear region | ECO:0000269 | PubMed:12829261 |
| Membrane | ECO:0000269 | PubMed:12829261 |
| Nucleus | ECO:0000250 |