Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
1.2.1.12
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor;
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
2.6.99.-
Transferases;
Transferring nitrogenous groups;
Transferring other nitrogenous groups;
PDB | Resolution (Å) | PDB name |
---|---|---|
1U8F | 1.75 | Crystal Structure Of Human Placental Glyceraldehyde-3-Phosphate Dehydrogenase At 1.75 Resolution |
1ZNQ | 2.5 | Crystal Structure of Human Liver GAPDH |
3GPD | 3.5 | TWINNING IN CRYSTALS OF HUMAN SKELETAL MUSCLE D-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE |
4WNC | 1.99 | Crystal structure of human wild-type GAPDH at 1.99 angstroms resolution |
4WNI | 2.3 | Crystal structure of the T229K mutant of human GAPDH at 2.3 angstroems resolution |
6ADE | 3.15 | Crystal structure of phosphorylated mutant of glyceraldehyde 3-phosphate dehydrogenase from human placenta at 3.15A resolution |
6IQ6 | 2.29 | Crystal structure of GAPDH |
6M61 | 1.8245 | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) with inhibitor heptelidic acid |
6YND | 1.525 | GAPDH purified from the supernatant of HEK293F cells: crystal form 1 of 4. |
6YNE | 1.853 | GAPDH purified from the supernatant of HEK293F cells: crystal form 2 of 4. |
6YNF | 2.394 | GAPDH purified from the supernatant of HEK293F cells: crystal form 3 of 4. |
6YNH | 2.621 | GAPDH purified from the supernatant of HEK293F cells: crystal form 4 of 4 |
8DNS | 3.22 | Human Brain Glyceraldehyde 3-phosphate dehydrogenase |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide |
Biological Process | GO:0071346 | cellular response to type II interferon |
Biological Process | GO:0050832 | defense response to fungus |
Biological Process | GO:0006006 | glucose metabolic process |
Biological Process | GO:0006096 | glycolytic process |
Biological Process | GO:0051873 | killing by host of symbiont cells |
Biological Process | GO:0031640 | killing of cells of another organism |
Biological Process | GO:0000226 | microtubule cytoskeleton organization |
Biological Process | GO:0010951 | negative regulation of endopeptidase activity |
Biological Process | GO:0017148 | negative regulation of translation |
Biological Process | GO:0051402 | neuron apoptotic process |
Biological Process | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation |
Biological Process | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
Biological Process | GO:0001819 | positive regulation of cytokine production |
Biological Process | GO:0032481 | positive regulation of type I interferon production |
Biological Process | GO:0050821 | protein stabilization |
Biological Process | GO:0016241 | regulation of macroautophagy |
Molecular Function | GO:0051287 | NAD binding |
Molecular Function | GO:0050661 | NADP binding |
Molecular Function | GO:0019828 | aspartic-type endopeptidase inhibitor activity |
Molecular Function | GO:0097718 | disordered domain specific binding |
Molecular Function | GO:0004365 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
Molecular Function | GO:0042802 | identical protein binding |
Molecular Function | GO:0008017 | microtubule binding |
Molecular Function | GO:0035605 | peptidyl-cysteine S-nitrosylase activity |
Cellular Component | GO:0097452 | GAIT complex |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
Cellular Component | GO:0005811 | lipid droplet |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0015630 | microtubule cytoskeleton |
Cellular Component | GO:0031965 | nuclear membrane |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
Cellular Component | GO:0005886 | plasma membrane |
Cellular Component | GO:1990904 | ribonucleoprotein complex |
Cellular Component | GO:0031982 | vesicle |
InterPro | InterPro name |
---|---|
IPR006424 | Glyceraldehyde-3-phosphate dehydrogenase, type I |
IPR020828 | Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain |
IPR020829 | Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain |
IPR020830 | Glyceraldehyde 3-phosphate dehydrogenase, active site |
IPR020831 | Glyceraldehyde/Erythrose phosphate dehydrogenase family |
IPR036291 | NAD(P)-binding domain superfamily |
Pfam | Pfam name |
---|---|
PF00044 | Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain |
PF02800 | Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-70171 | Glycolysis | Internal node | R-HSA-1430728 | Metabolism |
R-HSA-70263 | Gluconeogenesis | Leaf | R-HSA-1430728 | Metabolism |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm, cytoskeleton | ECO:0000250 | |
Cytoplasm, cytosol | ECO:0000269 | PubMed:12829261 |
Cytoplasm, perinuclear region | ECO:0000269 | PubMed:12829261 |
Membrane | ECO:0000269 | PubMed:12829261 |
Nucleus | ECO:0000250 |