MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
2MWO		Solution structure of 53BP1 tandem Tudor domains in complex with a p53K370me2 peptide
2FOJ	1.6	The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 364-367
2AHI	1.85	Structural Basis of DNA Recognition by p53 Tetramers (complex III)
1YCS	2.2	P53-53BP2 COMPLEX
3D09	1.9	Human p53 core domain with hot spot mutation R249S and second-site suppressor mutations H168R and T123A
6GGC	1.24	p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9320
5ABA	1.62	Structure of the p53 cancer mutant Y220C with bound small-molecule stabilizer PhiKan5149
5AOM	1.74	Structure of the p53 cancer mutant Y220C with bound small molecule PhiKan883
5MF7	1.59	New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-GADD45)
1YCQ	2.3	XENOPUS LAEVIS MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF HUMAN P53
1DT7		SOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)
5G4O	1.48	Crystal structure of the p53 cancer mutant Y220C in complex with a trifluorinated derivative of the small molecule stabilizer Phikan083
1C26	1.7	CRYSTAL STRUCTURE OF P53 TETRAMERIZATION DOMAIN
7DVD	2.59	The crystal structure of p53 DNA binding domain and PUMA complex
4KVP	1.5	Human p53 Core Domain Mutant V157F
1H26	2.24	CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53
6RKK	1.88	Fragment AZ-021 binding at the p53pT387/14-3-3 sigma interface
3D08	1.4	Human p53 core domain with hot spot mutation R249S and second-site suppressor mutation H168R
8A31	1.46	p53 cancer mutant Y220C in complex with iodophenol-based small-molecule stabilizer JC694
4IBQ	1.8	Human p53 core domain with hot spot mutation R273C
8DC6	1.60001	Crystal structure of p53 Y220C covalently bound to indole KG6
2PCX	1.54	Crystal structure of p53DBD(R282Q) at 1.54-angstrom Resolution
4MZR	2.9	Crystal structure of a polypeptide p53 mutant bound to DNA
4AGO	1.45	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5174
6VR5	2.38	Complex of HLA-A2, a class I MHC, with a p53 peptide
4HJE	1.907	Crystal structure of p53 core domain in complex with DNA
6GGF	1.32	Structure of the p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9328
6S40	1.9	Fragment AZ-001 binding at the p53pT387/14-3-3 sigma interface and additional sites
5MG7	1.45	New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-p53R2)
4XR8	2.25	Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution
5O1C	1.32	p53 cancer mutant Y220C in complex with compound MB184
2AC0	1.8	Structural Basis of DNA Recognition by p53 Tetramers (complex I)
4IJT	1.78	Human p53 core domain with hot spot mutation R273H (form II)
2BIP	1.8	human p53 core domain mutant M133L-H168R-V203A-N239Y-R249S-N268D
2WGX	1.75	HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y236F-N239Y-T253I-N268D
7B4D	1.85	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C/S240R double mutant bound to DNA and MQ: R273C/S240R-DNA-MQ
5LAP	1.42	p53 cancer mutant Y220C with Cys182 alkylation
4RP7	1.576	Structure of the amyloid-forming segment TIITLE from p53 (residues 253-258)
5O1I	1.4	p53 cancer mutant Y220C in complex with compound MB710
4HFZ	2.694	Crystal Structure of an MDM2/P53 Peptide Complex
5G4N	1.35	Crystal structure of the p53 cancer mutant Y220C in complex with a difluorinated derivative of the small molecule stabilizer Phikan083
2XWR	1.68	Crystal structure of the DNA-binding domain of human p53 with extended N terminus
5MCW	1.897	New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LWC2)
6LHD	2.499	Crystal structure of p53/BCL-xL fusion complex
6RKM	1.88	Fragment AZ-022 binding at the p53pT387/14-3-3 sigma interface
5MHC	1.2	Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide
1SAK		HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAC STRUCTURES)
6RL6	1.6	Fragment AZ-024 binding at the p53pT387/14-3-3 sigma interface
2BIO	1.9	human p53 core domain mutant M133L-V203A-N239Y-R249S-N268D
3D0A	1.8	Human p53 core domain with hot spot mutation R249S and second site suppressor mutation H168R in sequence-specific complex with DNA
8DC7	1.98701	Crystal structure of p53 Y220C covalently bound to indole KG10
5AOJ	1.47	Structure of the p53 cancer mutant Y220C in complex with 2-hydroxy-3, 5-diiodo-4-(1H-pyrrol-1-yl)benzoic acid
2J1Y	1.69	Human p53 core domain mutant M133L-V203A-N239Y-G245S-N268D
5O1G	1.35	p53 cancer mutant Y220C in complex with compound MB487
7B4B	1.76	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C mutant bound to MQ: R273C-MQ (I)
6RJZ	1.58	Fragment AZ-015 binding at the p53pT387/14-3-3 sigma interface
4AGM	1.52	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5086
7YGI	2.1	Crystal structure of p53 DBD domain in complex with azurin
6RWU	1.46	Fragment AZ-010 binding at the p53pT387/14-3-3 sigma interface
3DAB	1.9	Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
6VRM	2.61	T cell receptor-p53-HLA-A2 complex
2MZD		Characterization of the p300 Taz2-p53 TAD2 Complex and Comparison with the p300 Taz2-p53 TAD1 Complex
4AGL	1.7	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan784
3DAC	1.8	Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
2K8F		Structural Basis for the Regulation of p53 Function by p300
8F2I	5.0	P53 monomer structure
5HPD		Solution Structure of TAZ2-p53TAD
3Q01	2.1	An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
5O1D	1.36	p53 cancer mutant Y220C in complex with compound MB481
7DHZ	1.74	Arsenic-bound p53 DNA-binding domain mutant R249S
7RM4	3.33	Neoantigen p53R175H-specific TCR 6-11 binds to p53R175H-HLA-A2
7B48	2.05	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (II)
5AOK	1.35	Structure of the p53 cancer mutant Y220C with bound small molecule PhiKan7099
5MCU	1.7	New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LHG2)
5ECG	3.0	Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (gammaH2AX)
6V4H	1.53	Crystal Structure Analysis of Zebra Fish MDMX
6SI4	1.8	p53 cancer mutant Y220S in complex with small-molecule stabilizer PK9323
7XZX	4.53	Cryo-EM structure of the nucleosome in complex with p53 DNA-binding domain
2VUK	1.5	Structure of the p53 core domain mutant Y220C bound to the stabilizing small-molecule drug PhiKan083
7V97	2.02	Arsenic-bound p53 DNA-binding domain mutant V272M
7BWN	2.396	Crystal Structure of a Designed Protein Heterocatenane
6SL6	1.67	p53 charged core
7EL4	2.11	The crystal structure of p53p peptide fragment in complex with the N-terminal domain of MdmX
2H59	1.9	Sir2 H116A-deacetylated p53 peptide-3'-o-acetyl ADP ribose
3OQ5	2.5005	Crystal structure of the 3-MBT domain from human L3MBTL1 in complex with p53K382me1
3KZ8	1.91	Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 3)
5O1A	1.44	p53 cancer mutant Y220C in complex with compound MB240
1HS5		NMR SOLUTION STRUCTURE OF DESIGNED P53 DIMER
7B4A	1.9	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA: R273H-DNA
7EEU	2.9	Human p53 core domain with hot spot mutation R282W in complex with the natural CDKN1A(p21) p53-response element and Arsenic
6RK8	1.602	Fragment AZ-014 binding at the p53pT387/14-3-3 sigma interface
4IBT	1.7	Human p53 core domain with hot spot mutation R273H and second-site suppressor mutation T284R
2Z5T	2.3	Molecular basis for the inhibition of p53 by Mdmx
4ZZJ	2.7403	SIRT1/Activator/Substrate Complex
6RX2	1.82	Fragment AZ-005 binding at the p53pT387/14-3-3 sigma interface
6RL3	1.3	Fragment AZ-003 binding at the p53pT387/14-3-3 sigma interface
5OL0	1.99	Structure of Leishmania infantum Silent Information Regulator 2 related protein 1 (LiSIR2rp1) in complex with acetylated p53 peptide
3SAK		HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAC STRUCTURES)
6S9Q	1.69	Fragment AZ-004 binding at a primary and secondary site in a p53pT387/14-3-3 complex
5O1E	1.3	p53 cancer mutant Y220C im complex with compound MB577
6ZNC	1.64	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (I)
5XZC	10.7	Cryo-EM structure of p300-p53 protein complex
5HOU		Solution Structure of p53TAD-TAZ1
2MWP		Solution structure of 53BP1 tandem Tudor domains in complex with a p53K382me2 peptide
8A92	1.37	p53-Y220C Core Domain in Complex with a Bromo-trifluoro-pyrazole-amine
3LW1	1.28	Binary complex of 14-3-3 sigma and p53 pT387-peptide
6RL4	1.6	Fragment AZ-025 binding at the p53pT387/14-3-3 sigma interface
6GGD	1.40001	p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9324
2J10		p53 tetramerization domain mutant T329F Q331K
4BUZ	1.9	SIR2 COMPLEX STRUCTURE MIXTURE OF EX-527 INHIBITOR AND REACTION PRODUCTS OR OF REACTION SUBSTRATES P53 PEPTIDE AND NAD
7B4F	1.78	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (I)
7B4G	1.86	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (II)
2J20	1.8	Human p53 core domain mutant M133L-V203A-N239Y-N268D-R273C
7B47	1.8	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (I)
4LO9	2.5	Human p53 Core Domain Mutant N235K
6XRE	4.6	Structure of the p53/RNA polymerase II assembly
2J1W	1.8	Human p53 core domain mutant M133L-V143A-V203A-N239Y-N268D
2H4H	1.99	Sir2 H116Y mutant-p53 peptide-NAD
6RM5	1.884	Fragment AZ-016 binding at the p53pT387/14-3-3 sigma interface
6VRN	2.46	T cell receptor-p53-HLA-A2 complex
6RWS	1.53	Fragment AZ-009 binding at the p53pT387/14-3-3 sigma interface
1KZY	2.5	Crystal Structure of the 53bp1 BRCT Region Complexed to Tumor Suppressor P53
7EAX	2.55	Crystal complex of p53-V272M and antimony ion
1YCR	2.6	MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53
6GGE	1.25001	p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9327
7B46	2.02	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (P1)
5O1B	1.43	p53 cancer mutant Y220C in complex with compound MB84
2L14		Structure of CBP nuclear coactivator binding domain in complex with p53 TAD
4AGN	1.6	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5116
3Q05	2.4	An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
4LOF	2.0	Human p53 Core Domain Mutant V157F/N235K/N239Y
1PET		NMR SOLUTION STRUCTURE OF THE TETRAMERIC MINIMUM TRANSFORMING DOMAIN OF P53
4X34	1.801	Crystal structure of the 53BP1 tandem tudor domain in complex with p53K381acK382me2
4AGP	1.5	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5176
3TS8	2.8	Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element
4IBY	1.45	Human p53 core domain with hot spot mutation R273H and second-site suppressor mutation S240R
6RWH	1.68	Fragment AZ-007 binding at a primary and secondary binding site of the the p53pT387/14-3-3 sigma complex
7B4E	1.58	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA and MQ: R282W-DNA-MQ
3D06	1.2	Human p53 core domain with hot spot mutation R249S (I)
6SIN	1.64	Fragment AZ-020 binding at the p53pT387/14-3-3 sigma interface
8DC8	1.7201	Crystal structure of p53 Y220C covalently bound to azaindole KG13
5AB9	1.36	Structure of the p53 cancer mutant Y220C with bound small molecule 7- ethyl-3-(piperidin-4-yl)-1H-indole
2BIM	1.98	human p53 core domain mutant M133L-V203A-N239Y-N268D-R273H
6SI1	1.44	p53 cancer mutant Y220H
4AGQ	1.42	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5196
1PES		NMR SOLUTION STRUCTURE OF THE TETRAMERIC MINIMUM TRANSFORMING DOMAIN OF P53
5MOC	1.8	Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide
3PDH	1.8	Structure of Sir2Tm bound to a propionylated peptide
3D07	2.2	Human p53 core domain with hot spot mutation R249S (III)
7B49	1.42	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA and MQ: R273H-DNA-MQ
6T58	3.1	Structure determination of the transactivation domain of p53 in complex with S100A4 using annexin A2 as a crystallization chaperone
6RM7	1.6	Fragment AZ-026 binding at the p53pT387/14-3-3 sigma interface
4IBV	2.1	Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation S240R in sequence-specific complex with DNA
3KMD	2.15	Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer
6SI3	1.4	p53 cancer mutant Y220S in complex with small-molecule stabilizer PK9301
5HP0		Solution Structure of TAZ2-p53AD2
2RUK		Solution structure of the complex between p53 transactivation domain 2 and TFIIH p62 PH domain
2ATA	2.2	Structural Basis of DNA Recognition by p53 Tetramers (complex II)
3ZME	1.35	Structure of the p53 core domain mutant Y220C bound to the small molecule PhiKan7242
8DC4	2.4	Crystal structure of p53 Y220C covalently bound to carbazole KG3
3D05	1.7	Human p53 core domain with hot spot mutation R249S (II)
6FF9	2.0	Mutant R280K of human P53
5MCT	1.446	New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LHG1)
1TSR	2.2	P53 CORE DOMAIN IN COMPLEX WITH DNA
6W51	3.53	Structure of the antibody fragment H2 in complex with HLA-A*02:01/p53R175H
6R5L	1.884	Fragment AZ-006 binding at the p53pT387/14-3-3 sigma interface
2Z5S	2.3	Molecular basis for the inhibition of p53 by Mdmx
2H4J	2.1	Sir2-deacetylated peptide (from enzymatic turnover in crystal)
6RWI	1.65	Fragment AZ-002 binding at the p53pT387/14-3-3 sigma interface
2GS0		NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and the activation domain of p53
2J1X	1.65	Human p53 core domain mutant M133L-V203A-Y220C-N239Y-N268D
1GZH	2.6	Crystal structure of the BRCT domains of human 53BP1 bound to the p53 tumor supressor
6SLV	1.9	Fragment AZ-013 binding at the p53pT387/14-3-3 sigma interface
1JSP		NMR Structure of CBP Bromodomain in complex with p53 peptide
6VQO	3.0	T cell receptor-p53-HLA-A2 complex
1A1U		SOLUTION STRUCTURE DETERMINATION OF A P53 MUTANT DIMERIZATION DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
6RZ3	4.23	Crystal structure of a complex between the DNA-binding domain of p53 and the carboxyl-terminal conserved region of iASPP
5G4M	1.38	Crystal structure of the p53 cancer mutant Y220C in complex with a monofluorinated derivative of the small molecule stabilizer Phikan083
6V4F	1.35	Crystal Structure Analysis of Zebra Fish MDMX
5O1H	1.32	p53 cancer mutant Y220C in complex with compound MB539
5AOI	1.78	Structure of the p53 cancer mutant Y220C in complex with an indole- based small molecule
2X0U	1.6	STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO A 2-amino substituted benzothiazole scaffold
2H1L	3.16	The Structure of the Oncoprotein SV40 Large T Antigen and p53 Tumor Suppressor Complex
5BUA	1.812	Lysine 120-acetylated P53 DNA binding domain in a complex with DNA.
2H2D	1.7	The Structural Basis for Sirtuin Substrate Affinity
8A32	1.47	p53 cancer mutant Y220C in complex with iodophenol-based small-molecule stabilizer JC769
2BIN	1.9	human p53 core domain mutant M133L-H168R-V203A-N239Y-N268D
6SI0	1.53	p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9323
5MCV	1.6	New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LWC1)
2H2F	2.2	The Structural basis for Sirtuin Substrate affinity
7B4H	1.39	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (III)
3IGK	1.7	Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 2)
6GGB	1.32	p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9318
5LGY	2.92	Lysine 120-acetylated P53 DNA binding domain in a complex with the BAX response element.
6FJ5	2.051	New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-AGG-HG)
2B3G	1.6	p53N (fragment 33-60) bound to RPA70N
6RKI	1.88	Fragment AZ-023 binding at the p53pT387/14-3-3 sigma interface
7B4C	1.71	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C mutant bound to MQ: R273C-MQ (II)
3IGL	1.8	Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 1)
4QO1	1.924	p53 DNA binding domain in complex with Nb139
2FOO	2.2	The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 359-362
1SAE		HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAC STRUCTURES)
1SAL		HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAD STRUCTURES)
7DHY	2.15	Arsenic-bound p53 DNA-binding domain mutant G245S
1XQH	1.75	Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH
5AOL	1.5	Structure of the p53 cancer mutant Y220C with bound 3-bromo-5-(trifluoromethyl)benzene-1,2-diamine
4IBS	1.78	Human p53 core domain with hot spot mutation R273H (form I)
5O1F	1.38	p53 cancer mutant Y220C in complex with compound MB582
1OLH		HIGH-RESOLUTION SOLUTION STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR
4IBW	1.791	Human p53 core domain with hot spot mutation R273H and second-site suppressor mutation T284R in sequence-specific complex with DNA
2J11		p53 tetramerization domain mutant Y327S T329G Q331G
2YBG	1.9	Structure of Lys120-acetylated p53 core domain
6VR1	2.37	Complex of HLA-A2, a class I MHC, with a p53 peptide
5A7B	1.4	Structure of the p53 cancer Y220C bound to the stabilizing small molecule PhiKan5211
2X0V	1.8	STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(trifluoromethyl)benzene-1,2-diamine
1SAF		HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAD STRUCTURES)
2BIQ	1.8	human p53 core domain mutant T123A-M133L-H168R-V203A-N239Y-R249S- N268D
4IBU	1.7	Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation T284R in sequence-specific complex with DNA
5UN8	2.13	Crystal Structure of human O-GlcNAcase in complex with glycopeptide p53
2X0W	2.1	STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 5,6-dimethoxy- 2-methylbenzothiazole
2YDR	2.75	CpOGA D298N in complex with p53-derived O-GlcNAc peptide
2MEJ		Solution Structure of the Complex Between BCL-xL and the p53 Core Domain determined with PRE restraints
4IBZ	1.92	Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation T284R
6SI2	1.5	p53 cancer mutant Y220S
7NMI	2.1	Transactivation domain of p53 in complex with S100P, using annexin A2 as crystallization chaperone
2OCJ	2.05	Human p53 core domain in the absence of DNA
2J0Z		p53 tetramerization domain wild type
3TG5	2.3	Structure of SMYD2 in complex with p53 and SAH
1TUP	2.2	TUMOR SUPPRESSOR P53 COMPLEXED WITH DNA
4LOE	1.85	Human p53 Core Domain Mutant N239Y
7XZZ	4.07	Cryo-EM structure of the nucleosome in complex with p53
6S3C	2.0	Fragment AZ-019 binding at the p53pT387/14-3-3 sigma interface
2LY4		HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail
7B4N	1.32	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (II)
6SIP	1.60045	Fragment AZ-011 binding at the p53pT387/14-3-3 sigma interface
2J1Z	1.8	Human p53 core domain mutant M133L-V203A-N239Y-N268D-F270L
6SIQ	1.60121	Fragment AZ-012 binding at the p53pT387/14-3-3 sigma interface
3Q06	3.2	An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
1UOL	1.9	Crystal structure of the human p53 core domain mutant M133L/V203A/N239Y/N268D at 1.9 A resolution.
4RP6	1.703	Structure of the amyloid-forming segment LTIITLE from p53 (residues 252-258)
4MZI	1.25	Crystal structure of a human mutant p53
2J21	1.6	Human p53 core domain mutant M133L-V203A-N239Y-N268D-R282W
2H4F	2.0	Sir2-p53 peptide-NAD+
1YC5	1.4	Sir2-p53 peptide-nicotinamide
6SIO	1.60418	Fragment AZ-017 binding at the p53pT387/14-3-3 sigma interface
2ADY	2.5	Structural Basis of DNA Recognition by p53 Tetramers (complex IV)
7EDS	1.77	Human p53 core domain with germline hot spot mutation M133T in complex with the natural PIG3 p53-response element and Arsenic
2F1X	2.3	Crystal structure of the TRAF-like domain of HAUSP/USP7 bound to a p53 peptide
6SHZ	1.24	p53 cancer mutant Y220C
8F2H	4.2	Wild type P53 dimer structure from human cancer cells
2MWY		Mdmx-p53
4BV2	3.3	CRYSTAL STRUCTURE OF SIR2 IN COMPLEX WITH THE INHIBITOR EX-527, 2'-O-ACETYL-ADP-RIBOSE AND DEACETYLATED P53-PEPTIDE
1OLG		HIGH-RESOLUTION SOLUTION STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR
1MA3	2.0	Structure of a Sir2 enzyme bound to an acetylated p53 peptide
2FEJ		Solution structure of human p53 DNA binding domain.
6S39	1.88	Fragment AZ-018 binding at the p53pT387/14-3-3 sigma interface
6GGA	1.55	p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9284
1AIE	1.5	P53 TETRAMERIZATION DOMAIN CRYSTAL STRUCTURE

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006983	ER overload response
Biological Process	GO:0043153	entrainment of circadian clock by photoperiod
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0051276	chromosome organization
Biological Process	GO:2000774	positive regulation of cellular senescence
Biological Process	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress
Biological Process	GO:0050821	protein stabilization
Biological Process	GO:0045861	negative regulation of proteolysis
Biological Process	GO:0072331	signal transduction by p53 class mediator
Biological Process	GO:0071494	cellular response to UV-C
Biological Process	GO:0002326	B cell lineage commitment
Biological Process	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation
Biological Process	GO:0062100	positive regulation of programmed necrotic cell death
Biological Process	GO:2000647	negative regulation of stem cell proliferation
Biological Process	GO:1902253	regulation of intrinsic apoptotic signaling pathway by p53 class mediator
Biological Process	GO:0060333	type II interferon-mediated signaling pathway
Biological Process	GO:0060411	cardiac septum morphogenesis
Biological Process	GO:0008340	determination of adult lifespan
Biological Process	GO:0035794	positive regulation of mitochondrial membrane permeability
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process
Biological Process	GO:0060218	hematopoietic stem cell differentiation
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator
Biological Process	GO:0002360	T cell lineage commitment
Biological Process	GO:0008104	protein localization
Biological Process	GO:0071479	cellular response to ionizing radiation
Biological Process	GO:2000269	regulation of fibroblast apoptotic process
Biological Process	GO:1903451	negative regulation of G1 to G0 transition
Biological Process	GO:1903799	negative regulation of miRNA processing
Biological Process	GO:0043504	mitochondrial DNA repair
Biological Process	GO:0042981	regulation of apoptotic process
Biological Process	GO:0072089	stem cell proliferation
Biological Process	GO:0009651	response to salt stress
Biological Process	GO:0090403	oxidative stress-induced premature senescence
Biological Process	GO:0060253	negative regulation of glial cell proliferation
Biological Process	GO:0000423	mitophagy
Biological Process	GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process
Biological Process	GO:0008156	negative regulation of DNA replication
Biological Process	GO:0001756	somitogenesis
Biological Process	GO:0048147	negative regulation of fibroblast proliferation
Biological Process	GO:0006355	regulation of DNA-templated transcription
Biological Process	GO:0016032	viral process
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway
Biological Process	GO:0048512	circadian behavior
Biological Process	GO:0002931	response to ischemia
Biological Process	GO:0006302	double-strand break repair
Biological Process	GO:0034644	cellular response to UV
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
Biological Process	GO:0070245	positive regulation of thymocyte apoptotic process
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:1902895	positive regulation of miRNA transcription
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway
Biological Process	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Biological Process	GO:0042149	cellular response to glucose starvation
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway
Biological Process	GO:0021549	cerebellum development
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process
Biological Process	GO:0071480	cellular response to gamma radiation
Biological Process	GO:0007265	Ras protein signal transduction
Biological Process	GO:0051097	negative regulation of helicase activity
Biological Process	GO:0007406	negative regulation of neuroblast proliferation
Biological Process	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0048568	embryonic organ development
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0035264	multicellular organism growth
Biological Process	GO:0090399	replicative senescence
Biological Process	GO:0071466	cellular response to xenobiotic stimulus
Biological Process	GO:0065003	protein-containing complex assembly
Biological Process	GO:0030308	negative regulation of cell growth
Biological Process	GO:0001836	release of cytochrome c from mitochondria
Biological Process	GO:0051726	regulation of cell cycle
Biological Process	GO:0006289	nucleotide-excision repair
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0072717	cellular response to actinomycin D
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process
Biological Process	GO:1900119	positive regulation of execution phase of apoptosis
Biological Process	GO:0031571	mitotic G1 DNA damage checkpoint signaling
Biological Process	GO:1902749	regulation of cell cycle G2/M phase transition
Biological Process	GO:0010332	response to gamma radiation
Biological Process	GO:0046677	response to antibiotic
Biological Process	GO:0043065	positive regulation of apoptotic process
Biological Process	GO:0071456	cellular response to hypoxia
Biological Process	GO:0033077	T cell differentiation in thymus
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Biological Process	GO:0051402	neuron apoptotic process
Biological Process	GO:0006606	protein import into nucleus
Biological Process	GO:0045899	positive regulation of RNA polymerase II transcription preinitiation complex assembly
Biological Process	GO:0090398	cellular senescence
Biological Process	GO:0019661	glucose catabolic process to lactate via pyruvate
Biological Process	GO:0070242	thymocyte apoptotic process
Biological Process	GO:0002309	T cell proliferation involved in immune response
Biological Process	GO:0007405	neuroblast proliferation
Biological Process	GO:0043525	positive regulation of neuron apoptotic process
Biological Process	GO:0010659	cardiac muscle cell apoptotic process
Biological Process	GO:0048539	bone marrow development
Biological Process	GO:0014009	glial cell proliferation
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:0051262	protein tetramerization
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
Biological Process	GO:0001701	in utero embryonic development
Biological Process	GO:0007369	gastrulation
Biological Process	GO:0034103	regulation of tissue remodeling
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria
Biological Process	GO:0097252	oligodendrocyte apoptotic process
Biological Process	GO:0009303	rRNA transcription
Biological Process	GO:0051974	negative regulation of telomerase activity
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
Biological Process	GO:1990144	intrinsic apoptotic signaling pathway in response to hypoxia
Biological Process	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
Biological Process	GO:1901525	negative regulation of mitophagy
Biological Process	GO:0009299	mRNA transcription
Biological Process	GO:0072593	reactive oxygen species metabolic process
Biological Process	GO:0010035	response to inorganic substance
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:1905856	negative regulation of pentose-phosphate shunt
Biological Process	GO:0070266	necroptotic process
Biological Process	GO:0048144	fibroblast proliferation
Biological Process	GO:0006914	autophagy
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway
Biological Process	GO:0010165	response to X-ray
Biological Process	GO:1904024	negative regulation of glucose catabolic process to lactate via pyruvate
Biological Process	GO:0045815	transcription initiation-coupled chromatin remodeling
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Molecular Function	GO:0071889	14-3-3 protein binding
Molecular Function	GO:0036310	ATP-dependent DNA/DNA annealing activity
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function	GO:0003700	DNA-binding transcription factor activity
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function	GO:0097371	MDM2/MDM4 family protein binding
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function	GO:0001094	TFIID-class transcription factor complex binding
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0005507	copper ion binding
Molecular Function	GO:0001046	core promoter sequence-specific DNA binding
Molecular Function	GO:0097718	disordered domain specific binding
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0140296	general transcription initiation factor binding
Molecular Function	GO:0042826	histone deacetylase binding
Molecular Function	GO:0035033	histone deacetylase regulator activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0003730	mRNA 3'-UTR binding
Molecular Function	GO:0140677	molecular function activator activity
Molecular Function	GO:0002039	p53 binding
Molecular Function	GO:1990841	promoter-specific chromatin binding
Molecular Function	GO:0002020	protease binding
Molecular Function	GO:0046982	protein heterodimerization activity
Molecular Function	GO:0051721	protein phosphatase 2A binding
Molecular Function	GO:0043621	protein self-association
Molecular Function	GO:0051087	protein-folding chaperone binding
Molecular Function	GO:0030971	receptor tyrosine kinase binding
Molecular Function	GO:0000976	transcription cis-regulatory region binding
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Molecular Function	GO:0008270	zinc ion binding
Cellular Component	GO:0016605	PML body
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0043073	germ cell nucleus
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0016363	nuclear matrix
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0032991	protein-containing complex
Cellular Component	GO:0005657	replication fork
Cellular Component	GO:0035861	site of double-strand break
Cellular Component	GO:0005667	transcription regulator complex
Cellular Component	GO:0017053	transcription repressor complex

InterPro / Pfam

InterPro	InterPro name
IPR002117	p53 tumour suppressor family
IPR008967	p53-like transcription factor, DNA-binding domain superfamily
IPR010991	p53, tetramerisation domain
IPR011615	p53, DNA-binding domain
IPR012346	p53/RUNT-type transcription factor, DNA-binding domain superfamily
IPR013872	p53 transactivation domain
IPR036674	p53-like tetramerisation domain superfamily
IPR040926	Cellular tumor antigen p53, transactivation domain 2

Pfam	Pfam name
PF00870	P53 DNA-binding domain
PF07710	P53 tetramerisation motif
PF08563	P53 transactivation motif
PF18521	Transactivation domain 2

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-111448	Activation of NOXA and translocation to mitochondria	Leaf	R-HSA-5357801	Programmed Cell Death
R-HSA-139915	Activation of PUMA and translocation to mitochondria	Leaf	R-HSA-5357801	Programmed Cell Death
R-HSA-1912408	Pre-NOTCH Transcription and Translation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-2559580	Oxidative Stress Induced Senescence	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-2559585	Oncogene Induced Senescence	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	Internal node	R-HSA-8953897	Cellular responses to stimuli
R-HSA-3232118	SUMOylation of transcription factors	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-5620971	Pyroptosis	Leaf	R-HSA-5357801	Programmed Cell Death
R-HSA-5628897	TP53 Regulates Metabolic Genes	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-5689880	Ub-specific processing proteases	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-5689896	Ovarian tumor domain proteases	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Leaf	R-HSA-73894	DNA Repair
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	Leaf	R-HSA-168256	Immune System
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-6803205	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-6803207	TP53 Regulates Transcription of Caspase Activators and Caspases	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-6803211	TP53 Regulates Transcription of Death Receptors and Ligands	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-6804754	Regulation of TP53 Expression	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-6804757	Regulation of TP53 Degradation	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-6804758	Regulation of TP53 Activity through Acetylation	Internal node	R-HSA-74160	Gene expression (Transcription)
R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-6804760	Regulation of TP53 Activity through Methylation	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-6811555	PI5P Regulates TP53 Acetylation	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-69473	G2/M DNA damage checkpoint	Internal node	R-HSA-1640170	Cell Cycle
R-HSA-69481	G2/M Checkpoints	Internal node	R-HSA-1640170	Cell Cycle
R-HSA-69541	Stabilization of p53	Internal node	R-HSA-1640170	Cell Cycle
R-HSA-69895	Transcriptional activation of cell cycle inhibitor p21	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-8853884	Transcriptional Regulation by VENTX	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8941855	RUNX3 regulates CDKN1A transcription	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8943724	Regulation of PTEN gene transcription	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9723905	Loss of function of TP53 in cancer due to loss of tetramerization ability	Leaf	R-HSA-1643685	Disease
R-HSA-9758274	Regulation of NF-kappa B signaling	Leaf	R-HSA-168256	Immune System
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	Internal node	R-HSA-109582	Hemostasis

Subcellular location

Location	ECO term	Pubmed
Cytoplasm	ECO:0000269	PubMed:15340061
Cytoplasm	ECO:0000269	PubMed:17170702
Cytoplasm	ECO:0000269	PubMed:19011621
Cytoplasm	ECO:0000269	PubMed:21597459
Cytoplasm	ECO:0000269	PubMed:22726440
Cytoplasm	ECO:0000269	PubMed:23752197
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome	ECO:0000269	PubMed:28842590
Endoplasmic reticulum	ECO:0000269	PubMed:17170702
Mitochondrion matrix	ECO:0000269	PubMed:22726440
Mitochondrion matrix	ECO:0000269	PubMed:25168243
Mitochondrion matrix	ECO:0000269	PubMed:27323408
Nucleus	ECO:0000269	PubMed:15340061
Nucleus	ECO:0000269	PubMed:17170702
Nucleus	ECO:0000269	PubMed:17591690
Nucleus	ECO:0000269	PubMed:18206965
Nucleus	ECO:0000269	PubMed:19011621
Nucleus	ECO:0000269	PubMed:21597459
Nucleus	ECO:0000269	PubMed:23752197
Nucleus, PML body	ECO:0000269	PubMed:11025664
Nucleus, PML body	ECO:0000269	PubMed:12810724

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0003418	Back pain
HP:0025318	Ovarian carcinoma
HP:0012743	Abdominal obesity
HP:0002690	Large sella turcica
HP:0031589	Suicidal ideation
HP:0010885	Avascular necrosis
HP:0008404	Nail dystrophy
HP:0001061	Acne
HP:0006753	Neoplasm of the stomach
HP:0002953	Vertebral compression fracture
HP:0002859	Rhabdomyosarcoma
HP:0000939	Osteoporosis
HP:0011875	Abnormal platelet morphology
HP:0012189	Hodgkin lymphoma
HP:0500011	Moon facies
HP:0002890	Thyroid carcinoma
HP:0001626	Abnormality of the cardiovascular system
HP:0045040	Abnormal lactate dehydrogenase level
HP:0010741	Pedal edema
HP:0001956	Truncal obesity
HP:0001250	Seizure
HP:0000238	Hydrocephalus
HP:0200042	Skin ulcer
HP:0001974	Leukocytosis
HP:0001903	Anemia
HP:0000029	Testicular atrophy
HP:0004389	Intestinal pseudo-obstruction
HP:0030392	Choroid plexus carcinoma
HP:0030348	Increased circulating androgen concentration
HP:0004420	Arterial thrombosis
HP:0001962	Palpitations
HP:0002018	Nausea
HP:0006725	Pancreatic adenocarcinoma
HP:0004936	Venous thrombosis
HP:0003581	Adult onset
HP:0012531	Pain
HP:0002896	Neoplasm of the liver
HP:0004396	Poor appetite
HP:0009592	Astrocytoma
HP:0001249	Intellectual disability
HP:0000859	Hyperaldosteronism
HP:0000080	Abnormality of reproductive system physiology
HP:0011999	Paranoia
HP:0040270	Impaired glucose tolerance
HP:0001050	Plethora
HP:0001123	Visual field defect
HP:0012174	Glioblastoma multiforme
HP:0004322	Short stature
HP:0001386	Joint swelling
HP:0025017	Capillary fragility
HP:0012410	Pure red cell aplasia
HP:0012334	Extrahepatic cholestasis
HP:0002756	Pathologic fracture
HP:0003401	Paresthesia
HP:0001085	Papilledema
HP:0011974	Myelofibrosis
HP:0002888	Ependymoma
HP:0011370	Recurrent cutaneous fungal infections
HP:0002750	Delayed skeletal maturation
HP:0001276	Hypertonia
HP:0002910	Elevated hepatic transaminase
HP:0004324	Increased body weight
HP:0010788	Testicular neoplasm
HP:0006721	Acute lymphoblastic leukemia
HP:0030448	Soft tissue sarcoma
HP:0030406	Primary peritoneal carcinoma
HP:0000975	Hyperhidrosis
HP:0011027	Abnormal fallopian tube morphology
HP:0006744	Adrenocortical carcinoma
HP:0100605	Neoplasm of the larynx
HP:0012030	Increased urinary cortisol level
HP:0000712	Emotional lability
HP:0006491	Abnormal tibial metaphysis morphology
HP:0002069	Bilateral tonic-clonic seizure
HP:0100615	Ovarian neoplasm
HP:0025436	Elevated serum 11-deoxycortisol
HP:0012639	Abnormal nervous system morphology
HP:0004374	Hemiplegia/hemiparesis
HP:0100592	Peritoneal abscess
HP:0012432	Chronic fatigue
HP:0009919	Retinoblastoma
HP:0001872	Abnormality of thrombocytes
HP:0001263	Global developmental delay
HP:0002797	Osteolysis
HP:0001909	Leukemia
HP:0025435	Increased circulating lactate dehydrogenase concentration
HP:0000819	Diabetes mellitus
HP:0002885	Medulloblastoma
HP:0031845	Abnormal libido
HP:0025380	Increased circulating androstenedione concentration
HP:0012126	Stomach cancer
HP:0001065	Striae distensae
HP:0030070	Central primitive neuroectodermal tumor
HP:0003002	Breast carcinoma
HP:0012288	Neoplasm of head and neck
HP:0002894	Neoplasm of the pancreas
HP:0002716	Lymphadenopathy
HP:0003593	Infantile onset
HP:0200063	Colorectal polyposis
HP:0008221	Adrenal hyperplasia
HP:0006740	Transitional cell carcinoma of the bladder
HP:0004808	Acute myeloid leukemia
HP:0003118	Increased circulating cortisol level
HP:0100659	Abnormal cerebral vascular morphology
HP:0002315	Headache
HP:0001413	Micronodular cirrhosis
HP:0002326	Transient ischemic attack
HP:0000869	Secondary amenorrhea
HP:0410067	Increased level of L-fucose in urine
HP:0100006	Neoplasm of the central nervous system
HP:0030078	Lung adenocarcinoma
HP:0000716	Depression
HP:0002863	Myelodysplasia
HP:0002669	Osteosarcoma
HP:0002354	Memory impairment
HP:0000979	Purpura
HP:0100576	Amaurosis fugax
HP:0002039	Anorexia
HP:0008291	Pituitary corticotropic cell adenoma
HP:0000953	Hyperpigmentation of the skin
HP:0002665	Lymphoma
HP:0000978	Bruising susceptibility
HP:0002900	Hypokalemia
HP:0500022	Abnormal circulating dehydroepiandrosterone concentration
HP:0003154	Increased circulating ACTH level
HP:0002891	Uterine leiomyosarcoma
HP:0200022	Choroid plexus papilloma
HP:0100768	Choriocarcinoma
HP:0003010	Prolonged bleeding time
HP:0007807	Optic nerve compression
HP:0001888	Lymphopenia
HP:0100630	Neoplasia of the nasopharynx
HP:0010284	Intra-oral hyperpigmentation
HP:0002086	Abnormality of the respiratory system
HP:0000505	Visual impairment
HP:0100787	Prostate neoplasm
HP:0002254	Intermittent diarrhea
HP:0001738	Exocrine pancreatic insufficiency
HP:0001939	Abnormality of metabolism/homeostasis
HP:0001945	Fever
HP:0002206	Pulmonary fibrosis
HP:0012133	Erythroid hypoplasia
HP:0002861	Melanoma
HP:0005513	Increased megakaryocyte count
HP:0010982	Polygenic inheritance
HP:0005249	Functional intestinal obstruction
HP:0009726	Renal neoplasm
HP:0000822	Hypertension
HP:0001007	Hirsutism
HP:0002017	Nausea and vomiting
HP:0001428	Somatic mutation
HP:0000725	Psychotic episodes
HP:0004313	Decreased circulating antibody level
HP:0002027	Abdominal pain
HP:0000952	Jaundice
HP:0012539	Non-Hodgkin lymphoma
HP:0002721	Immunodeficiency
HP:0025709	Intermediate young adult onset
HP:0025269	Panic attack
HP:0000737	Irritability
HP:0002488	Acute leukemia
HP:0031413	Short telomere length
HP:0005584	Renal cell carcinoma
HP:0100749	Chest pain
HP:0003466	Paradoxical increased cortisol secretion on dexamethasone suppression test
HP:0001058	Poor wound healing
HP:0002209	Sparse scalp hair
HP:0000876	Oligomenorrhea
HP:0000709	Psychosis
HP:0001433	Hepatosplenomegaly
HP:0030200	Fatiguable weakness of proximal limb muscles
HP:0007126	Proximal amyotrophy
HP:0006572	Subacute progressive viral hepatitis
HP:0006716	Hereditary nonpolyposis colorectal carcinoma
HP:0000141	Amenorrhea
HP:0000252	Microcephaly
HP:0002745	Oral leukoplakia
HP:0007378	Neoplasm of the gastrointestinal tract
HP:0003110	Abnormality of urine homeostasis
HP:0000998	Hypertrichosis
HP:0002664	Neoplasm
HP:0002667	Nephroblastoma
HP:0011748	Adrenocorticotropic hormone deficiency
HP:0000006	Autosomal dominant inheritance
HP:0031284	Flushing
HP:0006489	Abnormal femoral metaphysis morphology
HP:0100543	Cognitive impairment
HP:0001324	Muscle weakness
HP:0007588	Reticular hyperpigmentation
HP:0000726	Dementia
HP:0025383	Dorsocervical fat pad
HP:0031364	Ecchymosis
HP:0003623	Neonatal onset
HP:0031891	Decreased eosinophil count
HP:0001402	Hepatocellular carcinoma
HP:0000944	Abnormal metaphysis morphology
HP:0100743	Neoplasm of the rectum
HP:0025134	Increased serum estradiol
HP:0002013	Vomiting
HP:0100526	Neoplasm of the lung
HP:0005561	Abnormality of bone marrow cell morphology
HP:0000963	Thin skin
HP:0000135	Hypogonadism
HP:0003155	Elevated circulating alkaline phosphatase concentration
HP:0001297	Stroke
HP:0001510	Growth delay
HP:0012125	Prostate cancer
HP:0000739	Anxiety
HP:0000708	Atypical behavior
HP:0001744	Splenomegaly
HP:0003003	Colon cancer
HP:0001824	Weight loss
HP:0001658	Myocardial infarction

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
appendix	enterocytes	Low	Enhanced
colon	enterocytes	Medium	Enhanced
duodenum	enterocytes	Low	Enhanced
esophagus	squamous epithelial cells	Medium	Enhanced
oral mucosa	squamous epithelial cells	Medium	Enhanced
placenta	syncytiotrophoblasts - cell body	Medium	Enhanced
placenta	syncytiotrophoblasts - microvilli	Medium	Enhanced
rectum	enterocytes	Medium	Enhanced
skin 1	melanocytes	Low	Enhanced
skin 2	epidermal cells	Low	Enhanced
small intestine	enterocytes	Low	Enhanced
testis	Leydig cells	Medium	Enhanced
testis	preleptotene spermatocytes	Medium	Enhanced
testis	sertoli cells	Low	Enhanced
testis	spermatogonia cells	Medium	Enhanced
tonsil	squamous epithelial cells	Low	Enhanced
urinary bladder	urothelial cells	Low	Enhanced

Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM	Orphanet
bone osteosarcoma	MONDO:0002629	C41	chapter2, Neoplasms	OMIM:259500	Orphanet:668
b-cell chronic lymphocytic leukemia	MONDO:0004948	C91	chapter2, Neoplasms	OMIM:151400	Orphanet:67038
rhabdomyosarcoma	MONDO:0005212	C49	chapter2, Neoplasms		Orphanet:780
ovarian serous cystadenocarcinoma	MONDO:0006046	G56	chapter6, Diseases of the nervous system
esophageal cancer	MONDO:0007576	C15	chapter2, Neoplasms	OMIM:133239
li-fraumeni syndrome 1	MONDO:0007903	D48	chapter2, Neoplasms	OMIM:151623
li-fraumeni syndrome 1	MONDO:0007903	D48	chapter2, Neoplasms	OMIM:609266
pectus excavatum	MONDO:0008213	Q67	chapter17, Congenital malformations, deformations and chromosomal abnormalities	OMIM:169300
small cell lung carcinoma	MONDO:0008433	C34	chapter2, Neoplasms	OMIM:182280	Orphanet:70573
adrenocortical carcinoma, hereditary	MONDO:0008734	C74	chapter2, Neoplasms	OMIM:202300
choroid plexus papilloma	MONDO:0009837	D33	chapter2, Neoplasms	OMIM:260500	Orphanet:251899
choroid plexus papilloma	MONDO:0009837	D33	chapter2, Neoplasms	OMIM:260500	Orphanet:2807
head and neck squamous cell carcinoma	MONDO:0010150	C76	chapter2, Neoplasms	OMIM:275355	Orphanet:67037
nasopharyngeal carcinoma, susceptibility to, 1	MONDO:0011775	C11	chapter2, Neoplasms	OMIM:607107
basal cell carcinoma- susceptibility to- 7	MONDO:0013876	-	-	OMIM:614740
familial pancreatic carcinoma	MONDO:0015278	C25	chapter2, Neoplasms	OMIM:260350	Orphanet:1333
hereditary breast carcinoma	MONDO:0016419	C50	chapter2, Neoplasms	OMIM:114480	Orphanet:227535
anaplastic astrocytoma	MONDO:0016684	C71	chapter2, Neoplasms		Orphanet:251589
pleomorphic xanthoastrocytoma	MONDO:0016690	C71	chapter2, Neoplasms		Orphanet:251607
pleomorphic xanthoastrocytoma	MONDO:0016690	C79	chapter2, Neoplasms		Orphanet:251607
choroid plexus carcinoma	MONDO:0016718	C71	chapter2, Neoplasms		Orphanet:251899
hepatoblastoma	MONDO:0018666	C22	chapter2, Neoplasms		Orphanet:449
acute myeloid leukemia	MONDO:0018874	C92	chapter2, Neoplasms	OMIM:601626	Orphanet:519
atypical teratoid rhabdoid tumor	MONDO:0020560	C49	chapter2, Neoplasms		Orphanet:99966
bone marrow failure syndrome 5	MONDO:0032573	D75	chapter3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	OMIM:618165

Summary of P04637

Gene: TP53, P53
Protein: Cellular tumor antigen p53

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P04637

Gene: TP53, P53 Protein: Cellular tumor antigen p53

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: TP53, P53
Protein: Cellular tumor antigen p53