MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
1.14.14.1	Oxidoreductases; Acting on paired donors, with incorporation or reduction of molecular oxygen; With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor; unspecific monooxygenase
4.2.1.152	Lyases; Carbon-oxygen lyases; Hydro-lyases; hydroperoxy icosatetraenoate dehydratase

Structure

PDB	Resolution (Å)	PDB name
4I8V	2.6	Human Cytochrome P450 1A1 in complex with alpha-naphthoflavone
6DWM	2.85	Structure of Human Cytochrome P450 1A1 with Bergamottin
6DWN	3.0	Structure of Human Cytochrome P450 1A1 with Erlotinib
6O5Y	3.17	Structure of Human Cytochrome P450 1A1 with 5-amino-N-(5-((4R,5R)-4-amino-5-fluoroazepan-1-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide)
6UDL	2.85	Structure of Human Cytochrome P450 1A1 with Duocarmycin Prodrug (S) ICT-2700
6UDM	3.075	Structure of Human Cytochrome P450 1A1 with Duocarmycin Prodrug (S) ICT-2726

GO term

GO ontology	GO term	GO description
Biological Process	GO:0042904	9-cis-retinoic acid biosynthetic process
Biological Process	GO:0006306	DNA methylation
Biological Process	GO:0007568	aging
Biological Process	GO:0009308	amine metabolic process
Biological Process	GO:0043010	camera-type eye development
Biological Process	GO:0008283	cell population proliferation
Biological Process	GO:0071280	cellular response to copper ion
Biological Process	GO:0071407	cellular response to organic cyclic compound
Biological Process	GO:0009804	coumarin metabolic process
Biological Process	GO:0019341	dibenzo-p-dioxin catabolic process
Biological Process	GO:0048565	digestive tract development
Biological Process	GO:0019373	epoxygenase P450 pathway
Biological Process	GO:0008210	estrogen metabolic process
Biological Process	GO:0009692	ethylene metabolic process
Biological Process	GO:0006631	fatty acid metabolic process
Biological Process	GO:0009812	flavonoid metabolic process
Biological Process	GO:0070365	hepatocyte differentiation
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process
Biological Process	GO:0017143	insecticide metabolic process
Biological Process	GO:0002933	lipid hydroxylation
Biological Process	GO:0042759	long-chain fatty acid biosynthetic process
Biological Process	GO:0001676	long-chain fatty acid metabolic process
Biological Process	GO:0060137	maternal process involved in parturition
Biological Process	GO:0097267	omega-hydroxylase P450 pathway
Biological Process	GO:0006778	porphyrin-containing compound metabolic process
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
Biological Process	GO:0046677	response to antibiotic
Biological Process	GO:0046685	response to arsenic-containing substance
Biological Process	GO:0032094	response to food
Biological Process	GO:0009635	response to herbicide
Biological Process	GO:0055093	response to hyperoxia
Biological Process	GO:0001666	response to hypoxia
Biological Process	GO:0035902	response to immobilization stress
Biological Process	GO:0010041	response to iron(III) ion
Biological Process	GO:0032496	response to lipopolysaccharide
Biological Process	GO:0009624	response to nematode
Biological Process	GO:0009615	response to virus
Biological Process	GO:0033189	response to vitamin A
Biological Process	GO:0009611	response to wounding
Biological Process	GO:0042572	retinol metabolic process
Biological Process	GO:0006694	steroid biosynthetic process
Biological Process	GO:0008202	steroid metabolic process
Biological Process	GO:0042359	vitamin D metabolic process
Biological Process	GO:0006805	xenobiotic metabolic process
Molecular Function	GO:0030544	Hsp70 protein binding
Molecular Function	GO:0051879	Hsp90 protein binding
Molecular Function	GO:0008391	arachidonic acid monooxygenase activity
Molecular Function	GO:0070330	aromatase activity
Molecular Function	GO:0032451	demethylase activity
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0101020	estrogen 16-alpha-hydroxylase activity
Molecular Function	GO:0101021	estrogen 2-hydroxylase activity
Molecular Function	GO:0016711	flavonoid 3'-monooxygenase activity
Molecular Function	GO:0020037	heme binding
Molecular Function	GO:0106256	hydroperoxy icosatetraenoate dehydratase activity
Molecular Function	GO:0005506	iron ion binding
Molecular Function	GO:0120319	long-chain fatty acid omega-1 hydroxylase activity
Molecular Function	GO:0102033	long-chain fatty acid omega-hydroxylase activity
Molecular Function	GO:0004497	monooxygenase activity
Molecular Function	GO:0016491	oxidoreductase activity
Molecular Function	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors
Molecular Function	GO:0019825	oxygen binding
Molecular Function	GO:0070576	vitamin D 24-hydroxylase activity
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0005743	mitochondrial inner membrane

InterPro	InterPro name
IPR001128	Cytochrome P450
IPR002401	Cytochrome P450, E-class, group I
IPR008066	Cytochrome P450, E-class, group I, CYP1
IPR017972	Cytochrome P450, conserved site
IPR036396	Cytochrome P450 superfamily

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1989781	PPARA activates gene expression	Leaf	R-HSA-1430728	Metabolism
R-HSA-211981	Xenobiotics	Internal node	R-HSA-1430728	Metabolism
R-HSA-2142670	Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	Leaf	R-HSA-1430728	Metabolism
R-HSA-2142816	Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	Leaf	R-HSA-1430728	Metabolism
R-HSA-9018681	Biosynthesis of protectins	Leaf	R-HSA-1430728	Metabolism

Location	ECO term	Pubmed
Cytoplasm	ECO:0000250
Endoplasmic reticulum membrane	ECO:0000250
Microsome membrane	ECO:0000250
Mitochondrion inner membrane	ECO:0000250

Summary of P04798

Gene: CYP1A1
Protein: Cytochrome P450 1A1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P04798

Gene: CYP1A1 Protein: Cytochrome P450 1A1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: CYP1A1
Protein: Cytochrome P450 1A1