| 1HVY |
1.9 |
Human thymidylate synthase complexed with dUMP and Raltitrexed, an antifolate drug, is in the closed conformation |
| 1HW3 |
2.0 |
STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS |
| 1HW4 |
2.06 |
STRUCTURE OF THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS |
| 1HZW |
2.0 |
CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE |
| 1I00 |
2.5 |
CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE, TERNARY COMPLEX WITH DUMP AND TOMUDEX |
| 1JU6 |
2.89 |
Human Thymidylate Synthase Complex with dUMP and LY231514, A Pyrrolo(2,3-d)pyrimidine-based Antifolate |
| 1JUJ |
3.0 |
Human Thymidylate Synthase Bound to dUMP and LY231514, a Pyrrolo(2,3-d)pyrimidine-based Antifolate |
| 1YPV |
1.8 |
Structure of human thymidylate synthase at low salt conditions |
| 2ONB |
2.7 |
Human Thymidylate Synthase at low salt conditions with PDPA bound |
| 2RD8 |
2.5 |
Human Thymidylate Synthase Stabilized in Active Conformation by R163K Mutation: Asymmetry and Reactivity of Cys195 |
| 2RDA |
2.67 |
Human Thymidylate Synthase Stabilized in Active Conformation by R163K Mutation: Asymmetry and Reactivity of Cys195 |
| 3EAW |
1.86 |
Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability |
| 3EBU |
2.05 |
Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability |
| 3ED7 |
1.56 |
Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability |
| 3EDW |
1.75 |
Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability |
| 3EF9 |
3.2 |
Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability |
| 3EGY |
2.18 |
Crystal Structure of Human Thymidyalte Synthase A191K with Loop 181-197 stabilized in the inactive conformation |
| 3EHI |
2.0 |
Crystal Structure of Human Thymidyalte Synthase M190K with Loop 181-197 stabilized in the inactive conformation |
| 3EJL |
3.2 |
Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability |
| 3GG5 |
2.77 |
Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability |
| 3GH0 |
1.56 |
Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability |
| 3GH2 |
1.75 |
Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability |
| 3H9K |
2.65 |
Structures of Thymidylate Synthase R163K with Substrates and Inhibitors Show Subunit Asymmetry |
| 3HB8 |
2.74 |
Structures of Thymidylate Synthase R163K with Substrates and Inhibitors Show Subunit Asymmetry |
| 3N5E |
2.26 |
Crystal Structure of human thymidylate synthase bound to a peptide inhibitor |
| 3N5G |
2.27 |
Crystal Structure of histidine-tagged human thymidylate synthase |
| 3OB7 |
2.75 |
Human Thymidylate Synthase R163K with Cys 195 covalently modified by Glutathione |
| 4E28 |
2.302 |
Structure of human thymidylate synthase in inactive conformation with a novel non-peptidic inhibitor |
| 4FGT |
2.0 |
Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme. |
| 4G2O |
2.25 |
Human Thymidylate Synthase M190K with bound Purpurogallin |
| 4G6W |
2.3 |
Human Thymidylate Synthase M190K with bound 4-Bromobenzene-1,2,3-triol |
| 4GD7 |
2.29 |
Wild-Type Human Thymidylate Synthase with bound Purpurogallin |
| 4GYH |
3.005 |
Structure of human thymidylate synthase at high salt conditions |
| 4H1I |
3.095 |
Structure of human thymidylate synthase at low salt conditions |
| 4JEF |
2.311 |
Crystal structure of human thymidylate synthase Y202A in inactive conformation. |
| 4KPW |
2.03 |
Crystal structure of His-tagged human thymidylate synthase R175A mutant |
| 4O1U |
2.26 |
Crystal structure of human thymidylate synthase mutant Y202C |
| 4O1X |
2.32 |
Crystal structure of human thymidylate synthase double mutant C195S-Y202C |
| 4UP1 |
2.991 |
Crystal structure of native human Thymidylate synthase in active form |
| 5HS3 |
3.103 |
Human thymidylate synthase complexed with dUMP and 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol |
| 5WRN |
2.39 |
Human thymidylate synthase complexed with dCMP |
| 5X4W |
2.1 |
Mutant human thymidylate synthase A191K crystallized in a sulfate-free condition |
| 5X4X |
2.31 |
Mutant human thymidylate synthase A191K crystallized in a sulfate-containing condition |
| 5X4Y |
2.2 |
Mutant human thymidylate synthase M190K crystallized in a sulfate-containing condition |
| 5X5A |
2.39 |
Human thymidylate synthase bound with phosphate ion |
| 5X5D |
2.0 |
Human thymidylate synthase bound with dUMP |
| 5X5Q |
2.79 |
Human thymidylate synthase complexed with dUMP and raltitrexed |
| 5X66 |
1.99 |
Human thymidylate synthase in complex with dUMP and methotrexate |
| 5X67 |
2.13 |
Human thymidylate synthase in complex with dUMP and nolatrexed |
| 5X69 |
2.69 |
Human thymidylate synthase with a fragment bound in the dimer interface |
| 6OJU |
2.884 |
Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-D-glutamic acid |
| 6OJV |
2.593 |
Crystal structure of human thymidylate synthase delta(7-29) in complex with dUMP and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid |
| 6PF3 |
2.391 |
Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-chlorobenzoic acid |
| 6PF4 |
2.854 |
Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)phenyl)acetic acid |
| 6PF5 |
2.39 |
Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-methoxyphenyl)acetic acid |
| 6PF6 |
2.502 |
Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)terephthalic acid |
| 6QXG |
2.08 |
Crystal structure of His-tag human thymidylate synthase (HT-hTS) in complex with FdUMP |
| 6QXH |
2.04 |
Crystal structure of His-tag human thymidylate synthase (HT-hTS) in complex with dUMP |
| 6QYQ |
2.25 |
Crystal structure of human thymidylate synthase (hTS) variant R175C |
| 6R2E |
2.55 |
Crystal structure of the human thymidylate synthase (hTS) interface variant Q62R |
| 6ZXO |
2.6 |
Crystal structure of His-tagged human thymidylate synthase (HT-hTS) in complex with FdUMP and Raltitrexed (Tomudex) |
