MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
4.1.2.13	Lyases; Carbon-carbon lyases; Aldehyde-lyases; fructose-bisphosphate aldolase

PDB	Resolution (Å)	PDB name
1QO5	2.5	Fructose 1,6-bisphosphate Aldolase from Human Liver Tissue
1XDL	3.0	Structure of human aldolase B associated with hereditary fructose intolerance (A149P), at 277K
1XDM	3.0	Structure of human aldolase B associated with hereditary fructose intolerance (A149P), at 291K
8D44	2.8	Cryo-electron microscopy structure of human kidney Fructose-bisphosphate aldolase B

GO ontology	GO term	GO description
Biological Process	GO:0006116	NADH oxidation
Biological Process	GO:0030388	fructose 1,6-bisphosphate metabolic process
Biological Process	GO:0061624	fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
Biological Process	GO:0006000	fructose metabolic process
Biological Process	GO:0006096	glycolytic process
Biological Process	GO:0032781	positive regulation of ATP-dependent activity
Biological Process	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly
Molecular Function	GO:0051117	ATPase binding
Molecular Function	GO:0008092	cytoskeletal protein binding
Molecular Function	GO:0070061	fructose binding
Molecular Function	GO:0061609	fructose-1-phosphate aldolase activity
Molecular Function	GO:0004332	fructose-bisphosphate aldolase activity
Molecular Function	GO:0042802	identical protein binding
Cellular Component	GO:0034451	centriolar satellite
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005815	microtubule organizing center

InterPro	InterPro name
IPR000741	Fructose-bisphosphate aldolase, class-I
IPR013785	Aldolase-type TIM barrel
IPR029768	Fructose-bisphosphate aldolase class-I active site

Pfam	Pfam name
PF00274	Fructose-bisphosphate aldolase class-I

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-5657560	Hereditary fructose intolerance	Leaf	R-HSA-1643685	Disease
R-HSA-70171	Glycolysis	Internal node	R-HSA-1430728	Metabolism
R-HSA-70263	Gluconeogenesis	Leaf	R-HSA-1430728	Metabolism
R-HSA-70350	Fructose catabolism	Leaf	R-HSA-1430728	Metabolism

Location	ECO term	Pubmed
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite	ECO:0000269	PubMed:18000879

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000083	Renal insufficiency
HP:0000114	Proximal tubulopathy
HP:0000518	Cataract
HP:0000670	Carious teeth
HP:0000952	Jaundice
HP:0001069	Episodic hyperhidrosis
HP:0001249	Intellectual disability
HP:0001250	Seizure
HP:0001254	Lethargy
HP:0001259	Coma
HP:0001394	Cirrhosis
HP:0001397	Hepatic steatosis
HP:0001508	Failure to thrive
HP:0001510	Growth delay
HP:0001942	Metabolic acidosis
HP:0001943	Hypoglycemia
HP:0002013	Vomiting
HP:0002014	Diarrhea
HP:0002018	Nausea
HP:0002019	Constipation
HP:0002027	Abdominal pain
HP:0002049	Proximal renal tubular acidosis
HP:0002148	Hypophosphatemia
HP:0002149	Hyperuricemia
HP:0002239	Gastrointestinal hemorrhage
HP:0002240	Hepatomegaly
HP:0002904	Hyperbilirubinemia
HP:0002910	Elevated hepatic transaminase
HP:0002918	Hypermagnesemia
HP:0003076	Glycosuria
HP:0003109	Hyperphosphaturia
HP:0003128	Lactic acidosis
HP:0003149	Hyperuricosuria
HP:0003256	Abnormality of the coagulation cascade
HP:0003270	Abdominal distention
HP:0003646	Bicarbonaturia
HP:0004395	Malnutrition
HP:0005973	Fructose intolerance
HP:0008273	Transient aminoaciduria
HP:0012051	Reactive hypoglycemia
HP:0012545	Reduced circulating aldolase concentration
HP:0012622	Chronic kidney disease
HP:0100626	Chronic hepatic failure

Tissue	Cell type	Expression level	Reliability
duodenum	endocrine cells	Medium	Enhanced
duodenum	enterocytes	Medium	Enhanced
duodenum	enterocytes - Gradient	Ascending	Enhanced
duodenum	goblet cells	Medium	Enhanced
kidney	cells in tubules	High	Enhanced
liver	hepatocytes	High	Enhanced
small intestine	endocrine cells	High	Enhanced
small intestine	enterocytes	High	Enhanced
stomach 1	glandular cells	Low	Enhanced