Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
3.5.3.1
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amidines;
arginase
PDB | Resolution (Å) | PDB name |
---|---|---|
1WVA | 1.94 | Crystal structure of human arginase I from twinned crystal |
1WVB | 2.3 | Crystal structure of human arginase I: the mutant E256Q |
2AEB | 1.29 | Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in immune response. |
2PHA | 1.9 | Crystal structure of native, unliganded human arginase at 1.90 resolution |
2PHO | 1.95 | Crystal structure of human arginase I complexed with thiosemicarbazide at 1.95 resolution |
2PLL | 1.9 | Crystal structure of perdeuterated human arginase I |
2ZAV | 1.7 | Arginase I (homo sapiens): native and unliganded structure at 1.70 A resolution |
3DJ8 | 1.51 | Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I |
3E6K | 2.1 | X-ray structure of Human Arginase I: the mutant D183A in complex with ABH |
3E6V | 1.72 | X-ray structure of human arginase I-D183N mutant: the complex with ABH |
3F80 | 1.6 | (S)-2-amino-6-nitrohexanoic acid binds to human arginase I through multiple nitro-metal coordination interactions in the binuclear manganese cluster. Resolution 1.60 A. |
3GMZ | 1.43 | Crystal of human arginase in complex with L-ornithine. Resolution 1.43 A. |
3GN0 | 1.7 | Crystal structure of human arginase I in complex with difluoromethylornithine (DFMO) |
3KV2 | 1.55 | HIGH RESOLUTION STRUCTURE OF HUMAN ARGINASE I IN COMPLEX WITH THE STRONG INHIBITOR N(omega)-hydroxy-nor-L-arginine (nor-NOHA) |
3LP4 | 1.9 | Crystal structure of human arginase I in complex with L-LYSINE, 1.90A Resolution. |
3LP7 | 2.04 | Crystal structure of Human Arginase I in complex with inhibitor N(omega)-hydroxy-L-arginine (NOHA), 2.04A Resolution |
3MFV | 1.9 | Crystal structure of human arginase I in complex with 2-aminohomohistidine |
3MFW | 1.47 | Crystal structure of human arginase I in complex with L-2-aminohistidine and sulphate |
3MJL | 1.9 | Crystal structure of human arginase I in complex with 2-aminoimidazole. Resolution 1.90 A. |
3SJT | 1.597 | Crystal structure of human arginase I in complex with the inhibitor Me-ABH, Resolution 1.60 A, twinned structure |
3SKK | 1.701 | Crystal structure of human arginase I in complex with the inhibitor FABH, Resolution 1.70 A, twinned structure |
3TF3 | 1.64 | Crystal structure of metal-free Human Arginase I |
3TH7 | 2.1 | Crystal structure of unliganded Co2+2-HAI (pH 7.0) |
3THE | 1.97 | Crystal structure of Co2+2-HAI (pH 8.5) |
3THH | 1.85 | Crystal structure of the Co2+2-HAI-ABH complex |
3THJ | 1.5 | Crystal structure of the Co2+2-HAI-L-Orn complex |
4FCI | 1.82 | Crystal Structure of the Mn2+2-Human Arginase I-AGPA Complex |
4FCK | 1.9 | Crystal Structure of the Co2+2-Human Arginase I-AGPA Complex |
4GSM | 1.7 | Crystal Structure of Ni2+2-Human Arginase I |
4GSV | 1.48 | Crystal Structure of the Ni2+2-Human Arginase I-ABH complex |
4GSZ | 2.2 | Crystal Structure of the Zn2+5-Human Arginase I-ABH Complex |
4GWC | 1.9 | Crystal Structure of Mn2+2,Zn2+-Human Arginase I |
4GWD | 1.53 | Crystal Structure of the Mn2+2,Zn2+-Human Arginase I-ABH Complex |
4HWW | 1.298 | Crystal structure of human Arginase-1 complexed with inhibitor 9 |
4HXQ | 1.45 | Crystal structure of human Arginase-1 complexed with inhibitor 14 |
4IE1 | 2.0006 | Crystal structure of human Arginase-1 complexed with inhibitor 1h |
6Q92 | 1.5 | Crystal structure of human Arginase-1 at pH 7.0 in complex with ABH |
6Q9P | 1.66 | Crystal structure of human Arginase-1 at pH 9.0 in complex with ABH |
6QAF | 1.61 | Crystal structure of human Arginase-1 at pH 9.0 in complex with CB-1158/INCB001158 |
6V7C | 1.8 | Human Arginase1 Complexed with Bicyclic Inhibitor Compound 3 |
6V7D | 1.82 | Human Arginase1 Complexed with Bicyclic Inhibitor Compound 10 |
6V7E | 1.99 | Human Arginase1 Complexed with Bicyclic Inhibitor Compound 12 |
6V7F | 2.02 | Human Arginase1 Complexed with Bicyclic Inhibitor Compound 13 |
7K4G | 1.8 | Human Arginase 1 in complex with compound 01. |
7K4H | 1.65 | Human Arginase 1 in complex with compound 04. |
7K4I | 1.98 | Human Arginase 1 in complex with compound 06. |
7K4J | 1.94 | Human Arginase 1 in complex with compound 51. |
7K4K | 2.27 | Human Arginase 1 in complex with compound 52. |
7KLK | 1.801 | Human Arginase1 Complexed with Inhibitor Compound 3a |
7KLL | 2.22 | Human Arginase1 Complexed with Inhibitor Compound 18 |
7KLM | 2.27 | Human Arginase1 Complexed with Inhibitor Compound 24a |
7LEX | 3.6 | Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:3 mAb1 complex |
7LEY | 3.05 | Trimeric human Arginase 1 in complex with mAb5 |
7LEZ | 4.15 | Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:2 mAb1 complex |
7LF0 | 3.68 | Trimeric human Arginase 1 in complex with mAb2 |
7LF1 | 4.04 | Trimeric human Arginase 1 in complex with mAb3 |
7LF2 | 3.72 | Trimeric human Arginase 1 in complex with mAb4 |
8AUP | 2.17 | Structure of hARG1 with a novel inhibitor. |
8E5M | 1.84 | Structure of ARG1 complex with pyrrolidine-based non-boronic acid inhibitor 6 |
8E5N | 2.538 | Structure of ARG1 complex with pyrrolidine-based non-boronic acid inhibitor 10 |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0002250 | adaptive immune response |
Biological Process | GO:0007568 | aging |
Biological Process | GO:0006527 | arginine catabolic process |
Biological Process | GO:0019547 | arginine catabolic process to ornithine |
Biological Process | GO:0071549 | cellular response to dexamethasone stimulus |
Biological Process | GO:0071377 | cellular response to glucagon stimulus |
Biological Process | GO:0070301 | cellular response to hydrogen peroxide |
Biological Process | GO:0071353 | cellular response to interleukin-4 |
Biological Process | GO:0071222 | cellular response to lipopolysaccharide |
Biological Process | GO:0071560 | cellular response to transforming growth factor beta stimulus |
Biological Process | GO:0032964 | collagen biosynthetic process |
Biological Process | GO:0042832 | defense response to protozoan |
Biological Process | GO:0045087 | innate immune response |
Biological Process | GO:0001889 | liver development |
Biological Process | GO:0030324 | lung development |
Biological Process | GO:0060056 | mammary gland involution |
Biological Process | GO:0060135 | maternal process involved in female pregnancy |
Biological Process | GO:0042130 | negative regulation of T cell proliferation |
Biological Process | GO:2000552 | negative regulation of T-helper 2 cell cytokine production |
Biological Process | GO:0046007 | negative regulation of activated T cell proliferation |
Biological Process | GO:0060336 | negative regulation of type II interferon-mediated signaling pathway |
Biological Process | GO:0001938 | positive regulation of endothelial cell proliferation |
Biological Process | GO:0070965 | positive regulation of neutrophil mediated killing of fungus |
Biological Process | GO:1905541 | regulation of L-arginine import across plasma membrane |
Biological Process | GO:0014075 | response to amine |
Biological Process | GO:0043200 | response to amino acid |
Biological Process | GO:0048678 | response to axon injury |
Biological Process | GO:0046686 | response to cadmium ion |
Biological Process | GO:0009635 | response to herbicide |
Biological Process | GO:0010042 | response to manganese ion |
Biological Process | GO:0051597 | response to methylmercury |
Biological Process | GO:0010269 | response to selenium ion |
Biological Process | GO:0033189 | response to vitamin A |
Biological Process | GO:0033197 | response to vitamin E |
Biological Process | GO:0009410 | response to xenobiotic stimulus |
Biological Process | GO:0010043 | response to zinc ion |
Biological Process | GO:0000050 | urea cycle |
Molecular Function | GO:0004053 | arginase activity |
Molecular Function | GO:0042802 | identical protein binding |
Molecular Function | GO:0030145 | manganese ion binding |
Cellular Component | GO:0035578 | azurophil granule lumen |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0005576 | extracellular region |
Cellular Component | GO:0005615 | extracellular space |
Cellular Component | GO:0005741 | mitochondrial outer membrane |
Cellular Component | GO:0043005 | neuron projection |
Cellular Component | GO:0043025 | neuronal cell body |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:0035580 | specific granule lumen |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-6798695 | Neutrophil degranulation | Leaf | R-HSA-168256 | Immune System |
R-HSA-70635 | Urea cycle | Leaf | R-HSA-1430728 | Metabolism |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm | ECO:0000269 | PubMed:16141327 |
Cytoplasmic granule | ECO:0000269 | PubMed:15546957 |
HPO ID | HPO name |
---|---|
HP:0000007 | Autosomal recessive inheritance |
HP:0000708 | Atypical behavior |
HP:0000737 | Irritability |
HP:0000752 | Hyperactivity |
HP:0001249 | Intellectual disability |
HP:0001250 | Seizure |
HP:0001263 | Global developmental delay |
HP:0001272 | Cerebellar atrophy |
HP:0001396 | Cholestasis |
HP:0001413 | Micronodular cirrhosis |
HP:0001987 | Hyperammonemia |
HP:0002013 | Vomiting |
HP:0002039 | Anorexia |
HP:0002064 | Spastic gait |
HP:0002167 | Abnormality of speech or vocalization |
HP:0002240 | Hepatomegaly |
HP:0002313 | Spastic paraparesis |
HP:0002353 | EEG abnormality |
HP:0002359 | Frequent falls |
HP:0002478 | Progressive spastic quadriplegia |
HP:0002572 | Episodic vomiting |
HP:0003218 | Oroticaciduria |
HP:0003623 | Neonatal onset |
HP:0004374 | Hemiplegia/hemiparesis |
HP:0006580 | Portal fibrosis |
HP:0008339 | Diaminoaciduria |
HP:0008897 | Postnatal growth retardation |
HP:0010864 | Intellectual disability, severe |
HP:0011463 | Childhood onset |
HP:0500153 | Hyperargininemia |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
hyperargininemia | MONDO:0008814 | E72 | chapter4, Endocrine, nutritional and metabolic diseases | OMIM:207800 | Orphanet:90 |