Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
1.14.14.19
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor;
steroid 17α-monooxygenase
1.14.14.32
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor;
17α-hydroxyprogesterone deacetylase
PDB | Resolution (Å) | PDB name |
---|---|---|
3RUK | 2.6 | Human Cytochrome P450 CYP17A1 in complex with Abiraterone |
3SWZ | 2.4 | Human Cytochrome P450 17A1 in complex with TOK-001 |
4NKV | 2.646 | Human steroidogenic cytochrome P450 17A1 mutant A105L with inhibitor abiraterone |
4NKW | 2.5 | Human steroidogenic cytochrome P450 17A1 mutant A105L with substrate pregnenolone |
4NKX | 2.794 | Human steroidogenic cytochrome P450 17A1 mutant A105L with substrate progesterone |
4NKY | 2.55 | Human steroidogenic cytochrome P450 17A1 mutant A105L with substrate 17alpha-hydroxyprogesterone |
4NKZ | 3.003 | Human steroidogenic cytochrome P450 17A1 mutant A105L with substrate 17alpha-hydroxypregnenolone |
5IRQ | 2.202 | Human cytochrome P450 17A1 bound to inhibitors (R)- and (S)- orteronel |
5IRV | 3.098 | Human cytochrome P450 17A1 bound to inhibitor VT-464 |
5UYS | 2.392 | Human steroidogenic cytochrome P450 17A1 with 3alphaOH-5alpha-abiraterone analog |
6CHI | 2.698 | Human Cytochrome P450 17A1 in complex with inhibitor: abiraterone C6 amide |
6CIR | 2.648 | Human Cytochrome P450 17A1 in complex with inhibitor: abiraterone C6 oxime |
6CIZ | 2.601 | Human Cytochrome P450 17A1 in complex with inhibitor: abiraterone C6 nitrile |
6WR0 | 2.7 | Human steroidogenic cytochrome P450 17A1 with 3-keto-delta4-abiraterone analog |
6WR1 | 1.85 | Human steroidogenic cytochrome P450 17A1 mutant N52Y with inhibitor abiraterone |
6WW0 | 2.01 | Human steroidogenic cytochrome P450 17A1 with 3-keto-5alpha-abiraterone analog |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006702 | androgen biosynthetic process |
Biological Process | GO:0006704 | glucocorticoid biosynthetic process |
Biological Process | GO:0042446 | hormone biosynthetic process |
Biological Process | GO:0042448 | progesterone metabolic process |
Biological Process | GO:0007548 | sex differentiation |
Biological Process | GO:0006694 | steroid biosynthetic process |
Biological Process | GO:0008202 | steroid metabolic process |
Molecular Function | GO:0047442 | 17-alpha-hydroxyprogesterone aldolase activity |
Molecular Function | GO:0020037 | heme binding |
Molecular Function | GO:0005506 | iron ion binding |
Molecular Function | GO:0019825 | oxygen binding |
Molecular Function | GO:0004508 | steroid 17-alpha-monooxygenase activity |
Cellular Component | GO:0030424 | axon |
Cellular Component | GO:0005783 | endoplasmic reticulum |
Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
Cellular Component | GO:0043025 | neuronal cell body |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-193048 | Androgen biosynthesis | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-194002 | Glucocorticoid biosynthesis | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-5579028 | Defective CYP17A1 causes AH5 | Leaf | R-HSA-1643685 | Disease |
Location | ECO term | Pubmed |
---|---|---|
Endoplasmic reticulum membrane | ECO:0000305 | PubMed:2808364 |
Microsome membrane | ECO:0000305 | PubMed:2808364 |
HPO ID | HPO name |
---|---|
HP:0000007 | Autosomal recessive inheritance |
HP:0000013 | Hypoplasia of the uterus |
HP:0000026 | Male hypogonadism |
HP:0000028 | Cryptorchidism |
HP:0000033 | Ambiguous genitalia, male |
HP:0000037 | Male pseudohermaphroditism |
HP:0000047 | Hypospadias |
HP:0000048 | Bifid scrotum |
HP:0000054 | Micropenis |
HP:0000062 | Ambiguous genitalia |
HP:0000138 | Ovarian cyst |
HP:0000144 | Decreased fertility |
HP:0000147 | Polycystic ovaries |
HP:0000151 | Aplasia of the uterus |
HP:0000771 | Gynecomastia |
HP:0000786 | Primary amenorrhea |
HP:0000815 | Hypergonadotropic hypogonadism |
HP:0000822 | Hypertension |
HP:0000823 | Delayed puberty |
HP:0000837 | Increased circulating gonadotropin level |
HP:0000840 | Adrenogenital syndrome |
HP:0000858 | Irregular menstruation |
HP:0000868 | Decreased fertility in females |
HP:0000939 | Osteoporosis |
HP:0001508 | Failure to thrive |
HP:0001949 | Hypokalemic alkalosis |
HP:0002215 | Sparse axillary hair |
HP:0002221 | Absent axillary hair |
HP:0002225 | Sparse pubic hair |
HP:0002231 | Sparse body hair |
HP:0002555 | Absent pubic hair |
HP:0002750 | Delayed skeletal maturation |
HP:0002900 | Hypokalemia |
HP:0003251 | Male infertility |
HP:0003351 | Decreased circulating renin level |
HP:0003394 | Muscle spasm |
HP:0004319 | Decreased circulating aldosterone level |
HP:0004322 | Short stature |
HP:0004349 | Reduced bone mineral density |
HP:0008163 | Decreased circulating cortisol level |
HP:0008187 | Absence of secondary sex characteristics |
HP:0008193 | Primary gonadal insufficiency |
HP:0008197 | Absence of pubertal development |
HP:0008207 | Primary adrenal insufficiency |
HP:0008214 | Decreased serum estradiol |
HP:0008221 | Adrenal hyperplasia |
HP:0008232 | Elevated circulating follicle stimulating hormone level |
HP:0008258 | Congenital adrenal hyperplasia |
HP:0008675 | Enlarged polycystic ovaries |
HP:0008689 | Bilateral cryptorchidism |
HP:0008726 | Hypoplasia of the vagina |
HP:0008730 | Female external genitalia in individual with 46,XY karyotype |
HP:0008734 | Decreased testicular size |
HP:0010465 | Precocious puberty in females |
HP:0011749 | Adrenocorticotropic hormone excess |
HP:0011969 | Elevated circulating luteinizing hormone level |
HP:0012041 | Decreased fertility in males |
HP:0012112 | Abnormal circulating corticosterone level |
HP:0012244 | Abnormal sex determination |
HP:0030349 | Decreased circulating androgen concentration |
HP:0031074 | Abnormal response to ACTH stimulation test |
HP:0031216 | Increased circulating progesterone |
HP:0032330 | Increased urinary 11-deoxycorticosterone level |
HP:0032362 | Increased circulating corticosterone level |
HP:0040171 | Decreased serum testosterone concentration |
HP:0040314 | Blind vagina |
HP:0100607 | Dysmenorrhea |
HP:0500022 | Abnormal circulating dehydroepiandrosterone concentration |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
primary ovarian failure | MONDO:0005387 | E28 | chapter4, Endocrine, nutritional and metabolic diseases | Orphanet:619 | |
46,xy disorder of sex development due to isolated 17,20-lyase deficiency | MONDO:0019597 | E29 | chapter4, Endocrine, nutritional and metabolic diseases | Orphanet:90796 |