MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1MR8	1.9	MIGRATION INHIBITORY FACTOR-RELATED PROTEIN 8 FROM HUMAN
1XK4	1.8	Crystal structure of human calprotectin(S100A8/S100A9)
4GGF	1.6	Crystal structure of Mn2+ bound calprotectin
4XJK	1.76	Crystal structure of Mn(II) Ca(II) Na(I) bound calprotectin
5HLO	2.1	Crystal structure of calcium and zinc-bound human S100A8 in space group C2221
5HLV	2.2	Crystal structure of calcium and zinc-bound human S100A8 in space group P212121
5W1F	2.6	Crystal structure of Ni(II)- and Ca(II)-bound human calprotectin
6DS2	2.1	Crystal structure of Ni(II)-bound human calprotectin
7QUV	1.85	Crystal structure of human Calprotectin (S100A8/S100A9) in complex with Peptide 3

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process	GO:0002526	acute inflammatory response
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0014002	astrocyte development
Biological Process	GO:0035425	autocrine signaling
Biological Process	GO:0006914	autophagy
Biological Process	GO:0002544	chronic inflammatory response
Biological Process	GO:0042742	defense response to bacterium
Biological Process	GO:0050832	defense response to fungus
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0045087	innate immune response
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response
Biological Process	GO:0070488	neutrophil aggregation
Biological Process	GO:0030593	neutrophil chemotaxis
Biological Process	GO:0002790	peptide secretion
Biological Process	GO:0018119	peptidyl-cysteine S-nitrosylation
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity
Biological Process	GO:0030307	positive regulation of cell growth
Biological Process	GO:0050729	positive regulation of inflammatory response
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway
Biological Process	GO:0002793	positive regulation of peptide secretion
Biological Process	GO:0051493	regulation of cytoskeleton organization
Biological Process	GO:0045471	response to ethanol
Biological Process	GO:0032496	response to lipopolysaccharide
Biological Process	GO:0010043	response to zinc ion
Biological Process	GO:0032119	sequestering of zinc ion
Biological Process	GO:0042060	wound healing
Molecular Function	GO:0050786	RAGE receptor binding
Molecular Function	GO:0035662	Toll-like receptor 4 binding
Molecular Function	GO:0050544	arachidonic acid binding
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0008017	microtubule binding
Molecular Function	GO:0008270	zinc ion binding
Cellular Component	GO:0062023	collagen-containing extracellular matrix
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0045111	intermediate filament cytoskeleton
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0034774	secretory granule lumen

InterPro / Pfam

InterPro	InterPro name
IPR001751	S100/Calcium binding protein 7/8-like, conserved site
IPR002048	EF-hand domain
IPR011992	EF-hand domain pair
IPR013787	S100/CaBP-9k-type, calcium binding, subdomain
IPR018247	EF-Hand 1, calcium-binding site

Pfam	Pfam name
PF01023	S-100/ICaBP type calcium binding domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1236974	ER-Phagosome pathway	Leaf	R-HSA-168256	Immune System
R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	Internal node	R-HSA-168256	Immune System
R-HSA-5602498	MyD88 deficiency (TLR2/4)	Leaf	R-HSA-1643685	Disease
R-HSA-5603041	IRAK4 deficiency (TLR2/4)	Leaf	R-HSA-1643685	Disease
R-HSA-5668599	RHO GTPases Activate NADPH Oxidases	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5686938	Regulation of TLR by endogenous ligand	Leaf	R-HSA-168256	Immune System
R-HSA-6798695	Neutrophil degranulation	Leaf	R-HSA-168256	Immune System
R-HSA-6799990	Metal sequestration by antimicrobial proteins	Leaf	R-HSA-168256	Immune System

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
appendix	lymphoid tissue	Medium	Enhanced
bone marrow	hematopoietic cells	High	Enhanced
cervix	squamous epithelial cells	Medium	Enhanced
esophagus	squamous epithelial cells	High	Enhanced
lymph node	non-germinal center cells	Medium	Enhanced
oral mucosa	squamous epithelial cells	High	Enhanced
skin 2	cells in basal layer	Low	Enhanced
skin 2	cells in corneal layer	Medium	Enhanced
skin 2	cells in granular layer	High	Enhanced
skin 2	cells in spinous layer	High	Enhanced
skin 2	fibrohistiocytic cells	High	Enhanced
skin 2	langerhans cells	High	Enhanced
spleen	cells in red pulp	Medium	Enhanced
tonsil	squamous epithelial cells	High	Enhanced
vagina	squamous epithelial cells	High	Enhanced

Location	ECO term	Pubmed
Cell membrane
Cytoplasm
Cytoplasm, cytoskeleton
Secreted

Summary of P05109

Gene: S100A8, CAGA, CFAG, MRP8
Protein: Protein S100-A8

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P05109

Gene: S100A8, CAGA, CFAG, MRP8 Protein: Protein S100-A8

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: S100A8, CAGA, CFAG, MRP8
Protein: Protein S100-A8