MultifacetedProtDB - Bologna Biocomputing Group

Structure

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006325	chromatin organization
Biological Process	GO:0032786	positive regulation of DNA-templated transcription, elongation
Biological Process	GO:1901666	positive regulation of NAD+ ADP-ribosyltransferase activity
Biological Process	GO:0048597	post-embryonic camera-type eye morphogenesis
Biological Process	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair
Biological Process	GO:0040034	regulation of development, heterochronic
Biological Process	GO:0050678	regulation of epithelial cell proliferation
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0010224	response to UV-B
Biological Process	GO:0010225	response to UV-C
Biological Process	GO:0006283	transcription-coupled nucleotide-excision repair
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0031492	nucleosomal DNA binding
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0001674	female germ cell nucleus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus

InterPro	InterPro name
IPR000079	High mobility group protein HMGN

Pfam	Pfam name
PF01101	HMG14 and HMG17

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	Leaf	R-HSA-73894	DNA Repair
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	Internal node	R-HSA-73894	DNA Repair
R-HSA-6782135	Dual incision in TC-NER	Leaf	R-HSA-73894	DNA Repair
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	Leaf	R-HSA-73894	DNA Repair

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	High	Supported
adrenal gland	glandular cells	High	Supported
appendix	endocrine cells	High	Supported
appendix	enterocytes	High	Supported
appendix	germinal center cells	Low	Supported
appendix	goblet cells	High	Supported
appendix	non-germinal center cells	High	Supported
bone marrow	hematopoietic cells	High	Supported
breast	adipocytes	High	Supported
breast	glandular cells	Medium	Supported
breast	myoepithelial cells	Low	Supported
bronchus	respiratory epithelial cells	High	Supported
caudate	glial cells	High	Supported
caudate	neuronal cells	Low	Supported
cerebellum	cells in granular layer	High	Supported
cerebellum	cells in molecular layer	High	Supported
cerebral cortex	endothelial cells	Medium	Supported
cerebral cortex	glial cells	High	Supported
cervix	glandular cells	High	Supported
cervix	squamous epithelial cells	High	Supported
colon	endocrine cells	High	Supported
colon	endothelial cells	High	Supported
colon	enterocytes	High	Supported
colon	fibroblasts	High	Supported
colon	goblet cells	High	Supported
colon	mucosal lymphoid cells	High	Supported
colon	peripheral nerve/ganglion	High	Supported
duodenum	endocrine cells	High	Supported
duodenum	enterocytes	High	Supported
duodenum	glands of Brunner	High	Supported
duodenum	goblet cells	High	Supported
duodenum	paneth cells	High	Supported
endometrium 1	cells in endometrial stroma	High	Supported
endometrium 1	glandular cells	High	Supported
endometrium 2	cells in endometrial stroma	High	Supported
endometrium 2	glandular cells	High	Supported
epididymis	glandular cells	High	Supported
esophagus	squamous epithelial cells	High	Supported
fallopian tube	glandular cells	High	Supported
gallbladder	glandular cells	High	Supported
hippocampus	glial cells	High	Supported
kidney	cells in glomeruli	High	Supported
kidney	cells in tubules	High	Supported
liver	cholangiocytes	High	Supported
liver	hepatocytes	High	Supported
lung	alveolar cells type I	High	Supported
lung	alveolar cells type II	High	Supported
lung	endothelial cells	Medium	Supported
lung	macrophages	High	Supported
lymph node	germinal center cells	High	Supported
lymph node	non-germinal center cells	High	Supported
nasopharynx	respiratory epithelial cells	High	Supported
oral mucosa	squamous epithelial cells	High	Supported
ovary	follicle cells	High	Supported
ovary	ovarian stroma cells	High	Supported
pancreas	exocrine glandular cells	High	Supported
pancreas	pancreatic endocrine cells	High	Supported
parathyroid gland	glandular cells	High	Supported
placenta	decidual cells	High	Supported
placenta	trophoblastic cells	High	Supported
prostate	glandular cells	High	Supported
rectum	endocrine cells	High	Supported
rectum	endothelial cells	High	Supported
rectum	enterocytes	High	Supported
rectum	fibroblasts	High	Supported
rectum	goblet cells	High	Supported
rectum	mucosal lymphoid cells	High	Supported
salivary gland	glandular cells	High	Supported
seminal vesicle	glandular cells	High	Supported
skin 1	cells in basal layer	Medium	Supported
skin 1	cells in granular layer	High	Supported
skin 1	cells in spinous layer	High	Supported
skin 1	endothelial cells	High	Supported
skin 1	fibrohistiocytic cells	High	Supported
skin 1	langerhans cells	High	Supported
skin 1	lymphocytes	High	Supported
skin 1	melanocytes	Low	Supported
skin 1	vascular mural cells	High	Supported
skin 2	cells in basal layer	Medium	Supported
skin 2	cells in granular layer	High	Supported
skin 2	cells in spinous layer	High	Supported
skin 2	endothelial cells	High	Supported
skin 2	fibrohistiocytic cells	High	Supported
skin 2	langerhans cells	High	Supported
skin 2	lymphocytes	High	Supported
skin 2	melanocytes	Low	Supported
skin 2	vascular mural cells	High	Supported
small intestine	endocrine cells	High	Supported
small intestine	enterocytes	High	Supported
small intestine	goblet cells	High	Supported
small intestine	paneth cells	High	Supported
smooth muscle	smooth muscle cells	High	Supported
soft tissue 1	fibroblasts	High	Supported
soft tissue 1	peripheral nerve	High	Supported
soft tissue 2	fibroblasts	High	Supported
soft tissue 2	peripheral nerve	High	Supported
spleen	cells in red pulp	High	Supported
spleen	cells in white pulp	High	Supported
stomach 1	glandular cells	High	Supported
stomach 2	glandular cells	High	Supported
testis	Leydig cells	High	Supported
testis	peritubular cells	High	Supported
testis	sertoli cells	High	Supported
thyroid gland	glandular cells	High	Supported
tonsil	germinal center cells	High	Supported
tonsil	non-germinal center cells	High	Supported
tonsil	squamous epithelial cells	High	Supported
urinary bladder	urothelial cells	High	Supported
vagina	squamous epithelial cells	High	Supported

Location	ECO term	Pubmed
Cytoplasm
Nucleus
The RNA edited version localizes to the nucleus

Summary of P05114

Gene: HMGN1, HMG14
Protein: Non-histone chromosomal protein HMG-14

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P05114

Gene: HMGN1, HMG14 Protein: Non-histone chromosomal protein HMG-14

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: HMGN1, HMG14
Protein: Non-histone chromosomal protein HMG-14