MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
1.14.14.1	Oxidoreductases; Acting on paired donors, with incorporation or reduction of molecular oxygen; With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor; unspecific monooxygenase
4.2.1.152	Lyases; Carbon-oxygen lyases; Hydro-lyases; hydroperoxy icosatetraenoate dehydratase

Structure

PDB	Resolution (Å)	PDB name
2HI4	1.95	Crystal Structure of Human Microsomal P450 1A2 in complex with alpha-naphthoflavone

GO term

GO ontology	GO term	GO description
Biological Process	GO:0046222	aflatoxin metabolic process
Biological Process	GO:0009820	alkaloid metabolic process
Biological Process	GO:0045333	cellular respiration
Biological Process	GO:0071276	cellular response to cadmium ion
Biological Process	GO:0008203	cholesterol metabolic process
Biological Process	GO:0018894	dibenzo-p-dioxin metabolic process
Biological Process	GO:0019373	epoxygenase P450 pathway
Biological Process	GO:0008210	estrogen metabolic process
Biological Process	GO:0046483	heterocycle metabolic process
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process
Biological Process	GO:0042759	long-chain fatty acid biosynthetic process
Biological Process	GO:0030324	lung development
Biological Process	GO:0032259	methylation
Biological Process	GO:0032787	monocarboxylic acid metabolic process
Biological Process	GO:0016098	monoterpenoid metabolic process
Biological Process	GO:0097267	omega-hydroxylase P450 pathway
Biological Process	GO:0070989	oxidative demethylation
Biological Process	GO:0006778	porphyrin-containing compound metabolic process
Biological Process	GO:0009791	post-embryonic development
Biological Process	GO:0010468	regulation of gene expression
Biological Process	GO:0042572	retinol metabolic process
Biological Process	GO:0006706	steroid catabolic process
Biological Process	GO:0009403	toxin biosynthetic process
Biological Process	GO:0042178	xenobiotic catabolic process
Biological Process	GO:0006805	xenobiotic metabolic process
Molecular Function	GO:0070330	aromatase activity
Molecular Function	GO:0034875	caffeine oxidase activity
Molecular Function	GO:0032451	demethylase activity
Molecular Function	GO:0009055	electron transfer activity
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0101020	estrogen 16-alpha-hydroxylase activity
Molecular Function	GO:0101021	estrogen 2-hydroxylase activity
Molecular Function	GO:0020037	heme binding
Molecular Function	GO:0106256	hydroperoxy icosatetraenoate dehydratase activity
Molecular Function	GO:0005506	iron ion binding
Molecular Function	GO:0004497	monooxygenase activity
Molecular Function	GO:0016491	oxidoreductase activity
Molecular Function	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0043231	intracellular membrane-bounded organelle

InterPro	InterPro name
IPR001128	Cytochrome P450
IPR002401	Cytochrome P450, E-class, group I
IPR008066	Cytochrome P450, E-class, group I, CYP1
IPR017972	Cytochrome P450, conserved site
IPR036396	Cytochrome P450 superfamily

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-156581	Methylation	Leaf	R-HSA-1430728	Metabolism
R-HSA-211957	Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2	Leaf	R-HSA-1430728	Metabolism
R-HSA-2142670	Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	Leaf	R-HSA-1430728	Metabolism
R-HSA-2142816	Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	Leaf	R-HSA-1430728	Metabolism
R-HSA-5423646	Aflatoxin activation and detoxification	Leaf	R-HSA-1430728	Metabolism
R-HSA-9018681	Biosynthesis of protectins	Leaf	R-HSA-1430728	Metabolism
R-HSA-9027307	Biosynthesis of maresin-like SPMs	Leaf	R-HSA-1430728	Metabolism

Location	ECO term	Pubmed
Endoplasmic reticulum membrane
Microsome membrane	ECO:0000269	PubMed:21576599

Summary of P05177

Gene: CYP1A2
Protein: Cytochrome P450 1A2

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P05177

Gene: CYP1A2 Protein: Cytochrome P450 1A2

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: CYP1A2
Protein: Cytochrome P450 1A2